Journal of Drug Design and Medicinal Chemistry

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Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases

Received: 04 March 2016    Accepted: 03 June 2016    Published: 30 June 2016
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Abstract

A new series of bidentate nitrogen donor type Schiff bases (L1)-(L3) were prepared by the condensation reaction of ethylene-1, 2-diamine with 3, 4, 6-trimethylacetophenone, 2-aminoacetophenone and 2, 4-dimethylacetophenone in 1:2 molar ratio. The ligands were further coordinated with Co(II), Cu(II), Ni(II) and Zn(II) metals to produce their new metal complexes having an octahedral geometry. These compounds were characterized on the basis of their physical, spectral and analytical data. Elemental analysis and spectral data of the uncomplexed ligands and their metal(II) complexes were found to be in good agreement with their structures, indicating high purity of all the newly synthesized compounds. All ligands and their metal complexes were screened for antimicrobial activity. The results of antimicrobial activity indicated that metal complexes have significantly higher activity compared to their corresponding ligands. This higher activity might be due to chelation process which reduces the polarity of metal ion by coordinating with ligands.

DOI 10.11648/j.jddmc.20160203.11
Published in Journal of Drug Design and Medicinal Chemistry (Volume 2, Issue 3, June 2016)
Page(s) 26-34
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Nitrogen Donor Schiff Bases, Bidentate Ligands, Metal(II) Complexes, Antibacterial and Antifungal Activities

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Author Information
  • Department of Chemistry, University of Gujrat, Gujrat, Pakistan

  • Department of Applied Chemistry, Govt. College University, Faisalabad, Pakistan

  • Department of Chemistry, University of Karachi, Karachi, Pakistan

  • Department of Chemistry, Ghazi University, Dera Ghazi Khan, Pakistan

  • Department of Chemistry, Quaid-e-Azam University, Islamabad, Pakistan

  • Department of Chemistry, University of Gujrat, Gujrat, Pakistan

  • Department of Chemistry, University of Karachi, Karachi, Pakistan

Cite This Article
  • APA Style

    Sajjad Hussain Sumrra, Muhammad Ibrahim, Sabahat Ambreen, Muhammad Imran, Muhammad Naveed Zafar, et al. (2016). Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases. Journal of Drug Design and Medicinal Chemistry, 2(3), 26-34. https://doi.org/10.11648/j.jddmc.20160203.11

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    ACS Style

    Sajjad Hussain Sumrra; Muhammad Ibrahim; Sabahat Ambreen; Muhammad Imran; Muhammad Naveed Zafar, et al. Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases. J. Drug Des. Med. Chem. 2016, 2(3), 26-34. doi: 10.11648/j.jddmc.20160203.11

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    AMA Style

    Sajjad Hussain Sumrra, Muhammad Ibrahim, Sabahat Ambreen, Muhammad Imran, Muhammad Naveed Zafar, et al. Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases. J Drug Des Med Chem. 2016;2(3):26-34. doi: 10.11648/j.jddmc.20160203.11

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  • @article{10.11648/j.jddmc.20160203.11,
      author = {Sajjad Hussain Sumrra and Muhammad Ibrahim and Sabahat Ambreen and Muhammad Imran and Muhammad Naveed Zafar and Muhammad Faizan Nazar and Fouzia Sultana Rehmani},
      title = {Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases},
      journal = {Journal of Drug Design and Medicinal Chemistry},
      volume = {2},
      number = {3},
      pages = {26-34},
      doi = {10.11648/j.jddmc.20160203.11},
      url = {https://doi.org/10.11648/j.jddmc.20160203.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jddmc.20160203.11},
      abstract = {A new series of bidentate nitrogen donor type Schiff bases (L1)-(L3) were prepared by the condensation reaction of ethylene-1, 2-diamine with 3, 4, 6-trimethylacetophenone, 2-aminoacetophenone and 2, 4-dimethylacetophenone in 1:2 molar ratio. The ligands were further coordinated with Co(II), Cu(II), Ni(II) and Zn(II) metals to produce their new metal complexes having an octahedral geometry. These compounds were characterized on the basis of their physical, spectral and analytical data. Elemental analysis and spectral data of the uncomplexed ligands and their metal(II) complexes were found to be in good agreement with their structures, indicating high purity of all the newly synthesized compounds. All ligands and their metal complexes were screened for antimicrobial activity. The results of antimicrobial activity indicated that metal complexes have significantly higher activity compared to their corresponding ligands. This higher activity might be due to chelation process which reduces the polarity of metal ion by coordinating with ligands.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Design, Synthesis, Spectral Characterization and Antimicrobial Studies of Metals Based Nitrogen Donor Schiff Bases
    AU  - Sajjad Hussain Sumrra
    AU  - Muhammad Ibrahim
    AU  - Sabahat Ambreen
    AU  - Muhammad Imran
    AU  - Muhammad Naveed Zafar
    AU  - Muhammad Faizan Nazar
    AU  - Fouzia Sultana Rehmani
    Y1  - 2016/06/30
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    DO  - 10.11648/j.jddmc.20160203.11
    T2  - Journal of Drug Design and Medicinal Chemistry
    JF  - Journal of Drug Design and Medicinal Chemistry
    JO  - Journal of Drug Design and Medicinal Chemistry
    SP  - 26
    EP  - 34
    PB  - Science Publishing Group
    SN  - 2472-3576
    UR  - https://doi.org/10.11648/j.jddmc.20160203.11
    AB  - A new series of bidentate nitrogen donor type Schiff bases (L1)-(L3) were prepared by the condensation reaction of ethylene-1, 2-diamine with 3, 4, 6-trimethylacetophenone, 2-aminoacetophenone and 2, 4-dimethylacetophenone in 1:2 molar ratio. The ligands were further coordinated with Co(II), Cu(II), Ni(II) and Zn(II) metals to produce their new metal complexes having an octahedral geometry. These compounds were characterized on the basis of their physical, spectral and analytical data. Elemental analysis and spectral data of the uncomplexed ligands and their metal(II) complexes were found to be in good agreement with their structures, indicating high purity of all the newly synthesized compounds. All ligands and their metal complexes were screened for antimicrobial activity. The results of antimicrobial activity indicated that metal complexes have significantly higher activity compared to their corresponding ligands. This higher activity might be due to chelation process which reduces the polarity of metal ion by coordinating with ligands.
    VL  - 2
    IS  - 3
    ER  - 

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