Blackwater Fever (BWF): About a Case in the Intensive Care Unit of the Hospital University Centre Souro-Sanou in Bobo-Dioulasso, Burkina Faso

Barro Sie Drissa; Traore Ibrahim Alain; Sawadogo Appolinaire; Ki Kelan Bertille; Kamboule Bebard Euloges; Rouamba Alexis; Bayala Bale

doi:doi:10.11648/j.jdmp.20160201.12

Blackwater Fever (BWF): About a Case in the Intensive Care Unit of the Hospital University Centre Souro-Sanou in Bobo-Dioulasso, Burkina Faso

Barro Sie Drissa, Traore Ibrahim Alain, Sawadogo Appolinaire, Ki Kelan Bertille, Kamboule Bebard Euloges, Rouamba Alexis, Bayala Bale

Published in Journal of Diseases and Medicinal Plants (Volume 2, Issue 1)

Received: 6 January 2016 Accepted: 21 January 2016 Published: 19 February 2016

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Abstract

Intravascular hemolysis, particularly blackwater fever is a rare but severe clinical syndrome, occurring after ingestion of antimalarials. Diagnosis relies on clinical symptoms and on the color of the urines. A resurgence of this affection which occurred frequently during the colonization has lately been noticed. We report a case of blackwater fever complicated with severe renal failure and severe acute hemolysis having evolved favorably with modest resuscitation means. A 16 year teenager from Burkina Faso, who regularly takes quinine to treat malaria presumptive access, presented the waning of an undocumented malaria, fever, consciousness disorders, anemia, jaundice and blackish urine. The thick drop, blood cultures and urine cultures were negative. Biology revealed leukocytosis 14,000/mm³, anemia in 6.5 g/dL, total bilirubin 80 μmol/L and kidney failure at 13 mmol/L of azotemia and 700 μmol/L creatinine. The evolution was favorable after a modest resuscitation. Blackwater fever still exists in our daily practice. We need to think about in front of sudden onset of hemolysis and acute renal failure with dark-red colored urine during treatment of malaria. We are facing an issue thus a rational use of antimalarials is necessary.

Published in	Journal of Diseases and Medicinal Plants (Volume 2, Issue 1)
DOI	10.11648/j.jdmp.20160201.12
Page(s)	5-7
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Blackwater Fever, Malaria, Hemoglobinuria, Quinine

References

[1]	F Bruneel, B Gachot, M Wolff, JP Bedos, B Regnier, M Damis, F Vachon. Blackwater fever. Presse Med. 2002; 31 (28): 1329-34.
[2]	A Thiongane, AA Ndongo, PM Faye, A Sylla, Y Kéïta, D Boiro, I Basse, NR Diagne-Guèye, O Ndiaye. Blackwater fever of late apparition: about one case in CHU of Dakar. The Pan African Medical Journal. 2015; 22: 301.
[3]	AA Oumar, B Poudiougou, M Sylla, A Sall, S Konate, B Togo, M Diakite, MM Keita. Blackwater fever in children during cerebral malaria: 3 case-report in Bamako. Pediatr Arch. 2007; 14(8): 993-5.
[4]	F Bruneel, B Gachot, M Wolff, B Regnier, M Danis, F Vachon. Resurgence of black water fever in long-term European expatriates in Africa: report of 21 cases and review. Clin Infect Dis. 2001; 32(8): 1133-40.
[5]	M Danis, JP Nozais, L Paris, C Robert, C Katlama, M Gentilini, C Raynaud de Lage. Blackwater fever after taking mefloquine. Three observations. Presse Med 1993; 22 (2): 80.
[6]	C Delacollette, L Isabella, C Atzori, A Cargnel. Blackwater fever after-halofantrine. Lancet 1996; 347: 1408-1409.
[7]	MA Bouldouyre, D Dia, T Carmoi, K Ba Fall, B Chevalier, JM Debonne. A Blackwater fever of medium gravity. Med Mal Infect. 2006; 36(6): 343-345.
[8]	A Djibo A-Sunna Adamou, S Brah Bouzou. Blackwater fever in adults with sickle cell disease about two deaths. Med Trop 2000; 60: 156-158.
[9]	EWC Nacoulma, H Tieno, R Traoré, C Ouédraogo, A Lengani, J Drabo. Blackwater fever of the service in the internal medicine Centre Hospitaler National Yalgado Ouédraogo of Ouagadougou. Med Afr Noire. 2004; 51: 575-578.
[10]	LE Assi, Y Brouh, J Sissokho, AA Amonkou, B Vilasco, A Gnionsahe, DS Coffi. Blackwater fever: clinical, paraclinical, therapeutic and evolving aspects: about 13 cases in Abidjan. Med Afr Noire. 1999; 46(10): 451-3.
[11]	TH Daubrey-Potey, H Die-Kacou, M Kamagate, M Vamy, E Balayssac, JC Yavo. Blackwater fever during antimalarial treatment in Abidjan: 41 cases report. Bull Soc Pathol Exot. 2004; 97(5): 325-8.
[12]	C Lon, M Spring, S Sok, S Chann, R Bun, M Ittiverakul, N Buathong, K Thay, N Kong, Y You, W Kuntawunginn, C A Lanteri, D L Saunders. Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine. Malar J. 2014; 13(1): 96-9.
[13]	World Health Organization. Severe and complicated malaria. Trans R Soc Trop Med Hyg 1990; 84 (suppl. 2): 1-64.
[14]	O Lesieur, P Dudeffant, B Courtriade, P Haglund. Blackwater fever: a fatal case. Intensive Care Med 1997; 23: 1188.
[15]	TH Tran, NP Day, LV Chuong, NTH Mai, PP Loc, NH Phu, DB Bethell, DX Sinh, TT Hien, NJ White. Blackwater fever in southern Vietnam: a prospective descriptive study of 50 cases. Clin Infect Dis 1996; 23: 1274-1278.
[16]	F Gobbi, S Audagnotto, L Trentini, I Nkurunziza, M Corachan, G Di Perri. Blackwater fever in children, Burundi. Emerg Infect Dis. 2005; 11(7): 1118-20.
[17]	A O'Donnell, DJ Weatherall, AM Taylor, JC Reeder, SJ Allen. Muscle cell injury, haemolysis and dark urine children with falciparum malaria in Papua New Guinea. Trans R Soc Trop Med Hyg. 2006, 100(9): 817-25.
[18]	JM Bodi, CN Nsibu, RL Longenge, MN Aloni, PZ Akilimali, PM Tshibassu, PK Kayembe, A H Omar, K Hirayama, J Verhaegen. Blackwater fever in Congolese children: a report of clinical, laboratory features and risk factors. Malar J. 2013; 12(1): 205-10.

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APA Style

Barro Sie Drissa, Traore Ibrahim Alain, Sawadogo Appolinaire, Ki Kelan Bertille, Kamboule Bebard Euloges, et al. (2016). Blackwater Fever (BWF): About a Case in the Intensive Care Unit of the Hospital University Centre Souro-Sanou in Bobo-Dioulasso, Burkina Faso. Journal of Diseases and Medicinal Plants, 2(1), 5-7. https://doi.org/10.11648/j.jdmp.20160201.12

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ACS Style

Barro Sie Drissa; Traore Ibrahim Alain; Sawadogo Appolinaire; Ki Kelan Bertille; Kamboule Bebard Euloges, et al. Blackwater Fever (BWF): About a Case in the Intensive Care Unit of the Hospital University Centre Souro-Sanou in Bobo-Dioulasso, Burkina Faso. J. Dis. Med. Plants 2016, 2(1), 5-7. doi: 10.11648/j.jdmp.20160201.12

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AMA Style

Barro Sie Drissa, Traore Ibrahim Alain, Sawadogo Appolinaire, Ki Kelan Bertille, Kamboule Bebard Euloges, et al. Blackwater Fever (BWF): About a Case in the Intensive Care Unit of the Hospital University Centre Souro-Sanou in Bobo-Dioulasso, Burkina Faso. J Dis Med Plants. 2016;2(1):5-7. doi: 10.11648/j.jdmp.20160201.12

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@article{10.11648/j.jdmp.20160201.12,
  author = {Barro Sie Drissa and Traore Ibrahim Alain and Sawadogo Appolinaire and Ki Kelan Bertille and Kamboule Bebard Euloges and Rouamba Alexis and Bayala Bale},
  title = {Blackwater Fever (BWF): About a Case in the Intensive Care Unit of the Hospital University Centre Souro-Sanou in Bobo-Dioulasso, Burkina Faso},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {2},
  number = {1},
  pages = {5-7},
  doi = {10.11648/j.jdmp.20160201.12},
  url = {https://doi.org/10.11648/j.jdmp.20160201.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20160201.12},
  abstract = {Intravascular hemolysis, particularly blackwater fever is a rare but severe clinical syndrome, occurring after ingestion of antimalarials. Diagnosis relies on clinical symptoms and on the color of the urines. A resurgence of this affection which occurred frequently during the colonization has lately been noticed. We report a case of blackwater fever complicated with severe renal failure and severe acute hemolysis having evolved favorably with modest resuscitation means. A 16 year teenager from Burkina Faso, who regularly takes quinine to treat malaria presumptive access, presented the waning of an undocumented malaria, fever, consciousness disorders, anemia, jaundice and blackish urine. The thick drop, blood cultures and urine cultures were negative. Biology revealed leukocytosis 14,000/mm3, anemia in 6.5 g/dL, total bilirubin 80 μmol/L and kidney failure at 13 mmol/L of azotemia and 700 μmol/L creatinine. The evolution was favorable after a modest resuscitation. Blackwater fever still exists in our daily practice. We need to think about in front of sudden onset of hemolysis and acute renal failure with dark-red colored urine during treatment of malaria. We are facing an issue thus a rational use of antimalarials is necessary.},
 year = {2016}
}

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TY - JOUR
T1 - Blackwater Fever (BWF): About a Case in the Intensive Care Unit of the Hospital University Centre Souro-Sanou in Bobo-Dioulasso, Burkina Faso
AU - Barro Sie Drissa
AU - Traore Ibrahim Alain
AU - Sawadogo Appolinaire
AU - Ki Kelan Bertille
AU - Kamboule Bebard Euloges
AU - Rouamba Alexis
AU - Bayala Bale
Y1 - 2016/02/19
PY - 2016
N1 - https://doi.org/10.11648/j.jdmp.20160201.12
DO - 10.11648/j.jdmp.20160201.12
T2 - Journal of Diseases and Medicinal Plants
JF - Journal of Diseases and Medicinal Plants
JO - Journal of Diseases and Medicinal Plants
SP - 5
EP - 7
PB - Science Publishing Group
SN - 2469-8210
UR - https://doi.org/10.11648/j.jdmp.20160201.12
AB - Intravascular hemolysis, particularly blackwater fever is a rare but severe clinical syndrome, occurring after ingestion of antimalarials. Diagnosis relies on clinical symptoms and on the color of the urines. A resurgence of this affection which occurred frequently during the colonization has lately been noticed. We report a case of blackwater fever complicated with severe renal failure and severe acute hemolysis having evolved favorably with modest resuscitation means. A 16 year teenager from Burkina Faso, who regularly takes quinine to treat malaria presumptive access, presented the waning of an undocumented malaria, fever, consciousness disorders, anemia, jaundice and blackish urine. The thick drop, blood cultures and urine cultures were negative. Biology revealed leukocytosis 14,000/mm3, anemia in 6.5 g/dL, total bilirubin 80 μmol/L and kidney failure at 13 mmol/L of azotemia and 700 μmol/L creatinine. The evolution was favorable after a modest resuscitation. Blackwater fever still exists in our daily practice. We need to think about in front of sudden onset of hemolysis and acute renal failure with dark-red colored urine during treatment of malaria. We are facing an issue thus a rational use of antimalarials is necessary.
VL - 2
IS - 1
ER -

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Author Information

Barro Sie Drissa

Service of Anesthesia and Resuscitation, Departement of Surgery, Souro-Sanou University Hospital Centre of Bobo-Dioulasso, Bobo-Dioulasso, Burkina Faso
Traore Ibrahim Alain

Service of Anesthesia and Resuscitation, Departement of Surgery, Souro-Sanou University Hospital Centre of Bobo-Dioulasso, Bobo-Dioulasso, Burkina Faso
Sawadogo Appolinaire

Department of Medicine, Souro-Sanou University Hospital Centre of Bobo-Dioulasso, Bobo-Dioulasso, Burkina Faso
Ki Kelan Bertille

Service of Anesthesia and Resuscitation, Departement of Surgery, Souro-Sanou University Hospital Centre of Bobo-Dioulasso, Bobo-Dioulasso, Burkina Faso
Kamboule Bebard Euloges

Department of Medicine, Souro-Sanou University Hospital Centre of Bobo-Dioulasso, Bobo-Dioulasso, Burkina Faso
Rouamba Alexis

Service of Anesthesia and Resuscitation, Departement of Surgery, Souro-Sanou University Hospital Centre of Bobo-Dioulasso, Bobo-Dioulasso, Burkina Faso
Bayala Bale

Laboratory of Animal Physiology, Training and Research Unit in Life and Earth Sciences, University of Ouagadougou, Ouagadougou, Burkina Faso

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APA Style

Barro Sie Drissa, Traore Ibrahim Alain, Sawadogo Appolinaire, Ki Kelan Bertille, Kamboule Bebard Euloges, et al. (2016). Blackwater Fever (BWF): About a Case in the Intensive Care Unit of the Hospital University Centre Souro-Sanou in Bobo-Dioulasso, Burkina Faso. Journal of Diseases and Medicinal Plants, 2(1), 5-7. https://doi.org/10.11648/j.jdmp.20160201.12

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ACS Style

Barro Sie Drissa; Traore Ibrahim Alain; Sawadogo Appolinaire; Ki Kelan Bertille; Kamboule Bebard Euloges, et al. Blackwater Fever (BWF): About a Case in the Intensive Care Unit of the Hospital University Centre Souro-Sanou in Bobo-Dioulasso, Burkina Faso. J. Dis. Med. Plants 2016, 2(1), 5-7. doi: 10.11648/j.jdmp.20160201.12

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AMA Style

Barro Sie Drissa, Traore Ibrahim Alain, Sawadogo Appolinaire, Ki Kelan Bertille, Kamboule Bebard Euloges, et al. Blackwater Fever (BWF): About a Case in the Intensive Care Unit of the Hospital University Centre Souro-Sanou in Bobo-Dioulasso, Burkina Faso. J Dis Med Plants. 2016;2(1):5-7. doi: 10.11648/j.jdmp.20160201.12

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@article{10.11648/j.jdmp.20160201.12,
  author = {Barro Sie Drissa and Traore Ibrahim Alain and Sawadogo Appolinaire and Ki Kelan Bertille and Kamboule Bebard Euloges and Rouamba Alexis and Bayala Bale},
  title = {Blackwater Fever (BWF): About a Case in the Intensive Care Unit of the Hospital University Centre Souro-Sanou in Bobo-Dioulasso, Burkina Faso},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {2},
  number = {1},
  pages = {5-7},
  doi = {10.11648/j.jdmp.20160201.12},
  url = {https://doi.org/10.11648/j.jdmp.20160201.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20160201.12},
  abstract = {Intravascular hemolysis, particularly blackwater fever is a rare but severe clinical syndrome, occurring after ingestion of antimalarials. Diagnosis relies on clinical symptoms and on the color of the urines. A resurgence of this affection which occurred frequently during the colonization has lately been noticed. We report a case of blackwater fever complicated with severe renal failure and severe acute hemolysis having evolved favorably with modest resuscitation means. A 16 year teenager from Burkina Faso, who regularly takes quinine to treat malaria presumptive access, presented the waning of an undocumented malaria, fever, consciousness disorders, anemia, jaundice and blackish urine. The thick drop, blood cultures and urine cultures were negative. Biology revealed leukocytosis 14,000/mm3, anemia in 6.5 g/dL, total bilirubin 80 μmol/L and kidney failure at 13 mmol/L of azotemia and 700 μmol/L creatinine. The evolution was favorable after a modest resuscitation. Blackwater fever still exists in our daily practice. We need to think about in front of sudden onset of hemolysis and acute renal failure with dark-red colored urine during treatment of malaria. We are facing an issue thus a rational use of antimalarials is necessary.},
 year = {2016}
}

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