Aberrations in Renal Function Parameters Following Oral Administration of <i>Phyllanthus amarus</i> in Cadmium-Induced Kidney Damage in Adult Wistar Rats

Ogunnaike Philip Olubunmi; Olatunji Sunday Yinka; Owolabi Joshua Oladele; Olanrewaju Afees John; Baderinwa Deborah Boluwatife; Fabiyi Sunday Oluseyi

doi:doi:10.11648/j.jdmp.20170304.11

Aberrations in Renal Function Parameters Following Oral Administration of Phyllanthus amarus in Cadmium-Induced Kidney Damage in Adult Wistar Rats

Ogunnaike Philip Olubunmi, Olatunji Sunday Yinka, Owolabi Joshua Oladele, Olanrewaju Afees John, Baderinwa Deborah Boluwatife, Fabiyi Sunday Oluseyi

Published in Journal of Diseases and Medicinal Plants (Volume 3, Issue 4)

Received: 22 September 2017 Accepted: 4 October 2017 Published: 28 October 2017

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Abstract

Renal disease has been found to be the ninth leading cause of death. Environmental pollution is a serious cause for concern nowadays and the exposure of humans to heavy metals released into the environment by several sources produces deleterious and lethal effects. Cadmium (Cd) which is a non-essential heavy metal known to possess toxic effects on living things can be found almost anywhere and its toxicity is of concern to industrial workers and all humans due to its use in some industrial products and also in agriculture. The chief organ of toxic impact in the human is the kidney, where the proximal tubule is a major target of Cd deposition. The present study investigated if ethanolic extract of Chanca Piedra (CP) (Phyllantus amarus) has any prophylactic or ameliorative effects against nephrotoxicity induced by cadmium sulphate in adult male Wistar rats. A total of forty-two (42) adult male Wistar rats were used for this study and were divided into seven (7) groups (n=6) as follows: Group A (control), Group B (40mg/kg BW), Group C (100mg/kg BW of CP and 40mg/kg BW of Cd), Group D (200mg/kg BW of CP and 40mg/kg BW), Group E (40mg/kg BW and 100mg/kg BW of CP), Group F (40mg/kg BW and 200mg/kg BW of CP), Group G (200mg/kg BW of CP). Both cadmium and Chanca Piedra were administered orally through oro-gastric cannula. Results showed that exposure to Cd lowered the activities of the kidney by increasing the plasma creatinine and urea levels. Exposure to CP also lowered the activities of the kidney by increasing the plasma creatinine and urea levels. The findings suggest that the administration of CP extract has no prophylactic or ameliorative effects on cadmium induced kidney damage and continue use of this extracts in the treatment of some diseases may be deleterious to the kidney.

Published in	Journal of Diseases and Medicinal Plants (Volume 3, Issue 4)
DOI	10.11648/j.jdmp.20170304.11
Page(s)	60-67
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Nephrotoxicity, Cadmium, Plasma, Creatinine, Urea, Total Protein

References

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APA Style

Ogunnaike Philip Olubunmi, Olatunji Sunday Yinka, Owolabi Joshua Oladele, Olanrewaju Afees John, Baderinwa Deborah Boluwatife, et al. (2017). Aberrations in Renal Function Parameters Following Oral Administration of Phyllanthus amarus in Cadmium-Induced Kidney Damage in Adult Wistar Rats. Journal of Diseases and Medicinal Plants, 3(4), 60-67. https://doi.org/10.11648/j.jdmp.20170304.11

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ACS Style

Ogunnaike Philip Olubunmi; Olatunji Sunday Yinka; Owolabi Joshua Oladele; Olanrewaju Afees John; Baderinwa Deborah Boluwatife, et al. Aberrations in Renal Function Parameters Following Oral Administration of Phyllanthus amarus in Cadmium-Induced Kidney Damage in Adult Wistar Rats. J. Dis. Med. Plants 2017, 3(4), 60-67. doi: 10.11648/j.jdmp.20170304.11

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AMA Style

Ogunnaike Philip Olubunmi, Olatunji Sunday Yinka, Owolabi Joshua Oladele, Olanrewaju Afees John, Baderinwa Deborah Boluwatife, et al. Aberrations in Renal Function Parameters Following Oral Administration of Phyllanthus amarus in Cadmium-Induced Kidney Damage in Adult Wistar Rats. J Dis Med Plants. 2017;3(4):60-67. doi: 10.11648/j.jdmp.20170304.11

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@article{10.11648/j.jdmp.20170304.11,
  author = {Ogunnaike Philip Olubunmi and Olatunji Sunday Yinka and Owolabi Joshua Oladele and Olanrewaju Afees John and Baderinwa Deborah Boluwatife and Fabiyi Sunday Oluseyi},
  title = {Aberrations in Renal Function Parameters Following Oral Administration of Phyllanthus amarus in Cadmium-Induced Kidney Damage in Adult Wistar Rats},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {3},
  number = {4},
  pages = {60-67},
  doi = {10.11648/j.jdmp.20170304.11},
  url = {https://doi.org/10.11648/j.jdmp.20170304.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20170304.11},
  abstract = {Renal disease has been found to be the ninth leading cause of death. Environmental pollution is a serious cause for concern nowadays and the exposure of humans to heavy metals released into the environment by several sources produces deleterious and lethal effects. Cadmium (Cd) which is a non-essential heavy metal known to possess toxic effects on living things can be found almost anywhere and its toxicity is of concern to industrial workers and all humans due to its use in some industrial products and also in agriculture. The chief organ of toxic impact in the human is the kidney, where the proximal tubule is a major target of Cd deposition. The present study investigated if ethanolic extract of Chanca Piedra (CP) (Phyllantus amarus) has any prophylactic or ameliorative effects against nephrotoxicity induced by cadmium sulphate in adult male Wistar rats. A total of forty-two (42) adult male Wistar rats were used for this study and were divided into seven (7) groups (n=6) as follows: Group A (control), Group B (40mg/kg BW), Group C (100mg/kg BW of CP and 40mg/kg BW of Cd), Group D (200mg/kg BW of CP and 40mg/kg BW), Group E (40mg/kg BW and 100mg/kg BW of CP), Group F (40mg/kg BW and 200mg/kg BW of CP), Group G (200mg/kg BW of CP). Both cadmium and Chanca Piedra were administered orally through oro-gastric cannula. Results showed that exposure to Cd lowered the activities of the kidney by increasing the plasma creatinine and urea levels. Exposure to CP also lowered the activities of the kidney by increasing the plasma creatinine and urea levels. The findings suggest that the administration of CP extract has no prophylactic or ameliorative effects on cadmium induced kidney damage and continue use of this extracts in the treatment of some diseases may be deleterious to the kidney.},
 year = {2017}
}

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TY  - JOUR
T1  - Aberrations in Renal Function Parameters Following Oral Administration of Phyllanthus amarus in Cadmium-Induced Kidney Damage in Adult Wistar Rats
AU  - Ogunnaike Philip Olubunmi
AU  - Olatunji Sunday Yinka
AU  - Owolabi Joshua Oladele
AU  - Olanrewaju Afees John
AU  - Baderinwa Deborah Boluwatife
AU  - Fabiyi Sunday Oluseyi
Y1  - 2017/10/28
PY  - 2017
N1  - https://doi.org/10.11648/j.jdmp.20170304.11
DO  - 10.11648/j.jdmp.20170304.11
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 60
EP  - 67
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20170304.11
AB  - Renal disease has been found to be the ninth leading cause of death. Environmental pollution is a serious cause for concern nowadays and the exposure of humans to heavy metals released into the environment by several sources produces deleterious and lethal effects. Cadmium (Cd) which is a non-essential heavy metal known to possess toxic effects on living things can be found almost anywhere and its toxicity is of concern to industrial workers and all humans due to its use in some industrial products and also in agriculture. The chief organ of toxic impact in the human is the kidney, where the proximal tubule is a major target of Cd deposition. The present study investigated if ethanolic extract of Chanca Piedra (CP) (Phyllantus amarus) has any prophylactic or ameliorative effects against nephrotoxicity induced by cadmium sulphate in adult male Wistar rats. A total of forty-two (42) adult male Wistar rats were used for this study and were divided into seven (7) groups (n=6) as follows: Group A (control), Group B (40mg/kg BW), Group C (100mg/kg BW of CP and 40mg/kg BW of Cd), Group D (200mg/kg BW of CP and 40mg/kg BW), Group E (40mg/kg BW and 100mg/kg BW of CP), Group F (40mg/kg BW and 200mg/kg BW of CP), Group G (200mg/kg BW of CP). Both cadmium and Chanca Piedra were administered orally through oro-gastric cannula. Results showed that exposure to Cd lowered the activities of the kidney by increasing the plasma creatinine and urea levels. Exposure to CP also lowered the activities of the kidney by increasing the plasma creatinine and urea levels. The findings suggest that the administration of CP extract has no prophylactic or ameliorative effects on cadmium induced kidney damage and continue use of this extracts in the treatment of some diseases may be deleterious to the kidney.
VL  - 3
IS  - 4
ER  -

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Author Information

Ogunnaike Philip Olubunmi

Department of Anatomy, Ben Carson Senior School of Medicine, Babcock University, Ilisan Remo, Nigeria
Olatunji Sunday Yinka

Department of Anatomy, Ben Carson Senior School of Medicine, Babcock University, Ilisan Remo, Nigeria; Department of Anatomy and Cell Biology, Obafemi Awolowo University, Ile-Ife, Nigeria
Owolabi Joshua Oladele

Department of Anatomy, Ben Carson Senior School of Medicine, Babcock University, Ilisan Remo, Nigeria
Olanrewaju Afees John

Department of Anatomy, Ben Carson Senior School of Medicine, Babcock University, Ilisan Remo, Nigeria
Baderinwa Deborah Boluwatife

Department of Anatomy, Ben Carson Senior School of Medicine, Babcock University, Ilisan Remo, Nigeria
Fabiyi Sunday Oluseyi

Department of Anatomy, Ben Carson Senior School of Medicine, Babcock University, Ilisan Remo, Nigeria

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APA Style

Ogunnaike Philip Olubunmi, Olatunji Sunday Yinka, Owolabi Joshua Oladele, Olanrewaju Afees John, Baderinwa Deborah Boluwatife, et al. (2017). Aberrations in Renal Function Parameters Following Oral Administration of Phyllanthus amarus in Cadmium-Induced Kidney Damage in Adult Wistar Rats. Journal of Diseases and Medicinal Plants, 3(4), 60-67. https://doi.org/10.11648/j.jdmp.20170304.11

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ACS Style

Ogunnaike Philip Olubunmi; Olatunji Sunday Yinka; Owolabi Joshua Oladele; Olanrewaju Afees John; Baderinwa Deborah Boluwatife, et al. Aberrations in Renal Function Parameters Following Oral Administration of Phyllanthus amarus in Cadmium-Induced Kidney Damage in Adult Wistar Rats. J. Dis. Med. Plants 2017, 3(4), 60-67. doi: 10.11648/j.jdmp.20170304.11

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AMA Style

Ogunnaike Philip Olubunmi, Olatunji Sunday Yinka, Owolabi Joshua Oladele, Olanrewaju Afees John, Baderinwa Deborah Boluwatife, et al. Aberrations in Renal Function Parameters Following Oral Administration of Phyllanthus amarus in Cadmium-Induced Kidney Damage in Adult Wistar Rats. J Dis Med Plants. 2017;3(4):60-67. doi: 10.11648/j.jdmp.20170304.11

Copy | Download

@article{10.11648/j.jdmp.20170304.11,
  author = {Ogunnaike Philip Olubunmi and Olatunji Sunday Yinka and Owolabi Joshua Oladele and Olanrewaju Afees John and Baderinwa Deborah Boluwatife and Fabiyi Sunday Oluseyi},
  title = {Aberrations in Renal Function Parameters Following Oral Administration of Phyllanthus amarus in Cadmium-Induced Kidney Damage in Adult Wistar Rats},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {3},
  number = {4},
  pages = {60-67},
  doi = {10.11648/j.jdmp.20170304.11},
  url = {https://doi.org/10.11648/j.jdmp.20170304.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20170304.11},
  abstract = {Renal disease has been found to be the ninth leading cause of death. Environmental pollution is a serious cause for concern nowadays and the exposure of humans to heavy metals released into the environment by several sources produces deleterious and lethal effects. Cadmium (Cd) which is a non-essential heavy metal known to possess toxic effects on living things can be found almost anywhere and its toxicity is of concern to industrial workers and all humans due to its use in some industrial products and also in agriculture. The chief organ of toxic impact in the human is the kidney, where the proximal tubule is a major target of Cd deposition. The present study investigated if ethanolic extract of Chanca Piedra (CP) (Phyllantus amarus) has any prophylactic or ameliorative effects against nephrotoxicity induced by cadmium sulphate in adult male Wistar rats. A total of forty-two (42) adult male Wistar rats were used for this study and were divided into seven (7) groups (n=6) as follows: Group A (control), Group B (40mg/kg BW), Group C (100mg/kg BW of CP and 40mg/kg BW of Cd), Group D (200mg/kg BW of CP and 40mg/kg BW), Group E (40mg/kg BW and 100mg/kg BW of CP), Group F (40mg/kg BW and 200mg/kg BW of CP), Group G (200mg/kg BW of CP). Both cadmium and Chanca Piedra were administered orally through oro-gastric cannula. Results showed that exposure to Cd lowered the activities of the kidney by increasing the plasma creatinine and urea levels. Exposure to CP also lowered the activities of the kidney by increasing the plasma creatinine and urea levels. The findings suggest that the administration of CP extract has no prophylactic or ameliorative effects on cadmium induced kidney damage and continue use of this extracts in the treatment of some diseases may be deleterious to the kidney.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Aberrations in Renal Function Parameters Following Oral Administration of Phyllanthus amarus in Cadmium-Induced Kidney Damage in Adult Wistar Rats
AU  - Ogunnaike Philip Olubunmi
AU  - Olatunji Sunday Yinka
AU  - Owolabi Joshua Oladele
AU  - Olanrewaju Afees John
AU  - Baderinwa Deborah Boluwatife
AU  - Fabiyi Sunday Oluseyi
Y1  - 2017/10/28
PY  - 2017
N1  - https://doi.org/10.11648/j.jdmp.20170304.11
DO  - 10.11648/j.jdmp.20170304.11
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 60
EP  - 67
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20170304.11
AB  - Renal disease has been found to be the ninth leading cause of death. Environmental pollution is a serious cause for concern nowadays and the exposure of humans to heavy metals released into the environment by several sources produces deleterious and lethal effects. Cadmium (Cd) which is a non-essential heavy metal known to possess toxic effects on living things can be found almost anywhere and its toxicity is of concern to industrial workers and all humans due to its use in some industrial products and also in agriculture. The chief organ of toxic impact in the human is the kidney, where the proximal tubule is a major target of Cd deposition. The present study investigated if ethanolic extract of Chanca Piedra (CP) (Phyllantus amarus) has any prophylactic or ameliorative effects against nephrotoxicity induced by cadmium sulphate in adult male Wistar rats. A total of forty-two (42) adult male Wistar rats were used for this study and were divided into seven (7) groups (n=6) as follows: Group A (control), Group B (40mg/kg BW), Group C (100mg/kg BW of CP and 40mg/kg BW of Cd), Group D (200mg/kg BW of CP and 40mg/kg BW), Group E (40mg/kg BW and 100mg/kg BW of CP), Group F (40mg/kg BW and 200mg/kg BW of CP), Group G (200mg/kg BW of CP). Both cadmium and Chanca Piedra were administered orally through oro-gastric cannula. Results showed that exposure to Cd lowered the activities of the kidney by increasing the plasma creatinine and urea levels. Exposure to CP also lowered the activities of the kidney by increasing the plasma creatinine and urea levels. The findings suggest that the administration of CP extract has no prophylactic or ameliorative effects on cadmium induced kidney damage and continue use of this extracts in the treatment of some diseases may be deleterious to the kidney.
VL  - 3
IS  - 4
ER  -

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