Eucalyptus oil (EO), an essential oil isolated from Eucalyptus leaves, was examined for its effect on LPS and Klebsiella pneumoniae - induced COPD in rats. The COPD model was induced by instilling intratracheally with LPS and Klebsiella pneumoniae (K. P). The test compound, EO (30, 100 and 300 mg/kg), Prednisone Acetate (10 mg/kg) or vehicle was instilled intragastrically after three weeks exposure of LPS and K. P, lasted for 4 weeks. EO significantly reduced amounts of inflammatory cells in bronchoalveolar lavage fluid (BALF) and blood, and decreased bronchiolitis, emphysematous changes and thickness of bronchioles. It also significantly reduced the increased AB-PAS-positive goblet cells in bronchioles. Prednisone Acetate attenuated pulmonary inflammation and airway mucus hypersecretion, but no significant difference was found on emphysema. Pretreatment with EO markly reduced the production of proinflammatory cytokines TNF-α and IL-β in lung homogenate, significantly decreased the elevated malondialdehyde (MDA) level and and increased superoxide dismutase (SOD) activity. These findings indicate that EO could exert an protective effect against LPS plus K. P-induced lung indury via inhibition of proinflammatory cytokines production and improvement of anti-oxidant status. Our results provide evidence that EO might have its potential to be a proper candidate drug in the treatment of COPD.
| Published in | Journal of Diseases and Medicinal Plants (Volume 3, Issue 1) |
| DOI | 10.11648/j.jdmp.20170301.14 |
| Page(s) | 17-22 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Eucalyptus Globulus, Lipopolysaccharide, Cytokine, Chronic Obstructive Pulmonary Disease
| [1] | Samareh Fekri, M., et al., Detection of helicobacter pylori in bronchoalveolar lavage of patients with chronic obstructive pulmonary disease by real time polymerase chain reaction. Jundishapur J Microbiol, 2015. 8 (1): p. e14551. |
| [2] | Cukic, V., The Most Common Detected Bacteria in Sputum of Patients with the Acute Exacerbation of COPD. Mater Sociomed, 2013. 25 (4): p. 226-9. |
| [3] | Garcha, D. S., et al., Changes in prevalence and load of airway bacteria using quantitative PCR in stable and exacerbated COPD. Thorax, 2012. 67 (12): p. 1075-80. |
| [4] | Korsgren, M., et al., Inhalation of LPS induces inflammatory airway responses mimicking characteristics of chronic obstructive pulmonary disease. Clin Physiol Funct Imaging, 2012. 32 (1): p. 71-9. |
| [5] | Xu, H., M. Xiong, and Q. Huang, [The study on COPD rat model produced by bacterial infection]. Zhonghua Jie He He Hu Xi Za Zhi, 1999. 22 (12): p. 739-42. |
| [6] | Juergens, U. R., Anti-inflammatory properties of the monoterpene 1.8-cineole: current evidence for co-medication in inflammatory airway diseases. Drug Res (Stuttg), 2014. 64 (12): p. 638-46. |
| [7] | Rantzsch, U., et al., Anti-inflammatory effects of Myrtol standardized and other essential oils on alveolar macrophages from patients with chronic obstructive pulmonary disease. Eur J Med Res, 2009. 14 Suppl 4: p. 205-9. |
| [8] | Vigo, E., et al., In-vitro anti-inflammatory effect of Eucalyptus globulus and Thymus vulgaris: nitric oxide inhibition in J774A.1 murine macrophages. J Pharm Pharmacol, 2004. 56 (2): p. 257-63. |
| [9] | Worth, H., C. Schacher, and U. Dethlefsen, Concomitant therapy with Cineole (Eucalyptole) reduces exacerbations in COPD: a placebo-controlled double-blind trial. Respir Res, 2009. 10: p. 69. |
| [10] | Anthonisen, N. R., The British hypothesis revisited. Eur Respir J, 2004. 23 (5): p. 657-8. |
| [11] | Sethi, S., et al., Strain-specific immune response to Haemophilus influenzae in chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2004. 169 (4): p. 448-53. |
| [12] | Sethi, S., et al., Inflammatory profile of new bacterial strain exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2008. 177 (5): p. 491-7. |
| [13] | Sethi, S., et al., New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. N Engl J Med, 2002. 347(7): p. 465-71. |
| [14] | Zanini, A., et al., Bronchial hyperresponsiveness, airway inflammation, and reversibility in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis, 2015. 10: p. 1155-61. |
| [15] | Mroz, R. M., et al., Anti-inflammatory effects of atorvastatin treatment in chronic obstructive pulmonary disease. A controlled pilot study. J Physiol Pharmacol, 2015. 66 (1): p. 111-28. |
| [16] | Tang, Y., et al., The role of the serum IL-33/sST2 axis and inflammatory cytokines in chronic obstructive pulmonary disease. J Interferon Cytokine Res, 2014. 34 (3): p. 162-8. |
| [17] | Shen, L. L., et al., Inhalation of glycopyrronium inhibits cigarette smoke-induced acute lung inflammation in a murine model of COPD. Int Immunopharmacol, 2014. 18 (2): p. 358-64. |
| [18] | Tsai, M. L., et al., Antimicrobial, antioxidant, and anti-inflammatory activities of essential oils from five selected herbs. Biosci Biotechnol Biochem, 2011. 75 (10): p. 1977-83. |
| [19] | Mulyaningsih, S., et al., Antibacterial activity of essential oils from Eucalyptus and of selected components against multidrug-resistant bacterial pathogens. Pharm Biol, 2011. 49 (9): p. 893-9. |
| [20] | Cermelli, C., et al., Effect of eucalyptus essential oil on respiratory bacteria and viruses. Curr Microbiol, 2008. 56 (1): p. 89-92. |
| [21] | Zhao, C., et al., 1,8-cineol attenuates LPS-induced acute pulmonary inflammation in mice. Inflammation, 2014. 37 (2): p. 566-72. |
| [22] | van der Strate, B. W., et al., Cigarette smoke-induced emphysema: A role for the B cell? Am J Respir Crit Care Med, 2006. 173 (7): p. 751-8. |
| [23] | Ismail, M., et al., Effect of spirulina intervention on oxidative stress, antioxidant status, and lipid profile in chronic obstructive pulmonary disease patients. Biomed Res Int, 2015. 2015: p. 486120. |
| [24] | Ben Hassine, D., et al., Chemical composition and in vitro evaluation of the antioxidant and antimicrobial activities of Eucalyptus gillii essential oil and extracts. Molecules, 2012. 17 (8): p. 9540-58. |
| [25] | Bouzabata, A., et al., Composition and chemical variability of Eucalyptus bosistoana essential oil from Algerian Sahara. Nat Prod Commun, 2014. 9 (5): p. 701-2. |
| [26] | Lu, X. Q., et al., [Effect of Eucalyptus globulus oil on lipopolysaccharide-induced chronic bronchitis and mucin hypersecretion in rats]. Zhongguo Zhong Yao Za Zhi, 2004. 29 (2): p. 168-71. |
| [27] | Worth, H. and U. Dethlefsen, Patients with asthma benefit from concomitant therapy with cineole: a placebo-controlled, double-blind trial. J Asthma, 2012. 49 (8): p. 849-53. |
| [28] | Shirole, R. L., et al., Investigation into the mechanism of action of essential oil of Pistacia integerrima for its antiasthmatic activity. J Ethnopharmacol, 2014. 153 (3): p. 541-51. |
| [29] | Wang, C., et al., Treatment with total alkaloids from Radix Linderae reduces inflammation and joint destruction in type II collagen-induced model for rheumatoid arthritis. J Ethnopharmacol, 2007. 111 (2): p. 322-8. |
| [30] | Ram, A., et al., Medicinal plants useful for treating chronic obstructive pulmonary disease (COPD): current status and future perspectives. Fitoterapia, 2011. 82 (2): p. 141-51. |
APA Style
Lin Wang, Jianbo Sun, Wanzhong Li, Yanna Lv, Weiwei Shi, et al. (2017). Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats. Journal of Diseases and Medicinal Plants, 3(1), 17-22. https://doi.org/10.11648/j.jdmp.20170301.14
ACS Style
Lin Wang; Jianbo Sun; Wanzhong Li; Yanna Lv; Weiwei Shi, et al. Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats. J. Dis. Med. Plants 2017, 3(1), 17-22. doi: 10.11648/j.jdmp.20170301.14
AMA Style
Lin Wang, Jianbo Sun, Wanzhong Li, Yanna Lv, Weiwei Shi, et al. Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats. J Dis Med Plants. 2017;3(1):17-22. doi: 10.11648/j.jdmp.20170301.14
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Download@article{10.11648/j.jdmp.20170301.14,
author = {Lin Wang and Jianbo Sun and Wanzhong Li and Yanna Lv and Weiwei Shi and Chunzhen Zhao},
title = {Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats},
journal = {Journal of Diseases and Medicinal Plants},
volume = {3},
number = {1},
pages = {17-22},
doi = {10.11648/j.jdmp.20170301.14},
url = {https://doi.org/10.11648/j.jdmp.20170301.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20170301.14},
abstract = {Eucalyptus oil (EO), an essential oil isolated from Eucalyptus leaves, was examined for its effect on LPS and Klebsiella pneumoniae - induced COPD in rats. The COPD model was induced by instilling intratracheally with LPS and Klebsiella pneumoniae (K. P). The test compound, EO (30, 100 and 300 mg/kg), Prednisone Acetate (10 mg/kg) or vehicle was instilled intragastrically after three weeks exposure of LPS and K. P, lasted for 4 weeks. EO significantly reduced amounts of inflammatory cells in bronchoalveolar lavage fluid (BALF) and blood, and decreased bronchiolitis, emphysematous changes and thickness of bronchioles. It also significantly reduced the increased AB-PAS-positive goblet cells in bronchioles. Prednisone Acetate attenuated pulmonary inflammation and airway mucus hypersecretion, but no significant difference was found on emphysema. Pretreatment with EO markly reduced the production of proinflammatory cytokines TNF-α and IL-β in lung homogenate, significantly decreased the elevated malondialdehyde (MDA) level and and increased superoxide dismutase (SOD) activity. These findings indicate that EO could exert an protective effect against LPS plus K. P-induced lung indury via inhibition of proinflammatory cytokines production and improvement of anti-oxidant status. Our results provide evidence that EO might have its potential to be a proper candidate drug in the treatment of COPD.},
year = {2017}
}
TY - JOUR T1 - Protective Effect of Eucalyptus Oil Against Pulmonary Destruction and Inflammation in COPD Rats AU - Lin Wang AU - Jianbo Sun AU - Wanzhong Li AU - Yanna Lv AU - Weiwei Shi AU - Chunzhen Zhao Y1 - 2017/03/01 PY - 2017 N1 - https://doi.org/10.11648/j.jdmp.20170301.14 DO - 10.11648/j.jdmp.20170301.14 T2 - Journal of Diseases and Medicinal Plants JF - Journal of Diseases and Medicinal Plants JO - Journal of Diseases and Medicinal Plants SP - 17 EP - 22 PB - Science Publishing Group SN - 2469-8210 UR - https://doi.org/10.11648/j.jdmp.20170301.14 AB - Eucalyptus oil (EO), an essential oil isolated from Eucalyptus leaves, was examined for its effect on LPS and Klebsiella pneumoniae - induced COPD in rats. The COPD model was induced by instilling intratracheally with LPS and Klebsiella pneumoniae (K. P). The test compound, EO (30, 100 and 300 mg/kg), Prednisone Acetate (10 mg/kg) or vehicle was instilled intragastrically after three weeks exposure of LPS and K. P, lasted for 4 weeks. EO significantly reduced amounts of inflammatory cells in bronchoalveolar lavage fluid (BALF) and blood, and decreased bronchiolitis, emphysematous changes and thickness of bronchioles. It also significantly reduced the increased AB-PAS-positive goblet cells in bronchioles. Prednisone Acetate attenuated pulmonary inflammation and airway mucus hypersecretion, but no significant difference was found on emphysema. Pretreatment with EO markly reduced the production of proinflammatory cytokines TNF-α and IL-β in lung homogenate, significantly decreased the elevated malondialdehyde (MDA) level and and increased superoxide dismutase (SOD) activity. These findings indicate that EO could exert an protective effect against LPS plus K. P-induced lung indury via inhibition of proinflammatory cytokines production and improvement of anti-oxidant status. Our results provide evidence that EO might have its potential to be a proper candidate drug in the treatment of COPD. VL - 3 IS - 1 ER -
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