Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment
International Journal of Clinical and Experimental Medical Sciences
Volume 5, Issue 5, September 2019, Pages: 70-79
Received: Sep. 6, 2019; Accepted: Sep. 24, 2019; Published: Oct. 17, 2019
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Authors
Arasch Bareksei, Dental Concept, Voerde, Germany
Gerd Hafner, Institut Für Laboratoriumsmedizin, Mikrobiologie Und Hygiene, Evangelisches Klinikum Bethel, Bielefeld, Germany
Sebastian Pfeiffer, Labor Todorov, Düsseldorf, Germany
Kathrin Schlatterer, Departments of Dermatology, Venereology, Allergology and Immunology, Brandenburg Medical School Theodor Fontane, Dessau, Germany
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Abstract
A well-defined group of patients of a German Fertility Centre, all supplemented periconceptually with omega-3-fatty acids, was monitored for specific alterations in the immunological laboratory status in correlation with the outcome of in-vitro-fertilization-(IVF)-treatment. For 36 of 52 IVF-patients IVF-treatment was successful. Patients with IVF-success revealed statistically significant lower soluble interleukin-2-receptor concentrations than unsuccessfully treated patients. Decreased numbers of CD4-positive T-cells could be correlated with increased failure rates of IVF, increased numbers of regulatory T-cells on the other hand with significantly improved success rates. Six of the parameters analyzed (T-lymphocytes, T-helper cells, B-lymphocytes, CD4/CD8 ratio and both classes of regulatory T-cells) significantly more often were below the median of the respective distribution in patients without IVF-success than in successfully treated. These results offer the possibility of developing a simple prognostic measure for the outcome of an IVF-therapy by assessing these parameters in relation to the median of the respective distribution. With increasing numbers of parameters lying below the median, the probability of successful IVF-treatment is decreasing.
Keywords
Omega-3-Fatty Acid Supplementation, In Vitro Fertilization, Immunological Laboratory Status
To cite this article
Arasch Bareksei, Gerd Hafner, Sebastian Pfeiffer, Kathrin Schlatterer, Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment, International Journal of Clinical and Experimental Medical Sciences. Vol. 5, No. 5, 2019, pp. 70-79. doi: 10.11648/j.ijcems.20190505.13
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Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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