International Journal of HIV/AIDS Prevention, Education and Behavioural Science

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From HIV/AIDS to HIV Cancer: An Analysis of Transition from HIV Infection to Cancer Amongst Patients in Cameroon

Received: 22 October 2015    Accepted: 13 November 2015    Published: 13 November 2015
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Abstract

A total of 288 cases of HIV cancers were retained among 3785 HIV infected patients in this retrospective multi-centre pilot study that lasted 18 months between 1st January 2013 and June 30 2014 in Cameroon. This gave a cancer prevalence among HIV infected patients of 7.6%.The study was aimed at looking at the transition time between HIV infection to development of cancer amongst patients. Data on cancer and HIV infection of patients with both diseases in the randomly selected pilot centres were retrieved, assembled and analyzed.The mean age of patients was 44.1years with 30% of them aged between 30-39 years. HIV malignancies occurred predominantly in females (71%). 45.5% of the patients had AIDS-Defining Cancers against 47.6% Non-AIDS-Defining Cancers. Kaposi sarcoma was the commonest cancer, accounting for 50.4% of all AIDS-defining cancers; while breast cancer was the most prevalent non-AIDS-defining cancer, contributing to 32.8% of all cancers in this group. Diagnosis of cancers in these patients (100%) was all made after the diagnosis of HIV at a mean time interval of 3.6 years. Most cancers (16.7%) were diagnosed within 1 year of HIV infection, at CD4 counts between 300-399cells/µL in females, which was significantly different from CD4 counts ˂100cells/µL in males. HIV serotyping showed a predominance of HIV I (67.7%). There was no sex predilection for any HIV serotype, similarly, there was no association between a particular HIV serotype and cancer type. HIV malignancies are not rare in Cameroon. Though the prevalence of the infection in the entire nation has tipped off in recent years, it is likely that more malignancies would be detected in future amongst HIV/AIDS patients due to prolonged survival as a consequence of increased availability of Highly Active Anti-Retroviral Therapy (HAART). Knowledge of the transition time between HIV infection and the apparition of cancer is a vital tool for comprehensive management of these patients that could improve on the outcome of both diseases. Further in-depth studies to document incidence and trends of HIV malignancies in our community are recommended.

DOI 10.11648/j.ijhpebs.20150102.11
Published in International Journal of HIV/AIDS Prevention, Education and Behavioural Science (Volume 1, Issue 2, August 2015)
Page(s) 14-20
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

HIV/AIDS, Transition, HIV Cancer, Cameroon

References
[1] Lima DV. AIDS incidence and AIDS-related mortality in British Columbia, Canada, between 1981 and 2013: a retrospective study. The Lancet HIV 2015; 2(3): 92-97.
[2] Schwartlander B, Grubb I, Perriens J. The 10-year struggle to provide antiretroviral treatment to people with HIV in the developing world. The Lancet HIV 2006; 368(9534): 541-546.
[3] The 1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and Adults. MMWR Recomm Rep 1992; 41:1-19.
[4] Engels EA, Biggar RJ, Hall HI, et al. Cancer risk in people infected with human immunodeficiency virus in the United States. International Journal of Cancer 2008; 123(1): 187–194.
[5] Powles T, Macdonald D, Nelson M, Stebbing J. Hepatocellular cancer in HIV-infected individuals: tomorrow's problem? Expert Review of Anticancer Therapy 2006; 6(11): 1553–1558.
[6] Enow Orock GE, Ndom P, Doh AS. Current cancer incidence and trends in Yaounde, Cameroon. Oncol Gastroenterol Hepatol Reports 2012; 1(1): 58-63.
[7] 3e RPGH: La population du Cameroun en 2010, 2010.
[8] Lucy Agyingi, Luzia M Mayr, Thompson Kinge, George Enow Orock, Johnson Ngai, Bladine Asaah, Mbida Mpoame, Indira Hewlett, Phillipe Nyambi. The evolution of HIV-I group M genetic variability in Southern Cameroon is characterized by several emerging recombinant forms of CRF02_AG and viruses with drug resistance mutations. J Med Virology 2014; 86: 385-393.
[9] Gotti D, Raffetti E, Albini L, Sighinolfi L, Maggiolo F, Di Filippo E, et al. Survival in HIV-infected patients after a cancer diagnosis in the cART era: results of an Italian multicenter study. PLOS ONE 2014; 11: 25.
[10] Crum-Cianflone N, Hullsiek KH, Marconi V, Weintrob A, Ganesan A, Barthel RV, et al. Trends in the incidence of cancers among HIV-infected persons and the impact of antiretroviral therapy: a 20-year cohort study. AIDS 2009; 23(1): 41-50.
[11] Mbulaiteye SM, Katabira ET, Wabinga H, Donald M, Virgo PP, Ochai R, et al. Spectrum of cancers among HIV-infected persons in Africa: The Uganda AIDS-Cancer Registry match study. Int J Cancer. 2006; 118(4): 985-990.
[12] Joint United Nations Programme on HIV and AIDS. Access to antiretroviral therapy in Africa: status report on progress towards the 2015 targets; 2013.
[13] Mbulaiteye SM, Katabira ET, Wabinga H, Donald M, Virgo PP, Ochai R, et al. Spectrum of cancers among HIV-infected persons in Africa: The Uganda AIDS-Cancer Registry match study. Int J Cancer. 2006; 118(4): 985-990.
[14] Park LS, Tate JP, Rodriguez-Barradas MC, Rimland D, Goetz MD, Gilbert C, et al. Cancer incidence in HIV-infected versus uninfected veterans: comparison of cancer registry and ICD-9 code diagnoses. J AIDS Clin Res 2014; 5(7): 1000318.
[15] Crum-Cianflone N, Hullsiek KH, Marconi V, Weintrob A, Ganesan A, Barthel RV, et al. Trends in the incidence of cancers among HIV-infected persons and the impact of antiretroviral therapy: a 20-year cohort study. AIDS 2009; 23(1): 41-50.
[16] Akarolo-Anthony SN, Dal Maso L, Igbinoba F, Mbulaiteye SM, Adebamowo CA. Cancer burden among HIV-positive persons in Nigeria: preliminary findings from the Nigerian AIDS-cancer match study. Infect Agents and Cancer 2014; 9:1.
[17] Ocheni S, Aken' Ova YA. Association between HIV/AIDS and malignancies in a Nigerian tertiary institution. West Afri J Med 2004; 23(2).
[18] Sackoff JE, Hanna DB, Pfeiffer MR, Torian LV. Causes of death among persons with AIDS in the era of highly active antiretroviral therapy: New York City. Ann Intern Med. 2006; 145: 397–406.
[19] Seaberg EC, Wiley D, Martinez-Maza O, Chimiel JS, Kingsley L, Tang Y, et al. Cancer incidence in the multicenter aids cohort study before and during the HAART era. ACS 2010; 116(23): 5507-5516.
[20] Biggar RJ, Cross H, Engels EA,Hall M, Crutchfield A, Finch JL, et al. Cancer risk in people infected with human immunodeficiency virus in the United States. Int J Cancer 2008; 123(1): 187-194.
[21] Albini L, Calabresi A, Gotti D, Ferraresi A, Festa A, Donato F, et al. Burden of non-AIDS-defining and non-virus-related cancers among HIV-infected patients in the combined antiretroviral therapy era. BMC Public Health 2013; 29(8): 1097-1104.
[22] Devaleenal B, Flanigan TP, Kumarasamy N, Mayer KH, Poongulali S, Saghayam S, et al. Spectrum of malignancies among HIV -infected patients in South India. Indian J Cancer. 2012; 49(1): 176-180.
[23] Castilho JL, Luz PM, Shepherd BE, Turner M, Ribeiro SR, Bebawy SS, et al. HIV and cancers: a comparative retrospective study of Brazilian and U.S. clinical cohorts. InfectAgents and Cancer 2015; 10:4.
[24] Burgi A, Brodine S, Wegner S, Milazzo M, Wallace MR, et al. Incidence and risk factors for the occurrence of non-AIDS-defining cancers among human immunodeficiency virus-infected individuals. Cancer. 2005; 104: 1505–1511.
[25] Meng Q, Walker DM, Olivero OA, Shi X, Antiochos BB, et al. Zidovudine-didanosinecoexposure potentiates DNA incorporation of zidovudine and mutagenesis in human cells. Proc Natl Acad Sci U S A. 2000; 97: 12667–12671
[26] Grulich AE, van Leeuwen MT, Falster MO, Vajdic CM. Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet 2007; 370(9581): 59–67.
[27] Chokunonga E, Levy LM, Bassett MT, Mauchaza BG, Thomas DB, Parkin DM. Cancer incidence in the African population of Harare, Zimbabwe: second results from the cancer registry 1993-1995. Int J Cancer 2000; 85(1): 54-9.
[28] Patil P, Elum B, Zumla A. Pattern of adult malignancies in Zambia (1980-1989) in light of the human immunodeficiency virus type I epidemic. J Trop Med Hyg. 1995; 98: 281-284.
[29] Hajjar M, Lacoste D, Brossard G, Morlat P, Dupon m, Salmi LR, et al. Non-aquired deficiency syndrome-defining malignancies in a hospital-based cohort of human immunodeficiency virus –infected patients: Bordeaux, France, (1985-1991). Groupe d´Epidemiologie Clinique du SIDA en Aquitaine. J Natl Cancer Inst 1992; 84: 1593-1595.
[30] Ryan M. Ford, MD, Matthew M. McMahon, MD, and Mohammad A. Wehbi. HIV/AIDS and colorectal cancer. Gastroenterol Hepatol (N Y). 2008; 4(4): 274–278.
[31] Klugman AD, Schaffner J. Colon adenocarcinoma in HIV infection: a case report and review. Am J Gastroenterol. 1994; 89: 254–256.
[32] Monfardini S, Vaccher E, Pizzocaro G, Stellini R, Sinicco A, et al. Unusual malignant tumors in 49 patients with HIV infection. AIDS. 1989; 3: 449–452.
[33] Cappell MS, Yao F, Cho KC. Colonic adenocarcinoma associated with the acquired immune deficiency syndrome. Cancer. 1988; 62: 616–619.
[34] Ravalli S, Chabon AB, Khan AA. Gastrointestinal neoplasia in young HIV antibody-positive patients. Am J Clin Pathol. 1989; 91: 458–461.
[35] Engels EA, Pfeiffer RM, Goedert JJ, Virgo P, McNeel TS, et al. Trends in cancer risk among people with AIDS in the United States 1980-2002. AIDS. 2006; 20: 1645–1654.
[36] Enow Orock GE, Ndom P, Essame-Oyono JL, Muna WFT, Doh AS. Cancer Incidence in Yaounde 2004-2006/2010-2011: Yaounde Cancer Registry Technical Report, Yaounde: National Cancer Control Committee, Cameroon, 2012, 13-15.
[37] Mbulaiteye SM, Biggar RJ, Goedert JJ, Engels EA. Immune deficiency and risk for malignancy among persons with AIDS. J Acquir Immune Defic Syndr. 2003; 32: 527–533.
[38] Sitas F, Pacella-Norman R, Carrara H, Patel M, Ruff P, Sur R, et al. The spectrum of HIV-1 related cancers in South Africa. Int J Cancer 2000; 88(3): 489-492.
[39] Stuardo V, Agusti C, Godinez JM, Montoliu A, Torné A, Tarrats A, et al. Human papillomavirus infection in HIV-1 infected women in Catalonia (Spain): Implications for prevention of cervical cancer. Clin Infect Disease 2012; 205(1): 681-90.
[40] Hleyhel M, Belot A, Bouvier AM, Tattevin P, Pacanowski J, Genet P, et al. Risk of AIDS-defining cancers among HIV-1-infected patients in France between 1992 and 2009: results from the FHDH-ANRS CO4 cohort. Clin Infect Dis 2013; 57(11): 1638-47.
Author Information
  • Faculty of Health Science, University of Buea, Regional Hospital Buea, Buea, Cameroon

  • Faculty of Health Science, University of Dschang; Medical Diagnostic Center Yaounde, Dschang/Yaounde, Cameroon

  • Faculty of Health Science, University of Buea, Buea, Cameroon

  • Pathology Unit, Regional Hospital Buea, Buea, Cameroon

  • Medical Diagnostic Center Yaounde, Yaounde, Cameroon

  • Faculty of Medicine and Biomedical Science, University of Douala, Douala, Cameroon

  • National Cancer Control Committee, Yaounde, Cameroon

  • National Cancer Control Committee, Yaounde, Cameroon

  • New York University School of Medicine, Veterans Affairs New York Habor Healthcare Systems, New York, USA

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  • APA Style

    Enow Orock G., Agyingi L., Nnap L., Ewane T. P., Ngai J., et al. (2015). From HIV/AIDS to HIV Cancer: An Analysis of Transition from HIV Infection to Cancer Amongst Patients in Cameroon. International Journal of HIV/AIDS Prevention, Education and Behavioural Science, 1(2), 14-20. https://doi.org/10.11648/j.ijhpebs.20150102.11

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    ACS Style

    Enow Orock G.; Agyingi L.; Nnap L.; Ewane T. P.; Ngai J., et al. From HIV/AIDS to HIV Cancer: An Analysis of Transition from HIV Infection to Cancer Amongst Patients in Cameroon. Int. J. HIV/AIDS Prev. Educ. Behav. Sci. 2015, 1(2), 14-20. doi: 10.11648/j.ijhpebs.20150102.11

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    AMA Style

    Enow Orock G., Agyingi L., Nnap L., Ewane T. P., Ngai J., et al. From HIV/AIDS to HIV Cancer: An Analysis of Transition from HIV Infection to Cancer Amongst Patients in Cameroon. Int J HIV/AIDS Prev Educ Behav Sci. 2015;1(2):14-20. doi: 10.11648/j.ijhpebs.20150102.11

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  • @article{10.11648/j.ijhpebs.20150102.11,
      author = {Enow Orock G. and Agyingi L. and Nnap L. and Ewane T. P. and Ngai J. and Fewou A. and Ndom P. and Doh A. and Nyambi P.},
      title = {From HIV/AIDS to HIV Cancer: An Analysis of Transition from HIV Infection to Cancer Amongst Patients in Cameroon},
      journal = {International Journal of HIV/AIDS Prevention, Education and Behavioural Science},
      volume = {1},
      number = {2},
      pages = {14-20},
      doi = {10.11648/j.ijhpebs.20150102.11},
      url = {https://doi.org/10.11648/j.ijhpebs.20150102.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijhpebs.20150102.11},
      abstract = {A total of 288 cases of HIV cancers were retained among 3785 HIV infected patients in this retrospective multi-centre pilot study that lasted 18 months between 1st January 2013 and June 30 2014 in Cameroon. This gave a cancer prevalence among HIV infected patients of 7.6%.The study was aimed at looking at the transition time between HIV infection to development of cancer amongst patients. Data on cancer and HIV infection of patients with both diseases in the randomly selected pilot centres were retrieved, assembled and analyzed.The mean age of patients was 44.1years with 30% of them aged between 30-39 years. HIV malignancies occurred predominantly in females (71%). 45.5% of the patients had AIDS-Defining Cancers against 47.6% Non-AIDS-Defining Cancers. Kaposi sarcoma was the commonest cancer, accounting for 50.4% of all AIDS-defining cancers; while breast cancer was the most prevalent non-AIDS-defining cancer, contributing to 32.8% of all cancers in this group. Diagnosis of cancers in these patients (100%) was all made after the diagnosis of HIV at a mean time interval of 3.6 years. Most cancers (16.7%) were diagnosed within 1 year of HIV infection, at CD4 counts between 300-399cells/µL in females, which was significantly different from CD4 counts ˂100cells/µL in males. HIV serotyping showed a predominance of HIV I (67.7%). There was no sex predilection for any HIV serotype, similarly, there was no association between a particular HIV serotype and cancer type. HIV malignancies are not rare in Cameroon. Though the prevalence of the infection in the entire nation has tipped off in recent years, it is likely that more malignancies would be detected in future amongst HIV/AIDS patients due to prolonged survival as a consequence of increased availability of Highly Active Anti-Retroviral Therapy (HAART). Knowledge of the transition time between HIV infection and the apparition of cancer is a vital tool for comprehensive management of these patients that could improve on the outcome of both diseases. Further in-depth studies to document incidence and trends of HIV malignancies in our community are recommended.},
     year = {2015}
    }
    

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    T1  - From HIV/AIDS to HIV Cancer: An Analysis of Transition from HIV Infection to Cancer Amongst Patients in Cameroon
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    AU  - Agyingi L.
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    AU  - Ndom P.
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    JF  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
    JO  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
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    AB  - A total of 288 cases of HIV cancers were retained among 3785 HIV infected patients in this retrospective multi-centre pilot study that lasted 18 months between 1st January 2013 and June 30 2014 in Cameroon. This gave a cancer prevalence among HIV infected patients of 7.6%.The study was aimed at looking at the transition time between HIV infection to development of cancer amongst patients. Data on cancer and HIV infection of patients with both diseases in the randomly selected pilot centres were retrieved, assembled and analyzed.The mean age of patients was 44.1years with 30% of them aged between 30-39 years. HIV malignancies occurred predominantly in females (71%). 45.5% of the patients had AIDS-Defining Cancers against 47.6% Non-AIDS-Defining Cancers. Kaposi sarcoma was the commonest cancer, accounting for 50.4% of all AIDS-defining cancers; while breast cancer was the most prevalent non-AIDS-defining cancer, contributing to 32.8% of all cancers in this group. Diagnosis of cancers in these patients (100%) was all made after the diagnosis of HIV at a mean time interval of 3.6 years. Most cancers (16.7%) were diagnosed within 1 year of HIV infection, at CD4 counts between 300-399cells/µL in females, which was significantly different from CD4 counts ˂100cells/µL in males. HIV serotyping showed a predominance of HIV I (67.7%). There was no sex predilection for any HIV serotype, similarly, there was no association between a particular HIV serotype and cancer type. HIV malignancies are not rare in Cameroon. Though the prevalence of the infection in the entire nation has tipped off in recent years, it is likely that more malignancies would be detected in future amongst HIV/AIDS patients due to prolonged survival as a consequence of increased availability of Highly Active Anti-Retroviral Therapy (HAART). Knowledge of the transition time between HIV infection and the apparition of cancer is a vital tool for comprehensive management of these patients that could improve on the outcome of both diseases. Further in-depth studies to document incidence and trends of HIV malignancies in our community are recommended.
    VL  - 1
    IS  - 2
    ER  - 

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