Maternal Age/Delivery Times-specific Reference Intervals of Fibrin Related Biomarkers During Normal Late Pregnancy in Han Population from Southwest China
International Journal of Clinical and Experimental Medical Sciences
Volume 6, Issue 3, May 2020, Pages: 46-50
Received: Jun. 9, 2020;
Accepted: Jun. 23, 2020;
Published: Jun. 29, 2020
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Liu Dinghua, Department of Clinical Laboratory, University-Town Hospital of Chongqing Medical University, Chongqing, China
Liu Huan, Department of Clinical Laboratory, University-Town Hospital of Chongqing Medical University, Chongqing, China
He Qi, Department of Clinical Laboratory, University-Town Hospital of Chongqing Medical University, Chongqing, China
Li Xin, Department of Clinical Laboratory, University-Town Hospital of Chongqing Medical University, Chongqing, China
Cai Wei, Department of Clinical Laboratory, University-Town Hospital of Chongqing Medical University, Chongqing, China
Objective: Human pregnancy requires hypercoagulation of blood, which means haemostatic reference intervals based on normal people may not be suitable for pregnant women. The aim of this study was to establish reference intervals of fibrin related biomarkers during normal late pregnancy in Han population from southwest China. Methods: Plasma samples were collected from 2374 healthy pregnant women (35-40 gestational weeks) and 326 healthy non-pregnant women at University-Town Hospital of Chongqing Medical University from January 2017 to December 2019. All of the subjects were assigned to 4 groups by age: A (18-29 years), B (30-34 years), C (35-39 years) and D (40-45 years). Further, the pregnant subjects were assigned to 2 groups by delivery times: I (first-delivery) and II (second-delivery). Fibrinogen (Fbg), D-Dimer and fibrin (-ogen) degradation products (FDP) were measured by Sysmex CS-5100 coagulation analyzer. Results: The Fbg reference intervals during late pregnancy in local Han population were 4.09±1.12 g/L. The D-Dimer reference interval for first-delivery pregnancy was <2.77mg/L, and those of second-delivering women were <3.37mg/L (18-34 years) and <3.99mg/L (35-45 years). The FDP reference interval for first-delivery pregnancy was <9.28mg/L, and those of second-delivering women were <10.52mg/L (18-34 years) and <11.72mg/L (35-45 years). Conclusion: In the current study, maternal age/delivery times-specific reference intervals of plasma Fbg, D-Dimer and FDP during normal late pregnancy in Han population from southwest China were presented, which could assist in clinical diagnosis and treatment. Furthermore, we demonstrated maternal age and delivery times did significantly affect the plasma levels of D-dimer and FDP in normal late pregnant women.
Maternal Age/Delivery Times-specific Reference Intervals of Fibrin Related Biomarkers During Normal Late Pregnancy in Han Population from Southwest China, International Journal of Clinical and Experimental Medical Sciences.
Vol. 6, No. 3,
2020, pp. 46-50.
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