Correlation of Sex and Remission of Acute Lymphoblastic Leukemia-L1 (ALL-L1) in Children
International Journal of Clinical and Experimental Medical Sciences
Volume 1, Issue 2, July 2015, Pages: 11-15
Received: Apr. 8, 2015;
Accepted: May 25, 2015;
Published: Jun. 8, 2015
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Trisna Silawati, Department of Pediatrics, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Nadirah Rasyid Ridha, Department of Pediatrics, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Dasril Daud, Department of Pediatrics, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia
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Introduction: Acute Lymphoblastic Leukemia (ALL) is a malignancy often found in children with peak incidence of 2-5 years. The symptoms and biological factors affect the ALL prognosis; age, leukocyte count, sex, nutritional state, ALL phenotype, CNS infiltration, chromosome abnormalities, and early response to chemotherapy. Objective: The aim of this study was to determine the role of sex on the patient’s remission with ALL-L1. Methods: The retrospective cohort study was conducted to determine the role of sex on the patient’s remission with ALL-L1. The study was conducted in the pediatric ward of Dr. Wahidin Sudirohusodo hospital in Makassar from March until November 2014. The cases were taken from the pediatric ward that met both the inclusion and exclusion criteria. The data were taken from the patient’s medical records related to the study. Results: Revealed of 70 cases that met the criteria was consisted of 42 males and 28 females. Frequency of remission in male group was 41 (97.6%) and in female group was 27 (96.4%). The statistical analysis revealed that there was no significant difference between sex and remission, as it was shown by p = 0.643 (p>0.05). Conclusion: Sex did not have any effects on the frequency of remission in children with ALL-L1 in Dr. Wahidin Sudirohusodo hospital. The frequency of remission in male group was 97.6%, and in female group was 96.4%.
Sex, Remission, ALL-L1, Child
To cite this article
Nadirah Rasyid Ridha,
Correlation of Sex and Remission of Acute Lymphoblastic Leukemia-L1 (ALL-L1) in Children, International Journal of Clinical and Experimental Medical Sciences.
Vol. 1, No. 2,
2015, pp. 11-15.
Schuster JJ., Walker P., Pullen J., Humbert J., Land VJ., Mahoney DH., et al. Prognostic significance of sex in childhood B=Precursor acute lymphoblastic leukemia: A Pediatric Oncology Group Study. J Clin oncol. 1998; 16: 2854-2863.
Pui CH., Boyett JM., Relling MV. Sex differences in prognosis for children with acute lymphoblastic leukemia. Journal of Clinical Oncology. 1999; 17 (3): 818-24.
Chessells JM., Hall E., Pretinence HGM., Bailey CC., Richards SM. The impact of age on outcome in lymphoblastic leukemia; MRC UKALL X and XA compared: a report from the MRC Pediatric and Adult Working Parties. Leukemia. 1998; 12: 463-73.
Margolin JR, Stember CP, Poplack DG. Acute lymphoblastic leukemia, In: Pizzo PA, Poplack DG, Eds. Principles and practice of pediatric Oncology. Philadelpia. 2002; 489-544.
Niemeyer CM., Reiter A., Riehm H. Comparative results of two intensive treatment programs for childhood acute lymphoblastic leukemia: The Berlin-Frankfurt-Munster and Dana-Farber Cancer Institute Protocols. Ann Oncol. 1991; 2: 745-749.
Reiter A., Schrappe M., Ludwig WD., et al. Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients: results and conclusion of the multicenter trial ALL-BFM 86. Blood. 1994; 84:3122-33.
Permatasari E., Widyastuti E., Satari H.I. Survival and prognostic factors of childhood acute lymphoblastic leukemia. Paediatrica Indonesiana. 2009; 49 (6): 365-71.
Haryani, Yeni. Sex and survival variability in children with acute lymphoblastic leukemia. PPDS of Medical Faculty, Hasanuddin University. 2013; 51-57.
Coustan-Smith E., Behm F.G., Sanchez J., Boyett J.M. Immunological detection of minimal residual disease in children with acute lymphoblastic leukemia. Lancet. 1998; 21: 550-04.
Rana Ali. Outcome of childhood acute lymphoblastic leukemia after induction therapy-3 years experience at a single paediatric oncology centre. J Ayub Med Coll Abbottabad. 2009; 21(4):150-3.