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Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives

Received: 18 March 2020     Accepted: 1 April 2020     Published: 30 April 2020
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Abstract

Chalcone derivatives were synthesis by the reaction of some 4-nitrobenzaldehyde derivatives with acotophenone then the product obtained E-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one. This product is chalcone is another react with guanidine nitrate. The hetrocyclic derivatives of guanidine nitrate respectively the final product have been characterized by elemental analysis. the product obtained is 1,6 dihydro 6(4-nitrophenyl) 4-phenylpyridine 2-amine. In present report novel pyrimidines were prepared from starting materials chalcone and guanidine nitrate. The resulting compound 1,6-dihydro-6-(4-nitrophenyl)-4 phenylpyrimidin 2 amine (2) was further reacted with 2 bis(methylthio)methylene malononitrile in the presence of catalytic amount of potassium carbonate in DMF under reflux condition that offered novel 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl) 6 phenyl 1H pyrimido[1,2 a]pyrimidine 3 carbonitrile (3). The synthesized compounds were characterized by spectral methods. The compound (3) possesses replaceable methylthio (-SCH3) group at 2 position. The compound (3) react with various nucleophiles like substituted aromatic amines, aromatic phenols, hetryl amines and active methylene compounds to give 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl)-6-phenyl-1H-pyrimido[1,2-a]pyrimidine-3-carbonitrile –carbonitrile in good yields.

Published in International Journal of Pharmacy and Chemistry (Volume 6, Issue 1)
DOI 10.11648/j.ijpc.20200601.11
Page(s) 1-5
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Claisen Schmidt Condensation, 2 bis(methylthio)methylene malononitrile Michael Addition Reaction, Pyrimidine

References
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  • APA Style

    Sirsat Shivraj Balajirao, Jadhav Anilkumar Govindrao, Nilesh B Chavhan. (2020). Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives. International Journal of Pharmacy and Chemistry, 6(1), 1-5. https://doi.org/10.11648/j.ijpc.20200601.11

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    ACS Style

    Sirsat Shivraj Balajirao; Jadhav Anilkumar Govindrao; Nilesh B Chavhan. Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives. Int. J. Pharm. Chem. 2020, 6(1), 1-5. doi: 10.11648/j.ijpc.20200601.11

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    AMA Style

    Sirsat Shivraj Balajirao, Jadhav Anilkumar Govindrao, Nilesh B Chavhan. Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives. Int J Pharm Chem. 2020;6(1):1-5. doi: 10.11648/j.ijpc.20200601.11

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  • @article{10.11648/j.ijpc.20200601.11,
      author = {Sirsat Shivraj Balajirao and Jadhav Anilkumar Govindrao and Nilesh B Chavhan},
      title = {Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives},
      journal = {International Journal of Pharmacy and Chemistry},
      volume = {6},
      number = {1},
      pages = {1-5},
      doi = {10.11648/j.ijpc.20200601.11},
      url = {https://doi.org/10.11648/j.ijpc.20200601.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20200601.11},
      abstract = {Chalcone derivatives were synthesis by the reaction of some 4-nitrobenzaldehyde derivatives with acotophenone then the product obtained E-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one. This product is chalcone is another react with guanidine nitrate. The hetrocyclic derivatives of guanidine nitrate respectively the final product have been characterized by elemental analysis. the product obtained is 1,6 dihydro 6(4-nitrophenyl) 4-phenylpyridine 2-amine. In present report novel pyrimidines were prepared from starting materials chalcone and guanidine nitrate. The resulting compound 1,6-dihydro-6-(4-nitrophenyl)-4 phenylpyrimidin 2 amine (2) was further reacted with 2 bis(methylthio)methylene malononitrile in the presence of catalytic amount of potassium carbonate in DMF under reflux condition that offered novel 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl) 6 phenyl 1H pyrimido[1,2 a]pyrimidine 3 carbonitrile (3). The synthesized compounds were characterized by spectral methods. The compound (3) possesses replaceable methylthio (-SCH3) group at 2 position. The compound (3) react with various nucleophiles like substituted aromatic amines, aromatic phenols, hetryl amines and active methylene compounds to give 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl)-6-phenyl-1H-pyrimido[1,2-a]pyrimidine-3-carbonitrile –carbonitrile in good yields.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Synthesis of Novel Pyrimido Pyrimidine and Their Derivatives
    AU  - Sirsat Shivraj Balajirao
    AU  - Jadhav Anilkumar Govindrao
    AU  - Nilesh B Chavhan
    Y1  - 2020/04/30
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ijpc.20200601.11
    DO  - 10.11648/j.ijpc.20200601.11
    T2  - International Journal of Pharmacy and Chemistry
    JF  - International Journal of Pharmacy and Chemistry
    JO  - International Journal of Pharmacy and Chemistry
    SP  - 1
    EP  - 5
    PB  - Science Publishing Group
    SN  - 2575-5749
    UR  - https://doi.org/10.11648/j.ijpc.20200601.11
    AB  - Chalcone derivatives were synthesis by the reaction of some 4-nitrobenzaldehyde derivatives with acotophenone then the product obtained E-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one. This product is chalcone is another react with guanidine nitrate. The hetrocyclic derivatives of guanidine nitrate respectively the final product have been characterized by elemental analysis. the product obtained is 1,6 dihydro 6(4-nitrophenyl) 4-phenylpyridine 2-amine. In present report novel pyrimidines were prepared from starting materials chalcone and guanidine nitrate. The resulting compound 1,6-dihydro-6-(4-nitrophenyl)-4 phenylpyrimidin 2 amine (2) was further reacted with 2 bis(methylthio)methylene malononitrile in the presence of catalytic amount of potassium carbonate in DMF under reflux condition that offered novel 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl) 6 phenyl 1H pyrimido[1,2 a]pyrimidine 3 carbonitrile (3). The synthesized compounds were characterized by spectral methods. The compound (3) possesses replaceable methylthio (-SCH3) group at 2 position. The compound (3) react with various nucleophiles like substituted aromatic amines, aromatic phenols, hetryl amines and active methylene compounds to give 4,6,9,9a-tetrahydro-4-imino-2-(methylthio)-8-(4-nitrophenyl)-6-phenyl-1H-pyrimido[1,2-a]pyrimidine-3-carbonitrile –carbonitrile in good yields.
    VL  - 6
    IS  - 1
    ER  - 

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Author Information
  • P. G. Research Centre, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded, India

  • P. G. Research Centre, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded, India

  • P. G. Research Centre, Department of Chemistry, Yeshwant Mahavidyalaya, Nanded, India

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