Journal of Drug Design and Medicinal Chemistry

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Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents

Received: 29 February 2016    Accepted: 29 March 2016    Published: 01 August 2016
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Abstract

A series of new ferrocenylphenylguanidines (d-1 to d-4) were synthesized via multistep protocol. The purity of synthesized compounds were determined by melting point and TLC and their structures were established by various analytical techniques such as elemental analysis, multinuclear (1H and 13C) NMR and FTIR spectroscopy. The newly synthesized compounds were screened for antimicrobial activity against a panel of microorganisms (five bacterial strains, i.e three Gram positive, Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 6538), Bacillus subtilis (ATCC 6633) and two Gram negative, Klebsiella pneumonia (ATCC 43816), Escherichia coli (ATCC 15224) and three fungal strains, i.e. Fusa riumm oniliforme, Aspergillus fumigates and Aspergillusflavus. These compounds were found to have moderate antibacterial and good antifungal activities, especially for compounds having electronegative substituent on phenyl group.

DOI 10.11648/j.jddmc.20160204.11
Published in Journal of Drug Design and Medicinal Chemistry (Volume 2, Issue 4, August 2016)
Page(s) 35-39
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Synthesis, Antifungal Activity, Antibacterial Activity

References
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[19] Gul R, Altaf A. A, Khan A, Badshah A, Shah A, Rehman ZU, Naz R, Tahir MN, Junaid A. Biologically Active New N, N', N''-Tri-Substituted Ferrocenyl Phenylguanidines and their Characterization. Medicinal Chemistry. 2016 Jan 28 [Epub ahead of print].
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Author Information
  • Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan

  • Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan

  • Department of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan

  • Institute of Chemical Sciences, Gomal University, Dera Ismail Khan, Pakistan

  • Department of Microbiology, Kohat University of Science and Technology, Kohat, Pakistan

  • Department of Plant Sciences, Quaid-i-Azam University, Islamabad, Pakistan

  • Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan

  • Institute of Chemical Sciences, Gomal University, Dera Ismail Khan, Pakistan

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  • APA Style

    Rukhsana Gul, Zainab Nawaz, Amin Badshah, Azim Khan, Asif Junaid, et al. (2016). Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents. Journal of Drug Design and Medicinal Chemistry, 2(4), 35-39. https://doi.org/10.11648/j.jddmc.20160204.11

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    ACS Style

    Rukhsana Gul; Zainab Nawaz; Amin Badshah; Azim Khan; Asif Junaid, et al. Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents. J. Drug Des. Med. Chem. 2016, 2(4), 35-39. doi: 10.11648/j.jddmc.20160204.11

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    AMA Style

    Rukhsana Gul, Zainab Nawaz, Amin Badshah, Azim Khan, Asif Junaid, et al. Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents. J Drug Des Med Chem. 2016;2(4):35-39. doi: 10.11648/j.jddmc.20160204.11

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  • @article{10.11648/j.jddmc.20160204.11,
      author = {Rukhsana Gul and Zainab Nawaz and Amin Badshah and Azim Khan and Asif Junaid and Rabia Naz and Muhammad Kamran Rauf and Saima Hayat},
      title = {Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents},
      journal = {Journal of Drug Design and Medicinal Chemistry},
      volume = {2},
      number = {4},
      pages = {35-39},
      doi = {10.11648/j.jddmc.20160204.11},
      url = {https://doi.org/10.11648/j.jddmc.20160204.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jddmc.20160204.11},
      abstract = {A series of new ferrocenylphenylguanidines (d-1 to d-4) were synthesized via multistep protocol. The purity of synthesized compounds were determined by melting point and TLC and their structures were established by various analytical techniques such as elemental analysis, multinuclear (1H and 13C) NMR and FTIR spectroscopy. The newly synthesized compounds were screened for antimicrobial activity against a panel of microorganisms (five bacterial strains, i.e three Gram positive, Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 6538), Bacillus subtilis (ATCC 6633) and two Gram negative, Klebsiella pneumonia (ATCC 43816), Escherichia coli (ATCC 15224) and three fungal strains, i.e. Fusa riumm oniliforme, Aspergillus fumigates and Aspergillusflavus. These compounds were found to have moderate antibacterial and good antifungal activities, especially for compounds having electronegative substituent on phenyl group.},
     year = {2016}
    }
    

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    T1  - Synthesis and Biological Evaluation of Some New Ferrocenyl Phenyl Guanidines as Antibacterial, Antifungal Agents
    AU  - Rukhsana Gul
    AU  - Zainab Nawaz
    AU  - Amin Badshah
    AU  - Azim Khan
    AU  - Asif Junaid
    AU  - Rabia Naz
    AU  - Muhammad Kamran Rauf
    AU  - Saima Hayat
    Y1  - 2016/08/01
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    T2  - Journal of Drug Design and Medicinal Chemistry
    JF  - Journal of Drug Design and Medicinal Chemistry
    JO  - Journal of Drug Design and Medicinal Chemistry
    SP  - 35
    EP  - 39
    PB  - Science Publishing Group
    SN  - 2472-3576
    UR  - https://doi.org/10.11648/j.jddmc.20160204.11
    AB  - A series of new ferrocenylphenylguanidines (d-1 to d-4) were synthesized via multistep protocol. The purity of synthesized compounds were determined by melting point and TLC and their structures were established by various analytical techniques such as elemental analysis, multinuclear (1H and 13C) NMR and FTIR spectroscopy. The newly synthesized compounds were screened for antimicrobial activity against a panel of microorganisms (five bacterial strains, i.e three Gram positive, Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 6538), Bacillus subtilis (ATCC 6633) and two Gram negative, Klebsiella pneumonia (ATCC 43816), Escherichia coli (ATCC 15224) and three fungal strains, i.e. Fusa riumm oniliforme, Aspergillus fumigates and Aspergillusflavus. These compounds were found to have moderate antibacterial and good antifungal activities, especially for compounds having electronegative substituent on phenyl group.
    VL  - 2
    IS  - 4
    ER  - 

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