Treatment Outcomes and Associated Factors of Childhood Tuberculosis: Treated Under Dots Program in Health Centers of Mekelle Town, Tigray Regional State, Ethiopia

Misganaw Daniel Daemo; Abraham Getachew Kelbore

doi:doi:10.11648/j.cajph.20160201.12

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Treatment Outcomes and Associated Factors of Childhood Tuberculosis: Treated Under Dots Program in Health Centers of Mekelle Town, Tigray Regional State, Ethiopia

Misganaw Daniel Daemo, Abraham Getachew Kelbore

Published in Central African Journal of Public Health (Volume 2, Issue 1)

Received: 10 December 2015 Accepted: 8 June 2016 Published: 26 September 2016

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Abstract

Background: Tuberculosis in children has been less of a public health priority in recent years, despite the fact that TB is an important cause of childhood morbidity and mortality worldwide. WHO report in 2008 estimates 450,000 deaths from TB occurs in children each year, Nevertheless childhood TB remains neglected for various reasons, mainly the difficulty in diagnosing pulmonary TB.Therefore identifying potential risk factors associated with treatment outcomesisimportant activity to improve quality of TB care and treatment. Method: A retrospective cross-sectional study was conducted in Mekelle town on pediatric TB patients treated in three health centers. The study employed a record review of patients registered for TB treatment from September 2007 to August 2011. Health facilities are selected purposively and patient’s records were selected by simple random sampling. A total of 226 patients’ record was collected from registers using data extraction format. Data entry was done using Epi info 3.5. 1and exported and analyzed by SPSS V 20. Results: According to this study success of treatment was 84%. Among all patients treated under DOTS, 15 (6.6%) of cases had unfavorable outcomes, death 8/226 and default 7/226, 13(5.8%) were transferred out and outcome was unknown in 8 (3.5%) of patients. Deaths were more frequent in older age groups 5 – 14 years, although there is high number of death in HIV co-infection, rural residents and extra-pulmonary tuberculosis than other forms. In multivariate analysis, independent predictors for unfavorable outcomes were HIV co-infection AOR = 5.57 with 95% C.I = [1.6, 18.6] and patients from rural residence were more likely to have unfavorable outcomes OR = 18.6 with 95% C.I = [2.4, 144]. Conclusion: The treatment success rate in this study was come within reach of to the minimum target set by WHO 85%. HIV contributes substantiallyto childhood TB burden and also cases fromruraldistricts associated with high mortality and default from treatment.

Published in	Central African Journal of Public Health (Volume 2, Issue 1)
DOI	10.11648/j.cajph.20160201.12
Page(s)	11-17
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Tuberculosis, Treatment Outcomes, Children and Mekelle

References

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[3]	WHO: Global Tuberculosis Control: A short update to the 2009 report [http://www.who.int/tb/publications/global report, 2009.
[4]	Dye C, Scheele S, Dolin P, Pathania V, and Raviglione MC: For the WHO Global Surveillance and Monitoring Project, Global Burden of Tuberculosis Estimated Incidence, Prevalence, and Mortality by Country. JAMA 1999, 282: 677-686.
[5]	WHO: Global Tuberculosis Control Surveillance, Planning, Financing; 2005 [http://www.who.int/tb/publications/global_report/2005/en/].
[6]	Federal Ministry of Health: Manual of Tuberculosis and Leprosy and TB/HIV Prevention and Control; 4th edition. Addis Ababa, Ethiopia. EthioTikur Printing Press; 2008.
[7]	Graham SM, Gie RP, Schaaf HS, and Et al: Childhood tuberculosis: clinical research needs. Int J Tuberc Lung Dis 2004, 8: 648-57.
[8]	Amsalu S, Hurrisa Z, Nuri S: Tuberculosis in children, Northwest Ethiopia. Ethiop Med J 2007, 45: 159-63.
[9]	Munoz M, Yassin MA, Tumato M, Merid Y, Cuevas LE: Treatment Outcome in children with tuberculosis in southern Ethiopia. Scand J Infect Dis 2009, 41: 450-5.
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[11]	Shargie EB, Lindtjørn B: DOTS improves treatment outcomes and service coverage for tuberculosis in South Ethiopia: a retrospective trend analysis. BMC Public Health 2005, 5: 62.
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[14]	Kassu A, Mengistu G, Ayele B, Diro E, and Et al. F: HIV and intestinal parasites in adult TB patients in a teaching hospital in Northwest Ethiopia. Trop Doct2007, 37: 222-4.
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[16]	Rangsima L, Amornrat A, Sriprapa N, et al, Childhood TB epidemiology and treatment outcomes in Thailand: a TB active surveillance network, 2004 to 2006,2008: BMC Infectious Diseases 2008, 8: 94.
[17]	Tigray Health Bureau, 1997 Ethiopian fiscal year Profile: Tigray region health profile, page 2.
[18]	UNFPA, Federal democratic Republic of Ethiopia population census commission, National Population and Housing Census of Ethiopia, 2007.
[19]	Julius p, Tuberculosis in children at mbarara University teaching hospital, Uganda: diagnosis and outcome of treatment 2002; African health sciences Vol 2 No 3 December 2002: 84.
[20]	Ramos JM, Reyes Fand Tesfamariam A. Childhood and adult tuberculosis in a rural hospital in Southeast Ethiopia: a ten-year retrospective study: BMC Public Health 2010, 10: 215: 3.
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Misganaw Daniel Daemo, Abraham Getachew Kelbore. (2016). Treatment Outcomes and Associated Factors of Childhood Tuberculosis: Treated Under Dots Program in Health Centers of Mekelle Town, Tigray Regional State, Ethiopia. Central African Journal of Public Health, 2(1), 11-17. https://doi.org/10.11648/j.cajph.20160201.12

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ACS Style

Misganaw Daniel Daemo; Abraham Getachew Kelbore. Treatment Outcomes and Associated Factors of Childhood Tuberculosis: Treated Under Dots Program in Health Centers of Mekelle Town, Tigray Regional State, Ethiopia. Cent. Afr. J. Public Health 2016, 2(1), 11-17. doi: 10.11648/j.cajph.20160201.12

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Misganaw Daniel Daemo, Abraham Getachew Kelbore. Treatment Outcomes and Associated Factors of Childhood Tuberculosis: Treated Under Dots Program in Health Centers of Mekelle Town, Tigray Regional State, Ethiopia. Cent Afr J Public Health. 2016;2(1):11-17. doi: 10.11648/j.cajph.20160201.12

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@article{10.11648/j.cajph.20160201.12,
  author = {Misganaw Daniel Daemo and Abraham Getachew Kelbore},
  title = {Treatment Outcomes and Associated Factors of Childhood Tuberculosis: Treated Under Dots Program in Health Centers of Mekelle Town, Tigray Regional State, Ethiopia},
  journal = {Central African Journal of Public Health},
  volume = {2},
  number = {1},
  pages = {11-17},
  doi = {10.11648/j.cajph.20160201.12},
  url = {https://doi.org/10.11648/j.cajph.20160201.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cajph.20160201.12},
  abstract = {Background: Tuberculosis in children has been less of a public health priority in recent years, despite the fact that TB is an important cause of childhood morbidity and mortality worldwide. WHO report in 2008 estimates 450,000 deaths from TB occurs in children each year, Nevertheless childhood TB remains neglected for various reasons, mainly the difficulty in diagnosing pulmonary TB.Therefore identifying potential risk factors associated with treatment outcomesisimportant activity to improve quality of TB care and treatment. Method: A retrospective cross-sectional study was conducted in Mekelle town on pediatric TB patients treated in three health centers. The study employed a record review of patients registered for TB treatment from September 2007 to August 2011. Health facilities are selected purposively and patient’s records were selected by simple random sampling. A total of 226 patients’ record was collected from registers using data extraction format. Data entry was done using Epi info 3.5. 1and exported and analyzed by SPSS V 20. Results: According to this study success of treatment was 84%. Among all patients treated under DOTS, 15 (6.6%) of cases had unfavorable outcomes, death 8/226 and default 7/226, 13(5.8%) were transferred out and outcome was unknown in 8 (3.5%) of patients. Deaths were more frequent in older age groups 5 – 14 years, although there is high number of death in HIV co-infection, rural residents and extra-pulmonary tuberculosis than other forms. In multivariate analysis, independent predictors for unfavorable outcomes were HIV co-infection AOR = 5.57 with 95% C.I = [1.6, 18.6] and patients from rural residence were more likely to have unfavorable outcomes OR = 18.6 with 95% C.I = [2.4, 144]. Conclusion: The treatment success rate in this study was come within reach of to the minimum target set by WHO 85%. HIV contributes substantiallyto childhood TB burden and also cases fromruraldistricts associated with high mortality and default from treatment.},
 year = {2016}
}

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TY - JOUR
T1 - Treatment Outcomes and Associated Factors of Childhood Tuberculosis: Treated Under Dots Program in Health Centers of Mekelle Town, Tigray Regional State, Ethiopia
AU - Misganaw Daniel Daemo
AU - Abraham Getachew Kelbore
Y1 - 2016/09/26
PY - 2016
N1 - https://doi.org/10.11648/j.cajph.20160201.12
DO - 10.11648/j.cajph.20160201.12
T2 - Central African Journal of Public Health
JF - Central African Journal of Public Health
JO - Central African Journal of Public Health
SP - 11
EP - 17
PB - Science Publishing Group
SN - 2575-5781
UR - https://doi.org/10.11648/j.cajph.20160201.12
AB - Background: Tuberculosis in children has been less of a public health priority in recent years, despite the fact that TB is an important cause of childhood morbidity and mortality worldwide. WHO report in 2008 estimates 450,000 deaths from TB occurs in children each year, Nevertheless childhood TB remains neglected for various reasons, mainly the difficulty in diagnosing pulmonary TB.Therefore identifying potential risk factors associated with treatment outcomesisimportant activity to improve quality of TB care and treatment. Method: A retrospective cross-sectional study was conducted in Mekelle town on pediatric TB patients treated in three health centers. The study employed a record review of patients registered for TB treatment from September 2007 to August 2011. Health facilities are selected purposively and patient’s records were selected by simple random sampling. A total of 226 patients’ record was collected from registers using data extraction format. Data entry was done using Epi info 3.5. 1and exported and analyzed by SPSS V 20. Results: According to this study success of treatment was 84%. Among all patients treated under DOTS, 15 (6.6%) of cases had unfavorable outcomes, death 8/226 and default 7/226, 13(5.8%) were transferred out and outcome was unknown in 8 (3.5%) of patients. Deaths were more frequent in older age groups 5 – 14 years, although there is high number of death in HIV co-infection, rural residents and extra-pulmonary tuberculosis than other forms. In multivariate analysis, independent predictors for unfavorable outcomes were HIV co-infection AOR = 5.57 with 95% C.I = [1.6, 18.6] and patients from rural residence were more likely to have unfavorable outcomes OR = 18.6 with 95% C.I = [2.4, 144]. Conclusion: The treatment success rate in this study was come within reach of to the minimum target set by WHO 85%. HIV contributes substantiallyto childhood TB burden and also cases fromruraldistricts associated with high mortality and default from treatment.
VL - 2
IS - 1
ER -

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Author Information

Misganaw Daniel Daemo

Child Health and Pediatrics, Aids Health Care, Addis Ababa, Ethiopia
Abraham Getachew Kelbore

Tropical Dermatology, Dermatology Department, WolaitaSodo University, Southern, Ethiopia

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APA Style

Misganaw Daniel Daemo, Abraham Getachew Kelbore. (2016). Treatment Outcomes and Associated Factors of Childhood Tuberculosis: Treated Under Dots Program in Health Centers of Mekelle Town, Tigray Regional State, Ethiopia. Central African Journal of Public Health, 2(1), 11-17. https://doi.org/10.11648/j.cajph.20160201.12

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ACS Style

Misganaw Daniel Daemo; Abraham Getachew Kelbore. Treatment Outcomes and Associated Factors of Childhood Tuberculosis: Treated Under Dots Program in Health Centers of Mekelle Town, Tigray Regional State, Ethiopia. Cent. Afr. J. Public Health 2016, 2(1), 11-17. doi: 10.11648/j.cajph.20160201.12

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Misganaw Daniel Daemo, Abraham Getachew Kelbore. Treatment Outcomes and Associated Factors of Childhood Tuberculosis: Treated Under Dots Program in Health Centers of Mekelle Town, Tigray Regional State, Ethiopia. Cent Afr J Public Health. 2016;2(1):11-17. doi: 10.11648/j.cajph.20160201.12

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@article{10.11648/j.cajph.20160201.12,
  author = {Misganaw Daniel Daemo and Abraham Getachew Kelbore},
  title = {Treatment Outcomes and Associated Factors of Childhood Tuberculosis: Treated Under Dots Program in Health Centers of Mekelle Town, Tigray Regional State, Ethiopia},
  journal = {Central African Journal of Public Health},
  volume = {2},
  number = {1},
  pages = {11-17},
  doi = {10.11648/j.cajph.20160201.12},
  url = {https://doi.org/10.11648/j.cajph.20160201.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cajph.20160201.12},
  abstract = {Background: Tuberculosis in children has been less of a public health priority in recent years, despite the fact that TB is an important cause of childhood morbidity and mortality worldwide. WHO report in 2008 estimates 450,000 deaths from TB occurs in children each year, Nevertheless childhood TB remains neglected for various reasons, mainly the difficulty in diagnosing pulmonary TB.Therefore identifying potential risk factors associated with treatment outcomesisimportant activity to improve quality of TB care and treatment. Method: A retrospective cross-sectional study was conducted in Mekelle town on pediatric TB patients treated in three health centers. The study employed a record review of patients registered for TB treatment from September 2007 to August 2011. Health facilities are selected purposively and patient’s records were selected by simple random sampling. A total of 226 patients’ record was collected from registers using data extraction format. Data entry was done using Epi info 3.5. 1and exported and analyzed by SPSS V 20. Results: According to this study success of treatment was 84%. Among all patients treated under DOTS, 15 (6.6%) of cases had unfavorable outcomes, death 8/226 and default 7/226, 13(5.8%) were transferred out and outcome was unknown in 8 (3.5%) of patients. Deaths were more frequent in older age groups 5 – 14 years, although there is high number of death in HIV co-infection, rural residents and extra-pulmonary tuberculosis than other forms. In multivariate analysis, independent predictors for unfavorable outcomes were HIV co-infection AOR = 5.57 with 95% C.I = [1.6, 18.6] and patients from rural residence were more likely to have unfavorable outcomes OR = 18.6 with 95% C.I = [2.4, 144]. Conclusion: The treatment success rate in this study was come within reach of to the minimum target set by WHO 85%. HIV contributes substantiallyto childhood TB burden and also cases fromruraldistricts associated with high mortality and default from treatment.},
 year = {2016}
}

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