Role of Aged Garlic Extract Against Radiation Induced Oxidative Stress Associated with Some Biochemical Disorders in Male Albino Rats
Journal of Diseases and Medicinal Plants
Volume 2, Issue 6, December 2016, Pages: 96-116
Received: Oct. 19, 2016; Accepted: Nov. 23, 2016; Published: Jan. 11, 2017
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Kouam Foubi Brice Bertrand, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Chuisseu Djamen Dieudonné Pascal, Faculty of Health Sciences, Université des Montagnes, Bangangté, Bangangté, Cameroon
Dzeufiet Djomeni Paul Désiré, Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon
Mopia Foubi Myriam Arielle, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Samba Ngano Odette, Faculty of Sciences, University of Dschang, Dschang, Cameroon
Mouelle Sone, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
Tiedeu Alain Bertin, National Advanced School of Engineering, University of Yaoundé I, Yaoundé, Cameroon
Gonsu Fotsin Joseph, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon
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This study was conducted to clarify the potential role of AGE against damages induced in rats due to exposure to gamma radiation. Adult male albino rats (214-230g). Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E+Alpha Lipoïc Acid. Blood samples were collected at day 8 post irradiation for biochemical assay. Exposure of rats to gamma radiation caused a significant increase in the level of total cholesterol (TC), triglycerides (TG), LDL-Cholesterol, Malondialdehyde (MDA), Nitrite (NO2-), Creatinine and AST, ALT, ALP and Bilirubin (Total Serum Bilirubin, Direct Bilirubin and Unconjugated Bilirubin)while a significant decrease was recorded in HDL-Cholesterol, serum total proteins, glutathione content (GSH), superoxide dismutase (SOD), catalase (CAT) activities and total protein level in organs tissues. In rats treated with AGE then exposed to radiation, the results showed an improvement in all previous parameters. It could be concluded that AGE might reduce the biological hazards in rats induced by gamma irradiation.
γ-Radiation, Biochemical Disorders, Age, Antioxidant Enzymes, Rats
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Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Mopia Foubi Myriam Arielle, Samba Ngano Odette, Mouelle Sone, Tiedeu Alain Bertin, Gonsu Fotsin Joseph, Role of Aged Garlic Extract Against Radiation Induced Oxidative Stress Associated with Some Biochemical Disorders in Male Albino Rats, Journal of Diseases and Medicinal Plants. Vol. 2, No. 6, 2016, pp. 96-116. doi: 10.11648/j.jdmp.20160206.16
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