Frequency and Antimicrobial Resistance Pattern among Bacterial Clinical Isolates Recovered from Different Specimens in Egypt
Central African Journal of Public Health
Volume 5, Issue 1, February 2019, Pages: 36-45
Received: Dec. 5, 2018; Accepted: Jan. 2, 2019; Published: Jan. 29, 2019
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Authors
Rania Ibrahim Shebl, Microbiology and Immunology Department, Faculty of Pharmacy, Ahram Canadian University, Cairo, Egypt
Yasser Omar Mosaad, Pharmacology, Toxicology and Biochemistry Department, Faculty of Pharmaceutical Sciences & Pharmaceutical Industries, Future University in Egypt, Cairo, Egypt
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Abstract
Antimicrobial resistance (AMR) is a global public health threat resulting in high mortality rates. Current study aimed to identify the most prevalent pathogens among variable infection sites and their AMR pattern. Data concerning cultures and antibiotic susceptibilities were retrieved from Microbiology Department’s records and statistically analyzed. Out of 554 bacterial isolates, Gram negative isolates (68.4%) were predominant. Urine specimens showed the highest incidence of recovery of total isolates (41.5%, n=230) followed by blood (23.1%, n=128), while sputum specimens exhibited the least frequency (17%, n=94). E. coli (30.7%, n=170), S. aureus (21.1%, n=117) and Klebsiella spp (20.9%, n=116) were the most frequently isolated pathogens. Recovery of isolates was significantly more frequent among males (P<0.05) except in case of urine specimens. Highest incidence of resistance in both Gram positive and Gram negative isolates was recorded in case of cephalosporins and penicillin/β-lactamase. Gram positive isolates exhibited the least resistance to linezolid (10.8%) and vancomycin (9.5%) whereas colistin was the most effective against Gram negative isolates as it recorded 16.4% resistance. Higher frequency of multiple drug resistance (MDR) was also observed in Gram negative isolates compared to Gram positive ones. Resistance to uropathogens and MDR were significantly more frequent in males. Although E. coli was the most prevalent uropathogen but it showed the least incidence of MDR however Pseudomonas spp exhibited the highest MDR rate. The high incidence of resistance in the current study is alarming and highlights the necessity of routinely monitoring the local prevalence of resistance for selecting the best antimicrobial treatment and as a guide for empirical therapy.
Keywords
Prevalence, Multiple Drug Resistance, Pattern, Egypt
To cite this article
Rania Ibrahim Shebl, Yasser Omar Mosaad, Frequency and Antimicrobial Resistance Pattern among Bacterial Clinical Isolates Recovered from Different Specimens in Egypt, Central African Journal of Public Health. Vol. 5, No. 1, 2019, pp. 36-45. doi: 10.11648/j.cajph.20190501.16
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Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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