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A Review of Ochratoxin A Occurrence, Condition for the Formation and Determination Methods
Journal of Drug Design and Medicinal Chemistry
Volume 6, Issue 2, June 2020, Pages: 15-21
Received: Sep. 18, 2020; Accepted: Oct. 5, 2020; Published: Oct. 26, 2020
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Author
Salasib Atumo, Department of Chemistry, College of Natural and Computational Science, Bonga University, Bonga, Ethiopian
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Abstract
Ochratoxin A (OTA) is a mycotoxin produced by several fungal species including Aspergillus ochraceus, A. carbonarius, A. niger and Penicillium verrucosum. Various studies report shown that Ochratoxin A can be leads several health problems for both animal and human health through the consumption of Ochratoxin A contaminated plant and animal origin foods. For instance, OTA has been shown to be nephrotoxic, teratogenic, immunotoxic, and carcinogenic in human health. Therefore, the main aim of this review focused on the occurrence, analytical methods and the condition for the formation of Ochratoxin A. Number of studies finding report indicate that Ochratoxin A was existed in several processed and unprocessed food stuffs, species and different alcoholic beverage. Primarily, cereals and cereals contained food products have highly vulnerable for Ochratoxin A due the presence of high moisture contents. On the other hand, several environmental conditions are playing an important for the formation of Ochratoxin A in different food stuffs. For example, most important abiotic factors which influence the growth and OTA production by such Spoilage fungi include water availability, temperature and gas composition. Finally, several analytical methods are used for detection of Ochratoxin A from different plant and animal origin foods such as Thin layer chromatography, Enzyme linked immunosorbent assay and High performance liquid chromatography. However, based on the sensitivity, resolution and efficiency currently high performance liquid chromatography techniques are more popular and advanced techniques for Ochratoxin A detection.
Keywords
Ochratoxin A Occurence, Condition for Ochratoxin A, Detection Methods of Ochratoxin A
To cite this article
Salasib Atumo, A Review of Ochratoxin A Occurrence, Condition for the Formation and Determination Methods, Journal of Drug Design and Medicinal Chemistry. Vol. 6, No. 2, 2020, pp. 15-21. doi: 10.11648/j.jddmc.20200602.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Angelina. P and Celeste. L (2010). Mycotoxin food and feed regulation and specific case of Ochratoxin A: A review of the worldwide status. Journal of food additives and contaminations, 10: 1-11.
[2]
Rosa. V, Antonella. A, Carlo. G and Francesco. P (2008). Determination of Ochratoxin A in green coffee beans by solid phase micro extraction and liquid chromatography with fluorescence detection. Journal of chromatography, 1187: 145-150.
[3]
Stoev. D and Vet. H (2010). Toxicol. Journal of food science, 6: 40-46.
[4]
IARC (1993), monography on the evaluation of carcinogenic risks to humans some naturally occurring substance. Journal of International agency for research on cancer, 56: 489-496.
[5]
Lucchetta. G, Bazzo. G, Dal. C and Bellotto. M (2010). Occurrence of black aspergilli and Ochratoxin A on grapes in Italy. Journal of toxins, 2: 840–855.
[6]
Ali. A, Shehzad. A, Muhammad. R and Muhammad. S (2013). Ochratoxin A in Cereal Products, Potential Hazards and Prevention strategies: A Review. Journal of Food Sciences, 23: 52-61.
[7]
Molhannad. R, Ali. A, Mohammad. S and Shehzad. A (2013). Ochratoxin A in cereal products potential hazards and prevention strategies: A review Journal of food science, 23: 52–61.
[8]
Temesgen. A and Teshome. G (2018). Major mycotoxin, occurrence, prevention and control approach. Journal of biotechnology, 12 (1): 1-11.
[9]
Sofia. C Angelina. P and Celeste. M (2011). Human Ochratoxin A biomarkers from exposure to effect. Journal of toxicology, 41 (3): 187-212.
[10]
Gumus. R, Ercan. N, and Imik. H (2018). Determination of Ochratoxin A levels in mixed feed and feed stuffs used in some laying hens and ruminants enterprises of Sivas city. Journal of poultry science, 20 (1): 85-90.
[11]
Andre. K and Ali. A (2010). Ochratoxin A: General overview and actual molecular status. Journal of toxins, 2: 461-493.
[12]
Frantisek. M, Vladimir. O, Annie. P and Jakub. T (2016). Ochratoxin A: 50 years of research of toxins. Journal of toxins, 2: 2-50.
[13]
Pittet. A (1998). Natural occurrence of mycotoxin in foods and feeds. Journal of rev. med. vet, 6: 479-492.
[14]
Zhao. Y, Yuan. Y, Bai. X and Liao. X (2020). Multi mycotoxins analysis in liquid milk by UHPLC after magnetic solid phase extraction based on PEGYLATED multi walled carbon nano tube. Journal of food science, 305: 206-218.
[15]
Meftah. S, Abid. S and Dias. T (2015). Mechanisms underlying the effect of commercial starter culture and a native yeast on Ochratoxin A production in meat product. Journal of risk assessment, 33: 157-166.
[16]
El. D, Gambacorta. L, Solfrizzo. M (2019). Multi mycotoxin occurrence in species and herbs commercialized in Lebanon. Journal of food control, 95: 63-70.
[17]
Balendres. M, Karlousky. P and Cumagun. C (2019). Mycotogenic fungi and mycotoxin agricultural crop commodities in Philippines. Journal of food science, 8: 1-10.
[18]
Peter. K (2016). Assessment of the levels of Ochratoxin a in coffee bean from the coffee growing region of Kamba, Kenya. Journal of food science and quality management, 53: 55-70.
[19]
Eskola. M, Kos. G, Elliott. T and Krska. R (2019). Worldwide contamination of food crops with mycotoxins. Journal of nutrition and food science, 59: 1-17.
[20]
Durate. S, Pena. A, Lino. C (2010). A review on Ochratoxin A occurrence and effects of processing of cereal and cereal derived food products. Journal of food microbiology, 27: 187-198.
[21]
Maria. P, Maria. L, Juan. M and Sofia. C (2012). Control of Ochratoxin A production in grapes. Journal of toxin, 4: 364-372.
[22]
Mantle. P (2002). Risk assessment and the importance of Ochratoxins. International journal of biodeteri or, 50: 143-146.
[23]
Scudamore. K and MacDonald. S (1998). A collaborative studies of an HPLC method for determination of Ochratoxin a in wheat using Immunoaffinity Column clean-up. Journal of food Additives and Contaminations, 15: 401-410.
[24]
Marechera. G (2015). Estimation of the potential adoption of Ala safe among smallholder maize farmers in lower eastern Kenya. African Journal of Agriculture and Resource Economics, 10 (1): 72-85.
[25]
Medina. A, Akbar. A, Baazeem. A and Magan. N (2017). Climate change, food security and mycotoxins. Journal of food science, 31 (3): 143-154.
[26]
Kulandaivelu. V, Thirukonda. N, Rajeev. B and Periyasamy. P (2011). Management of Aspergillus ochraceus and Ochratoxin-A contamination in coffee during on-farm processing through commercial yeast inoculation. Journal of biological control, 57: 215-222.
[27]
Naresh. M and David. A (2005). Conditions of formation of Ochratoxin A in drying, transport and in different commodities. Journal of food additives and contaminants, 1: 10-16.
[28]
Bucheli, P and Taniwaki. M (2002). Research on the origin and the impact of postharvest handling and manufacturing on the presence of ochratoxin A in coffee – Review. Journal of Food Additives and Contaminants, 19: 655–665.
[29]
Lalini. R and Kanti. B (2010). Ochratoxin food contaminants: impacts on human health. Journal on human of toxins, 2: 771-779.
[30]
Muzaffer. D and Jose. F (2010). Ochratoxins in feeds, a risk for animal and human health. Journal of toxins, 2: 1-13.
[31]
Ferrao. J, Bell. V, Chabite. T and Fernades. T (2017). Mycotoxins, food and health. Journal of health and food science, 5: 1-10.
[32]
Madhavan. T and Gopalan. C (1968). The effects of dietary protein on carcinogens of ochratoxins. Journal of microbiological, 80: 133–137.
[33]
Patterson. D and Allcroft. R (1970). Metabolism of ochratoxins in susceptible and resistance animal species. Journal of food and toxicology, 8: 43–53.
[34]
Robens. J and Richord. J (1992). Contamination and Toxicological. Journal of environmental contamination, 127: 69–85.
[35]
Alim. N, Naseem. Z, Yasha. N and Sajia. H (2014). Aflatoxin: a potential threat to human health. Journal of food science, 24: 256–271.
[36]
Ramos. A, Labernia. N, Marın. S, Sanchis. V and Magan. N (1998). Effect of water activity and temperature on growth and ochratoxin production by three strains of Aspergillus ochraceus on a barley extract medium and on barley grains. Journal of Food Microbiology, 44: 133-140.
[37]
Bellí. N, Mitchell. D, Marín, S and Alegre. I (2005). Ochratoxin A-producing fungi in Spanish wine grapes and their relationship with meteorological conditions. Journal of Plant Pathology, 113: 233-239.
[38]
Esteban. A, Abarca. M, Bragulat. R and Cabañes. F (2006). Effect of water activity on ochratoxin A production by Aspergillus niger aggregate species. Journal of food microbiology, 108: 188-95.
[39]
Lee. H and Magan. N (2000). Impact of environment and interspecific interactions between spoilage fungi and Aspergillus ochraceus on growth and Ochratoxin production in maize grain. Journal of food microbiology, 61: 11-16.
[40]
Kuruc. J, Hegstad. H Lee. K and Wolf-Hall. C (2015). Infestation and Quantification of Ochratoxigenic Fungi in Barley and Wheat Naturally Contaminated with Ochratoxin A. Journal of Food Protection, 78: 1350-1356.
[41]
Cairns. V, Aldred. D and Magan. N (2005). Water, temperature and gas composition interactions affect growth and Ochratoxin A production by isolates of Penicillium verrucosum on.
[42]
Marta. T, Bedaso. K (2016). Occurrence, importance and control of mycotoxins: A review. Journal of Cogent Food & Agriculture 2: 1191-1203.
[43]
Ogara. M, Zarafi. A, Alabi. O, Banwo. O and Krska R (2017). Mycotoxin patterns in ear rot infected maize: A review comprehensive case study in Nigeria. Journal of food Control, 73: 1159-1168.
[44]
Ahmad A and Jae. H (2017). Occurrence, Toxicity, and Analysis of major Mycotoxins in Food. Journal of environmental, 14: 632-638.
[45]
Nicholas. W, Turnera. S, Subrah. M, Sergey. A (2009). Analytical methods for determination of mycotoxins: A review. Journal of Analytica Chimica Acta, 632: 168–180.
[46]
Reich, E and Schibli. A (2007). High-performance thin-layer chromatography for the analysis of medicinal plants. Theme.
[47]
Santos. E and Vargas. A (2002). Immunoaffinity column clean up and thin layer chromatography for determination of OTA in green coffee. Journal of food Additives and Contaminants, 19 (5): 447-458.
[48]
Pittet. A and Royer. D (2002). Rapid, low cost Thin Layer Chromatographic screening for the detection of OTA in green coffee. Journal of Agricultural and Food Chemistry, 50: 243-247.
[49]
Jarmila. S. S, Frantisek. M, Vladimir. O and Tomas. R (2013). Determination of Ochratoxin A in Food by High Performance Liquid Chromatography. Journal of Analytical Letters, 46: 1495-1504.
[50]
Flajs. D, Domijan. M, Ivic. D and Peraica. A (2009). ELISA and HPLC analysis of ochratoxin A in red wines of Croatia. Journal of food control, 20: 590–592.
[51]
Scott. P (2002). Methods of analysis for OTA. Journal of mycotoxins and Food Safety, 10: 117-134.
[52]
Sharaf. S, Moawiya. A Haddad. F and Salvatore Parisi (2020). Validation of HPLC and Enzyme-Linked Immunosorbent Assay (ELISA) Techniques for Detection and Quantification of Aflatoxins in Different Food Samples. Journal of food, 9: 1-9.
[53]
Pruslin. F, Winston. R (1991) Caveats and suggestions for the ELISA. Journal of Immunol Methods 137: 27–35.
[54]
Valenta. H (1998). Chromatographic techniques. Journal of chromatography, 75: 211-242.
[55]
Frantisek. M, Annie. L, Vladimir. O and Jakub. T (2016). Ochratoxin A: 50 Years of Research. Journal of toxins, 8: 1-49.
[56]
Scott. P, Trucksess. M (1997). Application of Immunoaffinity columns to mycotoxin analysis. Journal of AOAC, 80, 5: 941–94.
[57]
Castellari. M, Fabbri. S, Fabiani. A, Amati. A (2000). Comparison of different Immunoaffinity clean-up procedures for high-performance liquid chromatographic analysis of Ochratoxin A in wines. Journal of Chromatogram, 888: 129–136.
[58]
Castegnaro. M, Tozlovanu. M. Wild. C, Molinié. A and Pfoh. L (2006). A. Advantages and drawbacks of Immunoaffinity columns in analysis of mycotoxins in food. Journal of molecular nutrition of food science, 50: 480–487.
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