HIV infected patients have an increased incidence of venous thromboembolism and an important risk factor is antithrombin deficiency. Currently it is estimated that 10% of HIV/AIDS patients who developed venous thromboembolism had antithrombin deficiency with functional antithrombin levels less than 70%. The purpose of this study is to measure functional antithrombin levels in HIV patients prior to development of venous thromboembolic disorder. One hundred and twenty HIV positive and one hundred and twenty-six HIV negative apparently healthy blood donors were studied. Socio-demographic, medical history and clinical characteristics were obtained from the patients. Blood was analyzed for CD4+ lymphocytes count, full blood count and functional antithrombin levels. We also investigated the relationship between functional levels of antithrombin, CD4 + lymphocytes count and some haematological parameters. The functional antithrombin levels were significantly reduced in the people living with HIV/AIDS (72.6%) when compared with the controls (93.7%). There was no correlation between CD4 + lymphocytes count (by proxy the stage of the disease) and functional antithrombin levels in HIV positive patients (r = 0.02, p = 0.9). Patients with HIV infection have a mild deficiency of functional antithrombin that may lead to hypercoagulability.
| Published in | Central African Journal of Public Health (Volume 5, Issue 5) |
| DOI | 10.11648/j.cajph.20190505.13 |
| Page(s) | 198-202 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Functional, Antithrombin, HIV
| [1] | Geiben-Lynn R, Brown N, Walker BD, Luster AD. Purification of a modified form of bovine antithrombin III as an HIV-1 CD8+ T-cell antiviral factor. J Biol Chem. 2002; 277 (44): 42352-42357. |
| [2] | Saber AA, Aboolian A, Laraja RD, Baron H, Hanna K. HIV/AIDS and the risk of deep vein thrombosis: a study of 45 patients with lower extremity involvement. Am Surg. 2001; 67 (7): 645-647. |
| [3] | Huntington JA. Serpin structure, function and dysfunction. J Thromb Haemost. 2011; 9: 26-34. |
| [4] | Patella FJ, Delany JR, moorland AC, Fuhrer J. Declining morbidity and mortality amongst patients with advanced HIV. N Engl J Med. 1998; 338: 853-860. |
| [5] | John P. Greer JF, John N. Lukens, Editor. Wintrope's Clinical Heamatology. 11th Ed. New York: Lippincott Williams and Wilkins; 2003: 688-690. |
| [6] | Blajchman MA. An overview of the mechanism of action of antithrombin and its inherited deficiency states. Blood Coagul Fibrinolysis1994 Suppl 1: S5-11; discussion S59-S64. |
| [7] | Victor Hoffbrand DC, Edward G. D. Tuddenham, editor. Postgraduate Heamatology. 5th ed. New York: Blackwell and wiley; 2005: 378-399. |
| [8] | Mocroft A, Reiss P, Gasiorowski J, Ledergerber B, Kowalska J, Chiesi A, et al. Serious fatal and nonfatal non-AIDS-defining illnesses in Europe. J Acquir Immune Defic Syndr. 2010; 55 (2): 262-270. |
| [9] | Maclean PS. Hereditary and acquired antithrombin deficiency: epidemiology, pathogenesis and treatment options. Drugs. 2007; 67 (10): 1429-1440. |
| [10] | Delluc A, Le-Ven F, Mottier D, Le-Gal G. Epidemiology and risk factors of venous thromboembolism. Rev Mal Respir. 2012; 29 (2): 254-266. |
| [11] | Summer LM, Marso SP, Grant PJ. Atherothrombosis, thrombolysis and anti-platelet. In: Hoffbrand AV, Catovsky, Tuddenham EG, editors. Postgraduate Haematology. 5th ed. New-Delhi: Wiley; 2005: pp945-965. |
| [12] | Saif M, Bona R, Greenberg M. A Retrospective Study of 131 HIV infected Patients. AIDS PATIENTS CARE and STD. 2001; 15 (6): 311-324. |
| [13] | Sule A, Pandit N, Handa P, Chadachan V, Tan E, Sum FN et al. Risk of Venous Thromboembolism in Patients Infected with HIV: A Cohort Study. J Angiol. 2013; 22 (2): 95-100. |
| [14] | Bibas M, Biava G, Antinori A. HIV-Associated Venous Thromboembolism. Mediterr J Hematol Infect Dis. 2011; 3 (1): 1-26. |
| [15] | Cao YZ, Dieterich D, Thomas PA, Huang YX, Mirabile M. Identification and quantitation of HIV1 in the liver of patients with AIDS. AIDS. 1992; 6 (1): 65-70. |
| [16] | Huffert F, SChmitz J, Schreiber M, Schmitz H, Racz P and von Laer D. Human Kupffer cell Infected with HIV-1 In Vivo. J Acquir Immune Defic Syndr. 1993; 6: 74-79. |
| [17] | George SL, Swindells S, Knudson R, Stapleton JT. Unexplained Thrombosis in HIV-infected Patients Receiving Protease Inhibitors: Report of Seven Cases. Am J Med 1999; 107 (6): 624-626. |
| [18] | Jacobson MC, Dezube BJ, Aboulafia DM. Thrombotic Complications in Patient Infected with HIV in the Era of Highly Active antiretroviral therapy. A case series. HIV/AIDS. 2004; 39: 1214-1226. |
APA Style
Olutogun Tolulase Aderayo, Fasola Foluke Atinuke, Olufemi-Aworinde Kehinde Joyce, Aken’ova Yetunde Adebisi. (2019). Functional Antithrombin Levels in HIV/AIDS Patients at Ibadan, Nigeria. Central African Journal of Public Health, 5(5), 198-202. https://doi.org/10.11648/j.cajph.20190505.13
ACS Style
Olutogun Tolulase Aderayo; Fasola Foluke Atinuke; Olufemi-Aworinde Kehinde Joyce; Aken’ova Yetunde Adebisi. Functional Antithrombin Levels in HIV/AIDS Patients at Ibadan, Nigeria. Cent. Afr. J. Public Health 2019, 5(5), 198-202. doi: 10.11648/j.cajph.20190505.13
AMA Style
Olutogun Tolulase Aderayo, Fasola Foluke Atinuke, Olufemi-Aworinde Kehinde Joyce, Aken’ova Yetunde Adebisi. Functional Antithrombin Levels in HIV/AIDS Patients at Ibadan, Nigeria. Cent Afr J Public Health. 2019;5(5):198-202. doi: 10.11648/j.cajph.20190505.13
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.cajph.20190505.13,
author = {Olutogun Tolulase Aderayo and Fasola Foluke Atinuke and Olufemi-Aworinde Kehinde Joyce and Aken’ova Yetunde Adebisi},
title = {Functional Antithrombin Levels in HIV/AIDS Patients at Ibadan, Nigeria},
journal = {Central African Journal of Public Health},
volume = {5},
number = {5},
pages = {198-202},
doi = {10.11648/j.cajph.20190505.13},
url = {https://doi.org/10.11648/j.cajph.20190505.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cajph.20190505.13},
abstract = {HIV infected patients have an increased incidence of venous thromboembolism and an important risk factor is antithrombin deficiency. Currently it is estimated that 10% of HIV/AIDS patients who developed venous thromboembolism had antithrombin deficiency with functional antithrombin levels less than 70%. The purpose of this study is to measure functional antithrombin levels in HIV patients prior to development of venous thromboembolic disorder. One hundred and twenty HIV positive and one hundred and twenty-six HIV negative apparently healthy blood donors were studied. Socio-demographic, medical history and clinical characteristics were obtained from the patients. Blood was analyzed for CD4+ lymphocytes count, full blood count and functional antithrombin levels. We also investigated the relationship between functional levels of antithrombin, CD4 + lymphocytes count and some haematological parameters. The functional antithrombin levels were significantly reduced in the people living with HIV/AIDS (72.6%) when compared with the controls (93.7%). There was no correlation between CD4 + lymphocytes count (by proxy the stage of the disease) and functional antithrombin levels in HIV positive patients (r = 0.02, p = 0.9). Patients with HIV infection have a mild deficiency of functional antithrombin that may lead to hypercoagulability.},
year = {2019}
}
TY - JOUR T1 - Functional Antithrombin Levels in HIV/AIDS Patients at Ibadan, Nigeria AU - Olutogun Tolulase Aderayo AU - Fasola Foluke Atinuke AU - Olufemi-Aworinde Kehinde Joyce AU - Aken’ova Yetunde Adebisi Y1 - 2019/08/26 PY - 2019 N1 - https://doi.org/10.11648/j.cajph.20190505.13 DO - 10.11648/j.cajph.20190505.13 T2 - Central African Journal of Public Health JF - Central African Journal of Public Health JO - Central African Journal of Public Health SP - 198 EP - 202 PB - Science Publishing Group SN - 2575-5781 UR - https://doi.org/10.11648/j.cajph.20190505.13 AB - HIV infected patients have an increased incidence of venous thromboembolism and an important risk factor is antithrombin deficiency. Currently it is estimated that 10% of HIV/AIDS patients who developed venous thromboembolism had antithrombin deficiency with functional antithrombin levels less than 70%. The purpose of this study is to measure functional antithrombin levels in HIV patients prior to development of venous thromboembolic disorder. One hundred and twenty HIV positive and one hundred and twenty-six HIV negative apparently healthy blood donors were studied. Socio-demographic, medical history and clinical characteristics were obtained from the patients. Blood was analyzed for CD4+ lymphocytes count, full blood count and functional antithrombin levels. We also investigated the relationship between functional levels of antithrombin, CD4 + lymphocytes count and some haematological parameters. The functional antithrombin levels were significantly reduced in the people living with HIV/AIDS (72.6%) when compared with the controls (93.7%). There was no correlation between CD4 + lymphocytes count (by proxy the stage of the disease) and functional antithrombin levels in HIV positive patients (r = 0.02, p = 0.9). Patients with HIV infection have a mild deficiency of functional antithrombin that may lead to hypercoagulability. VL - 5 IS - 5 ER -
Information
Email: