International Journal of Clinical and Experimental Medical Sciences
Volume 1, Issue 3, September 2015, Pages: 65-69
Received: Sep. 1, 2015;
Accepted: Sep. 10, 2015;
Published: Sep. 14, 2015
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Milena Králíčková, Department of Histology and Embryology, Faculty of Medicine, Charles University, Karlovarska, Plzen, Czech Republic; Department of Obstetrics and Gynecology, University Hospital, Faculty of Medicine, Charles University, Alej Svobody, Plzen, Czech Republic; Biomedical Centre, Faculty of Medicine in Plzen, Charles University, Plzen, Czech Republic
Vaclav Vetvicka, University of Louisville, Department of Pathology, S. Floyd, Louisville, KY, U. S. A.
Endometriosis is a benign, but serious gynecologic condition affecting millions of women. This disease is defined by the presence of endometrial tissue outside the uterus. Despite decades of intensive research, the mechanisms of endometriosis are poorly understood. In the last decade, strong evidence seems to suggest the involvement of stem cells. Several possible hypotheses are discussed in this review.
Endometriosis: Are Stem Cells Involved?, International Journal of Clinical and Experimental Medical Sciences.
Vol. 1, No. 3,
2015, pp. 65-69.
Giudice LC, Kao LC. Endometriosis. Lancet. 2004;364:1789-1799.
Adamson GD, Kennedy SH, Hummelshoj L. Creating solutions in endometriosis: global collaboration through the World Endometriosis Research Foundation. J Endometriosis. 2010;2:3-6.
Giudice LC, Clinical practice. Endometriosis. N Engl J Med. 2010;362:2389-2398.
Ugur M, Turan C, Mungsan T, et al. Endometriosis in association with mullerian anomalies. Gyn Obst Inv. 1995;40:261-264.
Vercellini P, Vigano P, Somigliana E, Fedele L. Endometriosis: Pathogenesis and treatment. Nat Rev Endocrinol. 2014; 10:261-275.
Maruyama T, Yoshimura Y. Stem cell theory for the pathogenesis of endometriosis. Front Biosci (Elite Ed). 2012;4:2854-2863.
Sourial S, Tempest N, Hapangama DK. Theories on the pathogenesis of endometriosis. Int J Reprod Med. 2014;2014:179515. doi:10.11552014/179515
Masuda H, Matsuzaki Y, Hiratsu E, et al. Stem cell-like properties of the endometrial side population: implication in endometrial regeneration. PLoS One. 2010;5:e10387.
Deane JA, Gualano RC, Garrett CE. Regenerating endometrium from stem/progenitor cells: it is abnormal in endometriosis. Asherman’s syndrome and infertility? Curr Opin Obstet Gynecol. 2013;25:193-200.
Li L, Clevers H. Coexistence of quiescent and active adult stem cells in mammals. Science. 2010;327:542-545.
Dhesi AS, Morelli SS. Endometriosis: a role for stem cells. Womens Health (Lond Engl). 2015;11:35-49.
Sasson IE, Taylor HS. Stem cells and the pathogenesis of endometriosis. Ann N Y Acad Sci. 2008;1127:106-115.
Gargett GE, Chan RWS. Endometrial stem/progenitor cells and proliferative disorders of the endometrium. Minerva Gynecol. 2006;58:511-526.
Padykula HA. Regeneration in the primate uterus: the role of stem cells. Ann NY Acad Sci. 1991;622:47-56.
Chan RW, Ng EH, Yeung WS. Identification of cells with colony-forming activity, self-renewal capacity, and multipotency in ovarian endometriosis. Am J Pathol. 2011;178:2832-2844.
Gotte M, Wolf M, Staeber A, Buchweitz O, Kiesel L, Schuring AN. Aberrant expression of the plutipotent marker SOX-2 in endometriosis. Fertil Steril 2011;95:338-342.
Pittatore G, Moggio A, Benedetto C, Bussolati B, Revelli A. Endometrial adult/progenitor stem cells: pathogenetic theory and new antiangiogenic approach for endometriosis therapy. Reprod Sci. 2014;21:296-304.
Gargett CE, Masuda H. Adult stem cells in the endometrium. Mol Human Reprod. 2010;16:818-838.
Kao AP, Wang KH, Long, CY, et al. Interleukin-1β induces cyclooxygenase-2 expression and promotes the invasive ability of human mesenchymal stem cells derived from ovarian endometrioma. Fertil Steril. 2011;96:678-684.
Chen Y, Li D, Zhang Z, Takishige N, Kong BH, Wang GY. Effect of human umbilical cord mesenchymal stem cells transplantation on nerve fibers of a rat model of endometriosis. Int J Fert Ster. 2015;9:71-81.
Cho NH, Park YK, Kim YT, Yang H, Kim SK. Lifetime expression of stem cell markers in the uterine endometrium. Fertil Steril. 2004;81:403-407.
Koippallil Gopalakrishnan Nair AR, Pandit H, Warty N, Madan T. Endometriotic mesenchymal stem cells exhibit a distinct immune phenotype. Int Immunol. 2014;27:195-204.
Sakr S, Naqvi H, Komm B, Taylor HS. Endometriosis impairs bone marrow-derived stem cell requitment to the uterus whereas baxedoxifene treatment leads to endometriosis regression and improved uterine stem cell engraftment. Endocrinology. 2014;155:1489-1497.
Prianishnikov VA. On the concept of stem cell and a model of functional-morphological structure of the endometrium. Contraception. 1978;18:213-223.
Djorkovic D, Calhaz-Jorge C. Somatic stem cells and their dysfunction in endometriosis. Front Surg. 2015;1:51. doi:10.3389/fsurg.2014/00051
Hapangama DK, Turner NA, Drury JA, et al. Endometriosis is associated with aberrant endometriotic expression of telomerase and increased telomere length. Hum Reprod. 2008;23:1511-1519.
Schuring AN, Schulte N, Kelsch R, Ropke A, Kiesel L, Gotte, M. characterization of endometrial mesenchymal stem-like cells obtained by endometrial biopsy during routine diagnostics. Fertil Sterol. 2011;95:423-426.
Gargett CE, Schwab KE, Zillwood RM, Nguyen HP, Wu D. Isolation and culture of epithelial progenitors and mesenchymal stem cells from human endometrium. Biol Reprod. 2009;80:1136-1145.
Gargett, CE, Schab KE, Bronsen JJ, Puttemans P, Benagiano G, Brosens I. Potential role of endometrial stem/progenitor cells in the pathogenesis of early-onset endometriosis. Mol Hum Reprod. 2014;7:591-598.
Weimar CH, Macklon NS, Post Uiterweer ED, Brosens JJ, Gellersen B. The motile and invasive capacity of human endometrial stromal cells: implication for normal and impaired reproductive function. Hum Repr Update. 2013;19:542-557.
Cervello I, Mas A, Gil-Sanchis C, Simon C. Somatic stem cells in the human endometrium. Sem Reprod Med. 2013;31:69-76.
Taylor HS. Endometerial cells derived from donor stem cells in bone marrow transplant recipients. J Am Med Assoc. 2004;292:85.
Du H, Taylor HS. Contribution of bone marrow-derived stem cells to endometrium and endometriosis. Stem Cells. 2007;25:2082-2086.
Wang X, Mamillapalli R, Mutlu L, Du H, Taylor HS. Chemoattraction of bone marrow-derived stem cells towards human endometrial stromal cells is mediated by estradiol regulated CXCL12 and CXCR4 expression. Stem Cell Res. 2015;15:14-22.
Becker CM, Beaudry P, Funakoshi T, et al. Circulating endothelial progenitor cells are up-regulated in a mouse model of endometriosis. Am J Pathol. 2011;178:1782-1791.
Lagana AS, Sturlese E, Retto G, Sofo V, Triolo O. Interplay between misplaced Mullerian-derived stem cells and peritoneal immune dysregulation in the pathogenesis of endometriosis. Obstet Gynecol Int. 2013;2013:527041. doi:10.1155/2013/527041
Guo SW. Epigenetics of endometriosis. Mol Hum Reprod. 2009;15:587-607.
Hsu CY, Hiseh TH, Tsai CF, et al. miRNA-199a-5p regulate VEGFA in endometrial mesenchymal stem cells and contributes to the pathogenesis of endometriosis. J Pathol. 2014;232:330-343.
Oliveira FR, Dela Cruz C, Del Puerto HL, Vilamil QT, Reis FM, Camargos AF. Stem cells: Are they the answer to the puzzling etiology of endometriosis? Histol Histopathol. 2012;27:23-29.
Zhou Y, Gan Y, Traylor HS. Cigarette smoke inhibits recruitment of bone-marrow-derivbed stem cells into the uterus. Reprod Toxicol. 2011;31:123-127.
Yang J, Huang F. Stem cell and endometriosis: new knowledge may be producing novel therapies. Int J Clin Exp Med. 2014;7:3853-3858.
Figueira PGM, Abrao MS, Krikun G, Taylor H. Stem cells in endometrium and their role in the pathogenesis of endometriosis. Ann N Y Acad Sci. 2011;1221:10-17.
Taylor HS, Osteen KG, Brunner-Tran KL, et al. Novel therapies targeting endometriosis. Reprod Sci. 2011;18:814-823.
Gargett CE. Uterine stem cells: What is the evidence? Hum Reprod Update. 2007;13:87-101.