Journal of Diseases and Medicinal Plants

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Role of Aged Garlic Extract Against Radiation Induced Oxidative Stress Associated with Some Biochemical Disorders in Male Albino Rats

Received: 19 October 2016    Accepted: 23 November 2016    Published: 11 January 2017
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Abstract

This study was conducted to clarify the potential role of AGE against damages induced in rats due to exposure to gamma radiation. Adult male albino rats (214-230g). Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E+Alpha Lipoïc Acid. Blood samples were collected at day 8 post irradiation for biochemical assay. Exposure of rats to gamma radiation caused a significant increase in the level of total cholesterol (TC), triglycerides (TG), LDL-Cholesterol, Malondialdehyde (MDA), Nitrite (NO2-), Creatinine and AST, ALT, ALP and Bilirubin (Total Serum Bilirubin, Direct Bilirubin and Unconjugated Bilirubin)while a significant decrease was recorded in HDL-Cholesterol, serum total proteins, glutathione content (GSH), superoxide dismutase (SOD), catalase (CAT) activities and total protein level in organs tissues. In rats treated with AGE then exposed to radiation, the results showed an improvement in all previous parameters. It could be concluded that AGE might reduce the biological hazards in rats induced by gamma irradiation.

DOI 10.11648/j.jdmp.20160206.16
Published in Journal of Diseases and Medicinal Plants (Volume 2, Issue 6, December 2016)
Page(s) 96-116
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

γ-Radiation, Biochemical Disorders, Age, Antioxidant Enzymes, Rats

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Author Information
  • Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

  • Faculty of Health Sciences, Université des Montagnes, Bangangté, Bangangté, Cameroon

  • Faculty of Sciences, University of Yaoundé I, Yaoundé, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

  • Faculty of Sciences, University of Dschang, Dschang, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

  • National Advanced School of Engineering, University of Yaoundé I, Yaoundé, Cameroon

  • Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

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    Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Mopia Foubi Myriam Arielle, Samba Ngano Odette, et al. (2017). Role of Aged Garlic Extract Against Radiation Induced Oxidative Stress Associated with Some Biochemical Disorders in Male Albino Rats. Journal of Diseases and Medicinal Plants, 2(6), 96-116. https://doi.org/10.11648/j.jdmp.20160206.16

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    Kouam Foubi Brice Bertrand; Chuisseu Djamen Dieudonné Pascal; Dzeufiet Djomeni Paul Désiré; Mopia Foubi Myriam Arielle; Samba Ngano Odette, et al. Role of Aged Garlic Extract Against Radiation Induced Oxidative Stress Associated with Some Biochemical Disorders in Male Albino Rats. J. Dis. Med. Plants 2017, 2(6), 96-116. doi: 10.11648/j.jdmp.20160206.16

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    Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Mopia Foubi Myriam Arielle, Samba Ngano Odette, et al. Role of Aged Garlic Extract Against Radiation Induced Oxidative Stress Associated with Some Biochemical Disorders in Male Albino Rats. J Dis Med Plants. 2017;2(6):96-116. doi: 10.11648/j.jdmp.20160206.16

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  • @article{10.11648/j.jdmp.20160206.16,
      author = {Kouam Foubi Brice Bertrand and Chuisseu Djamen Dieudonné Pascal and Dzeufiet Djomeni Paul Désiré and Mopia Foubi Myriam Arielle and Samba Ngano Odette and Mouelle Sone and Tiedeu Alain Bertin and Gonsu Fotsin Joseph},
      title = {Role of Aged Garlic Extract Against Radiation Induced Oxidative Stress Associated with Some Biochemical Disorders in Male Albino Rats},
      journal = {Journal of Diseases and Medicinal Plants},
      volume = {2},
      number = {6},
      pages = {96-116},
      doi = {10.11648/j.jdmp.20160206.16},
      url = {https://doi.org/10.11648/j.jdmp.20160206.16},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jdmp.20160206.16},
      abstract = {This study was conducted to clarify the potential role of AGE against damages induced in rats due to exposure to gamma radiation. Adult male albino rats (214-230g). Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E+Alpha Lipoïc Acid. Blood samples were collected at day 8 post irradiation for biochemical assay. Exposure of rats to gamma radiation caused a significant increase in the level of total cholesterol (TC), triglycerides (TG), LDL-Cholesterol, Malondialdehyde (MDA), Nitrite (NO2-), Creatinine and AST, ALT, ALP and Bilirubin (Total Serum Bilirubin, Direct Bilirubin and Unconjugated Bilirubin)while a significant decrease was recorded in HDL-Cholesterol, serum total proteins, glutathione content (GSH), superoxide dismutase (SOD), catalase (CAT) activities and total protein level in organs tissues. In rats treated with AGE then exposed to radiation, the results showed an improvement in all previous parameters. It could be concluded that AGE might reduce the biological hazards in rats induced by gamma irradiation.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Role of Aged Garlic Extract Against Radiation Induced Oxidative Stress Associated with Some Biochemical Disorders in Male Albino Rats
    AU  - Kouam Foubi Brice Bertrand
    AU  - Chuisseu Djamen Dieudonné Pascal
    AU  - Dzeufiet Djomeni Paul Désiré
    AU  - Mopia Foubi Myriam Arielle
    AU  - Samba Ngano Odette
    AU  - Mouelle Sone
    AU  - Tiedeu Alain Bertin
    AU  - Gonsu Fotsin Joseph
    Y1  - 2017/01/11
    PY  - 2017
    N1  - https://doi.org/10.11648/j.jdmp.20160206.16
    DO  - 10.11648/j.jdmp.20160206.16
    T2  - Journal of Diseases and Medicinal Plants
    JF  - Journal of Diseases and Medicinal Plants
    JO  - Journal of Diseases and Medicinal Plants
    SP  - 96
    EP  - 116
    PB  - Science Publishing Group
    SN  - 2469-8210
    UR  - https://doi.org/10.11648/j.jdmp.20160206.16
    AB  - This study was conducted to clarify the potential role of AGE against damages induced in rats due to exposure to gamma radiation. Adult male albino rats (214-230g). Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E+Alpha Lipoïc Acid. Blood samples were collected at day 8 post irradiation for biochemical assay. Exposure of rats to gamma radiation caused a significant increase in the level of total cholesterol (TC), triglycerides (TG), LDL-Cholesterol, Malondialdehyde (MDA), Nitrite (NO2-), Creatinine and AST, ALT, ALP and Bilirubin (Total Serum Bilirubin, Direct Bilirubin and Unconjugated Bilirubin)while a significant decrease was recorded in HDL-Cholesterol, serum total proteins, glutathione content (GSH), superoxide dismutase (SOD), catalase (CAT) activities and total protein level in organs tissues. In rats treated with AGE then exposed to radiation, the results showed an improvement in all previous parameters. It could be concluded that AGE might reduce the biological hazards in rats induced by gamma irradiation.
    VL  - 2
    IS  - 6
    ER  - 

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