Most people die in Africa due to plasmodium with lead to complication cases principally in Plasmodium falciparum infection. For unknown reasons, P. falciparum progress to severe malaria resulting in high mortality rate in children mostly in sub-Saharan Africa. Difficulties in severe malaria therapy result in complexity to predict early symptoms and when people can develop severe malaria. For adjunctive therapy, New drug are need, to improve outcome in cerebral malaria. Asparagus schweinfurthii is a perennial plants with multiple proprieties including antiprotozoal, antioxidant and anti-inflammatory properties with emerging antimalarial potential. The influence of A. schweinfurthii administration to rescue and prior to Plasmodium berghei infection on parasitemia induction is there reported. Extract of A. schweinfurthii was administered at doses of 38. 12, 19.06, 9. 5 and 3. 8 mg/kg to mice (15–18 g) 72h before intraperitoneal infection with P. berghei (prophylaxis test) or days 6 post-infection (pi) (rescues therapy). Parasitemia induction and progression, clinical signs of experimental cerebral malaria and temperature were recorded during sub-chronic studies (18 days). Administration of A. schweinfurthii in pre-infected animals preserved significantly temperature loss (p<0,001). The plant extract also abolish significantly (p<0, 001) parasitemia and clinical signs of experimental cerebral malaria while oral Cofantrine (10 mg/kg) failed to prevent malaria induction. Administered orally, prior to the infestation of mice with plasmodium berghei; A. schweinfurthii administration influenced parasitemia patency and parasitemia progression as well as temperature loss. This may suggest possible chemoprophylaxis effects of A. schweinfurthii on malaria parasite.
| Published in | Journal of Diseases and Medicinal Plants (Volume 6, Issue 3) |
| DOI | 10.11648/j.jdmp.20200603.11 |
| Page(s) | 56-64 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Asparagus schweinfurthii, Cerebral Malaria, Plasmodium berghei, Prophylaxis Treatment
| [1] | Shikani H. J, Freeman B. D, Lisanti M. P, Weiss L. M, Tanowitz H. B, and Desruisseaux M. S, “Cerebral malaria: we have come a long way,” The American Journal of Pathology, vol. 181, no. 5, pp. 1484–1492, 2012. |
| [2] | World Health Organization, “Severe Malaria,” Tropical Medicine & International Health, vol. 19, pp. 7–131, 2014. |
| [3] | Kawai, S., M. Aikawa, S. Kano, and M. Suzuki. A primate model forsevere human malaria with cerebral involvement: Plasmodium coatneyi-in-fectedMacaca fuscata. Am. J. Trop. Med. 1993, Hyg. 48: 630–636. |
| [4] | Baker L, Blumberg L, Barnes KI, Hansford F, Duvenage C, Williams HV. Guidelines for the prevention of malaria in South Africa. Pretoria: Minisitry of Health, South Africa; 2003. |
| [5] | Landry PID, Darioli R, Burnier M, Genton B. Do travelers really take their mefloquine prophylaxis?Estimation of adherence by an electronic pill box. J Travel Med. 2006, 13: 8–14. |
| [6] | Senn N, D’Acremont V, Landry P, Genton G. Malaria chemoprophylaxis: what do the travelers choose, and how does pretravel consultation influ-ence their final decision. Am J Trop Med Hyg. 2007, 77: 1010–4. |
| [7] | Behrens R. H, Taylor R. B, Pryce D. I, Low A. S. Chemoprophylaxis compliance in travelers with malaria. J Travel Med. 1998, 5: 92–4. |
| [8] | Schlagenhauf P, Tschopp A, Johnson R, Nothdurft HD, Beck B, Schwartz E. Tolerability of malaria chemoprophylaxis in nonimmune travellers to sub-Saharan Africa: multicentre, randomised, double blind, four arm study. BMJ. 2003, 327: 1078. |
| [9] | Ogwang P. E, Ogwa J. O, Kasasa S, Olila D, Ejobi F, Kabasa D. Artemisia annua L. infusion consumed once a week reduces risk of multiple episodes of malaria: a randomised trial in a Ugandan community. Trop J Pharm Res. 2012; 11: 445–53. |
| [10] | Rath K, Taxis K, Walz G, Gleiter CH, Li S, Heide L. Pharmacokinetic study of artemisinin after oral intake of traditional preparation of Artemisia annua L. Am J Trop Med Hyg. 2004, 70: 128–32. |
| [11] | Guo W, Liu W, Hong S, Liu H, Qian C, Shen Y. Mitochondria-dependent apoptosis of con A-activated T lymphocytes induced by Asiatic acid for preventing murine fulminant hepatitis. PLoS ONE. 2012. |
| [12] | Patel H, Dhangar K, Sonawane Y, Surana S, Karpoormath R, Thapliyal N l. In search of selective 11 beta-HSD type 1 inhibitors without nephro-toxicity: an approach to resolve the metabolic syndrome by virtual based screening. Arab J Chem. 2015, in press. |
| [13] | Ramachandran V, Saravanan R. Antidiabetic and antihyperlipidemic activity of Asiatic acid in diabetic rats, role of HMG CoA: in vivo and in silico approaches. Phytomedicine. 2014, 21: 225–32. |
| [14] | Ramachandran V, Saravanan R. Efficacy of asiatic acid, a pentacyclic triterpene on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-induced diabetic rats. Phytomedicine. 2013, 20: 230–6. |
| [15] | Ruffo, C. K., Birnie, A. & Tengnäs, B. Edible wild plants of Tanzania. Technical Handbook No 27. Regional Land Management Unit/ SIDA, Nairobi, Kenya. 2002, 766 pp. |
| [16] | Vanden Berghen, C. Flore illustrée du Sénégal. Monocotylédones et Ptéridophytes. Volume 9. Monocotylédones: Agavacées à Orchidacées. Gouvernement du Sénégal, Ministère du Développement Rural et de l’Hydraulique, Direction des Eaux et Forêts, Dakar, Senegal. 1988, 522 pp. |
| [17] | Demissew Sebsebe. Asparagaceae. In: Edwards, S., Mesfin Tadesse, Demissew Sebsebe & Hedberg, I. (Editors). Flora of Ethiopia and Eritrea. Volume 6. Hydrocharitaceae to Arecaceae. The National Herbarium, Addis Ababa University, Addis Ababa, Ethiopia and Department of Systematic Botany, Uppsala University, Uppsala, Sweden. 1997, pp. 67–73. |
| [18] | Adegoke, E. A., Akinsaya, A. & Naqvi, H. Z. Studies of Nigeria medicinal plants: a preliminary survey of plant alkaloids. Journal of the West African Science Association. 1968, 13: 13–33. |
| [19] | Kokwaro, J. O. Medicinal plants of East Africa. 2nd Edition. Kenya Literature Bureau, Nairobi, Kenya. 1993, 401 pp. |
| [20] | Watt, J. M. & Breyer-Brandwijk, M. G. The medicinal and poisonous plants of southern and eastern Africa. 2nd Edition. E. and S. Livingstone, London, United Kingdom. 1962, 1457 pp. |
| [21] | Oketch-Rabah, H. A., Dossaji, S. F., Christensen, S. B., Frydenvang, K., Lemmich, E., Cornett, C., Olsen, C. E., Chen, M., Kharazmi, A. & Theander, T. Antiprotozoal compounds from Asparagus africanus. Journal of Natural Products 60 (10): 1997, 1017–1022. |
| [22] | OECD 425, “OECD guidelines for the testing of chemicals. Acute Oral Toxicity – Up-and-Down-Procedure (UDP),” 27p, 2008. |
| [23] | Rogers D. C, Fisher E. M, Brown S. D, Peters J, Hunter A. J, Martin J. E. Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment. Mamm Genome 1997, 8: 711-713. |
| [24] | Lackner P, Beer R, Heussler V, Goebel G, Rudzki D, Hel-bok. Behavioural and histopathological alterations in mice with cerebral malaria. Neuropathol Appl Neurobiol 2006, 32: 177-188. |
| [25] | Oseni L. A. and Akwetey G. M. “An in-vivo evaluation of antiplasmodial activity of aqueous and ethanolic leaf extractsof Azadirachta indica in Plasmodium berghei infectedbalb/cmice,” InternationalJournal of Pharmaceutical Sciences and Research, vol. 3, no. 5, pp. 1406–1410, 2012. |
| [26] | Langhorne, S. J. Quin, and L. A. Sanni, “Mouse Models of Blood-Stage Malaria Infections: Immune Responses and Cytokines Involved in Protection and Pathology,” in Malaria Immunology, P. Perlmann and M. Troye-Blomberg, Eds., Stock-holm, Karger publisher, pp. 204-228, 2002. |
| [27] | Mengiste. B, Mekonnen E. E, and Urga. K, “In vivo an imalarialactivity of Dodonaea angustifolia seed extracts against Plasmodium berghei in mice model,” MEJS, vol. 4, pp. 147–163, 2012. |
| [28] | Bantie. L, Assefa. S, Teklehaimanot. T and Engida work. E, “In vivoantimalarial activity of the crude leaf extract and solventfractions of Croton macrostachyus Hocsht. (Euphorbiaceae) against Plasmodium bergheiin mice,” BMC Complementary and Alternative Medicine, vol. 14, article 79, 2014. |
| [29] | Tarkang. P. A., Okalebo. F. A., Ayong. L. S., Agbor. G. A., and Guantai. A. N. “Anti-malarial activity of a polyherbal product (Nefang) during early and established Plasmodium infection inrodent models,” Malaria Journal, vol. 13, no. 1, articleno. 456, 2014. |
| [30] | Nardos. A, and Makonnen. E, “In vivo antiplasmodial activity and toxicological assessment of hydro ethanolic crude extract of Ajugaremota,” Malaria Journal, vol. 16, no. 1, articleno. 25, 2017. against Plasmodium berghei in mice” BMC Complementary and Alternative Medicine, vol. 14, article 79, 2014. |
| [31] | Hintsa G, Sibhat GG, Karim A. Evaluation of antimalarial activity of the leaf latex and TLC isolates from Aloe megalacantha Baker in Plasmodium berghei infected mice. Evid-Based Complement Altern Med. 2019, 2019 6459498. |
| [32] | Mzena T, Swai H, Chacha M. Antimalarial activity of Cucumis metuliferusand Lippia kituiensis against Plasmodium berghei infection in mice. Res Rep Trop Med. 2018, 9: 81–8. |
| [33] | Nureye D, Assefa S, Nedi T, Engidawork E. In vivo antimalarial activity of the 80% methanolic root bark extract and solvent fractions of Gardenia ternifolia Schumach. & Thonn. (Rubiaceae) against Plasmodium berghei. Evid-Based Complement Altern Med. 2018, 2018: 9217835. |
| [34] | Dunst J, Kamena F, Matuschewski K. Cytokines and chemokines in cer-ebral malaria pathogenesis. Front Cell Infect Microbiol. 2017, 7: 324. |
| [35] | Howland S. W, Poh C. M, Rénia L. Activated brain endothelial cells cross-present malaria antigen. PLoS Pathog. 2015, 11: e1004963. |
APA Style
Foutchou Angèle, Njan Nlôga Alexandre Michel. (2020). Seeds of Asparagus schweinfurthii (Liliaceae) Protects Mice from Fatal Murine Experimental Cerebral Malaria. Journal of Diseases and Medicinal Plants, 6(3), 56-64. https://doi.org/10.11648/j.jdmp.20200603.11
ACS Style
Foutchou Angèle; Njan Nlôga Alexandre Michel. Seeds of Asparagus schweinfurthii (Liliaceae) Protects Mice from Fatal Murine Experimental Cerebral Malaria. J. Dis. Med. Plants 2020, 6(3), 56-64. doi: 10.11648/j.jdmp.20200603.11
AMA Style
Foutchou Angèle, Njan Nlôga Alexandre Michel. Seeds of Asparagus schweinfurthii (Liliaceae) Protects Mice from Fatal Murine Experimental Cerebral Malaria. J Dis Med Plants. 2020;6(3):56-64. doi: 10.11648/j.jdmp.20200603.11
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Download@article{10.11648/j.jdmp.20200603.11,
author = {Foutchou Angèle and Njan Nlôga Alexandre Michel},
title = {Seeds of Asparagus schweinfurthii (Liliaceae) Protects Mice from Fatal Murine Experimental Cerebral Malaria},
journal = {Journal of Diseases and Medicinal Plants},
volume = {6},
number = {3},
pages = {56-64},
doi = {10.11648/j.jdmp.20200603.11},
url = {https://doi.org/10.11648/j.jdmp.20200603.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20200603.11},
abstract = {Most people die in Africa due to plasmodium with lead to complication cases principally in Plasmodium falciparum infection. For unknown reasons, P. falciparum progress to severe malaria resulting in high mortality rate in children mostly in sub-Saharan Africa. Difficulties in severe malaria therapy result in complexity to predict early symptoms and when people can develop severe malaria. For adjunctive therapy, New drug are need, to improve outcome in cerebral malaria. Asparagus schweinfurthii is a perennial plants with multiple proprieties including antiprotozoal, antioxidant and anti-inflammatory properties with emerging antimalarial potential. The influence of A. schweinfurthii administration to rescue and prior to Plasmodium berghei infection on parasitemia induction is there reported. Extract of A. schweinfurthii was administered at doses of 38. 12, 19.06, 9. 5 and 3. 8 mg/kg to mice (15–18 g) 72h before intraperitoneal infection with P. berghei (prophylaxis test) or days 6 post-infection (pi) (rescues therapy). Parasitemia induction and progression, clinical signs of experimental cerebral malaria and temperature were recorded during sub-chronic studies (18 days). Administration of A. schweinfurthii in pre-infected animals preserved significantly temperature loss (pplasmodium berghei; A. schweinfurthii administration influenced parasitemia patency and parasitemia progression as well as temperature loss. This may suggest possible chemoprophylaxis effects of A. schweinfurthii on malaria parasite.},
year = {2020}
}
TY - JOUR T1 - Seeds of Asparagus schweinfurthii (Liliaceae) Protects Mice from Fatal Murine Experimental Cerebral Malaria AU - Foutchou Angèle AU - Njan Nlôga Alexandre Michel Y1 - 2020/08/10 PY - 2020 N1 - https://doi.org/10.11648/j.jdmp.20200603.11 DO - 10.11648/j.jdmp.20200603.11 T2 - Journal of Diseases and Medicinal Plants JF - Journal of Diseases and Medicinal Plants JO - Journal of Diseases and Medicinal Plants SP - 56 EP - 64 PB - Science Publishing Group SN - 2469-8210 UR - https://doi.org/10.11648/j.jdmp.20200603.11 AB - Most people die in Africa due to plasmodium with lead to complication cases principally in Plasmodium falciparum infection. For unknown reasons, P. falciparum progress to severe malaria resulting in high mortality rate in children mostly in sub-Saharan Africa. Difficulties in severe malaria therapy result in complexity to predict early symptoms and when people can develop severe malaria. For adjunctive therapy, New drug are need, to improve outcome in cerebral malaria. Asparagus schweinfurthii is a perennial plants with multiple proprieties including antiprotozoal, antioxidant and anti-inflammatory properties with emerging antimalarial potential. The influence of A. schweinfurthii administration to rescue and prior to Plasmodium berghei infection on parasitemia induction is there reported. Extract of A. schweinfurthii was administered at doses of 38. 12, 19.06, 9. 5 and 3. 8 mg/kg to mice (15–18 g) 72h before intraperitoneal infection with P. berghei (prophylaxis test) or days 6 post-infection (pi) (rescues therapy). Parasitemia induction and progression, clinical signs of experimental cerebral malaria and temperature were recorded during sub-chronic studies (18 days). Administration of A. schweinfurthii in pre-infected animals preserved significantly temperature loss (pplasmodium berghei; A. schweinfurthii administration influenced parasitemia patency and parasitemia progression as well as temperature loss. This may suggest possible chemoprophylaxis effects of A. schweinfurthii on malaria parasite. VL - 6 IS - 3 ER -
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