In this present study combination tablets containing diclofenac sodium, dried aluminium hydroxide gel and magnesium trisilicate were prepared using customized formula and common properties of tablets like hardness, thickness, diameter, weight and disintegration time along with the flow properties of granules were determined. Our results showed that most properties of the tablets complied with the official limit of acceptance. The pH, water absorption index, dissolution behavior and organoleptic property of tablets were also checked. Results showed that pH of combination tablets was 8.27 ± 0.04 when dissolved in purified water. Water absorption index varied from 0.1% to 0.2%. Tablets were undergone dissolution by 85% and 96% in 45 and 90 minutes respectively. In the study the organoleptic properties of the tablets remained the same over a period of 60 days.
| Published in | Journal of Drug Design and Medicinal Chemistry (Volume 3, Issue 5) |
| DOI | 10.11648/j.jddmc.20170305.11 |
| Page(s) | 67-70 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Diclofenac Sodium, Dried Aluminium Hydroxide Gel, Magnesium Trisilicate, Organoleptic Property and Combination Tablets
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APA Style
Jannatul Fardous, Faria Farzana Perveen, Md Zahidul Islam, A. H. M. Saifuddin, Sakina Sultana. (2017). Preparation and Evaluation of Combination Tablets of Diclofenac Sodium and Antacid Mixture. Journal of Drug Design and Medicinal Chemistry, 3(5), 67-70. https://doi.org/10.11648/j.jddmc.20170305.11
ACS Style
Jannatul Fardous; Faria Farzana Perveen; Md Zahidul Islam; A. H. M. Saifuddin; Sakina Sultana. Preparation and Evaluation of Combination Tablets of Diclofenac Sodium and Antacid Mixture. J. Drug Des. Med. Chem. 2017, 3(5), 67-70. doi: 10.11648/j.jddmc.20170305.11
AMA Style
Jannatul Fardous, Faria Farzana Perveen, Md Zahidul Islam, A. H. M. Saifuddin, Sakina Sultana. Preparation and Evaluation of Combination Tablets of Diclofenac Sodium and Antacid Mixture. J Drug Des Med Chem. 2017;3(5):67-70. doi: 10.11648/j.jddmc.20170305.11
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Download@article{10.11648/j.jddmc.20170305.11,
author = {Jannatul Fardous and Faria Farzana Perveen and Md Zahidul Islam and A. H. M. Saifuddin and Sakina Sultana},
title = {Preparation and Evaluation of Combination Tablets of Diclofenac Sodium and Antacid Mixture},
journal = {Journal of Drug Design and Medicinal Chemistry},
volume = {3},
number = {5},
pages = {67-70},
doi = {10.11648/j.jddmc.20170305.11},
url = {https://doi.org/10.11648/j.jddmc.20170305.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20170305.11},
abstract = {In this present study combination tablets containing diclofenac sodium, dried aluminium hydroxide gel and magnesium trisilicate were prepared using customized formula and common properties of tablets like hardness, thickness, diameter, weight and disintegration time along with the flow properties of granules were determined. Our results showed that most properties of the tablets complied with the official limit of acceptance. The pH, water absorption index, dissolution behavior and organoleptic property of tablets were also checked. Results showed that pH of combination tablets was 8.27 ± 0.04 when dissolved in purified water. Water absorption index varied from 0.1% to 0.2%. Tablets were undergone dissolution by 85% and 96% in 45 and 90 minutes respectively. In the study the organoleptic properties of the tablets remained the same over a period of 60 days.},
year = {2017}
}
TY - JOUR T1 - Preparation and Evaluation of Combination Tablets of Diclofenac Sodium and Antacid Mixture AU - Jannatul Fardous AU - Faria Farzana Perveen AU - Md Zahidul Islam AU - A. H. M. Saifuddin AU - Sakina Sultana Y1 - 2017/10/31 PY - 2017 N1 - https://doi.org/10.11648/j.jddmc.20170305.11 DO - 10.11648/j.jddmc.20170305.11 T2 - Journal of Drug Design and Medicinal Chemistry JF - Journal of Drug Design and Medicinal Chemistry JO - Journal of Drug Design and Medicinal Chemistry SP - 67 EP - 70 PB - Science Publishing Group SN - 2472-3576 UR - https://doi.org/10.11648/j.jddmc.20170305.11 AB - In this present study combination tablets containing diclofenac sodium, dried aluminium hydroxide gel and magnesium trisilicate were prepared using customized formula and common properties of tablets like hardness, thickness, diameter, weight and disintegration time along with the flow properties of granules were determined. Our results showed that most properties of the tablets complied with the official limit of acceptance. The pH, water absorption index, dissolution behavior and organoleptic property of tablets were also checked. Results showed that pH of combination tablets was 8.27 ± 0.04 when dissolved in purified water. Water absorption index varied from 0.1% to 0.2%. Tablets were undergone dissolution by 85% and 96% in 45 and 90 minutes respectively. In the study the organoleptic properties of the tablets remained the same over a period of 60 days. VL - 3 IS - 5 ER -
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