Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats
Journal of Diseases and Medicinal Plants
Volume 3, Issue 1, February 2017, Pages: 17-22
Received: Jan. 23, 2017;
Accepted: Feb. 13, 2017;
Published: Mar. 1, 2017
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Lin Wang, Department of Pharmacology and Applied Pharmacology Laboratory, Laboratory for Cognitive Neuroscience, Weifang Medical University, Weifang, China
Jianbo Sun, Department of Neurosurgery, Shouguang People’s Hospital, Shouguang, China
Wanzhong Li, Department of Pharmacology and Applied Pharmacology Laboratory, Laboratory for Cognitive Neuroscience, Weifang Medical University, Weifang, China
Yanna Lv, Department of Pharmacology and Applied Pharmacology Laboratory, Laboratory for Cognitive Neuroscience, Weifang Medical University, Weifang, China
Weiwei Shi, Department of Pharmacology and Applied Pharmacology Laboratory, Laboratory for Cognitive Neuroscience, Weifang Medical University, Weifang, China
Chunzhen Zhao, Department of Pharmacology and Applied Pharmacology Laboratory, Laboratory for Cognitive Neuroscience, Weifang Medical University, Weifang, China
Eucalyptus oil (EO), an essential oil isolated from Eucalyptus leaves, was examined for its effect on LPS and Klebsiella pneumoniae - induced COPD in rats. The COPD model was induced by instilling intratracheally with LPS and Klebsiella pneumoniae (K. P). The test compound, EO (30, 100 and 300 mg/kg), Prednisone Acetate (10 mg/kg) or vehicle was instilled intragastrically after three weeks exposure of LPS and K. P, lasted for 4 weeks. EO significantly reduced amounts of inflammatory cells in bronchoalveolar lavage fluid (BALF) and blood, and decreased bronchiolitis, emphysematous changes and thickness of bronchioles. It also significantly reduced the increased AB-PAS-positive goblet cells in bronchioles. Prednisone Acetate attenuated pulmonary inflammation and airway mucus hypersecretion, but no significant difference was found on emphysema. Pretreatment with EO markly reduced the production of proinflammatory cytokines TNF-α and IL-β in lung homogenate, significantly decreased the elevated malondialdehyde (MDA) level and and increased superoxide dismutase (SOD) activity. These findings indicate that EO could exert an protective effect against LPS plus K. P-induced lung indury via inhibition of proinflammatory cytokines production and improvement of anti-oxidant status. Our results provide evidence that EO might have its potential to be a proper candidate drug in the treatment of COPD.
Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats, Journal of Diseases and Medicinal Plants.
Vol. 3, No. 1,
2017, pp. 17-22.
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