International Journal of Pharmacy and Chemistry

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Chemometric Simultaneous Determination of Atorvastatin and Amlodipine in Bulk and Tablets

Received: 05 April 2019    Accepted: 22 July 2019    Published: 09 October 2019
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Abstract

A simple, accurate and precise UV-spectrophotometric method based inverse least-squares was developed for the simultaneous determination of atorvastatin and amlodipine in tablet formulation. The absorbance values of the two analytes were linear with the concentration at the wavelengths taken at 5 nm interval over the range of 230 -260 nm. The calibration equations were developed using the absorbance values of nine synthetic mixtures containing different concentrations of two analytes measured at 5 nm intervalsin the range of 230 -260 nm. The developed equations werethen validated by calculating the analytes recovery from the analysis of a set of another five synthetic mixtures, the mean% recoveries were 100.02% and 100.06% with the corresponding% RSD of ±0.36 and±0.51 for atorvastatin and amlodipine, respectively. The calibration equations obtained were then used to obtain the concentration of each analyte in commercial samples. The mean % recoveries were 100.43% and 100.28% with the corresponding% RSD of ±0.78 and±0.85 for atorvastatin and amlodipine, respectively. The validity of the proposed method was confirmed through the statistical comparison of the obtained results with those obtained by a reference method utilizing high performance liquid chromatography for the determination of the two actives, the calculated t-values at (P=0.05, n =6) were 1.47 and 0.73 compared to the tabulated value of 2.23.

DOI 10.11648/j.ijpc.20190504.12
Published in International Journal of Pharmacy and Chemistry (Volume 5, Issue 4, July 2019)
Page(s) 42-47
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Chemometric, Determination, Atorvastatin, Amlodipine

References
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Author Information
  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, National Al Ribat University, Khartoum, Sudan

  • Department of Pharmaceutical Chemistry, Faculty of Pharmacy, National Al Ribat University, Khartoum, Sudan

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    Imad Osman Abu Reid, Malak Elrasheed Mohamed. (2019). Chemometric Simultaneous Determination of Atorvastatin and Amlodipine in Bulk and Tablets. International Journal of Pharmacy and Chemistry, 5(4), 42-47. https://doi.org/10.11648/j.ijpc.20190504.12

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    Imad Osman Abu Reid; Malak Elrasheed Mohamed. Chemometric Simultaneous Determination of Atorvastatin and Amlodipine in Bulk and Tablets. Int. J. Pharm. Chem. 2019, 5(4), 42-47. doi: 10.11648/j.ijpc.20190504.12

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    AMA Style

    Imad Osman Abu Reid, Malak Elrasheed Mohamed. Chemometric Simultaneous Determination of Atorvastatin and Amlodipine in Bulk and Tablets. Int J Pharm Chem. 2019;5(4):42-47. doi: 10.11648/j.ijpc.20190504.12

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  • @article{10.11648/j.ijpc.20190504.12,
      author = {Imad Osman Abu Reid and Malak Elrasheed Mohamed},
      title = {Chemometric Simultaneous Determination of Atorvastatin and Amlodipine in Bulk and Tablets},
      journal = {International Journal of Pharmacy and Chemistry},
      volume = {5},
      number = {4},
      pages = {42-47},
      doi = {10.11648/j.ijpc.20190504.12},
      url = {https://doi.org/10.11648/j.ijpc.20190504.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijpc.20190504.12},
      abstract = {A simple, accurate and precise UV-spectrophotometric method based inverse least-squares was developed for the simultaneous determination of atorvastatin and amlodipine in tablet formulation. The absorbance values of the two analytes were linear with the concentration at the wavelengths taken at 5 nm interval over the range of 230 -260 nm. The calibration equations were developed using the absorbance values of nine synthetic mixtures containing different concentrations of two analytes measured at 5 nm intervalsin the range of 230 -260 nm. The developed equations werethen validated by calculating the analytes recovery from the analysis of a set of another five synthetic mixtures, the mean% recoveries were 100.02% and 100.06% with the corresponding% RSD of ±0.36 and±0.51 for atorvastatin and amlodipine, respectively. The calibration equations obtained were then used to obtain the concentration of each analyte in commercial samples. The mean % recoveries were 100.43% and 100.28% with the corresponding% RSD of ±0.78 and±0.85 for atorvastatin and amlodipine, respectively. The validity of the proposed method was confirmed through the statistical comparison of the obtained results with those obtained by a reference method utilizing high performance liquid chromatography for the determination of the two actives, the calculated t-values at (P=0.05, n =6) were 1.47 and 0.73 compared to the tabulated value of 2.23.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Chemometric Simultaneous Determination of Atorvastatin and Amlodipine in Bulk and Tablets
    AU  - Imad Osman Abu Reid
    AU  - Malak Elrasheed Mohamed
    Y1  - 2019/10/09
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ijpc.20190504.12
    DO  - 10.11648/j.ijpc.20190504.12
    T2  - International Journal of Pharmacy and Chemistry
    JF  - International Journal of Pharmacy and Chemistry
    JO  - International Journal of Pharmacy and Chemistry
    SP  - 42
    EP  - 47
    PB  - Science Publishing Group
    SN  - 2575-5749
    UR  - https://doi.org/10.11648/j.ijpc.20190504.12
    AB  - A simple, accurate and precise UV-spectrophotometric method based inverse least-squares was developed for the simultaneous determination of atorvastatin and amlodipine in tablet formulation. The absorbance values of the two analytes were linear with the concentration at the wavelengths taken at 5 nm interval over the range of 230 -260 nm. The calibration equations were developed using the absorbance values of nine synthetic mixtures containing different concentrations of two analytes measured at 5 nm intervalsin the range of 230 -260 nm. The developed equations werethen validated by calculating the analytes recovery from the analysis of a set of another five synthetic mixtures, the mean% recoveries were 100.02% and 100.06% with the corresponding% RSD of ±0.36 and±0.51 for atorvastatin and amlodipine, respectively. The calibration equations obtained were then used to obtain the concentration of each analyte in commercial samples. The mean % recoveries were 100.43% and 100.28% with the corresponding% RSD of ±0.78 and±0.85 for atorvastatin and amlodipine, respectively. The validity of the proposed method was confirmed through the statistical comparison of the obtained results with those obtained by a reference method utilizing high performance liquid chromatography for the determination of the two actives, the calculated t-values at (P=0.05, n =6) were 1.47 and 0.73 compared to the tabulated value of 2.23.
    VL  - 5
    IS  - 4
    ER  - 

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