Electrochemical Oxidation Effect of Each Ascorbic Acid and Folic Acid on Lead Ions in Human Blood
International Journal of Pharmacy and Chemistry
Volume 3, Issue 3, May 2017, Pages: 33-40
Received: Sep. 21, 2016; Accepted: Nov. 26, 2016; Published: May 6, 2017
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Authors
Muhammed Mizher Radhi, Health and Medical Technology College, Radiological Techniques Department, Middle Technical University, Baghdad, Iraq
Sura Ali Al-Assady, Health and Medical Technology College, Radiological Techniques Department, Middle Technical University, Baghdad, Iraq
Nadia Tareq Barakat, Iraqi Center for Cancer and Medical Genetic Research, Almustensyria University, Baghdad, Iraq
Ammani Jassim Mohammed, Health and Medical Technology College, Analytical Lab. Techniques Department, Middle Technical University, Baghdad, Iraq
Ibtihal Hashim Aziz, Health and Medical Technology College, Analytical Lab. Techniques Department, Middle Technical University, Baghdad, Iraq
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Abstract
Electrochemical studies by cyclic voltammetric (CV) method provide high potential for investigation of oxidant pollutant compounds such as Pb(II). Glassy carbon electrode (GCE) can be used for the potentiostatic analysis of the lead ions in different electrolyte especially human blood medium to studying the effect of the lead ions on the blood components. The results of this study were found that oxidation and reduction current peaks of lead ions in 1M KCl is high value and enhanced by adding ascorbic acid (AA) solution, while in human blood medium was disappearing the reduction current peak and enhance the oxidation current peak by lead ions. It means that lead ions in blood medium act as an oxidative reagent and causes problem in the decomposition of the blood component. Also, it was found that using folic acid (FA) solution with lead ions in blood medium causes the enhancement of reduction current peaks of lead ion and decreasing for oxidation current peaks, so this means that folic acid solution acts as antioxidative reagent in present of lead ions in blood medium, it may recommended to taking tablet of FA for the patients who suffers to lead pollution.
Keywords
Pb(II), Cyclic Voltammetry, Human Blood, Redox Process, FA, AA
To cite this article
Muhammed Mizher Radhi, Sura Ali Al-Assady, Nadia Tareq Barakat, Ammani Jassim Mohammed, Ibtihal Hashim Aziz, Electrochemical Oxidation Effect of Each Ascorbic Acid and Folic Acid on Lead Ions in Human Blood, International Journal of Pharmacy and Chemistry. Vol. 3, No. 3, 2017, pp. 33-40. doi: 10.11648/j.ijpc.20170303.12
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Heo Y1, Parsons PJ, Lawrence DA, Lead differentially modifies cytokine production in vitro and in vivo, Toxicol Appl Pharmacol. 1996 May; 138 (1): 149-57.
[2]
Zhao Y1, Xu L, Li S, Chen Q, Yang D, Chen L, Wang H, One-drop-of-blood" electroanalysis of lead levels in blood using a foam-like mesoporous polymer of melamine-formaldehyde and disposable screen-printed electrodes., Analyst. 2015 Mar 21; 140 (6): 1832-6.
[3]
Shinde Brijalal Ramdas, Ascorbic Effect on the endosulphan induced alterations in Blood Glucose level of the Freshwater Fish, Central European Journal of Experimental Biology, 2013, 2 (3): 1-3.
[4]
tiziana gugliotta, grazia de luca, pietro romano, caterina rigano, adriana scuteri and leonardo romano, effects of lead chloride on human erythrocyte membranes and on kinetic anion sulphate and glutathione concentrations, cellular & molecular biology letters Volume 17 (2012) pp 586-597.
[5]
M. G. Tan, G. L. Zhang, X. L. Li, Y. X. Zhang, W. S. Yue, J. M. Chen, Y. S. Wang, A. G. Li, Y. Li, Y. M. Zhang, and Z. C. Shan, Comprehensive Study of Lead Pollution in Shanghai by Multiple Techniques, Anal. Chem. 2006, 78, 8044-8050.
[6]
Md. Kawser Ahmed, Elora Parvin, Md Monirul Islam, Mosammat Salma Akter, Md. Shahneawz Khan, Md Habibullah Al Mamun, Lead- and cadmium-induced histopathological changes in gill, kidney and liver tissue of freshwater climbing perch Anabas testudineus (Bloch, 1792), Chemistry and Ecology 2014; 30 (6).
[7]
Muhammed Mizher Radhi, Wee Tee Tan, Mohamad Zaki B. Ab Rahman and Anuar Bin Kassim, Voltammetric Detection of Mn (II) in Blood Sample at C60 and MWCNT Modified Glassy Carbon Electrodes. American Journal of Applied Sciences 7 (3): 439-445, 2010.
[8]
Muhammed M. Radhi, Dawood S. Dawood, Nawfal K. Al-Damlooji and Tan W. Tee, Development of Electrochemical Sensors for the Detectionof Mercury by CNT/Li+, C60/Li+ and Activated Carbon Modified Glassy Carbon Electrode in Blood Medium Sensors & Transducers Journal, Vol. 146, Issue 11, November 2012, pp. 191-202.
[9]
Muhammed Mizher Radhi, Nawfal Khalid Al-Damlooji, Baquir Kareem Abed, Dawood Salman Dawood, and Tan Wee Tee, Electrochemical Sensors for Detecting Mn (II (in Blood Medium Sensors & Transducers, Vol. 149, Issue 2, February 2013, pp. 89-93.
[10]
Muhammed Mizher Radhi, Nawfal K. Al-Damlooj, Mahmood Radhi Jobayr, Dawood S. Dawood, Electrochemical Sensors of Cyclic Voltammetry to Detect Cd (II) in Blood Medium Sensors & Transducers, Vol. 155, Issue 8, August 2013, pp. 150-154.
[11]
11. Jiri Sochor, Jiri Dobes, Olga Krystofova, Branislav Ruttkay-Nedecky, Petr Babula, Miroslav Pohanka, Tunde Jurikova, Ondrej Zitka, Vojtech Adam, Borivoj Klejdus, Rene Kizek, Electrochemistry as a Tool for Studying Antioxidant Properties, Int. J. Electrochem. Sci., 8 (2013) 8464–8489.
[12]
Parsons P. J., Analytical procedures for the determination of lead in blood and urine; approved guideline. Wayne, PA, National Committee for Clinical Laboratory Standards, 2001.
[13]
Yin Wang, Jinping Jia, Electrochemical Determination of Lead (II) by Electrolyte Dropping Electrode Using 8-Hydroxyquinoline in Flow Injection System, 9 th OAPS Working Paper Series Paper No. 2012-059.
[14]
M. Ogunlesi, W. Okiei1, A. S. Akanmu and T. Popoola, K. Okafor, and O. Akore, Novel Method for the Determination of Haemoglobin Phenotypes by Cyclic Voltammetry using Glassy Carbon Electrode, Int. J. Electrochem. Sci., 4 (2009) 1593–1606.
[15]
Feldman BJ1, D'Alessandro A, Osterloh JD, Hata BH, Electrochemical determination of low blood lead concentrations with a disposable carbon microarray electrode, Clin Chem. 1995 Apr; 41 (4): 557-63.
[16]
David Hynek, Jan Prasek, Jiri Pikula, Vojtech Adam, Pavlina Hajkova, Ludmila Krejcova, Libuse Trnkova, Jiri Sochor, Miroslav Pohanka, Jaromir Hubalek, Miroslava Beklova, Radimir Vrba and Rene Kizek, Electrochemical Analysis of Lead Toxicosis in Vultures, Int. J. Electrochem. Sci., 6 (2011) 5980–6010.
[17]
Guo Mai, Lu Xia, Weixing Wang, Electrochemical detection of blood lead based on the enhancement effect of copper, Russian Journal of Electrochemistry May 2013, Volume 49, Issue 5, pp 447-452.
[18]
Yanfang Zhao, ab Lubin Xu, ab Shuying Li, a Qi Chen, a Daoshan Yang, a Lingxin Chenc and Hua Wang, “One-drop-of-blood” electroanalysis of lead levels in blood using a foam-like mesoporous polymer of melamine–formaldehyde and disposable screen-printed electrodes, Analyst, 2015, 140, 1832-1836.
[19]
Zhihong Nie, a Christian A. Nijhuis, a Jinlong Gong, a Xin Chen, a Alexander Kumachev, b Andres W. Martinez, a, Max Narovlyanskya and George M. Whitesides, Electrochemical sensing in paper-based microfluidic devices, Lab Chip, 2010, 10, 477–483.
[20]
Andrea Cserey, Determination of Lead (II) with the Rotating Sample System, Electroanalysis Volume 16, Issue 16, pages 1299–1304, August 2004.
[21]
Koh Sing Ngai, Wee Tee Tan, Zulkarnain Zainal, Ruzniza Mohd Zawawi, Mohammed Zidan, Voltammetry Detection of Ascorbic Acid at Glassy Carbon Electrode Modified by Single-Walled Carbon Nanotube/Zinc Oxide, Int. J. Electrochem. Sci., 8 (2013) 10557–10567.
[22]
Muhammed M. Radhi, Wee T. Tan, Mohamad Z. B Ab Rahman and Anuar Bin Kassim, Electrochemical Characterization of the Redox Couple of [Fe(CN)6]3+/[Fe(CN)6] 4+ Mediated by a Grafted Polymer Modified Glassy Carbon Electrode, journal of chemical engineering of Japan, vol. 43, no. 11, 2010.
[23]
M. R. Majidi, H. Dastangoo, M. Hasannejad and J. Malakouti, Voltammetric Determination of Folic Acid with a Overoxidized Polypyrrole Film Modified Sol-Gel Carbon Ceramic Electrode, International Journal of Polymer Analysis and Characterization, Volume 16, Issue 7, 2011.
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