Study of Physical and Chemical Properties of Zincas and Feras and Its Influence on the Processes of Rat’s Fetus Development
International Journal of Pharmacy and Chemistry
Volume 6, Issue 3, May 2020, Pages: 31-36
Received: May 6, 2020;
Accepted: Jun. 18, 2020;
Published: Jul. 17, 2020
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Umarali Rajabov, Department of Pharmaceutical and Toxicological Chemistry, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
Raufjon Sultonov, Department of Pharmaceutical and Toxicological Chemistry, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
Abdurasul Sanginov, Department of Pharmaceutical and Toxicological Chemistry, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
Savribegim Yormamadova, Department of Applied Chemistry, Avicenna Tajik National University, Dushanbe, Republic of Tajikistan
Gandjina Navruzova, Department of Pharmaceutical Technology and Biotechnology, Tajik National University, Dushanbe, Republic of Tajikistan
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Acetylcysteine (ACC) helps people with pulmonary fibrosis and it is preferred treatment for the often deadly adult respiratory distress syndrome. ACC is a precursor in the formation of the glutathione antioxidant in the body. Compounds of zinc (II) and iron (II) with ACC and mucolytic medications play an important role in medical practice for the prevention of respiratory diseases. The present article is about determining the embryotoxicity of the new coordination compounds of Zincas and Feras, which are synthesized by the interaction of zinc (II) and iron (II) sulfates with acetylcysteine in an aqueous solution and have mucolytic properties in relation to diseases, bronchial asthma with a predominance of an infectious-dependent component of the course, chronic asthmatic bronchitis and chronic obstructive bronchitis. Daily administration of a feed or a high dose of 0.60 ml / kg inside the gastric suspension for 3 weeks to pregnant rats and the result of observation of the 13th week of life did not have a marked effect on the fetal development process. With the introduction of Feras and Zincas in a therapeutic dose for 1-3 weeks of pregnancy, the death of rat pups in the first month of life was comparable with the control values. The physical development of the offspring proceeded without any deviations from the norm. All pups were born normal, responded to external irritants well, with а good appetite and led an active lifestyle.
Embryotoxicity, Feras, Zincas, Acetylcysteine, EPR, Conductometry
To cite this article
Study of Physical and Chemical Properties of Zincas and Feras and Its Influence on the Processes of Rat’s Fetus Development, International Journal of Pharmacy and Chemistry. Special Issue: Drug Research: Current Insights for Search, Development and Analysis.
Vol. 6, No. 3,
2020, pp. 31-36.
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/
) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
RT patent № TJ. 913 Zincas showing mucolytic activity / Rajabov U. R., Yusufi S. J., Sanginov A. B., Sultonov R. A., Yusupov I. Kh., Nurulkhakov N. S. Registered in the state registry on July 9, 2018. Application № 1801199.
RT patent № TJ. 975 Feras with an antioxidant action / Rajabov U. R., Yusufi S. J., Sultonov R. A., Yusupov I. Kh., Navruzova G. F., Holova Sh. A., Jalilov Gh. Q., Murodova N. M. Registered in the state registry on February 12, 2019. Application № 1801251.
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