Effect of Blood Transfusion on Platelet-Related Antibodies in ITP Patients

Li Meiling; Li Long; Meng Fuxue

doi:doi:10.11648/j.ijcems.20190501.12

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Effect of Blood Transfusion on Platelet-Related Antibodies in ITP Patients

Li Meiling, Li Long, Meng Fuxue

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 5, Issue 1)

Received: 24 December 2018 Accepted: 22 January 2019 Published: 19 February 2019

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Abstract

Objective: To detect the expression of platclet associated immunoglobulin (PAIg) on the ITP patients’ platelet surface and study the effect and correlation of blood transfusion therapy on PAIg. Methods: The 173 patients confirmed as ITP selected form the outpatients and inpatients of the Department of Hematology and Rheumatology in the Third Affiliated Hospital of Guizhou Medical University, were divided into the blood transfusion group and the non-blood transfusion group, FCM fluorescence immunolabeling was used to measure expression quantity of PAIg, the positive expression rate and fluorescence intensity of PAIgG, PAIgM and PAIgA expressed on the platelet surface of ITP patients and the control group respectively. The softwave SPSS12.0 was applied to analyze the correlation. Results: (1) PAIgG (2.96 + 8.31) %, PAIgM (2.27 + 1.78) %, PAIgA (4.48 + 3.88) % in the non-transfusion group were significantly lower than those in the transfusion group (11.44 + 20.04) %, (9.72 + 15.24) %, (10.13 + 9.53) %, P<0.001. (2) The number of platelets in the non-transfusion group was significantly negatively correlated with PAIgM, r=-0.457, P<0.05. There was no significant correlation with PAIgG and PAIgA, all P values were >0.05. Conclusion: (1) It can increase platelet antibody after blood transfusion, and patients with ITP are more likely to produce platelet antibody after blood transfusion. (2) There is a certain degree of correlation between PAIg and blood transfusion in ITP patients.

Published in	International Journal of Clinical and Experimental Medical Sciences (Volume 5, Issue 1)
DOI	10.11648/j.ijcems.20190501.12
Page(s)	5-9
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Idiopathic Thrombocytopenic Purpura, Platelet Related Antibodies, Blood Transfusion

References

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APA Style

Li Meiling, Li Long, Meng Fuxue. (2019). Effect of Blood Transfusion on Platelet-Related Antibodies in ITP Patients. International Journal of Clinical and Experimental Medical Sciences, 5(1), 5-9. https://doi.org/10.11648/j.ijcems.20190501.12

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ACS Style

Li Meiling; Li Long; Meng Fuxue. Effect of Blood Transfusion on Platelet-Related Antibodies in ITP Patients. Int. J. Clin. Exp. Med. Sci. 2019, 5(1), 5-9. doi: 10.11648/j.ijcems.20190501.12

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AMA Style

Li Meiling, Li Long, Meng Fuxue. Effect of Blood Transfusion on Platelet-Related Antibodies in ITP Patients. Int J Clin Exp Med Sci. 2019;5(1):5-9. doi: 10.11648/j.ijcems.20190501.12

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@article{10.11648/j.ijcems.20190501.12,
  author = {Li Meiling and Li Long and Meng Fuxue},
  title = {Effect of Blood Transfusion on Platelet-Related Antibodies in ITP Patients},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {5},
  number = {1},
  pages = {5-9},
  doi = {10.11648/j.ijcems.20190501.12},
  url = {https://doi.org/10.11648/j.ijcems.20190501.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20190501.12},
  abstract = {Objective: To detect the expression of platclet associated immunoglobulin (PAIg) on the ITP patients’ platelet surface and study the effect and correlation of blood transfusion therapy on PAIg. Methods: The 173 patients confirmed as ITP selected form the outpatients and inpatients of the Department of Hematology and Rheumatology in the Third Affiliated Hospital of Guizhou Medical University, were divided into the blood transfusion group and the non-blood transfusion group, FCM fluorescence immunolabeling was used to measure expression quantity of PAIg, the positive expression rate and fluorescence intensity of PAIgG, PAIgM and PAIgA expressed on the platelet surface of ITP patients and the control group respectively. The softwave SPSS12.0 was applied to analyze the correlation. Results: (1) PAIgG (2.96 + 8.31) %, PAIgM (2.27 + 1.78) %, PAIgA (4.48 + 3.88) % in the non-transfusion group were significantly lower than those in the transfusion group (11.44 + 20.04) %, (9.72 + 15.24) %, (10.13 + 9.53) %, PP values were >0.05. Conclusion: (1) It can increase platelet antibody after blood transfusion, and patients with ITP are more likely to produce platelet antibody after blood transfusion. (2) There is a certain degree of correlation between PAIg and blood transfusion in ITP patients.},
 year = {2019}
}

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TY  - JOUR
T1  - Effect of Blood Transfusion on Platelet-Related Antibodies in ITP Patients
AU  - Li Meiling
AU  - Li Long
AU  - Meng Fuxue
Y1  - 2019/02/19
PY  - 2019
N1  - https://doi.org/10.11648/j.ijcems.20190501.12
DO  - 10.11648/j.ijcems.20190501.12
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 5
EP  - 9
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20190501.12
AB  - Objective: To detect the expression of platclet associated immunoglobulin (PAIg) on the ITP patients’ platelet surface and study the effect and correlation of blood transfusion therapy on PAIg. Methods: The 173 patients confirmed as ITP selected form the outpatients and inpatients of the Department of Hematology and Rheumatology in the Third Affiliated Hospital of Guizhou Medical University, were divided into the blood transfusion group and the non-blood transfusion group, FCM fluorescence immunolabeling was used to measure expression quantity of PAIg, the positive expression rate and fluorescence intensity of PAIgG, PAIgM and PAIgA expressed on the platelet surface of ITP patients and the control group respectively. The softwave SPSS12.0 was applied to analyze the correlation. Results: (1) PAIgG (2.96 + 8.31) %, PAIgM (2.27 + 1.78) %, PAIgA (4.48 + 3.88) % in the non-transfusion group were significantly lower than those in the transfusion group (11.44 + 20.04) %, (9.72 + 15.24) %, (10.13 + 9.53) %, PP values were >0.05. Conclusion: (1) It can increase platelet antibody after blood transfusion, and patients with ITP are more likely to produce platelet antibody after blood transfusion. (2) There is a certain degree of correlation between PAIg and blood transfusion in ITP patients.
VL  - 5
IS  - 1
ER  -

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Author Information

Li Meiling

The Third Affiliated Hospital of Guizhou Medical University, Duyun, China; Department of Hematology, Zhongshan Hospital Affiliated of Xiamen University, Xiamen, China
Li Long

The Third Affiliated Hospital of Guizhou Medical University, Duyun, China
Meng Fuxue

The Third Affiliated Hospital of Guizhou Medical University, Duyun, China

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Plain Text BibTeX RIS

APA Style

Li Meiling, Li Long, Meng Fuxue. (2019). Effect of Blood Transfusion on Platelet-Related Antibodies in ITP Patients. International Journal of Clinical and Experimental Medical Sciences, 5(1), 5-9. https://doi.org/10.11648/j.ijcems.20190501.12

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ACS Style

Li Meiling; Li Long; Meng Fuxue. Effect of Blood Transfusion on Platelet-Related Antibodies in ITP Patients. Int. J. Clin. Exp. Med. Sci. 2019, 5(1), 5-9. doi: 10.11648/j.ijcems.20190501.12

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AMA Style

Li Meiling, Li Long, Meng Fuxue. Effect of Blood Transfusion on Platelet-Related Antibodies in ITP Patients. Int J Clin Exp Med Sci. 2019;5(1):5-9. doi: 10.11648/j.ijcems.20190501.12

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@article{10.11648/j.ijcems.20190501.12,
  author = {Li Meiling and Li Long and Meng Fuxue},
  title = {Effect of Blood Transfusion on Platelet-Related Antibodies in ITP Patients},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {5},
  number = {1},
  pages = {5-9},
  doi = {10.11648/j.ijcems.20190501.12},
  url = {https://doi.org/10.11648/j.ijcems.20190501.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20190501.12},
  abstract = {Objective: To detect the expression of platclet associated immunoglobulin (PAIg) on the ITP patients’ platelet surface and study the effect and correlation of blood transfusion therapy on PAIg. Methods: The 173 patients confirmed as ITP selected form the outpatients and inpatients of the Department of Hematology and Rheumatology in the Third Affiliated Hospital of Guizhou Medical University, were divided into the blood transfusion group and the non-blood transfusion group, FCM fluorescence immunolabeling was used to measure expression quantity of PAIg, the positive expression rate and fluorescence intensity of PAIgG, PAIgM and PAIgA expressed on the platelet surface of ITP patients and the control group respectively. The softwave SPSS12.0 was applied to analyze the correlation. Results: (1) PAIgG (2.96 + 8.31) %, PAIgM (2.27 + 1.78) %, PAIgA (4.48 + 3.88) % in the non-transfusion group were significantly lower than those in the transfusion group (11.44 + 20.04) %, (9.72 + 15.24) %, (10.13 + 9.53) %, PP values were >0.05. Conclusion: (1) It can increase platelet antibody after blood transfusion, and patients with ITP are more likely to produce platelet antibody after blood transfusion. (2) There is a certain degree of correlation between PAIg and blood transfusion in ITP patients.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Effect of Blood Transfusion on Platelet-Related Antibodies in ITP Patients
AU  - Li Meiling
AU  - Li Long
AU  - Meng Fuxue
Y1  - 2019/02/19
PY  - 2019
N1  - https://doi.org/10.11648/j.ijcems.20190501.12
DO  - 10.11648/j.ijcems.20190501.12
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 5
EP  - 9
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20190501.12
AB  - Objective: To detect the expression of platclet associated immunoglobulin (PAIg) on the ITP patients’ platelet surface and study the effect and correlation of blood transfusion therapy on PAIg. Methods: The 173 patients confirmed as ITP selected form the outpatients and inpatients of the Department of Hematology and Rheumatology in the Third Affiliated Hospital of Guizhou Medical University, were divided into the blood transfusion group and the non-blood transfusion group, FCM fluorescence immunolabeling was used to measure expression quantity of PAIg, the positive expression rate and fluorescence intensity of PAIgG, PAIgM and PAIgA expressed on the platelet surface of ITP patients and the control group respectively. The softwave SPSS12.0 was applied to analyze the correlation. Results: (1) PAIgG (2.96 + 8.31) %, PAIgM (2.27 + 1.78) %, PAIgA (4.48 + 3.88) % in the non-transfusion group were significantly lower than those in the transfusion group (11.44 + 20.04) %, (9.72 + 15.24) %, (10.13 + 9.53) %, PP values were >0.05. Conclusion: (1) It can increase platelet antibody after blood transfusion, and patients with ITP are more likely to produce platelet antibody after blood transfusion. (2) There is a certain degree of correlation between PAIg and blood transfusion in ITP patients.
VL  - 5
IS  - 1
ER  -

Copy | Download