Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease
International Journal of Clinical and Experimental Medical Sciences
Volume 5, Issue 4, July 2019, Pages: 58-61
Received: Aug. 14, 2019; Accepted: Sep. 10, 2019; Published: Sep. 26, 2019
Views 500      Downloads 144
Hui Huang, Department of Neurosurgery, Second Affiliation Hospital, Nanchang University, Nanchang, China
Liyuan Xie, Department of Neurosurgery, Second Affiliation Hospital, Nanchang University, Nanchang, China
Min Chen, Department of Neurosurgery, Second Affiliation Hospital, Nanchang University, Nanchang, China
Ming Guo, Psychosomatic Medicine, Second Affiliation Hospital, Nanchang University, Nanchang, China
Xingen Zhu, Department of Neurosurgery, Second Affiliation Hospital, Nanchang University, Nanchang, China
Suyue Zheng, Department of Neurosurgery, First Affiliation Hospital, Nanchang University, Nanchang, China
Mingwei Lu, Department of Neurosurgery, Second Affiliation Hospital, Nanchang University, Nanchang, China
Article Tools
Follow on us
Objectives: To study the therapeutic effect and complications of deep brain stimulation (DBS) to Parkinson’s disease (PD). Patients and Methods: A retrospective analysis of DBS performed on 44 patients with Parkinson’s disease who had complications in the post-operation. Results: 1). A stimulation effect was observed in all PD patients during the operation, with the most obvious effect being relief of muscular tension, followed by improvement in tremor and bradykinesia. 2). The implantable pulse generator was activated from 3 days to 1 month after the implantation of the stimulation electrode, and then had an obvious effect. 3). Clinical follow-up was performed from 3 months to 2.5 years post-implantation. The symptoms assessed using the UPDRS score were significantly improved. 4). Two cases of cerebral hemorrhage and vesicular effusion were related to surgical methods. There were several cases of pneumonia in the postoperative fever and two cases of urinary system infection. One case of traverse fracture also occurred. Postoperative electrode exposure and local infection occurred in 1 case. There were 3 cases of lethargy, 2 cases of hallucinations. In the postoperative period, intelligence decreased further in 1 case. One patient had no obvious improvement in rigidity. 5). One case had difficulties in eye opening within 1 month. One case of PD had poor rigidity control. There was also decrease memory after stimulation in 2 cases. Conclusion: Proper selection of patients, appropriate DBS surgical methods and reasonable adjustment of stimulation parameters can effectively prevent and treat related complications.
DBS, PD, Complications, Surgery
To cite this article
Hui Huang, Liyuan Xie, Min Chen, Ming Guo, Xingen Zhu, Suyue Zheng, Mingwei Lu, Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease, International Journal of Clinical and Experimental Medical Sciences. Vol. 5, No. 4, 2019, pp. 58-61. doi: 10.11648/j.ijcems.20190504.12
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Deuschl G, Schadebrittinger C, Krack P, et al:. A Randomized Trial of Deep-Brain Stimulation for Parkinson's Disease. N Engl J Med 2006; 355: 896-908.
Mehta SH and Sethi KD. Bilateral deep brain stimulation versus best medical therapy for patients with advanced Parkinson’s disease. Jama 2009; 9: 63-73.
Bermudez C, Rodriguez W, Huo Y, et al:. Towards Machine Learning Prediction of Deep Brain Stimulation (DBS) Intra-operative Efficacy Maps. 2018.
Pauls KAM, Hammesfahr S, Moro E, et al:. Deep brain stimulation in the ventrolateral thalamus/subthalamic area in dystonia with head tremor. Movement Disorders 2014; 29: 953-959.
Buhmann C, Moll CKE, Zittel S, et al:. Deep Brain Stimulation of the Ventrolateral Thalamic Base and Posterior Subthalamic Area in Dystonic Head Tremor. Acta Neurochir Suppl 2013; 117: 67-72.
Majdinasab F, Khatoonabadi A, Khoddami SM, et al:. The effect of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on the acoustic and prosodic features in patients with Parkinson's disease: A study protocol for the first trial on Iranian patients. Medical journal of the Islamic Republic of Iran 2017; 31: 786-791.
Golshan HM, Hebb AO, Nedrud J, et al:. Studying the Effects of Deep Brain Stimulation and Medication on the Dynamics of STN-LFP Signals for Human Behavior Analysis. 2018.
Chen T, Mirzadeh Z, Lambert M, et al:. Cost of Deep Brain Stimulation Infection Resulting in Explantation. Stereotactic & Functional Neurosurgery 2017; 95: 117.
Zsigmond P and Göransson N. Deep brain stimulation and intracerebral infection: A case report and review of the literature. Neurology & Clinical Neuroscience 2015; 2: 161-162.
Oluigbo CO, Salma A and Rezai AR. Deep Brain Stimulation for Neurological Disorders. IEEE Reviews in Biomedical Engineering 2012; 5: 88-99.
Costentin G, Derrey S, Gérardin E, et al:. White matter tracts lesions and decline of verbal fluency after deep brain stimulation in Parkinson's disease. Human Brain Mapping 2019; 40.
Buhmann C, Huckhagel T, Engel K, et al:. Adverse events in deep brain stimulation: A retrospective long-term analysis of neurological, psychiatric and other occurrences. Plos One 2017; 12: e0178984.
Mao G, Gigliotti MJ, Angle C, et al:. Craniotomy for subdural hematoma after deep brain stimulation surgery: Outcomes and satisfaction in a case series of two patients. Clin Neurol Neurosurg 2018; 170: 53-57.
Huang H, Hu S, Xie L, et al:. Fatal Hemorrhage from Infarction After Deep Brain Stimulation Surgery. 2018.
Ben-Haim S, Asaad WF, Gale JT, et al:. Risk factors for hemorrhage during microelectrode-guided deep brain stimulation and the introduction of an improved microelectrode design. Neurosurgery 2009; 64: 754-762; discussion 762-753.
Morishita T, Hilliard JD, Okun MS, et al:. Postoperative lead migration in deep brain stimulation surgery: Incidence, risk factors, and clinical impact. Plos One 2017; 12: e0183711.
Odekerken VJ, Van LT, Staal MJ, et al:. Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial. Lancet Neurology 2013; 12: 37-44.
Tröster AI, Jankovic J, Tagliati M, et al:. Neuropsychological outcomes from constant current deep brain stimulation for Parkinson's disease. Movement Disorders 2017; 32.
Timmermann L, Jain R, Chen L, et al:. Multiple-source current steering in subthalamic nucleus deep brain stimulation for Parkinson's disease (the VANTAGE study): a non-randomised, prospective, multicentre, open-label study. Lancet Neurology 2015; 14: 693-701.
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
Tel: (001)347-983-5186