Hepatoprotective Effect of Aqueous Extract of <i>Telfairia occidentalis</i> on Cadmium Chloride-Induced Oxidative Stress and Hepatotoxicity in Rats

Johnson Olaleye Oladele; Olu Israel Oyewole; Olamilekan Kabiru Bello; Oluwaseun Titilope Oladele

doi:doi:10.11648/j.jddmc.20170303.11

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Hepatoprotective Effect of Aqueous Extract of Telfairia occidentalis on Cadmium Chloride-Induced Oxidative Stress and Hepatotoxicity in Rats

Johnson Olaleye Oladele, Olu Israel Oyewole, Olamilekan Kabiru Bello, Oluwaseun Titilope Oladele

Published in Journal of Drug Design and Medicinal Chemistry (Volume 3, Issue 3)

Received: 6 April 2017 Accepted: 21 April 2017 Published: 4 July 2017

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Abstract

Cadmium and its compounds have been classified as known human carcinogens. Telfairia occidentalis is a medicinal plant with a number of pharmacological activities attributed to its extracts. This study was designed to investigate the possible hepatoprotective effect of aqueous extract of Telfairia occidentalis on cadmium chloride (CdCl2) induced oxidative stress and hepatotoxicity in experimental animals. Twenty-four (24) adult male rats were divided into 4 groups of 6 rats each. Group I received distilled water, group II, III, and IV were administered 5mg/kg body weight CdCl2, group III, IV were treated with 200 and 400mg/kg body weight (bw) respectively of aqueous extract of Telfairia occidentalis for 14 days. Results obtained showed that exposure of rats to cadmium induced hepatocellular injury as demonstrated by significant increased (P<0.05) in activities of Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Acid phosphatase (ACP) and alkaline phosphatase (ALP). Lipid peroxidation was induced as shown by significant increase (P<0.05) in malondialdehyde (MDA) level and induction of oxidative stress with significant decrease (P<0.05) in reduced glutathione (GSH), Glutathione S-transferase (GST), Superoxide dismutase (SOD), Catalase (CAT) levels. Histological study of the liver shows loss of normal architecture, small-sized cytoplasmic vacuole, cellular degeneration and necrosis. However, concomitant administration of aqueous extract of Telfairia occidentalis with cadmium chloride attenuated the induced hepatic injury, lipid peroxidation, and oxidative stress. In conclusion, aqueous extract of Telfairia occidentalis offer hepatoprotection by scavenging free radicals, reversing/inhibiting oxidative stress pathways and protecting the structural integrity of the liver.

Published in	Journal of Drug Design and Medicinal Chemistry (Volume 3, Issue 3)
DOI	10.11648/j.jddmc.20170303.11
Page(s)	32-36
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hepatotoxicity, Lipid Peroxidation, Oxidative Stress, Cadmium Chloride, Telfairia occidentalis

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APA Style

Johnson Olaleye Oladele, Olu Israel Oyewole, Olamilekan Kabiru Bello, Oluwaseun Titilope Oladele. (2017). Hepatoprotective Effect of Aqueous Extract of Telfairia occidentalis on Cadmium Chloride-Induced Oxidative Stress and Hepatotoxicity in Rats. Journal of Drug Design and Medicinal Chemistry, 3(3), 32-36. https://doi.org/10.11648/j.jddmc.20170303.11

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ACS Style

Johnson Olaleye Oladele; Olu Israel Oyewole; Olamilekan Kabiru Bello; Oluwaseun Titilope Oladele. Hepatoprotective Effect of Aqueous Extract of Telfairia occidentalis on Cadmium Chloride-Induced Oxidative Stress and Hepatotoxicity in Rats. J. Drug Des. Med. Chem. 2017, 3(3), 32-36. doi: 10.11648/j.jddmc.20170303.11

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AMA Style

Johnson Olaleye Oladele, Olu Israel Oyewole, Olamilekan Kabiru Bello, Oluwaseun Titilope Oladele. Hepatoprotective Effect of Aqueous Extract of Telfairia occidentalis on Cadmium Chloride-Induced Oxidative Stress and Hepatotoxicity in Rats. J Drug Des Med Chem. 2017;3(3):32-36. doi: 10.11648/j.jddmc.20170303.11

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@article{10.11648/j.jddmc.20170303.11,
  author = {Johnson Olaleye Oladele and Olu Israel Oyewole and Olamilekan Kabiru Bello and Oluwaseun Titilope Oladele},
  title = {Hepatoprotective Effect of Aqueous Extract of Telfairia occidentalis on Cadmium Chloride-Induced Oxidative Stress and Hepatotoxicity in Rats},
  journal = {Journal of Drug Design and Medicinal Chemistry},
  volume = {3},
  number = {3},
  pages = {32-36},
  doi = {10.11648/j.jddmc.20170303.11},
  url = {https://doi.org/10.11648/j.jddmc.20170303.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20170303.11},
  abstract = {Cadmium and its compounds have been classified as known human carcinogens. Telfairia occidentalis is a medicinal plant with a number of pharmacological activities attributed to its extracts. This study was designed to investigate the possible hepatoprotective effect of aqueous extract of Telfairia occidentalis on cadmium chloride (CdCl2) induced oxidative stress and hepatotoxicity in experimental animals. Twenty-four (24) adult male rats were divided into 4 groups of 6 rats each. Group I received distilled water, group II, III, and IV were administered 5mg/kg body weight CdCl2, group III, IV were treated with 200 and 400mg/kg body weight (bw) respectively of aqueous extract of Telfairia occidentalis for 14 days. Results obtained showed that exposure of rats to cadmium induced hepatocellular injury as demonstrated by significant increased (PTelfairia occidentalis with cadmium chloride attenuated the induced hepatic injury, lipid peroxidation, and oxidative stress. In conclusion, aqueous extract of Telfairia occidentalis offer hepatoprotection by scavenging free radicals, reversing/inhibiting oxidative stress pathways and protecting the structural integrity of the liver.},
 year = {2017}
}

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TY  - JOUR
T1  - Hepatoprotective Effect of Aqueous Extract of Telfairia occidentalis on Cadmium Chloride-Induced Oxidative Stress and Hepatotoxicity in Rats
AU  - Johnson Olaleye Oladele
AU  - Olu Israel Oyewole
AU  - Olamilekan Kabiru Bello
AU  - Oluwaseun Titilope Oladele
Y1  - 2017/07/04
PY  - 2017
N1  - https://doi.org/10.11648/j.jddmc.20170303.11
DO  - 10.11648/j.jddmc.20170303.11
T2  - Journal of Drug Design and Medicinal Chemistry
JF  - Journal of Drug Design and Medicinal Chemistry
JO  - Journal of Drug Design and Medicinal Chemistry
SP  - 32
EP  - 36
PB  - Science Publishing Group
SN  - 2472-3576
UR  - https://doi.org/10.11648/j.jddmc.20170303.11
AB  - Cadmium and its compounds have been classified as known human carcinogens. Telfairia occidentalis is a medicinal plant with a number of pharmacological activities attributed to its extracts. This study was designed to investigate the possible hepatoprotective effect of aqueous extract of Telfairia occidentalis on cadmium chloride (CdCl2) induced oxidative stress and hepatotoxicity in experimental animals. Twenty-four (24) adult male rats were divided into 4 groups of 6 rats each. Group I received distilled water, group II, III, and IV were administered 5mg/kg body weight CdCl2, group III, IV were treated with 200 and 400mg/kg body weight (bw) respectively of aqueous extract of Telfairia occidentalis for 14 days. Results obtained showed that exposure of rats to cadmium induced hepatocellular injury as demonstrated by significant increased (PTelfairia occidentalis with cadmium chloride attenuated the induced hepatic injury, lipid peroxidation, and oxidative stress. In conclusion, aqueous extract of Telfairia occidentalis offer hepatoprotection by scavenging free radicals, reversing/inhibiting oxidative stress pathways and protecting the structural integrity of the liver.
VL  - 3
IS  - 3
ER  -

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Author Information

Johnson Olaleye Oladele

Department of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria
Olu Israel Oyewole

Department of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria
Olamilekan Kabiru Bello

Department of Biochemistry, Faculty of Sciences, University of Ilorin, Ilorin, Nigeria
Oluwaseun Titilope Oladele

Department of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria

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APA Style

Johnson Olaleye Oladele, Olu Israel Oyewole, Olamilekan Kabiru Bello, Oluwaseun Titilope Oladele. (2017). Hepatoprotective Effect of Aqueous Extract of Telfairia occidentalis on Cadmium Chloride-Induced Oxidative Stress and Hepatotoxicity in Rats. Journal of Drug Design and Medicinal Chemistry, 3(3), 32-36. https://doi.org/10.11648/j.jddmc.20170303.11

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ACS Style

Johnson Olaleye Oladele; Olu Israel Oyewole; Olamilekan Kabiru Bello; Oluwaseun Titilope Oladele. Hepatoprotective Effect of Aqueous Extract of Telfairia occidentalis on Cadmium Chloride-Induced Oxidative Stress and Hepatotoxicity in Rats. J. Drug Des. Med. Chem. 2017, 3(3), 32-36. doi: 10.11648/j.jddmc.20170303.11

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AMA Style

Johnson Olaleye Oladele, Olu Israel Oyewole, Olamilekan Kabiru Bello, Oluwaseun Titilope Oladele. Hepatoprotective Effect of Aqueous Extract of Telfairia occidentalis on Cadmium Chloride-Induced Oxidative Stress and Hepatotoxicity in Rats. J Drug Des Med Chem. 2017;3(3):32-36. doi: 10.11648/j.jddmc.20170303.11

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@article{10.11648/j.jddmc.20170303.11,
  author = {Johnson Olaleye Oladele and Olu Israel Oyewole and Olamilekan Kabiru Bello and Oluwaseun Titilope Oladele},
  title = {Hepatoprotective Effect of Aqueous Extract of Telfairia occidentalis on Cadmium Chloride-Induced Oxidative Stress and Hepatotoxicity in Rats},
  journal = {Journal of Drug Design and Medicinal Chemistry},
  volume = {3},
  number = {3},
  pages = {32-36},
  doi = {10.11648/j.jddmc.20170303.11},
  url = {https://doi.org/10.11648/j.jddmc.20170303.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20170303.11},
  abstract = {Cadmium and its compounds have been classified as known human carcinogens. Telfairia occidentalis is a medicinal plant with a number of pharmacological activities attributed to its extracts. This study was designed to investigate the possible hepatoprotective effect of aqueous extract of Telfairia occidentalis on cadmium chloride (CdCl2) induced oxidative stress and hepatotoxicity in experimental animals. Twenty-four (24) adult male rats were divided into 4 groups of 6 rats each. Group I received distilled water, group II, III, and IV were administered 5mg/kg body weight CdCl2, group III, IV were treated with 200 and 400mg/kg body weight (bw) respectively of aqueous extract of Telfairia occidentalis for 14 days. Results obtained showed that exposure of rats to cadmium induced hepatocellular injury as demonstrated by significant increased (PTelfairia occidentalis with cadmium chloride attenuated the induced hepatic injury, lipid peroxidation, and oxidative stress. In conclusion, aqueous extract of Telfairia occidentalis offer hepatoprotection by scavenging free radicals, reversing/inhibiting oxidative stress pathways and protecting the structural integrity of the liver.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Hepatoprotective Effect of Aqueous Extract of Telfairia occidentalis on Cadmium Chloride-Induced Oxidative Stress and Hepatotoxicity in Rats
AU  - Johnson Olaleye Oladele
AU  - Olu Israel Oyewole
AU  - Olamilekan Kabiru Bello
AU  - Oluwaseun Titilope Oladele
Y1  - 2017/07/04
PY  - 2017
N1  - https://doi.org/10.11648/j.jddmc.20170303.11
DO  - 10.11648/j.jddmc.20170303.11
T2  - Journal of Drug Design and Medicinal Chemistry
JF  - Journal of Drug Design and Medicinal Chemistry
JO  - Journal of Drug Design and Medicinal Chemistry
SP  - 32
EP  - 36
PB  - Science Publishing Group
SN  - 2472-3576
UR  - https://doi.org/10.11648/j.jddmc.20170303.11
AB  - Cadmium and its compounds have been classified as known human carcinogens. Telfairia occidentalis is a medicinal plant with a number of pharmacological activities attributed to its extracts. This study was designed to investigate the possible hepatoprotective effect of aqueous extract of Telfairia occidentalis on cadmium chloride (CdCl2) induced oxidative stress and hepatotoxicity in experimental animals. Twenty-four (24) adult male rats were divided into 4 groups of 6 rats each. Group I received distilled water, group II, III, and IV were administered 5mg/kg body weight CdCl2, group III, IV were treated with 200 and 400mg/kg body weight (bw) respectively of aqueous extract of Telfairia occidentalis for 14 days. Results obtained showed that exposure of rats to cadmium induced hepatocellular injury as demonstrated by significant increased (PTelfairia occidentalis with cadmium chloride attenuated the induced hepatic injury, lipid peroxidation, and oxidative stress. In conclusion, aqueous extract of Telfairia occidentalis offer hepatoprotection by scavenging free radicals, reversing/inhibiting oxidative stress pathways and protecting the structural integrity of the liver.
VL  - 3
IS  - 3
ER  -

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