Cluster of Differentiation 4 Count and Left Ventricular Diastolic Function in Patients with Hiv - Aids
International Journal of HIV/AIDS Prevention, Education and Behavioural Science
Volume 4, Issue 1, June 2018, Pages: 5-10
Received: Feb. 23, 2018;
Accepted: Mar. 20, 2018;
Published: Apr. 12, 2018
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Farid Hidayat, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Dian Pratiwi, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Titus Kurnia, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Taslim, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Ahmad Syukri, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Paskalis Indra, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Muzakkir Amir, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Peter Kabo, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Robert Setiadji, Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia
Background: People with Acquired Immunodeficiency Syndrome (AIDS) are at risk of developing structural and functional cardiac abnormalities that are unrelated to common cardiac risk factors (e.g. Hypertension, Diabetes Mellitus, Smoking habit). AIDS may be associated with chronic inflammation related to multiple factors related to the Human Immunodeficiency Virus (HIV) infection and its complications. Cardiac abnormality with AIDS may be subclinical and may present long before the onset of clinical heart failure symptoms. Objectives: To anticipate the risk of cardiovascular morbidity in people with AIDS. Methods: The researchers studied 52 people with AIDS in this observational cross-sectional study, which were further categorized into those with cluster of differentiation 4 (CD4) count of less than 200/mm3 and those with CD4 count of more than 200/mm3. Echocardiographic examinations were done to evaluate cardiac structural and functional values. Results: Mean age was 33 years old, predominantly male (71.2%). The group with a CD4 count of less than 200/mm3 showed higher Left Ventricular Mass Index (LVMI) values (113.08 vs. 39.99, p=0.012), a higher risk of developing diastolic dysfunction (OR 9.35, CI 95%, p=0.018) and pericardial effusion (OR 3.83, CI 95%, p=0.048). Conclusion: A CD4 count of less than 200/mm3 is associated with a higher risk of developing cardiac diastolic dysfunction and structural abnormalities.
Cluster of Differentiation 4 Count and Left Ventricular Diastolic Function in Patients with Hiv - Aids, International Journal of HIV/AIDS Prevention, Education and Behavioural Science.
Vol. 4, No. 1,
2018, pp. 5-10.
The Joint United Nations Programme on HIV/AIDS (UNAIDS). Global HIV Statistics. n.d. Available from: http://www.unaids.org/en/resources/fact-sheet.pdf
Dasti MA, Hashmi SFA, Jaffri MSA, et al. Cardiac manifestations of pulmonary tuberculosis. Professional Med J. 2015;22(6):733–737.
The DAD Study Group. Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med 2007;356:1723–1735. https://doi.org/10.1056/NEJMoa062744
Bloomfield GS, Alenezi F, Barasa FA, Lumsden R, Mayosi BM, Velazquez EJ. Human Immunodeficiency Virus and Heart Failure in Low- and Middle-Income Countries. JACC Heart Fail. 2015;3(8):579–590. https://doi.org/10.1016/j.jchf.2015.05.003
Bozzette SA. HIV and Cardiovascular Disease. Clinical Infectious Disease. 2011;53:92–93. https://doi.org/10.1093/cid/cir275
Hunt SA, Abraham WT, Chin MH, et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation. 2005;112:154–235. https://doi.org/10.1161/CIRCULATIONAHA.105.167586
Frustaci A, Petrosillo N, Francone M, Verardo R, Ippolito G, Chimenti C. Biopsy-proven autoimmune myocarditis in HIV-associated dilated cardiomyopathy. BMC Infect Dis. 2014;14:3855–3860. https://doi.org/10.1186/s12879-014-0729-3
Topol EJ, Califf RM, Isner JM, et al. (2002). Textbook of cardiovascular medicine, second edition. Lippincott Williams & Wilkins. 2002;2:1991-97.
Bernard A., Boumsell L., Hill C. (1984) Joint Report of the First International Workshop on Human Leucocyte Differentiation Antigens by the Investigators of the Participating Laboratories. In: Bernard A., Boumsell L., Dausset J., Milstein C., Schlossman S.F. (eds) Leucocyte Typing. Springer, Berlin, Heidelberg. 1984. https://doi.org/10.1007/978-3-642-68857-7_3
Remick J, Georgiopoulou V, Marti C, et al. Heart failure in patients with human immunodeficiency virus infection: epidemiology, pathophysiology, treatment, and future research. Circulation. 2014;129(17):1781–1789. https://dx.doi.org/10.1161%2FCIRCULATIONAHA.113.004574
Bartel T, Muller S. How to relate diastolic left ventricular dysfunction to the results of stress echocardiography in aortic stenosis?. Cardiovasc Diagn Ther. 2013;3(4):190–192. https://dx.doi.org/10.3978%2Fj.issn.2223-3652.2013.11.01
Wu CK, Wang YC, Lee JK, et al. Connective tissue growth factor and cardiac diastolic dysfunction: human data from the Taiwan diastolic heart failure registry and molecular basis by cellular and animal models. Eur J Heart Fail. 2014;16(2):163-172. https://doi.org/10.1002/ejhf.33
Sipić T, Stambuk K, Trbović A, Kapov-Svilicić K, Szavits-Nossan J, Bernat R. Echocardiographic assessment of revascularization completeness impact on diastolic dysfunction in ischemic heart disease. Coll Antropol. 2013;37(4):1299-1305.
Paulus WJ, Tschöpe C. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol. 2013;62(4):263–271. https://doi.org/10.1016/j.jacc.2013.02.092
Nagueh SF, Appleton CP, Gillebert TC, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. J Am Soc Echocardiogr. 2009;22(2):107–133. https://doi.org/10.1016/j.echo.2008.11.023
Lang RM, Bierig M, Devereux RB, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18(12):1440–1463. https://doi.org/10.1016/j.echo.2005.10.005
Sliwa K, Carrington MJ, Becker A, Thienemann F, Ntsekhe M, Stewart S. Contribution of the human immunodeficiency virus/acquired immunodeficiency syndrome epidemic to de novo presentations of heart disease in the Heart of Soweto Study cohort. Eur Heart J. 2012;33(7):866–874. https://doi.org/10.1093/eurheartj/ehr398
Ntusi N, O’Dwyer E, Dorrell L, et al. HIV-1-related cardiovascular disease is associated with chronic inflammation, frequent pericardial effusions, and probable myocardial edema. Circ Cardiovasc Imaging. 2016;9(3):4430–4438. https://doi.org/10.1161/CIRCIMAGING.115.004430
Neumann T, Esser S, Potthoff A, et al. Prevalence and natural history of heart failure in outpatient HIV-infected subjects: rationale and design of the HIV-HEART study. Eur J Med Res. 2007;12(6):243–248.
Wan SH, Vogel MW, Chen HH. Preclinical Diastolic Dysfunction. J Am Coll Cardiol, 2014;63(5): 407–416. https://dx.doi.org/10.1016%2Fj.jacc.2013.10.063
Zile MR, Gaasch WH, Carroll JD, et al. Heart failure with a normal ejection fraction: is measurement of diastolic function necessary to make the diagnosis of diastolic heart failure?. Circulation. 2001;104(7):779–782. https://doi.org/10.1161/hc3201.094226
Schuster I, Thöni GJ, Edérhy S, et al. Subclinical cardiac abnormalities in human immunodeficiency virus–infected men receiving antiretroviral therapy. Am J Cardiol. 2008;101(8):1213–1217. https://doi.org/10.1016/j.amjcard.2007.11.073
Cerrato E, D'Ascenzo F, Biondi-Zoccai G, et al. Cardiac dysfunction in pauci symptomatic human immunodeficiency virus patients: a meta-analysis in the highly active antiretroviral therapy era. Eur Heart J. 2013;34(19):1432–1436. https://doi.org/10.1093/eurheartj/ehs471
Lipshultz SE, Fisher SD, Lai WW, Miller TL. Cardiovascular risk factors, monitoring, and therapy for HIV-infected patients. AIDS. 2003;17(1):96–122. http://insights.ovid.com/pubmed?pmid=12870537
Reinsch N, Kahlert P, Esser S, et al. Echocardiographic findings and abnormalities in HIV-infected patients: results from a large, prospective, multicenter HIV-heart study. Am J Cardiovasc Dis. 2011;1(2):176–184. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22254197/
Hsue PY, Hunt PW, Ho JE, et al. Impact of HIV infection on diastolic function and left ventricular mass. Circ Heart Fail. 2010;3(1):132–139. https://doi.org/10.1161/CIRCHEARTFAILURE.109.854943
Manner IW, Trøseid M, Oektedalen O, Baekken M, Os I. Low nadir CD4 cell count predicts sustained hypertension in HIV-infected individuals. J Clin Hypertens (Greenwich). 2013;15(2):101–106. https://doi.org/10.1111/jch.12029
Lind A, Reinsch N, Neuhaus K, et al. Pericardial effusion of HIV-infected patients ? Results of a prospective multicenter cohort study in the era of antiretroviral therapy. Eur J Med Res. 2011; 16(11):480–483. https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22027640/