Testicular Dysfunction in Male Rats Reversed by Ethanolic Extract of Pitaya Fruit

Mohammad Kanedi; Sutyarso; Siti Nurjanah; Lilik Koernia Wahidah

doi:doi:10.11648/j.jdmp.20160204.12

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Testicular Dysfunction in Male Rats Reversed by Ethanolic Extract of Pitaya Fruit

Mohammad Kanedi, Sutyarso, Siti Nurjanah, Lilik Koernia Wahidah

Received: 15 July 2016 Accepted: 18 July 2016 Published: 26 August 2016

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Abstract

Sexual disorders have a great impact on men's life, so that is why efforts in searching materials and techniques for the effective treatment of safe and cheap still continued. However, many of the natural material that is claimed efficacious drugs for the high content of bioactive, particularly for sexual disorders, has not been scientifically tested. This study was designed and conducted to ascertain whether the dragon fruit (Hylocereus sp) which is claimed to be efficacious as an antioxidant as well as anti-aging, can be used as a remedy for sexual function disorders and fertility in male rats. Male Sprague-Dawley rats (Rattus novergicus) aged 10 – 12 weeks, grouped in to four consisted of six rats each, treated once daily for 25 days. Group 1 (control) was given 1 ml CMC 1%; group 2 received extract of pitaya fruit at a dose of 500mg/kg; group 3 treated with cyproterone acetate (CPA) at a dose of 25mg/kg; whereas group 4 adminstered with 25mg/kg CPA and 500mg/kg of pitaya fruit extract. CPA treatment effectively reduces serum testosterone while pitaya fruit extract effectively enhances the androgen concentration; increases spermatozoa counts, sperm viability, sperm motility, and spermatid counts. However, pitaya fruit fail to restore the decrease of primary spermatocyte due to CPA induction. So, the conclusion white pitaya fruit extract effectively increase the synthesis of testosterone and play a role spermiogenesis, thus the pitaya fruit herbs can be used as an enhancer of sexual activity and fertility in male.

DOI	10.11648/j.jdmp.20160204.12
Published in	Journal of Diseases and Medicinal Plants (Volume 2, Issue 4, August 2016)
Page(s)	51-55
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Pitaya Fruit, Dragon Fruit, Hylocereus Sp, Antioxidant, Testicular Function, Steroidogenesis

References

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APA Style

Mohammad Kanedi, Sutyarso, Siti Nurjanah, Lilik Koernia Wahidah. (2016). Testicular Dysfunction in Male Rats Reversed by Ethanolic Extract of Pitaya Fruit. Journal of Diseases and Medicinal Plants, 2(4), 51-55. https://doi.org/10.11648/j.jdmp.20160204.12

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ACS Style

Mohammad Kanedi; Sutyarso; Siti Nurjanah; Lilik Koernia Wahidah. Testicular Dysfunction in Male Rats Reversed by Ethanolic Extract of Pitaya Fruit. J. Dis. Med. Plants 2016, 2(4), 51-55. doi: 10.11648/j.jdmp.20160204.12

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AMA Style

Mohammad Kanedi, Sutyarso, Siti Nurjanah, Lilik Koernia Wahidah. Testicular Dysfunction in Male Rats Reversed by Ethanolic Extract of Pitaya Fruit. J Dis Med Plants. 2016;2(4):51-55. doi: 10.11648/j.jdmp.20160204.12

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@article{10.11648/j.jdmp.20160204.12,
  author = {Mohammad Kanedi and Sutyarso and Siti Nurjanah and Lilik Koernia Wahidah},
  title = {Testicular Dysfunction in Male Rats Reversed by Ethanolic Extract of Pitaya Fruit},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {2},
  number = {4},
  pages = {51-55},
  doi = {10.11648/j.jdmp.20160204.12},
  url = {https://doi.org/10.11648/j.jdmp.20160204.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20160204.12},
  abstract = {Sexual disorders have a great impact on men's life, so that is why efforts in searching materials and techniques for the effective treatment of safe and cheap still continued. However, many of the natural material that is claimed efficacious drugs for the high content of bioactive, particularly for sexual disorders, has not been scientifically tested. This study was designed and conducted to ascertain whether the dragon fruit (Hylocereus sp) which is claimed to be efficacious as an antioxidant as well as anti-aging, can be used as a remedy for sexual function disorders and fertility in male rats. Male Sprague-Dawley rats (Rattus novergicus) aged 10 – 12 weeks, grouped in to four consisted of six rats each, treated once daily for 25 days. Group 1 (control) was given 1 ml CMC 1%; group 2 received extract of pitaya fruit at a dose of 500mg/kg; group 3 treated with cyproterone acetate (CPA) at a dose of 25mg/kg; whereas group 4 adminstered with 25mg/kg CPA and 500mg/kg of pitaya fruit extract. CPA treatment effectively reduces serum testosterone while pitaya fruit extract effectively enhances the androgen concentration; increases spermatozoa counts, sperm viability, sperm motility, and spermatid counts. However, pitaya fruit fail to restore the decrease of primary spermatocyte due to CPA induction. So, the conclusion white pitaya fruit extract effectively increase the synthesis of testosterone and play a role spermiogenesis, thus the pitaya fruit herbs can be used as an enhancer of sexual activity and fertility in male.},
 year = {2016}
}

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TY  - JOUR
T1  - Testicular Dysfunction in Male Rats Reversed by Ethanolic Extract of Pitaya Fruit
AU  - Mohammad Kanedi
AU  - Sutyarso
AU  - Siti Nurjanah
AU  - Lilik Koernia Wahidah
Y1  - 2016/08/26
PY  - 2016
N1  - https://doi.org/10.11648/j.jdmp.20160204.12
DO  - 10.11648/j.jdmp.20160204.12
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 51
EP  - 55
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20160204.12
AB  - Sexual disorders have a great impact on men's life, so that is why efforts in searching materials and techniques for the effective treatment of safe and cheap still continued. However, many of the natural material that is claimed efficacious drugs for the high content of bioactive, particularly for sexual disorders, has not been scientifically tested. This study was designed and conducted to ascertain whether the dragon fruit (Hylocereus sp) which is claimed to be efficacious as an antioxidant as well as anti-aging, can be used as a remedy for sexual function disorders and fertility in male rats. Male Sprague-Dawley rats (Rattus novergicus) aged 10 – 12 weeks, grouped in to four consisted of six rats each, treated once daily for 25 days. Group 1 (control) was given 1 ml CMC 1%; group 2 received extract of pitaya fruit at a dose of 500mg/kg; group 3 treated with cyproterone acetate (CPA) at a dose of 25mg/kg; whereas group 4 adminstered with 25mg/kg CPA and 500mg/kg of pitaya fruit extract. CPA treatment effectively reduces serum testosterone while pitaya fruit extract effectively enhances the androgen concentration; increases spermatozoa counts, sperm viability, sperm motility, and spermatid counts. However, pitaya fruit fail to restore the decrease of primary spermatocyte due to CPA induction. So, the conclusion white pitaya fruit extract effectively increase the synthesis of testosterone and play a role spermiogenesis, thus the pitaya fruit herbs can be used as an enhancer of sexual activity and fertility in male.
VL  - 2
IS  - 4
ER  -

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Author Information

Mohammad Kanedi

Department of Biology, Faculty of Mathematics and Sciences, University of Lampung, Bandar Lampung, Indonesia
Sutyarso

Department of Biology, Faculty of Mathematics and Sciences, University of Lampung, Bandar Lampung, Indonesia
Siti Nurjanah

Department of Pharmacy, Faculty of Mathematics and Sciences, Tulang Bawang University, Bandar Lampung, Indonesia
Lilik Koernia Wahidah

Department of Pharmacy, Faculty of Mathematics and Sciences, Tulang Bawang University, Bandar Lampung, Indonesia

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APA Style

Mohammad Kanedi, Sutyarso, Siti Nurjanah, Lilik Koernia Wahidah. (2016). Testicular Dysfunction in Male Rats Reversed by Ethanolic Extract of Pitaya Fruit. Journal of Diseases and Medicinal Plants, 2(4), 51-55. https://doi.org/10.11648/j.jdmp.20160204.12

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ACS Style

Mohammad Kanedi; Sutyarso; Siti Nurjanah; Lilik Koernia Wahidah. Testicular Dysfunction in Male Rats Reversed by Ethanolic Extract of Pitaya Fruit. J. Dis. Med. Plants 2016, 2(4), 51-55. doi: 10.11648/j.jdmp.20160204.12

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AMA Style

Mohammad Kanedi, Sutyarso, Siti Nurjanah, Lilik Koernia Wahidah. Testicular Dysfunction in Male Rats Reversed by Ethanolic Extract of Pitaya Fruit. J Dis Med Plants. 2016;2(4):51-55. doi: 10.11648/j.jdmp.20160204.12

Copy | Download

@article{10.11648/j.jdmp.20160204.12,
  author = {Mohammad Kanedi and Sutyarso and Siti Nurjanah and Lilik Koernia Wahidah},
  title = {Testicular Dysfunction in Male Rats Reversed by Ethanolic Extract of Pitaya Fruit},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {2},
  number = {4},
  pages = {51-55},
  doi = {10.11648/j.jdmp.20160204.12},
  url = {https://doi.org/10.11648/j.jdmp.20160204.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20160204.12},
  abstract = {Sexual disorders have a great impact on men's life, so that is why efforts in searching materials and techniques for the effective treatment of safe and cheap still continued. However, many of the natural material that is claimed efficacious drugs for the high content of bioactive, particularly for sexual disorders, has not been scientifically tested. This study was designed and conducted to ascertain whether the dragon fruit (Hylocereus sp) which is claimed to be efficacious as an antioxidant as well as anti-aging, can be used as a remedy for sexual function disorders and fertility in male rats. Male Sprague-Dawley rats (Rattus novergicus) aged 10 – 12 weeks, grouped in to four consisted of six rats each, treated once daily for 25 days. Group 1 (control) was given 1 ml CMC 1%; group 2 received extract of pitaya fruit at a dose of 500mg/kg; group 3 treated with cyproterone acetate (CPA) at a dose of 25mg/kg; whereas group 4 adminstered with 25mg/kg CPA and 500mg/kg of pitaya fruit extract. CPA treatment effectively reduces serum testosterone while pitaya fruit extract effectively enhances the androgen concentration; increases spermatozoa counts, sperm viability, sperm motility, and spermatid counts. However, pitaya fruit fail to restore the decrease of primary spermatocyte due to CPA induction. So, the conclusion white pitaya fruit extract effectively increase the synthesis of testosterone and play a role spermiogenesis, thus the pitaya fruit herbs can be used as an enhancer of sexual activity and fertility in male.},
 year = {2016}
}

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TY  - JOUR
T1  - Testicular Dysfunction in Male Rats Reversed by Ethanolic Extract of Pitaya Fruit
AU  - Mohammad Kanedi
AU  - Sutyarso
AU  - Siti Nurjanah
AU  - Lilik Koernia Wahidah
Y1  - 2016/08/26
PY  - 2016
N1  - https://doi.org/10.11648/j.jdmp.20160204.12
DO  - 10.11648/j.jdmp.20160204.12
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 51
EP  - 55
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20160204.12
AB  - Sexual disorders have a great impact on men's life, so that is why efforts in searching materials and techniques for the effective treatment of safe and cheap still continued. However, many of the natural material that is claimed efficacious drugs for the high content of bioactive, particularly for sexual disorders, has not been scientifically tested. This study was designed and conducted to ascertain whether the dragon fruit (Hylocereus sp) which is claimed to be efficacious as an antioxidant as well as anti-aging, can be used as a remedy for sexual function disorders and fertility in male rats. Male Sprague-Dawley rats (Rattus novergicus) aged 10 – 12 weeks, grouped in to four consisted of six rats each, treated once daily for 25 days. Group 1 (control) was given 1 ml CMC 1%; group 2 received extract of pitaya fruit at a dose of 500mg/kg; group 3 treated with cyproterone acetate (CPA) at a dose of 25mg/kg; whereas group 4 adminstered with 25mg/kg CPA and 500mg/kg of pitaya fruit extract. CPA treatment effectively reduces serum testosterone while pitaya fruit extract effectively enhances the androgen concentration; increases spermatozoa counts, sperm viability, sperm motility, and spermatid counts. However, pitaya fruit fail to restore the decrease of primary spermatocyte due to CPA induction. So, the conclusion white pitaya fruit extract effectively increase the synthesis of testosterone and play a role spermiogenesis, thus the pitaya fruit herbs can be used as an enhancer of sexual activity and fertility in male.
VL  - 2
IS  - 4
ER  -

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