Haemophilus influenzae is a bacterium that can cause severe infections, occurring mostly in infants and children younger than five years of age. Antibiotic treatment may cause the emergence of resistant H. influenzae strains, particularly ampicillin-resistant strains. Antimicrobial resistance is a public health threat worldwide, particularly in the developing world. H. influenzae strains have been isolated from broncho-alveolar lavages (BALs), nasopharyngeal swabs, and otitis media from children in two paediatric centers at Dakar, Senegal. Antibiotic susceptibility testing was carried out using strips E Test ®t method that provides the ability to precisely determine the minimum inhibitory concentration (MIC). A total of 16 H. influenzae strains have been isolated and identified, including 16.7% of ampicillin-resistant patterns (all β-lactamase-negative), 9.4% of the isolates were resistant to cefaclor (MIC90 = 16 µg/ml) while 100% were susceptible to cefixime to (MIC90 = 0.38 µg/ml). Interestingly, fluoroquinolones were fully active with very low MIC90. Macrolide were still active against H. influenzae isoles although with higher MIC azitrhomycin MIC90= 3µg/ml, clarithromycin MIC90= 12µg/ml. Ampicillin-resistance has become increasingly reported in H. influenzae, suggesting a continuous laboratory based surveillance for antimicrobial resistance pattern for a better management of acute respiratory infections, particularly in low incomes settings.
| DOI | 10.11648/j.ijbecs.20190503.12 |
| Published in | International Journal of Biomedical Engineering and Clinical Science (Volume 5, Issue 3, September 2019) |
| Page(s) | 40-44 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Respiratory Tract Infections, Haemophilus influenzae, Ampicillin Resistance
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APA Style
Abdoulaye Diop, Assane Dieng, Abdoulaye Seck, Amary Fall, Amadou Diop, et al. (2019). Ampicillin Resistance in Haemophilus influenzae Isolated from Acute Respiratory Infections in Pediatrics. International Journal of Biomedical Engineering and Clinical Science, 5(3), 40-44. https://doi.org/10.11648/j.ijbecs.20190503.12
ACS Style
Abdoulaye Diop; Assane Dieng; Abdoulaye Seck; Amary Fall; Amadou Diop, et al. Ampicillin Resistance in Haemophilus influenzae Isolated from Acute Respiratory Infections in Pediatrics. Int. J. Biomed. Eng. Clin. Sci. 2019, 5(3), 40-44. doi: 10.11648/j.ijbecs.20190503.12
AMA Style
Abdoulaye Diop, Assane Dieng, Abdoulaye Seck, Amary Fall, Amadou Diop, et al. Ampicillin Resistance in Haemophilus influenzae Isolated from Acute Respiratory Infections in Pediatrics. Int J Biomed Eng Clin Sci. 2019;5(3):40-44. doi: 10.11648/j.ijbecs.20190503.12
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Download@article{10.11648/j.ijbecs.20190503.12,
author = {Abdoulaye Diop and Assane Dieng and Abdoulaye Seck and Amary Fall and Amadou Diop and Djibril Boiro and Jean Baptisse Niokhor Diouf and Modou Gueye and Mbayame Niang and Makhtar Camara and Cheikh Saad Bouh Boye},
title = {Ampicillin Resistance in Haemophilus influenzae Isolated from Acute Respiratory Infections in Pediatrics},
journal = {International Journal of Biomedical Engineering and Clinical Science},
volume = {5},
number = {3},
pages = {40-44},
doi = {10.11648/j.ijbecs.20190503.12},
url = {https://doi.org/10.11648/j.ijbecs.20190503.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20190503.12},
abstract = {Haemophilus influenzae is a bacterium that can cause severe infections, occurring mostly in infants and children younger than five years of age. Antibiotic treatment may cause the emergence of resistant H. influenzae strains, particularly ampicillin-resistant strains. Antimicrobial resistance is a public health threat worldwide, particularly in the developing world. H. influenzae strains have been isolated from broncho-alveolar lavages (BALs), nasopharyngeal swabs, and otitis media from children in two paediatric centers at Dakar, Senegal. Antibiotic susceptibility testing was carried out using strips E Test ®t method that provides the ability to precisely determine the minimum inhibitory concentration (MIC). A total of 16 H. influenzae strains have been isolated and identified, including 16.7% of ampicillin-resistant patterns (all β-lactamase-negative), 9.4% of the isolates were resistant to cefaclor (MIC90 = 16 µg/ml) while 100% were susceptible to cefixime to (MIC90 = 0.38 µg/ml). Interestingly, fluoroquinolones were fully active with very low MIC90. Macrolide were still active against H. influenzae isoles although with higher MIC azitrhomycin MIC90= 3µg/ml, clarithromycin MIC90= 12µg/ml. Ampicillin-resistance has become increasingly reported in H. influenzae, suggesting a continuous laboratory based surveillance for antimicrobial resistance pattern for a better management of acute respiratory infections, particularly in low incomes settings.},
year = {2019}
}
TY - JOUR T1 - Ampicillin Resistance in Haemophilus influenzae Isolated from Acute Respiratory Infections in Pediatrics AU - Abdoulaye Diop AU - Assane Dieng AU - Abdoulaye Seck AU - Amary Fall AU - Amadou Diop AU - Djibril Boiro AU - Jean Baptisse Niokhor Diouf AU - Modou Gueye AU - Mbayame Niang AU - Makhtar Camara AU - Cheikh Saad Bouh Boye Y1 - 2019/10/16 PY - 2019 N1 - https://doi.org/10.11648/j.ijbecs.20190503.12 DO - 10.11648/j.ijbecs.20190503.12 T2 - International Journal of Biomedical Engineering and Clinical Science JF - International Journal of Biomedical Engineering and Clinical Science JO - International Journal of Biomedical Engineering and Clinical Science SP - 40 EP - 44 PB - Science Publishing Group SN - 2472-1301 UR - https://doi.org/10.11648/j.ijbecs.20190503.12 AB - Haemophilus influenzae is a bacterium that can cause severe infections, occurring mostly in infants and children younger than five years of age. Antibiotic treatment may cause the emergence of resistant H. influenzae strains, particularly ampicillin-resistant strains. Antimicrobial resistance is a public health threat worldwide, particularly in the developing world. H. influenzae strains have been isolated from broncho-alveolar lavages (BALs), nasopharyngeal swabs, and otitis media from children in two paediatric centers at Dakar, Senegal. Antibiotic susceptibility testing was carried out using strips E Test ®t method that provides the ability to precisely determine the minimum inhibitory concentration (MIC). A total of 16 H. influenzae strains have been isolated and identified, including 16.7% of ampicillin-resistant patterns (all β-lactamase-negative), 9.4% of the isolates were resistant to cefaclor (MIC90 = 16 µg/ml) while 100% were susceptible to cefixime to (MIC90 = 0.38 µg/ml). Interestingly, fluoroquinolones were fully active with very low MIC90. Macrolide were still active against H. influenzae isoles although with higher MIC azitrhomycin MIC90= 3µg/ml, clarithromycin MIC90= 12µg/ml. Ampicillin-resistance has become increasingly reported in H. influenzae, suggesting a continuous laboratory based surveillance for antimicrobial resistance pattern for a better management of acute respiratory infections, particularly in low incomes settings. VL - 5 IS - 3 ER -
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