Determining the Efficiency of Malaria Rapid Diagnostic Test to Diagnose Post Transfusion Malaria in Children Under Five Years Old at Komfo Anokye Teaching Hospital

Djeneba Bouare; Owusu Ofori Alex; Mohammed Abdul-Rahim; Der Muonir Edmund

doi:doi:10.11648/j.cajph.20200603.13

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Determining the Efficiency of Malaria Rapid Diagnostic Test to Diagnose Post Transfusion Malaria in Children Under Five Years Old at Komfo Anokye Teaching Hospital

Djeneba Bouare, Owusu Ofori Alex, Mohammed Abdul-Rahim, Der Muonir Edmund

Received: 19 February 2020 Accepted: 3 March 2020 Published: 17 March 2020

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Abstract

Background: Post-transfusion malaria in children under five years is associated with increased morbidity and mortality. The RDTs currently are used to supplement microscopy in the diagnosis of malaria in many endemic countries. However their efficiency as a screening tool for the detection of malaria in donors or in transfusion recipients has not been well evaluated. This study aimed to determine the efficiency of malaria RDT in the detection of post transfusion malaria. Material and methods: The study was conducted from November 2014 to April 2015. Blood samples from 179 patients and their corresponding donors were tested for Plasmodium parasitaemia using RDT and microscopy. The recipients’ blood samples were obtained within 48 hours after transfusion for malaria diagnosis. To determine the incidence of post transfusion malaria, 32 patients were purposefully selected. Their pre-transfusion, post transfusion and donor blood samples were tested for malaria using PCR. Results: Approximately 52% of the study population were within the age group of 0 - < 1 year. Prevalence of malaria in blood donors was 27% by RDT and 7% by microscopy. Prevalence at pre-transfusion was 34% by RDT and 13% by microscopy. Prevalence at post transfusion was 59% by RDT and 4% by microscopy. Incidence of post transfusion malaria by PCR was 57%. The sensitivity of RDT in detecting malaria at post transfusion was 100%. Conclusion: Efficiency of malaria RDT as a tool for malaria diagnosis at post transfusion, among children under five years old is good. Clinicians should consider implementing the use of malaria RDT at post transfusion.

DOI	10.11648/j.cajph.20200603.13
Published in	Central African Journal of Public Health (Volume 6, Issue 3, June 2020)
Page(s)	122-130
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Under-Five, Blood Transfusion-Associated Malaria, Post-Transfusion, RDT, PCR, Kumasi

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APA Style

Djeneba Bouare, Owusu Ofori Alex, Mohammed Abdul-Rahim, Der Muonir Edmund. (2020). Determining the Efficiency of Malaria Rapid Diagnostic Test to Diagnose Post Transfusion Malaria in Children Under Five Years Old at Komfo Anokye Teaching Hospital. Central African Journal of Public Health, 6(3), 122-130. https://doi.org/10.11648/j.cajph.20200603.13

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ACS Style

Djeneba Bouare; Owusu Ofori Alex; Mohammed Abdul-Rahim; Der Muonir Edmund. Determining the Efficiency of Malaria Rapid Diagnostic Test to Diagnose Post Transfusion Malaria in Children Under Five Years Old at Komfo Anokye Teaching Hospital. Cent. Afr. J. Public Health 2020, 6(3), 122-130. doi: 10.11648/j.cajph.20200603.13

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AMA Style

Djeneba Bouare, Owusu Ofori Alex, Mohammed Abdul-Rahim, Der Muonir Edmund. Determining the Efficiency of Malaria Rapid Diagnostic Test to Diagnose Post Transfusion Malaria in Children Under Five Years Old at Komfo Anokye Teaching Hospital. Cent Afr J Public Health. 2020;6(3):122-130. doi: 10.11648/j.cajph.20200603.13

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@article{10.11648/j.cajph.20200603.13,
  author = {Djeneba Bouare and Owusu Ofori Alex and Mohammed Abdul-Rahim and Der Muonir Edmund},
  title = {Determining the Efficiency of Malaria Rapid Diagnostic Test to Diagnose Post Transfusion Malaria in Children Under Five Years Old at Komfo Anokye Teaching Hospital},
  journal = {Central African Journal of Public Health},
  volume = {6},
  number = {3},
  pages = {122-130},
  doi = {10.11648/j.cajph.20200603.13},
  url = {https://doi.org/10.11648/j.cajph.20200603.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cajph.20200603.13},
  abstract = {Background: Post-transfusion malaria in children under five years is associated with increased morbidity and mortality. The RDTs currently are used to supplement microscopy in the diagnosis of malaria in many endemic countries. However their efficiency as a screening tool for the detection of malaria in donors or in transfusion recipients has not been well evaluated. This study aimed to determine the efficiency of malaria RDT in the detection of post transfusion malaria. Material and methods: The study was conducted from November 2014 to April 2015. Blood samples from 179 patients and their corresponding donors were tested for Plasmodium parasitaemia using RDT and microscopy. The recipients’ blood samples were obtained within 48 hours after transfusion for malaria diagnosis. To determine the incidence of post transfusion malaria, 32 patients were purposefully selected. Their pre-transfusion, post transfusion and donor blood samples were tested for malaria using PCR. Results: Approximately 52% of the study population were within the age group of 0 - < 1 year. Prevalence of malaria in blood donors was 27% by RDT and 7% by microscopy. Prevalence at pre-transfusion was 34% by RDT and 13% by microscopy. Prevalence at post transfusion was 59% by RDT and 4% by microscopy. Incidence of post transfusion malaria by PCR was 57%. The sensitivity of RDT in detecting malaria at post transfusion was 100%. Conclusion: Efficiency of malaria RDT as a tool for malaria diagnosis at post transfusion, among children under five years old is good. Clinicians should consider implementing the use of malaria RDT at post transfusion.},
 year = {2020}
}

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TY - JOUR
T1 - Determining the Efficiency of Malaria Rapid Diagnostic Test to Diagnose Post Transfusion Malaria in Children Under Five Years Old at Komfo Anokye Teaching Hospital
AU - Djeneba Bouare
AU - Owusu Ofori Alex
AU - Mohammed Abdul-Rahim
AU - Der Muonir Edmund
Y1 - 2020/03/17
PY - 2020
N1 - https://doi.org/10.11648/j.cajph.20200603.13
DO - 10.11648/j.cajph.20200603.13
T2 - Central African Journal of Public Health
JF - Central African Journal of Public Health
JO - Central African Journal of Public Health
SP - 122
EP - 130
PB - Science Publishing Group
SN - 2575-5781
UR - https://doi.org/10.11648/j.cajph.20200603.13
AB - Background: Post-transfusion malaria in children under five years is associated with increased morbidity and mortality. The RDTs currently are used to supplement microscopy in the diagnosis of malaria in many endemic countries. However their efficiency as a screening tool for the detection of malaria in donors or in transfusion recipients has not been well evaluated. This study aimed to determine the efficiency of malaria RDT in the detection of post transfusion malaria. Material and methods: The study was conducted from November 2014 to April 2015. Blood samples from 179 patients and their corresponding donors were tested for Plasmodium parasitaemia using RDT and microscopy. The recipients’ blood samples were obtained within 48 hours after transfusion for malaria diagnosis. To determine the incidence of post transfusion malaria, 32 patients were purposefully selected. Their pre-transfusion, post transfusion and donor blood samples were tested for malaria using PCR. Results: Approximately 52% of the study population were within the age group of 0 - < 1 year. Prevalence of malaria in blood donors was 27% by RDT and 7% by microscopy. Prevalence at pre-transfusion was 34% by RDT and 13% by microscopy. Prevalence at post transfusion was 59% by RDT and 4% by microscopy. Incidence of post transfusion malaria by PCR was 57%. The sensitivity of RDT in detecting malaria at post transfusion was 100%. Conclusion: Efficiency of malaria RDT as a tool for malaria diagnosis at post transfusion, among children under five years old is good. Clinicians should consider implementing the use of malaria RDT at post transfusion.
VL - 6
IS - 3
ER -

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Author Information

Djeneba Bouare

School of Medicine and Health Sciences, University for Developement Studies, Tamale, Ghana
Owusu Ofori Alex

Kumasi Centre for Collaborative Research (KCCR), Kumasi, Ghana
Mohammed Abdul-Rahim

Kumasi Centre for Collaborative Research (KCCR), Kumasi, Ghana
Der Muonir Edmund

Department of Pathology, School of Medicine and Health Sciences, University for Development Studies, Tamale, Ghana

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Djeneba Bouare, Owusu Ofori Alex, Mohammed Abdul-Rahim, Der Muonir Edmund. (2020). Determining the Efficiency of Malaria Rapid Diagnostic Test to Diagnose Post Transfusion Malaria in Children Under Five Years Old at Komfo Anokye Teaching Hospital. Central African Journal of Public Health, 6(3), 122-130. https://doi.org/10.11648/j.cajph.20200603.13

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Djeneba Bouare; Owusu Ofori Alex; Mohammed Abdul-Rahim; Der Muonir Edmund. Determining the Efficiency of Malaria Rapid Diagnostic Test to Diagnose Post Transfusion Malaria in Children Under Five Years Old at Komfo Anokye Teaching Hospital. Cent. Afr. J. Public Health 2020, 6(3), 122-130. doi: 10.11648/j.cajph.20200603.13

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AMA Style

Djeneba Bouare, Owusu Ofori Alex, Mohammed Abdul-Rahim, Der Muonir Edmund. Determining the Efficiency of Malaria Rapid Diagnostic Test to Diagnose Post Transfusion Malaria in Children Under Five Years Old at Komfo Anokye Teaching Hospital. Cent Afr J Public Health. 2020;6(3):122-130. doi: 10.11648/j.cajph.20200603.13

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@article{10.11648/j.cajph.20200603.13,
  author = {Djeneba Bouare and Owusu Ofori Alex and Mohammed Abdul-Rahim and Der Muonir Edmund},
  title = {Determining the Efficiency of Malaria Rapid Diagnostic Test to Diagnose Post Transfusion Malaria in Children Under Five Years Old at Komfo Anokye Teaching Hospital},
  journal = {Central African Journal of Public Health},
  volume = {6},
  number = {3},
  pages = {122-130},
  doi = {10.11648/j.cajph.20200603.13},
  url = {https://doi.org/10.11648/j.cajph.20200603.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cajph.20200603.13},
  abstract = {Background: Post-transfusion malaria in children under five years is associated with increased morbidity and mortality. The RDTs currently are used to supplement microscopy in the diagnosis of malaria in many endemic countries. However their efficiency as a screening tool for the detection of malaria in donors or in transfusion recipients has not been well evaluated. This study aimed to determine the efficiency of malaria RDT in the detection of post transfusion malaria. Material and methods: The study was conducted from November 2014 to April 2015. Blood samples from 179 patients and their corresponding donors were tested for Plasmodium parasitaemia using RDT and microscopy. The recipients’ blood samples were obtained within 48 hours after transfusion for malaria diagnosis. To determine the incidence of post transfusion malaria, 32 patients were purposefully selected. Their pre-transfusion, post transfusion and donor blood samples were tested for malaria using PCR. Results: Approximately 52% of the study population were within the age group of 0 - < 1 year. Prevalence of malaria in blood donors was 27% by RDT and 7% by microscopy. Prevalence at pre-transfusion was 34% by RDT and 13% by microscopy. Prevalence at post transfusion was 59% by RDT and 4% by microscopy. Incidence of post transfusion malaria by PCR was 57%. The sensitivity of RDT in detecting malaria at post transfusion was 100%. Conclusion: Efficiency of malaria RDT as a tool for malaria diagnosis at post transfusion, among children under five years old is good. Clinicians should consider implementing the use of malaria RDT at post transfusion.},
 year = {2020}
}

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