Solitary Extramedullary Plasmacytoma of the Trachea: A Case Report
International Journal of Cardiovascular and Thoracic Surgery
Volume 2, Issue 1, May 2016, Pages: 5-8
Received: Dec. 30, 2015; Accepted: Feb. 29, 2016; Published: May 5, 2016
Views 3281      Downloads 157
Authors
Antonello Cuttitta, IRCCS “Casa Sollievo della Sofferenza” Hospital, Unit of General Surgery 2nd and Thoracic Surgery, Viale Cappuccini 1, San Giovanni Rotondo, Foggia, Italy
Antonio Tancredi, Azienda Sanitaria Locale di Foggia, “San Camillo De Lellis” Hospital, Unit of General Surgery, Via Isonzo, Manfredonia, Foggia, Italy
Roberto Scaramuzzi, Second University of Naples, Unit of Thoracic Surgery, Piazza Miraglia 2, Naples, NA, Italy
Antonietta Falcone, IRCCS “Casa Sollievo della Sofferenza” Hospital, Unit of Haematology, Viale Cappuccini 1, San Giovanni Rotondo, Foggia, Italy
Gerardo Scaramuzzi, IRCCS “Casa Sollievo della Sofferenza” Hospital, Unit of General Surgery 2nd and Thoracic Surgery, Viale Cappuccini 1, San Giovanni Rotondo, Foggia, Italy
Marco Taurchini, IRCCS “Casa Sollievo della Sofferenza” Hospital, Unit of General Surgery 2nd and Thoracic Surgery, Viale Cappuccini 1, San Giovanni Rotondo, Foggia, Italy
Article Tools
Follow on us
Abstract
The extramedullary plasmacytomas is a plasma cell tumour arising outside the bone marrow and constitutes around 4 % of all plasma cell neoplasms. The Extramedullary Plasmacytoma of the Trachea (EPT) is an extremely rare condition and presents as a tracheal expanding mass. The most common symptoms consist of coughing, dyspnoea, voice change, stridor and expiratory wheezing. The diagnosis is done by computed tomography, bronchoscopy and histological examination which demonstrates neoplastic monoclonal plasma cells expressing specific antigens. The treatment of the EPT remains still speculative, current options are radiotherapy or surgery alone and surgery followed by radiotherapy. The adjuvant chemotherapy is considered only in case of relapse or systemic spread. The prognosis is comforting: the complete remission occurs in 60 % of cases, the recurrence in 22 %, the progression to multiple myeloma in 16 %. We report the case of a 51-year-old female affected by EPT and treated with the removal of the first four tracheal rings and subsequent PAD chemotherapy (bortezomib, adriamycin and dexamethasone). Although the stage of the tumour was early, we decided to administer chemotherapy conceiving it as a preventive systemic treatment.
Keywords
Tracheal Tumours, Tracheal Resection, Extramedullary Plasmacytoma, Airway Obstruction
To cite this article
Antonello Cuttitta, Antonio Tancredi, Roberto Scaramuzzi, Antonietta Falcone, Gerardo Scaramuzzi, Marco Taurchini, Solitary Extramedullary Plasmacytoma of the Trachea: A Case Report, International Journal of Cardiovascular and Thoracic Surgery. Vol. 2, No. 1, 2016, pp. 5-8. doi: 10.11648/j.ijcts.20160201.12
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Sukumaran R, Nair RA, Jacob PM, Koshy SM, Mathew AP. Extramedullary plasmacytoma of the trachea. Head Neck Pathol. 2014 Jun; 8(2): 220-4. doi: 10.1007/s12105-013-0491-7. Epub 2013 Sep 18.
[2]
Garelli M, Righini C, Faure C, Jankowski A, Brambilla C, Ferretti GR. Imaging of a case of extramedullary solitary plasmacytoma of the trachea. Case Rep Radiol.2011; 2011: 687203. doi: 10.1155/2011/687203. Epub 2011 Sep 22.
[3]
Rai SP, Kumar R, Bharadwaj R, Panda BN. Solitary tracheal plasmacytoma. Indian J Chest Dis Allied Sci. 2003 Oct-Dec; 45(4): 269-72.
[4]
Kober SJ. “Solitary plasmacytoma of the carina,” Thorax, vol. 34, no. 4, pp. 567–568, 1979.
[5]
Lomeo PE, McDonald JE, Finneman J. Shoreline. Extramedullary plasmacytoma of nasal sinus cavities. Am J Otolaryngol. 2007; 28: 50–1.
[6]
Zimmer W, Deluca SA. Primary tracheal neoplasms: Recognition, diagnosis and evaluation. Am Fam Physician 1992; 45: 2651-67.
[7]
Ferretti GR, Bithigoffer C, Righini CA, Arbib F, Lantuejoul S, Jankowski A. “Imaging of tumors of the trachea and central bronchi,” Thoracic Surgery Clinics, vol. 20, no. 1, pp. 31–45, 2010.
[8]
Wise JN, Schaefer RF, Read RC. “Primary pulmonary plasmacytoma: as case report,” Chest, vol. 120, no. 4, pp. 1405–1407, 2001.
[9]
Rutherford K, Parsons S, Cordes S. Extramedullary plasmacytoma of the larynx in an adolescent: a case report and review of the literature.Ear Nose Throat J. 2009 Feb; 88(2): E1-7.
[10]
Hill QA, Rawstron AC, de Tute RM, Owen RG. Outcome prediction in plasmacytoma of bone: a risk model utilizing bone marrow flow cytometry and light-chain analysis. Blood. 2014 Aug 21; 124(8): 1296-9.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186