International Journal of Clinical and Experimental Medical Sciences

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Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia

Received: 19 June 2015    Accepted: 30 June 2015    Published: 02 July 2015
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Abstract

The Philadelphia (Ph) chromosome, consisting of the t(9;22)(q34;q11.2) is observed in 90% with chronic myeloid leukemia (CML), while variant translocations are observed in 5 to 10%. In variant translocations, three way translocations are rare. We report two cases of three way translocation involving chromosomes 4, 9 and 22. Bone-marrow was subjected to conventional cytogenetic and fluorescence in situ hybridization (FISH) and three way translocation was identified as 46,XX,t(4;9;22)(p16;q34;q11.2). Although other chromosomes are frequently involved in three-way translocation, chromosome 4 is very rare event. So far five cases have been reported in the literature with translocation involving 4p16. We present a six case of chronic myeloid leukemia having 4p16 breakpoints whose clinical interpretation is still unclear.

DOI 10.11648/j.ijcems.20150102.16
Published in International Journal of Clinical and Experimental Medical Sciences (Volume 1, Issue 2, July 2015)
Page(s) 30-34
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Chronic Myeloid Leukemia, t(9;22), Three-Way Translocation Variant, FISH, Cytogenetic

References
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[5] Markovic VD, Bauman D, Bayani J, Al-Magharbi J, Kamel-Reid S, Sauire JA. Lack of BCR/ABL reciprocal fusion in variant Philadelphia chromosome translocations; a use of double fusion signal FISH and spectral karyotyping. Leukemia 2000; 14: 1157-1160.
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[14] Gudi R, Elizalde A, Gogeneni SK, Macera MJ, Badillo A, Verma RS Characterization of a complex translocation [t(4;9;22)(p16;q32;q11) ] inChronic myelogenousleukemia by fluorescence in situ hybridization technique.Can. Genet.Cytogenet.1996; 90: 142-145.
[15] Morel F, Herry A, Le Bris MI, Morice P, Bouguard P, Abgrall JF, Berthou C, De Braekekeer M. Contribution of fluorescence in situ hybridization analyses to the characterization of masked and complex Philadelphia chromosome translocation in CML. Can. Genet.Cytogenet. 2003; 147: 115-120.
[16] Gorush M, Benn P, Li Z, Fang M. On the genesis and prognosis of variant translocations in CML.Can. Genet.Cytogenet 2007; 173: 97 – 106.
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Author Information
  • Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, Surat, India

  • Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, Surat, India

  • Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, Surat, India

  • Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, Surat, India

  • Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, Surat, India

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    Salil Vaniawala, Pratik Chavda, Ganesh Jori, Keur Patil, Pankaj Gadhia. (2015). Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia. International Journal of Clinical and Experimental Medical Sciences, 1(2), 30-34. https://doi.org/10.11648/j.ijcems.20150102.16

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    ACS Style

    Salil Vaniawala; Pratik Chavda; Ganesh Jori; Keur Patil; Pankaj Gadhia. Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia. Int. J. Clin. Exp. Med. Sci. 2015, 1(2), 30-34. doi: 10.11648/j.ijcems.20150102.16

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    AMA Style

    Salil Vaniawala, Pratik Chavda, Ganesh Jori, Keur Patil, Pankaj Gadhia. Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia. Int J Clin Exp Med Sci. 2015;1(2):30-34. doi: 10.11648/j.ijcems.20150102.16

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  • @article{10.11648/j.ijcems.20150102.16,
      author = {Salil Vaniawala and Pratik Chavda and Ganesh Jori and Keur Patil and Pankaj Gadhia},
      title = {Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia},
      journal = {International Journal of Clinical and Experimental Medical Sciences},
      volume = {1},
      number = {2},
      pages = {30-34},
      doi = {10.11648/j.ijcems.20150102.16},
      url = {https://doi.org/10.11648/j.ijcems.20150102.16},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijcems.20150102.16},
      abstract = {The Philadelphia (Ph) chromosome, consisting of the t(9;22)(q34;q11.2) is observed in 90% with chronic myeloid leukemia (CML), while variant translocations are observed in 5 to 10%. In variant translocations, three way translocations are rare. We report two cases of three way translocation involving chromosomes 4, 9 and 22. Bone-marrow was subjected to conventional cytogenetic and fluorescence in situ hybridization (FISH) and three way translocation was identified as 46,XX,t(4;9;22)(p16;q34;q11.2). Although other chromosomes are frequently involved in three-way translocation, chromosome 4 is very rare event. So far five cases have been reported in the literature with translocation involving 4p16. We present a six case of chronic myeloid leukemia having 4p16 breakpoints whose clinical interpretation is still unclear.},
     year = {2015}
    }
    

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    T1  - Characterization of Three-Way Translocation [t(4;9;22)(p16;q34;q11.2)] in Chronic Myeloid Leukemia
    AU  - Salil Vaniawala
    AU  - Pratik Chavda
    AU  - Ganesh Jori
    AU  - Keur Patil
    AU  - Pankaj Gadhia
    Y1  - 2015/07/02
    PY  - 2015
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    DO  - 10.11648/j.ijcems.20150102.16
    T2  - International Journal of Clinical and Experimental Medical Sciences
    JF  - International Journal of Clinical and Experimental Medical Sciences
    JO  - International Journal of Clinical and Experimental Medical Sciences
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    EP  - 34
    PB  - Science Publishing Group
    SN  - 2469-8032
    UR  - https://doi.org/10.11648/j.ijcems.20150102.16
    AB  - The Philadelphia (Ph) chromosome, consisting of the t(9;22)(q34;q11.2) is observed in 90% with chronic myeloid leukemia (CML), while variant translocations are observed in 5 to 10%. In variant translocations, three way translocations are rare. We report two cases of three way translocation involving chromosomes 4, 9 and 22. Bone-marrow was subjected to conventional cytogenetic and fluorescence in situ hybridization (FISH) and three way translocation was identified as 46,XX,t(4;9;22)(p16;q34;q11.2). Although other chromosomes are frequently involved in three-way translocation, chromosome 4 is very rare event. So far five cases have been reported in the literature with translocation involving 4p16. We present a six case of chronic myeloid leukemia having 4p16 breakpoints whose clinical interpretation is still unclear.
    VL  - 1
    IS  - 2
    ER  - 

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