Phytochemical Screening and Biological Activity Studies of the Extract from the Bark of <i>Ricinodendron heudoletti</i>, Euphorbiaceae

Oyono Victor; Fokunang Charles; Tembe-Fokunang Estella; Tsague Marthe; Messi Angélique; Assam Jean; Ngameni Bethelemy; Kechia Frederick; Armel Herve Nwabo Kamdje; Penlap Veronique; Ngadjui Bonaventure

doi:doi:10.11648/j.jdmp.20160206.14

Phytochemical Screening and Biological Activity Studies of the Extract from the Bark of Ricinodendron heudoletti, Euphorbiaceae

Oyono Victor, Fokunang Charles, Tembe-Fokunang Estella, Tsague Marthe, Messi Angélique, Assam Jean, Ngameni Bethelemy, Kechia Frederick, Armel Herve Nwabo Kamdje, Penlap Veronique, Ngadjui Bonaventure

Published in Journal of Diseases and Medicinal Plants (Volume 2, Issue 6)

Received: 6 July 2016 Accepted: 12 July 2016 Published: 10 January 2017

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

The fractions and pure compounds isolated from the bark of R. heudoletti were tested for their antibacterial properties on negative and positive gram bacteria using the disc diffusion method. Phytochemical analysis of the fractions and pure compound isolated was also conducted. The inhibitions parameters of the fractions and pure compound were determined using macro dilution method. The results showed that fraction and isoflavonoid exhibited a significant antibacterial effect against twelve strains isolated from patients. These micro-organisms were Gram-negative (Escherichia coli, Salmonella typhi, Shigella flexneri, Pseudomonas aeroginosa, Enterobacter cloacae, Klebsiella pneumoniae, Klebsiella oxytoca, Morganella morganii, Citrobacter freundi, and Proteus vulgaris) and positive gram (Staphylococcus aureus, and Streptococcus feacalis). The ratio of minimal bactericidal concentration (MBC) over the minimal inhibitory concentration (MIC) indicated a promising bactericidal effect of fractions and pure compounds isolated. These results support the current common use of the bark of Ricinodendron heudoletti and flavonoids in the treatment of some infectious diseases.

Published in	Journal of Diseases and Medicinal Plants (Volume 2, Issue 6)
DOI	10.11648/j.jdmp.20160206.14
Page(s)	83-89
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Biochemistry Properties, Flavonoids, Infectious Diseases, Ricinodendron heudoletti

References

[1]	Zaharia, V., Ignat, A., Ngameni *, B., Kuete, V., Moungang, L. M., Fokunang, N. C., Vasilescu, M., Palibroda, N., Cristea, C., Dumitrescu, L. S., Bonaventure T. Ngadjui, T. B. (2013): Heterocycles 23. Synthesis, Characterization and Anticancer activity of New Hydrazinoselenazole derivatives. Medicinal Chemistry Research Volume: 22 Issue: 12, 5670-5679.
[2]	Ngameni Bathelemy, Ghislain W. Fotso, Justin Kamga, Pantaleon Ambassa, Tchoukoua Abdou, Aime´ G. Fankam, Igor K. Voukeng, Bonaventure T. Ngadjui, Berhanu M. Abegaz and Victor Kuete, (2013), Chapitre 9: Flavonoids and Related Compounds from the Medicinal Plants of Africa. Edited by Victor Kuete, Elsevier, First edition.
[3]	Awoussong, K. P., Zaharia, V., Ngameni, B., Kuete, V., Ntede, N. H., Abegaz, M. B., Ngadjui, T. B. (2014): Heterocycles 26. Synthesis, characterisation and anticancer activity of some thiazolic chalcones. Medicinal Chemistry Research, DOI: 10.1007/s00044-014-1096-8.
[4]	Ngameni B, G. W. Fotso, E. Ngachussi, H. M. Poumale, B. T. Ngadjui, Yoshihito Shiono, and Tetsuya Murayama (2014): Hemisynthesis and Spectroscopic Characterization of Two Novel Allylated Benzophenones from Garcinia punctata Oliv. (Clusiaceae). Asian Journal of Chemistry; V ol. 26, No. 24, 0000-0000. No 17478.
[5]	Oyono VA 1, Fokunang CN, 1, Assam JP, Voundi S, Tsafack P, Tetwe EM, Ngadjui BT. 2014. Acute toxicity studies, antioxidant and in vitro antibacterial activities of extract from the barks of Ricinodendron heudoletti (Euphorbiaceae). Journal of Pharmacognosy and Phytotherapy Vol. 6 (4), pp. 47-53, DOI: 10.5897/JPP2014.0312, http://www.academicjournals.org/JPP.
[6]	Momeni J, Djoulde RD, Akam MT, Kimbu SF. (2005). Chemical constituents and antibacterial activities of the stem bark extracts of Ricinodendron heudelotii (Euphorbiaceae). Indian J Pharm Sci. 67: 386-399.
[7]	Noumi E. et Yomi A. (2001). Medicinal plants used for intestinal diseases in Mbalmayo Region, Central Province, Cameroon. Fitoterapia, 72: 246-254.
[8]	Adjaouohan, J., Aboubakar, K., Ebot, E., Ekpere, J., Enow, G., Focho, D., Gbile, O., Kamanyi, A., KamsuKom, J., Mbeukeum, T., Mbi, N., Mbiele, L., Mbome, L., Mabiru, K., Nancy, L., Nkongmeneck, B., Satabie, B., Sofowara, A., Tanze, V., Wirmum, C., 1972. Traditionnal medecine and pharmacopoeia contribution to ethnobotanical and floristic studies in Cameroun. Trad. Med. Pharm. CST/OUA. P. 641.
[9]	Eyoh. A., Michel Toukam. M., Gonsu. H., Fokunang. C., Atashili. J,. Lyonga. E., Ikomey. G., Mukwele. B., Mesembe. M., Tsague. N., Mandi. H., Okomo. A., (2013) Antibiotics Susceptibility Profile of Staphylococcus Aureus Isolated from the Anterior Nares of Hospital Personnel in Yaounde, Cameroon. Health Sci. Dis: Vol 14 (2). 17-25.
[10]	Odebiyi. O and Sofowara. E. (1978). Phytochemical screening. Nigeria medical plants. Loydia 41: 231-234.
[11]	Bruneton J. Pharmacognosie, Phytochimie et plantes médicinales. Edition Technique et Documentation-Lavoisier, 3émé édition, Paris 1999: 421-499.
[12]	Lahouel M., 2007. Interaction flavonoides-mithochondrie et rôle de la propolis dans la prévention de l’apopose induite dans certains médicaments anticancereaux: Thèse de Doctorat de l’Université de Mentouri de Constantine 220 p.
[13]	Mangambu JDM, Kasali FM, Kadima JN. Contribution à l’étude phytochimique de quelques plantes médicinales antidiabétiques de la ville de Bukavu et ses environs (Sud-Kivu, R. D. Congo). Journal of Applied Biosciences 2014; 75: 6211– 6220.
[14]	Ngoupayo J, Mawouma NAR, Kwetché FPR, Matchawe C, Ngadjui TB. Phytochemical analysis and in vitro antimicrobial potential of the hydro alcoholic extract from the stem bark of Erythropleum guineensis: test on known resistance phenotypes-expressing strains. Int. J. Appl. Pharm. Biol. Chem. 2015; 4 (3): 719-728.
[15]	Wagner H., Bladt S., 2001. Plant Drug Analysis. A Thin Layer Chromatography Atlas: Springer. New-York: 199-245.
[16]	Nawel H., Ammar R. B., Afef W., Soumaya K., Amor M., Chibani J. B., Mariotte A. M., Ghedria K., Dijoux-Franca M. G., Ghedira L. C. (2005). Antibacterial and antimutagenic activity of extracts and essential oil from (Tunisia). Pistacia lentiscusToxicol Envir Chem, 87 (4): 567-573.
[17]	Ngoupayo J, Ebene NMS, Kasali FM, Mpondo ME. Phytochemical screening and antibacterial properties from extract of Alchornea cordifolia (Schumach. &Thonn.) Müll. Arg. Journal of Pharmacognosy and Phytochemistry 2015; 4 (3): 176-180.
[18]	Suh N, Luyengi L, Fong HHS, Kinghorn AD, Pezzuto J. (1995). Discovery of natural product chemopreventive agents utilizing HL-60 cell differentiation as a model. Anticancer Res 15: 233-9.

Cite This Article

Plain Text BibTeX RIS

APA Style

Oyono Victor, Fokunang Charles, Tembe-Fokunang Estella, Tsague Marthe, Messi Angélique, et al. (2017). Phytochemical Screening and Biological Activity Studies of the Extract from the Bark of Ricinodendron heudoletti, Euphorbiaceae. Journal of Diseases and Medicinal Plants, 2(6), 83-89. https://doi.org/10.11648/j.jdmp.20160206.14

Copy | Download

ACS Style

Oyono Victor; Fokunang Charles; Tembe-Fokunang Estella; Tsague Marthe; Messi Angélique, et al. Phytochemical Screening and Biological Activity Studies of the Extract from the Bark of Ricinodendron heudoletti, Euphorbiaceae. J. Dis. Med. Plants 2017, 2(6), 83-89. doi: 10.11648/j.jdmp.20160206.14

Copy | Download

AMA Style

Oyono Victor, Fokunang Charles, Tembe-Fokunang Estella, Tsague Marthe, Messi Angélique, et al. Phytochemical Screening and Biological Activity Studies of the Extract from the Bark of Ricinodendron heudoletti, Euphorbiaceae. J Dis Med Plants. 2017;2(6):83-89. doi: 10.11648/j.jdmp.20160206.14

Copy | Download

@article{10.11648/j.jdmp.20160206.14,
  author = {Oyono Victor and Fokunang Charles and Tembe-Fokunang Estella and Tsague Marthe and Messi Angélique and Assam Jean and Ngameni Bethelemy and Kechia Frederick and Armel Herve Nwabo Kamdje and Penlap Veronique and Ngadjui Bonaventure},
  title = {Phytochemical Screening and Biological Activity Studies of the Extract from the Bark of Ricinodendron heudoletti, Euphorbiaceae},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {2},
  number = {6},
  pages = {83-89},
  doi = {10.11648/j.jdmp.20160206.14},
  url = {https://doi.org/10.11648/j.jdmp.20160206.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20160206.14},
  abstract = {The fractions and pure compounds isolated from the bark of R. heudoletti were tested for their antibacterial properties on negative and positive gram bacteria using the disc diffusion method. Phytochemical analysis of the fractions and pure compound isolated was also conducted. The inhibitions parameters of the fractions and pure compound were determined using macro dilution method. The results showed that fraction and isoflavonoid exhibited a significant antibacterial effect against twelve strains isolated from patients. These micro-organisms were Gram-negative (Escherichia coli, Salmonella typhi, Shigella flexneri, Pseudomonas aeroginosa, Enterobacter cloacae, Klebsiella pneumoniae, Klebsiella oxytoca, Morganella morganii, Citrobacter freundi, and Proteus vulgaris) and positive gram (Staphylococcus aureus, and Streptococcus feacalis). The ratio of minimal bactericidal concentration (MBC) over the minimal inhibitory concentration (MIC) indicated a promising bactericidal effect of fractions and pure compounds isolated. These results support the current common use of the bark of Ricinodendron heudoletti and flavonoids in the treatment of some infectious diseases.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Phytochemical Screening and Biological Activity Studies of the Extract from the Bark of Ricinodendron heudoletti, Euphorbiaceae
AU  - Oyono Victor
AU  - Fokunang Charles
AU  - Tembe-Fokunang Estella
AU  - Tsague Marthe
AU  - Messi Angélique
AU  - Assam Jean
AU  - Ngameni Bethelemy
AU  - Kechia Frederick
AU  - Armel Herve Nwabo Kamdje
AU  - Penlap Veronique
AU  - Ngadjui Bonaventure
Y1  - 2017/01/10
PY  - 2017
N1  - https://doi.org/10.11648/j.jdmp.20160206.14
DO  - 10.11648/j.jdmp.20160206.14
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 83
EP  - 89
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20160206.14
AB  - The fractions and pure compounds isolated from the bark of R. heudoletti were tested for their antibacterial properties on negative and positive gram bacteria using the disc diffusion method. Phytochemical analysis of the fractions and pure compound isolated was also conducted. The inhibitions parameters of the fractions and pure compound were determined using macro dilution method. The results showed that fraction and isoflavonoid exhibited a significant antibacterial effect against twelve strains isolated from patients. These micro-organisms were Gram-negative (Escherichia coli, Salmonella typhi, Shigella flexneri, Pseudomonas aeroginosa, Enterobacter cloacae, Klebsiella pneumoniae, Klebsiella oxytoca, Morganella morganii, Citrobacter freundi, and Proteus vulgaris) and positive gram (Staphylococcus aureus, and Streptococcus feacalis). The ratio of minimal bactericidal concentration (MBC) over the minimal inhibitory concentration (MIC) indicated a promising bactericidal effect of fractions and pure compounds isolated. These results support the current common use of the bark of Ricinodendron heudoletti and flavonoids in the treatment of some infectious diseases.
VL  - 2
IS  - 6
ER  -

Copy | Download

Author Information

Oyono Victor

Department of Pharmaceutical Sciences and Traditional Pharmacopeia, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon
Fokunang Charles

Department of Pharmaceutical Sciences and Traditional Pharmacopeia, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon; Department of Biological Sciences, Faculty of Sciences, the University of Bamenda, Bamenda, Cameroon
Tembe-Fokunang Estella

Department of Pharmaceutical Sciences and Traditional Pharmacopeia, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon
Tsague Marthe

Department of Pharmaceutical Sciences and Traditional Pharmacopeia, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon
Messi Angélique

Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, Yaounde, Yaounde, Cameroon
Assam Jean

Department of Biochemistry, Faculty of Sciences, University of Douala, Douala, Cameroon
Ngameni Bethelemy

Department of Pharmaceutical Sciences and Traditional Pharmacopeia, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon
Kechia Frederick

Department of Pharmaceutical Sciences and Traditional Pharmacopeia, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon; Department of Biological Sciences, Faculty of Sciences, the University of Bamenda, Bamenda, Cameroon
Armel Herve Nwabo Kamdje

Department of Biological Sciences, University of Ngaoundere, Ngaoundere, Cameroon
Penlap Veronique

Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, Yaounde, Yaounde, Cameroon
Ngadjui Bonaventure

Department of Pharmaceutical Sciences and Traditional Pharmacopeia, Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Oyono Victor, Fokunang Charles, Tembe-Fokunang Estella, Tsague Marthe, Messi Angélique, et al. (2017). Phytochemical Screening and Biological Activity Studies of the Extract from the Bark of Ricinodendron heudoletti, Euphorbiaceae. Journal of Diseases and Medicinal Plants, 2(6), 83-89. https://doi.org/10.11648/j.jdmp.20160206.14

Copy | Download

ACS Style

Oyono Victor; Fokunang Charles; Tembe-Fokunang Estella; Tsague Marthe; Messi Angélique, et al. Phytochemical Screening and Biological Activity Studies of the Extract from the Bark of Ricinodendron heudoletti, Euphorbiaceae. J. Dis. Med. Plants 2017, 2(6), 83-89. doi: 10.11648/j.jdmp.20160206.14

Copy | Download

AMA Style

Oyono Victor, Fokunang Charles, Tembe-Fokunang Estella, Tsague Marthe, Messi Angélique, et al. Phytochemical Screening and Biological Activity Studies of the Extract from the Bark of Ricinodendron heudoletti, Euphorbiaceae. J Dis Med Plants. 2017;2(6):83-89. doi: 10.11648/j.jdmp.20160206.14

Copy | Download

@article{10.11648/j.jdmp.20160206.14,
  author = {Oyono Victor and Fokunang Charles and Tembe-Fokunang Estella and Tsague Marthe and Messi Angélique and Assam Jean and Ngameni Bethelemy and Kechia Frederick and Armel Herve Nwabo Kamdje and Penlap Veronique and Ngadjui Bonaventure},
  title = {Phytochemical Screening and Biological Activity Studies of the Extract from the Bark of Ricinodendron heudoletti, Euphorbiaceae},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {2},
  number = {6},
  pages = {83-89},
  doi = {10.11648/j.jdmp.20160206.14},
  url = {https://doi.org/10.11648/j.jdmp.20160206.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20160206.14},
  abstract = {The fractions and pure compounds isolated from the bark of R. heudoletti were tested for their antibacterial properties on negative and positive gram bacteria using the disc diffusion method. Phytochemical analysis of the fractions and pure compound isolated was also conducted. The inhibitions parameters of the fractions and pure compound were determined using macro dilution method. The results showed that fraction and isoflavonoid exhibited a significant antibacterial effect against twelve strains isolated from patients. These micro-organisms were Gram-negative (Escherichia coli, Salmonella typhi, Shigella flexneri, Pseudomonas aeroginosa, Enterobacter cloacae, Klebsiella pneumoniae, Klebsiella oxytoca, Morganella morganii, Citrobacter freundi, and Proteus vulgaris) and positive gram (Staphylococcus aureus, and Streptococcus feacalis). The ratio of minimal bactericidal concentration (MBC) over the minimal inhibitory concentration (MIC) indicated a promising bactericidal effect of fractions and pure compounds isolated. These results support the current common use of the bark of Ricinodendron heudoletti and flavonoids in the treatment of some infectious diseases.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Phytochemical Screening and Biological Activity Studies of the Extract from the Bark of Ricinodendron heudoletti, Euphorbiaceae
AU  - Oyono Victor
AU  - Fokunang Charles
AU  - Tembe-Fokunang Estella
AU  - Tsague Marthe
AU  - Messi Angélique
AU  - Assam Jean
AU  - Ngameni Bethelemy
AU  - Kechia Frederick
AU  - Armel Herve Nwabo Kamdje
AU  - Penlap Veronique
AU  - Ngadjui Bonaventure
Y1  - 2017/01/10
PY  - 2017
N1  - https://doi.org/10.11648/j.jdmp.20160206.14
DO  - 10.11648/j.jdmp.20160206.14
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 83
EP  - 89
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20160206.14
AB  - The fractions and pure compounds isolated from the bark of R. heudoletti were tested for their antibacterial properties on negative and positive gram bacteria using the disc diffusion method. Phytochemical analysis of the fractions and pure compound isolated was also conducted. The inhibitions parameters of the fractions and pure compound were determined using macro dilution method. The results showed that fraction and isoflavonoid exhibited a significant antibacterial effect against twelve strains isolated from patients. These micro-organisms were Gram-negative (Escherichia coli, Salmonella typhi, Shigella flexneri, Pseudomonas aeroginosa, Enterobacter cloacae, Klebsiella pneumoniae, Klebsiella oxytoca, Morganella morganii, Citrobacter freundi, and Proteus vulgaris) and positive gram (Staphylococcus aureus, and Streptococcus feacalis). The ratio of minimal bactericidal concentration (MBC) over the minimal inhibitory concentration (MIC) indicated a promising bactericidal effect of fractions and pure compounds isolated. These results support the current common use of the bark of Ricinodendron heudoletti and flavonoids in the treatment of some infectious diseases.
VL  - 2
IS  - 6
ER  -

Copy | Download