Haematological Abnormalities in <i>Visceral Leishmaniasis</i> Patients Attending Gondar University Hospital; Retrospective Study

Eyasu Tesfaye; Kinfe Fissehatsion; Bethelihem Terefe; Bamlaku Enawgaw

doi:doi:10.11648/j.ijhpebs.20170305.11

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Haematological Abnormalities in Visceral Leishmaniasis Patients Attending Gondar University Hospital; Retrospective Study

Eyasu Tesfaye, Kinfe Fissehatsion, Bethelihem Terefe, Bamlaku Enawgaw

Published in International Journal of HIV/AIDS Prevention, Education and Behavioural Science (Volume 3, Issue 5)

Received: 16 October 2017 Accepted: 3 November 2017 Published: 25 November 2017

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Abstract

Visceral Leishmaniasis (VL) or kalazar is a fatal neglected tropical disease caused by protozoan parasites of the genus Leishmania, belonging to the family Trypanosomatidae. Leishmania donovani complex are the causative agents of Visceral Leishmaniasis in Ethiopia and its burden is a public health problem where every year health facilities report thousands of cases and hundreds of deaths. Hematological abnormalities are the common presentation for human with Visceral Leishmaniasis, which comprises anemia, leucopenia and thrombocytopenia. Therefore; this study aimed to assess hematological abnormalities among Visceral Leishmaniasis patients attending Gondar University Hospital using a cross sectional study design. Socio-demographic data on 414 Visceral Leishmaniasis patients having complete records on hematological parameters collected from the laboratory log book and hospital chart by using a structured data collection sheet. Data was entered and analyze by using SPSS version 20. From the total 414 Visceral Leishmaniasis patients, 405(97.8%) were males and 9(2.2%) were females. The overall magnitude of anemia, leucopenia, thrombocytopenia, neutropenia and Lymphopenia was 94.4%, 95.4%, 90.1%, 90.1% and 37.9% respectively. There was a significant association between age and prevalence of anemia, neutropenia and thrombocytopenia. The finding of the study shows with predominant existence of anemia, leucopenia and thrombocytopenia. Thus, specific diagnosis and monitoring of hematological abnormalities is required for early treatment of the disease and decreases mortality rate due to these abnormalities.

Published in	International Journal of HIV/AIDS Prevention, Education and Behavioural Science (Volume 3, Issue 5)
DOI	10.11648/j.ijhpebs.20170305.11
Page(s)	48-53
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Visceral Leishmaniasis, Anemia, Leucopenia, Thrombocytopenia

References

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[5]	Desjeux P. The increase of risk factors for Leishmaniasis worldwide. Trans R Soc Trop Med Hyg. 2001; 95: 239–243.
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[7]	Bain BJ, Lewis SM, Practical hematology: Preparation and staining methods for blood and bone marrow films. 10thed. Churchill Livingston, Philadelphia. 2006; 59–78.
[8]	Dhingra KK, Gupta P, Saroha V, Setia N, Khurana N, Singh T. Morphological findings in bone marrow biopsy and aspirate smears of visceral kalaazar. Indian J PatholMicrobiol. 2010; 53:96-100.
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[17]	Hailu A, Gebre-Micheal T, Berhe N and Balkew M. Epidemiology and Ecology of Health and disease in Ethiopia: Leishmaniasis in Ethiopia. Shama press, Addis Ababa. 2006:615-634.
[18]	Livotti S, Fischer A, Hematological and serological aspects of Mediterranean kala azar in infancy and childhood. Acta Trop. 1980; 37:351.
[19]	Marwaha N, Sarode R, Gupta RK, Garewal G, Dash S Clinico-hematological characteristics in patients with kala-azar, a study from North-West India. Trop Geogr Med.1991;43:357–362.
[20]	Al-Jurrayan AM, Al-Nasser MN, Al-Fawaz IM, Al-Ayed IH, Al-Herbish A, Al-Mazrou AM, Al-Sohailbani MO. The hematological manifestations of visceral Leishmaniasis in infancy and childhood. J Trop Paediatr.1995; 41:143–148.
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APA Style

Eyasu Tesfaye, Kinfe Fissehatsion, Bethelihem Terefe, Bamlaku Enawgaw. (2017). Haematological Abnormalities in Visceral Leishmaniasis Patients Attending Gondar University Hospital; Retrospective Study. International Journal of HIV/AIDS Prevention, Education and Behavioural Science, 3(5), 48-53. https://doi.org/10.11648/j.ijhpebs.20170305.11

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ACS Style

Eyasu Tesfaye; Kinfe Fissehatsion; Bethelihem Terefe; Bamlaku Enawgaw. Haematological Abnormalities in Visceral Leishmaniasis Patients Attending Gondar University Hospital; Retrospective Study. Int. J. HIV/AIDS Prev. Educ. Behav. Sci. 2017, 3(5), 48-53. doi: 10.11648/j.ijhpebs.20170305.11

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AMA Style

Eyasu Tesfaye, Kinfe Fissehatsion, Bethelihem Terefe, Bamlaku Enawgaw. Haematological Abnormalities in Visceral Leishmaniasis Patients Attending Gondar University Hospital; Retrospective Study. Int J HIV/AIDS Prev Educ Behav Sci. 2017;3(5):48-53. doi: 10.11648/j.ijhpebs.20170305.11

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@article{10.11648/j.ijhpebs.20170305.11,
  author = {Eyasu Tesfaye and Kinfe Fissehatsion and Bethelihem Terefe and Bamlaku Enawgaw},
  title = {Haematological Abnormalities in Visceral Leishmaniasis Patients Attending Gondar University Hospital; Retrospective Study},
  journal = {International Journal of HIV/AIDS Prevention, Education and Behavioural Science},
  volume = {3},
  number = {5},
  pages = {48-53},
  doi = {10.11648/j.ijhpebs.20170305.11},
  url = {https://doi.org/10.11648/j.ijhpebs.20170305.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijhpebs.20170305.11},
  abstract = {Visceral Leishmaniasis (VL) or kalazar is a fatal neglected tropical disease caused by protozoan parasites of the genus Leishmania, belonging to the family Trypanosomatidae. Leishmania donovani complex are the causative agents of Visceral Leishmaniasis in Ethiopia and its burden is a public health problem where every year health facilities report thousands of cases and hundreds of deaths. Hematological abnormalities are the common presentation for human with Visceral Leishmaniasis, which comprises anemia, leucopenia and thrombocytopenia. Therefore; this study aimed to assess hematological abnormalities among Visceral Leishmaniasis patients attending Gondar University Hospital using a cross sectional study design. Socio-demographic data on 414 Visceral Leishmaniasis patients having complete records on hematological parameters collected from the laboratory log book and hospital chart by using a structured data collection sheet. Data was entered and analyze by using SPSS version 20. From the total 414 Visceral Leishmaniasis patients, 405(97.8%) were males and 9(2.2%) were females. The overall magnitude of anemia, leucopenia, thrombocytopenia, neutropenia and Lymphopenia was 94.4%, 95.4%, 90.1%, 90.1% and 37.9% respectively. There was a significant association between age and prevalence of anemia, neutropenia and thrombocytopenia. The finding of the study shows with predominant existence of anemia, leucopenia and thrombocytopenia. Thus, specific diagnosis and monitoring of hematological abnormalities is required for early treatment of the disease and decreases mortality rate due to these abnormalities.},
 year = {2017}
}

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TY  - JOUR
T1  - Haematological Abnormalities in Visceral Leishmaniasis Patients Attending Gondar University Hospital; Retrospective Study
AU  - Eyasu Tesfaye
AU  - Kinfe Fissehatsion
AU  - Bethelihem Terefe
AU  - Bamlaku Enawgaw
Y1  - 2017/11/25
PY  - 2017
N1  - https://doi.org/10.11648/j.ijhpebs.20170305.11
DO  - 10.11648/j.ijhpebs.20170305.11
T2  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
JF  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
JO  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
SP  - 48
EP  - 53
PB  - Science Publishing Group
SN  - 2575-5765
UR  - https://doi.org/10.11648/j.ijhpebs.20170305.11
AB  - Visceral Leishmaniasis (VL) or kalazar is a fatal neglected tropical disease caused by protozoan parasites of the genus Leishmania, belonging to the family Trypanosomatidae. Leishmania donovani complex are the causative agents of Visceral Leishmaniasis in Ethiopia and its burden is a public health problem where every year health facilities report thousands of cases and hundreds of deaths. Hematological abnormalities are the common presentation for human with Visceral Leishmaniasis, which comprises anemia, leucopenia and thrombocytopenia. Therefore; this study aimed to assess hematological abnormalities among Visceral Leishmaniasis patients attending Gondar University Hospital using a cross sectional study design. Socio-demographic data on 414 Visceral Leishmaniasis patients having complete records on hematological parameters collected from the laboratory log book and hospital chart by using a structured data collection sheet. Data was entered and analyze by using SPSS version 20. From the total 414 Visceral Leishmaniasis patients, 405(97.8%) were males and 9(2.2%) were females. The overall magnitude of anemia, leucopenia, thrombocytopenia, neutropenia and Lymphopenia was 94.4%, 95.4%, 90.1%, 90.1% and 37.9% respectively. There was a significant association between age and prevalence of anemia, neutropenia and thrombocytopenia. The finding of the study shows with predominant existence of anemia, leucopenia and thrombocytopenia. Thus, specific diagnosis and monitoring of hematological abnormalities is required for early treatment of the disease and decreases mortality rate due to these abnormalities.
VL  - 3
IS  - 5
ER  -

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Author Information

Eyasu Tesfaye

Department of Laboratory, Addis Ababa City Administration Health Bureau, Gandhi Memorial Hospital, Addis Ababa, Ethiopia
Kinfe Fissehatsion

Department of Laboratory, Addis Ababa City Administration Health Bureau, Gandhi Memorial Hospital, Addis Ababa, Ethiopia
Bethelihem Terefe

Department of Medical Laboratory Science, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
Bamlaku Enawgaw

Department of Medical Laboratory Science, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia

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Plain Text BibTeX RIS

APA Style

Eyasu Tesfaye, Kinfe Fissehatsion, Bethelihem Terefe, Bamlaku Enawgaw. (2017). Haematological Abnormalities in Visceral Leishmaniasis Patients Attending Gondar University Hospital; Retrospective Study. International Journal of HIV/AIDS Prevention, Education and Behavioural Science, 3(5), 48-53. https://doi.org/10.11648/j.ijhpebs.20170305.11

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ACS Style

Eyasu Tesfaye; Kinfe Fissehatsion; Bethelihem Terefe; Bamlaku Enawgaw. Haematological Abnormalities in Visceral Leishmaniasis Patients Attending Gondar University Hospital; Retrospective Study. Int. J. HIV/AIDS Prev. Educ. Behav. Sci. 2017, 3(5), 48-53. doi: 10.11648/j.ijhpebs.20170305.11

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AMA Style

Eyasu Tesfaye, Kinfe Fissehatsion, Bethelihem Terefe, Bamlaku Enawgaw. Haematological Abnormalities in Visceral Leishmaniasis Patients Attending Gondar University Hospital; Retrospective Study. Int J HIV/AIDS Prev Educ Behav Sci. 2017;3(5):48-53. doi: 10.11648/j.ijhpebs.20170305.11

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@article{10.11648/j.ijhpebs.20170305.11,
  author = {Eyasu Tesfaye and Kinfe Fissehatsion and Bethelihem Terefe and Bamlaku Enawgaw},
  title = {Haematological Abnormalities in Visceral Leishmaniasis Patients Attending Gondar University Hospital; Retrospective Study},
  journal = {International Journal of HIV/AIDS Prevention, Education and Behavioural Science},
  volume = {3},
  number = {5},
  pages = {48-53},
  doi = {10.11648/j.ijhpebs.20170305.11},
  url = {https://doi.org/10.11648/j.ijhpebs.20170305.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijhpebs.20170305.11},
  abstract = {Visceral Leishmaniasis (VL) or kalazar is a fatal neglected tropical disease caused by protozoan parasites of the genus Leishmania, belonging to the family Trypanosomatidae. Leishmania donovani complex are the causative agents of Visceral Leishmaniasis in Ethiopia and its burden is a public health problem where every year health facilities report thousands of cases and hundreds of deaths. Hematological abnormalities are the common presentation for human with Visceral Leishmaniasis, which comprises anemia, leucopenia and thrombocytopenia. Therefore; this study aimed to assess hematological abnormalities among Visceral Leishmaniasis patients attending Gondar University Hospital using a cross sectional study design. Socio-demographic data on 414 Visceral Leishmaniasis patients having complete records on hematological parameters collected from the laboratory log book and hospital chart by using a structured data collection sheet. Data was entered and analyze by using SPSS version 20. From the total 414 Visceral Leishmaniasis patients, 405(97.8%) were males and 9(2.2%) were females. The overall magnitude of anemia, leucopenia, thrombocytopenia, neutropenia and Lymphopenia was 94.4%, 95.4%, 90.1%, 90.1% and 37.9% respectively. There was a significant association between age and prevalence of anemia, neutropenia and thrombocytopenia. The finding of the study shows with predominant existence of anemia, leucopenia and thrombocytopenia. Thus, specific diagnosis and monitoring of hematological abnormalities is required for early treatment of the disease and decreases mortality rate due to these abnormalities.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Haematological Abnormalities in Visceral Leishmaniasis Patients Attending Gondar University Hospital; Retrospective Study
AU  - Eyasu Tesfaye
AU  - Kinfe Fissehatsion
AU  - Bethelihem Terefe
AU  - Bamlaku Enawgaw
Y1  - 2017/11/25
PY  - 2017
N1  - https://doi.org/10.11648/j.ijhpebs.20170305.11
DO  - 10.11648/j.ijhpebs.20170305.11
T2  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
JF  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
JO  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
SP  - 48
EP  - 53
PB  - Science Publishing Group
SN  - 2575-5765
UR  - https://doi.org/10.11648/j.ijhpebs.20170305.11
AB  - Visceral Leishmaniasis (VL) or kalazar is a fatal neglected tropical disease caused by protozoan parasites of the genus Leishmania, belonging to the family Trypanosomatidae. Leishmania donovani complex are the causative agents of Visceral Leishmaniasis in Ethiopia and its burden is a public health problem where every year health facilities report thousands of cases and hundreds of deaths. Hematological abnormalities are the common presentation for human with Visceral Leishmaniasis, which comprises anemia, leucopenia and thrombocytopenia. Therefore; this study aimed to assess hematological abnormalities among Visceral Leishmaniasis patients attending Gondar University Hospital using a cross sectional study design. Socio-demographic data on 414 Visceral Leishmaniasis patients having complete records on hematological parameters collected from the laboratory log book and hospital chart by using a structured data collection sheet. Data was entered and analyze by using SPSS version 20. From the total 414 Visceral Leishmaniasis patients, 405(97.8%) were males and 9(2.2%) were females. The overall magnitude of anemia, leucopenia, thrombocytopenia, neutropenia and Lymphopenia was 94.4%, 95.4%, 90.1%, 90.1% and 37.9% respectively. There was a significant association between age and prevalence of anemia, neutropenia and thrombocytopenia. The finding of the study shows with predominant existence of anemia, leucopenia and thrombocytopenia. Thus, specific diagnosis and monitoring of hematological abnormalities is required for early treatment of the disease and decreases mortality rate due to these abnormalities.
VL  - 3
IS  - 5
ER  -

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