The interest in the preclinical studies of the efficacy and safety of herbal drugs combinations with antidiabetic medicines increases. Aegopodium podagraria L. (goutweed) is a plant widely used in traditional medicine. The tincture obtained from its aerial part is characterized by antihyperglycemic, lipid-lowering, hepatoprotective and nephroprotective effects and is able to partially increase the efficacy of metformin in the animals receiving dexamethasone (permissive effect in regard to glucose and lipid metabolism normalization). The objective of this study is to determine the influence of goutweed tincture combined with metformin on protein and purine metabolism as well as the state of liver in dexamethasone-treated rats. The animals were divided into 5 groups as follows: intact control, dexamethasone (untreated), dexamethasone + metformin, 50 mg/kg; dexamethasone + A. podagraria tincture, 1 ml/kg intragastrically; dexamethasone + metformin, 50 mg/kg intragastrically + A. podagraria tincture, 1 ml/kg intragastrically. Dexamethasone was used at a dose of 5 mg/kg subcutaneously for 5 days. Body weight dynamics was registered, total protein and albumin level, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase activity was determined in blood plasma, uric acid and urea content – in blood plasma and urine. Several favourable effects of the combination of goutweed tincture and metformin were seen, namely, the reduction in plasma ALT activity and increase in urea clearance as well as normalization of ALP activity. In contrast to metformin, goutweed tincture limited the dexamethasone-induced increase in plasma albumin concentration and decreased De Ritis ratio. Dexamethasone tended to increase renal uric acid excretion, metformin led to the further increment, in the groups receiving goutweed tincture this value was unchanged, but, proceeding from the normal values of uricemia, extrarenal mechanisms of the influence on purine metabolism were possible in these animals. All of the investigated preparations did not influence on plasma AST activity and caused further decrease in body weight that was reduced under the influence of dexamethasone. In-depth research of the interaction of goutweed tincture with metformin is expedient.
| DOI | 10.11648/j.jdmp.20160206.17 |
| Published in | Journal of Diseases and Medicinal Plants (Volume 2, Issue 6, December 2016) |
| Page(s) | 117-126 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Aegopodium podagraria L., Goutweed, Dexamethasone, Metformin, Rats, Combined Drugs
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APA Style
O. V. Tovchiga. (2017). Metabolic Effects of Goutweed (Aegopodium podagraria L.) Tincture and Metformin in Dexamethasone-Treated Rats. Journal of Diseases and Medicinal Plants, 2(6), 117-126. https://doi.org/10.11648/j.jdmp.20160206.17
ACS Style
O. V. Tovchiga. Metabolic Effects of Goutweed (Aegopodium podagraria L.) Tincture and Metformin in Dexamethasone-Treated Rats. J. Dis. Med. Plants 2017, 2(6), 117-126. doi: 10.11648/j.jdmp.20160206.17
AMA Style
O. V. Tovchiga. Metabolic Effects of Goutweed (Aegopodium podagraria L.) Tincture and Metformin in Dexamethasone-Treated Rats. J Dis Med Plants. 2017;2(6):117-126. doi: 10.11648/j.jdmp.20160206.17
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Download@article{10.11648/j.jdmp.20160206.17,
author = {O. V. Tovchiga},
title = {Metabolic Effects of Goutweed (Aegopodium podagraria L.) Tincture and Metformin in Dexamethasone-Treated Rats},
journal = {Journal of Diseases and Medicinal Plants},
volume = {2},
number = {6},
pages = {117-126},
doi = {10.11648/j.jdmp.20160206.17},
url = {https://doi.org/10.11648/j.jdmp.20160206.17},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20160206.17},
abstract = {The interest in the preclinical studies of the efficacy and safety of herbal drugs combinations with antidiabetic medicines increases. Aegopodium podagraria L. (goutweed) is a plant widely used in traditional medicine. The tincture obtained from its aerial part is characterized by antihyperglycemic, lipid-lowering, hepatoprotective and nephroprotective effects and is able to partially increase the efficacy of metformin in the animals receiving dexamethasone (permissive effect in regard to glucose and lipid metabolism normalization). The objective of this study is to determine the influence of goutweed tincture combined with metformin on protein and purine metabolism as well as the state of liver in dexamethasone-treated rats. The animals were divided into 5 groups as follows: intact control, dexamethasone (untreated), dexamethasone + metformin, 50 mg/kg; dexamethasone + A. podagraria tincture, 1 ml/kg intragastrically; dexamethasone + metformin, 50 mg/kg intragastrically + A. podagraria tincture, 1 ml/kg intragastrically. Dexamethasone was used at a dose of 5 mg/kg subcutaneously for 5 days. Body weight dynamics was registered, total protein and albumin level, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase activity was determined in blood plasma, uric acid and urea content – in blood plasma and urine. Several favourable effects of the combination of goutweed tincture and metformin were seen, namely, the reduction in plasma ALT activity and increase in urea clearance as well as normalization of ALP activity. In contrast to metformin, goutweed tincture limited the dexamethasone-induced increase in plasma albumin concentration and decreased De Ritis ratio. Dexamethasone tended to increase renal uric acid excretion, metformin led to the further increment, in the groups receiving goutweed tincture this value was unchanged, but, proceeding from the normal values of uricemia, extrarenal mechanisms of the influence on purine metabolism were possible in these animals. All of the investigated preparations did not influence on plasma AST activity and caused further decrease in body weight that was reduced under the influence of dexamethasone. In-depth research of the interaction of goutweed tincture with metformin is expedient.},
year = {2017}
}
TY - JOUR T1 - Metabolic Effects of Goutweed (Aegopodium podagraria L.) Tincture and Metformin in Dexamethasone-Treated Rats AU - O. V. Tovchiga Y1 - 2017/01/11 PY - 2017 N1 - https://doi.org/10.11648/j.jdmp.20160206.17 DO - 10.11648/j.jdmp.20160206.17 T2 - Journal of Diseases and Medicinal Plants JF - Journal of Diseases and Medicinal Plants JO - Journal of Diseases and Medicinal Plants SP - 117 EP - 126 PB - Science Publishing Group SN - 2469-8210 UR - https://doi.org/10.11648/j.jdmp.20160206.17 AB - The interest in the preclinical studies of the efficacy and safety of herbal drugs combinations with antidiabetic medicines increases. Aegopodium podagraria L. (goutweed) is a plant widely used in traditional medicine. The tincture obtained from its aerial part is characterized by antihyperglycemic, lipid-lowering, hepatoprotective and nephroprotective effects and is able to partially increase the efficacy of metformin in the animals receiving dexamethasone (permissive effect in regard to glucose and lipid metabolism normalization). The objective of this study is to determine the influence of goutweed tincture combined with metformin on protein and purine metabolism as well as the state of liver in dexamethasone-treated rats. The animals were divided into 5 groups as follows: intact control, dexamethasone (untreated), dexamethasone + metformin, 50 mg/kg; dexamethasone + A. podagraria tincture, 1 ml/kg intragastrically; dexamethasone + metformin, 50 mg/kg intragastrically + A. podagraria tincture, 1 ml/kg intragastrically. Dexamethasone was used at a dose of 5 mg/kg subcutaneously for 5 days. Body weight dynamics was registered, total protein and albumin level, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase activity was determined in blood plasma, uric acid and urea content – in blood plasma and urine. Several favourable effects of the combination of goutweed tincture and metformin were seen, namely, the reduction in plasma ALT activity and increase in urea clearance as well as normalization of ALP activity. In contrast to metformin, goutweed tincture limited the dexamethasone-induced increase in plasma albumin concentration and decreased De Ritis ratio. Dexamethasone tended to increase renal uric acid excretion, metformin led to the further increment, in the groups receiving goutweed tincture this value was unchanged, but, proceeding from the normal values of uricemia, extrarenal mechanisms of the influence on purine metabolism were possible in these animals. All of the investigated preparations did not influence on plasma AST activity and caused further decrease in body weight that was reduced under the influence of dexamethasone. In-depth research of the interaction of goutweed tincture with metformin is expedient. VL - 2 IS - 6 ER -
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