Journal of Drug Design and Medicinal Chemistry

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Effect of Lead Graded Doses in Mactra Corallina Gills: Antioxidants Status, Cholinergic Function and Histopathological Studies

Received: 12 March 2019    Accepted: 27 April 2019    Published: 12 June 2019
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Abstract

Lead is non-essential toxic metal used in the industrial process causes severe risk to aquatic organisms. This study aimed (aims) to evaluate the effect of Pb on oxidative stress in gills of Mactra corallina. During the experiment, bivalves were randomly divided into four groups, control served as control and D1, D2 and D3 groups were exposed to Pb graded doses (1mg/L, 2.5mg/L and 5mg/L) during 5 days, respectively. Pb accumulation was significantly increased in all treated gills with doses dependent manner. The exposure of M. corallina to PbCl2 promoted oxidative stress in gills with an increase in malondialdehyde (MDA) and in metallothionein (MTs) levels. Moreover, a decline in glutathione (GSH), non-protein–SH (NPSH) and ascorbic acid (Vit C) levels were detected in all treated groups. Thus, alterations of enzymatic antioxidants systems were confirmed by a significant increase of catalase (CAT) and decreases of glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities in doses dependent manner. The cholinergic function was confirmed by a significant decrease of acetylcholinesterase (AChE) activity in the highest exposure dose. The impairment of the gill function was confirmed by the histological study.

DOI 10.11648/j.jddmc.20190501.11
Published in Journal of Drug Design and Medicinal Chemistry (Volume 5, Issue 1, March 2019)
Page(s) 1-9
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Gills, Histopathological Studies, Lead Exposure, Mactra corallina, Oxidative Stress

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Author Information
  • Faculty of Sciences of Tunis, Biology Department, Laboratory of Ecology, Biology and Physiology of Aquatic Environment, University of Tunis El Manar, Tunis, Tunisia

  • Faculty of Sciences of Tunis, Biology Department, Laboratory of Ecology, Biology and Physiology of Aquatic Environment, University of Tunis El Manar, Tunis, Tunisia

  • Faculty of Sciences of Tunis, Biology Department, Laboratory of Ecology, Biology and Physiology of Aquatic Environment, University of Tunis El Manar, Tunis, Tunisia

  • Faculty of Sciences of Tunis, Biology Department, Laboratory of Ecology, Biology and Physiology of Aquatic Environment, University of Tunis El Manar, Tunis, Tunisia

  • Anatomy and Cytology Service, Mohamed Taher Maamouri Hospital, Road Mrezka, Nabeul, Tunisia

  • Anatomy and Cytology Service, Mohamed Taher Maamouri Hospital, Road Mrezka, Nabeul, Tunisia

  • Higher Institute of Fisheries and Aquaculture, Bizerte, Tunisia

  • Faculty of Sciences of Tunis, Biology Department, Laboratory of Ecology, Biology and Physiology of Aquatic Environment, University of Tunis El Manar, Tunis, Tunisia

  • Faculty of Sciences of Tunis, Biology Department, Laboratory of Ecology, Biology and Physiology of Aquatic Environment, University of Tunis El Manar, Tunis, Tunisia

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    Imene Chetoui, Safa Bejaoui, Chaima Fouzai, Wafa Trabelsi, Salwa Nechi, et al. (2019). Effect of Lead Graded Doses in Mactra Corallina Gills: Antioxidants Status, Cholinergic Function and Histopathological Studies. Journal of Drug Design and Medicinal Chemistry, 5(1), 1-9. https://doi.org/10.11648/j.jddmc.20190501.11

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    Imene Chetoui; Safa Bejaoui; Chaima Fouzai; Wafa Trabelsi; Salwa Nechi, et al. Effect of Lead Graded Doses in Mactra Corallina Gills: Antioxidants Status, Cholinergic Function and Histopathological Studies. J. Drug Des. Med. Chem. 2019, 5(1), 1-9. doi: 10.11648/j.jddmc.20190501.11

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    AMA Style

    Imene Chetoui, Safa Bejaoui, Chaima Fouzai, Wafa Trabelsi, Salwa Nechi, et al. Effect of Lead Graded Doses in Mactra Corallina Gills: Antioxidants Status, Cholinergic Function and Histopathological Studies. J Drug Des Med Chem. 2019;5(1):1-9. doi: 10.11648/j.jddmc.20190501.11

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  • @article{10.11648/j.jddmc.20190501.11,
      author = {Imene Chetoui and Safa Bejaoui and Chaima Fouzai and Wafa Trabelsi and Salwa Nechi and Emna Chelbi and Mohamed Ghalghaf and M’hamed El Cafsi and Nejla Soudani},
      title = {Effect of Lead Graded Doses in Mactra Corallina Gills: Antioxidants Status, Cholinergic Function and Histopathological Studies},
      journal = {Journal of Drug Design and Medicinal Chemistry},
      volume = {5},
      number = {1},
      pages = {1-9},
      doi = {10.11648/j.jddmc.20190501.11},
      url = {https://doi.org/10.11648/j.jddmc.20190501.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jddmc.20190501.11},
      abstract = {Lead is non-essential toxic metal used in the industrial process causes severe risk to aquatic organisms. This study aimed (aims) to evaluate the effect of Pb on oxidative stress in gills of Mactra corallina. During the experiment, bivalves were randomly divided into four groups, control served as control and D1, D2 and D3 groups were exposed to Pb graded doses (1mg/L, 2.5mg/L and 5mg/L) during 5 days, respectively. Pb accumulation was significantly increased in all treated gills with doses dependent manner. The exposure of M. corallina to PbCl2 promoted oxidative stress in gills with an increase in malondialdehyde (MDA) and in metallothionein (MTs) levels. Moreover, a decline in glutathione (GSH), non-protein–SH (NPSH) and ascorbic acid (Vit C) levels were detected in all treated groups. Thus, alterations of enzymatic antioxidants systems were confirmed by a significant increase of catalase (CAT) and decreases of glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities in doses dependent manner. The cholinergic function was confirmed by a significant decrease of acetylcholinesterase (AChE) activity in the highest exposure dose. The impairment of the gill function was confirmed by the histological study.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Effect of Lead Graded Doses in Mactra Corallina Gills: Antioxidants Status, Cholinergic Function and Histopathological Studies
    AU  - Imene Chetoui
    AU  - Safa Bejaoui
    AU  - Chaima Fouzai
    AU  - Wafa Trabelsi
    AU  - Salwa Nechi
    AU  - Emna Chelbi
    AU  - Mohamed Ghalghaf
    AU  - M’hamed El Cafsi
    AU  - Nejla Soudani
    Y1  - 2019/06/12
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    N1  - https://doi.org/10.11648/j.jddmc.20190501.11
    DO  - 10.11648/j.jddmc.20190501.11
    T2  - Journal of Drug Design and Medicinal Chemistry
    JF  - Journal of Drug Design and Medicinal Chemistry
    JO  - Journal of Drug Design and Medicinal Chemistry
    SP  - 1
    EP  - 9
    PB  - Science Publishing Group
    SN  - 2472-3576
    UR  - https://doi.org/10.11648/j.jddmc.20190501.11
    AB  - Lead is non-essential toxic metal used in the industrial process causes severe risk to aquatic organisms. This study aimed (aims) to evaluate the effect of Pb on oxidative stress in gills of Mactra corallina. During the experiment, bivalves were randomly divided into four groups, control served as control and D1, D2 and D3 groups were exposed to Pb graded doses (1mg/L, 2.5mg/L and 5mg/L) during 5 days, respectively. Pb accumulation was significantly increased in all treated gills with doses dependent manner. The exposure of M. corallina to PbCl2 promoted oxidative stress in gills with an increase in malondialdehyde (MDA) and in metallothionein (MTs) levels. Moreover, a decline in glutathione (GSH), non-protein–SH (NPSH) and ascorbic acid (Vit C) levels were detected in all treated groups. Thus, alterations of enzymatic antioxidants systems were confirmed by a significant increase of catalase (CAT) and decreases of glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities in doses dependent manner. The cholinergic function was confirmed by a significant decrease of acetylcholinesterase (AChE) activity in the highest exposure dose. The impairment of the gill function was confirmed by the histological study.
    VL  - 5
    IS  - 1
    ER  - 

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