The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors
International Journal of Pharmacy and Chemistry
Volume 6, Issue 4, July 2020, Pages: 37-40
Received: Jun. 27, 2020;
Accepted: Jul. 10, 2020;
Published: Aug. 4, 2020
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Fahimeh Shamsi, Biotechnology Research Centre, Semnan University of Medical Sciences, Semnan, Iran; School of Chemical and Bimolecular Engineering, University of Sydney, Sydney, Australia
Background: Targeted drug delivery approaches are intended to increase the effectiveness of drugs by carrying large doses of chemotherapeutic agents to the cancer cells and reduce negative side effects. Self-assembly of peptides can organize molecules into stable and well-defined nanostructures being very attractive for many biomedical applications including drug delivery. Objective: The objective of the current mini-review is to investigate the self-assembly behavior of peptide amphiphiles as nanocarriers under different biological factors in the tumor microenvironment. Method: Data from a range of resources like Google Scholar, PubMed, Medline, Scopus and Elsevier, and other valued journals have been reviewed carefully. Results: Structural changes of peptide amphiphiles in response to tumor microenvironment or tumor-specific enzymes are the promising trend, allowing the development of targeted therapy with high efficiency. However, significant improvement in cytotoxicity is achieved when peptide amphiphiles are designed in such a way to respond to multiple stimuli in tumor microenvironments. Conclusion: A multi- disciplinary research area may permit both to reduce the off-target side effects of anticancer drugs and achieve triggered drug delivery at disease sites.
The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors, International Journal of Pharmacy and Chemistry.
Vol. 6, No. 4,
2020, pp. 37-40.
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