International Journal of HIV/AIDS Prevention, Education and Behavioural Science

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Cluster of Differentiation 4 Count and Left Ventricular Diastolic Function in Patients with Hiv - Aids

Received: 23 February 2018    Accepted: 20 March 2018    Published: 12 April 2018
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Abstract

Background: People with Acquired Immunodeficiency Syndrome (AIDS) are at risk of developing structural and functional cardiac abnormalities that are unrelated to common cardiac risk factors (e.g. Hypertension, Diabetes Mellitus, Smoking habit). AIDS may be associated with chronic inflammation related to multiple factors related to the Human Immunodeficiency Virus (HIV) infection and its complications. Cardiac abnormality with AIDS may be subclinical and may present long before the onset of clinical heart failure symptoms. Objectives: To anticipate the risk of cardiovascular morbidity in people with AIDS. Methods: The researchers studied 52 people with AIDS in this observational cross-sectional study, which were further categorized into those with cluster of differentiation 4 (CD4) count of less than 200/mm3 and those with CD4 count of more than 200/mm3. Echocardiographic examinations were done to evaluate cardiac structural and functional values. Results: Mean age was 33 years old, predominantly male (71.2%). The group with a CD4 count of less than 200/mm3 showed higher Left Ventricular Mass Index (LVMI) values (113.08 vs. 39.99, p=0.012), a higher risk of developing diastolic dysfunction (OR 9.35, CI 95%, p=0.018) and pericardial effusion (OR 3.83, CI 95%, p=0.048). Conclusion: A CD4 count of less than 200/mm3 is associated with a higher risk of developing cardiac diastolic dysfunction and structural abnormalities.

DOI 10.11648/j.ijhpebs.20180401.12
Published in International Journal of HIV/AIDS Prevention, Education and Behavioural Science (Volume 4, Issue 1, June 2018)
Page(s) 5-10
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

HIV, AIDS, Echocardiography, Diastolic Dysfunction

References
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Author Information
  • Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia

  • Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia

  • Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia

  • Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia

  • Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia

  • Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia

  • Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia

  • Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia

  • Cardiac Centre of Wahidin Sudirohusodo General Hospital, Department of Cardiology and Vascular Disease, Medical Faculty of Hasanuddin University, Makassar, Indonesia

Cite This Article
  • APA Style

    Farid Hidayat, Dian Pratiwi, Titus Kurnia, Taslim, Ahmad Syukri, et al. (2018). Cluster of Differentiation 4 Count and Left Ventricular Diastolic Function in Patients with Hiv - Aids. International Journal of HIV/AIDS Prevention, Education and Behavioural Science, 4(1), 5-10. https://doi.org/10.11648/j.ijhpebs.20180401.12

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    ACS Style

    Farid Hidayat; Dian Pratiwi; Titus Kurnia; Taslim; Ahmad Syukri, et al. Cluster of Differentiation 4 Count and Left Ventricular Diastolic Function in Patients with Hiv - Aids. Int. J. HIV/AIDS Prev. Educ. Behav. Sci. 2018, 4(1), 5-10. doi: 10.11648/j.ijhpebs.20180401.12

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    AMA Style

    Farid Hidayat, Dian Pratiwi, Titus Kurnia, Taslim, Ahmad Syukri, et al. Cluster of Differentiation 4 Count and Left Ventricular Diastolic Function in Patients with Hiv - Aids. Int J HIV/AIDS Prev Educ Behav Sci. 2018;4(1):5-10. doi: 10.11648/j.ijhpebs.20180401.12

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  • @article{10.11648/j.ijhpebs.20180401.12,
      author = {Farid Hidayat and Dian Pratiwi and Titus Kurnia and Taslim and Ahmad Syukri and Paskalis Indra and Muzakkir Amir and Peter Kabo and Robert Setiadji},
      title = {Cluster of Differentiation 4 Count and Left Ventricular Diastolic Function in Patients with Hiv - Aids},
      journal = {International Journal of HIV/AIDS Prevention, Education and Behavioural Science},
      volume = {4},
      number = {1},
      pages = {5-10},
      doi = {10.11648/j.ijhpebs.20180401.12},
      url = {https://doi.org/10.11648/j.ijhpebs.20180401.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijhpebs.20180401.12},
      abstract = {Background: People with Acquired Immunodeficiency Syndrome (AIDS) are at risk of developing structural and functional cardiac abnormalities that are unrelated to common cardiac risk factors (e.g. Hypertension, Diabetes Mellitus, Smoking habit). AIDS may be associated with chronic inflammation related to multiple factors related to the Human Immunodeficiency Virus (HIV) infection and its complications. Cardiac abnormality with AIDS may be subclinical and may present long before the onset of clinical heart failure symptoms. Objectives: To anticipate the risk of cardiovascular morbidity in people with AIDS. Methods: The researchers studied 52 people with AIDS in this observational cross-sectional study, which were further categorized into those with cluster of differentiation 4 (CD4) count of less than 200/mm3 and those with CD4 count of more than 200/mm3. Echocardiographic examinations were done to evaluate cardiac structural and functional values. Results: Mean age was 33 years old, predominantly male (71.2%). The group with a CD4 count of less than 200/mm3 showed higher Left Ventricular Mass Index (LVMI) values (113.08 vs. 39.99, p=0.012), a higher risk of developing diastolic dysfunction (OR 9.35, CI 95%, p=0.018) and pericardial effusion (OR 3.83, CI 95%, p=0.048). Conclusion: A CD4 count of less than 200/mm3 is associated with a higher risk of developing cardiac diastolic dysfunction and structural abnormalities.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Cluster of Differentiation 4 Count and Left Ventricular Diastolic Function in Patients with Hiv - Aids
    AU  - Farid Hidayat
    AU  - Dian Pratiwi
    AU  - Titus Kurnia
    AU  - Taslim
    AU  - Ahmad Syukri
    AU  - Paskalis Indra
    AU  - Muzakkir Amir
    AU  - Peter Kabo
    AU  - Robert Setiadji
    Y1  - 2018/04/12
    PY  - 2018
    N1  - https://doi.org/10.11648/j.ijhpebs.20180401.12
    DO  - 10.11648/j.ijhpebs.20180401.12
    T2  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
    JF  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
    JO  - International Journal of HIV/AIDS Prevention, Education and Behavioural Science
    SP  - 5
    EP  - 10
    PB  - Science Publishing Group
    SN  - 2575-5765
    UR  - https://doi.org/10.11648/j.ijhpebs.20180401.12
    AB  - Background: People with Acquired Immunodeficiency Syndrome (AIDS) are at risk of developing structural and functional cardiac abnormalities that are unrelated to common cardiac risk factors (e.g. Hypertension, Diabetes Mellitus, Smoking habit). AIDS may be associated with chronic inflammation related to multiple factors related to the Human Immunodeficiency Virus (HIV) infection and its complications. Cardiac abnormality with AIDS may be subclinical and may present long before the onset of clinical heart failure symptoms. Objectives: To anticipate the risk of cardiovascular morbidity in people with AIDS. Methods: The researchers studied 52 people with AIDS in this observational cross-sectional study, which were further categorized into those with cluster of differentiation 4 (CD4) count of less than 200/mm3 and those with CD4 count of more than 200/mm3. Echocardiographic examinations were done to evaluate cardiac structural and functional values. Results: Mean age was 33 years old, predominantly male (71.2%). The group with a CD4 count of less than 200/mm3 showed higher Left Ventricular Mass Index (LVMI) values (113.08 vs. 39.99, p=0.012), a higher risk of developing diastolic dysfunction (OR 9.35, CI 95%, p=0.018) and pericardial effusion (OR 3.83, CI 95%, p=0.048). Conclusion: A CD4 count of less than 200/mm3 is associated with a higher risk of developing cardiac diastolic dysfunction and structural abnormalities.
    VL  - 4
    IS  - 1
    ER  - 

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