DLS Characterization of Non-Ionic Surfactant Vesicles for Potential Nose to Brain Application
Nanoscience and Nanometrology
Volume 1, Issue 1, December 2015, Pages: 8-14
Received: Jul. 7, 2015;
Accepted: Jul. 28, 2015;
Published: Jul. 29, 2015
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Federica Rinaldi, Center for Life Nano Science@Sapienza, Fondazione Istituto Italiano di Tecnologia, Rome, Italy
Patrizia N. Hanieh, Department of Drug Chemistry and Technology, University of Rome “Sapienza”, Rome, Italy
Carlotta Marianecci, Department of Drug Chemistry and Technology, University of Rome “Sapienza”, Rome, Italy
Maria Carafa, Department of Drug Chemistry and Technology, University of Rome “Sapienza”, Rome, Italy
The aim of this paper is the preparation and characterization of drug delivery systems for a potential brain delivery by intranasal administration. It is possible to reach the central nervous system with alternative routes through which therapeutic agents can bypass the blood brain barrier: that is the nasal administration. Intranasal drug administration is non-invasive and it could be a promising drug delivery method for patients who suffer from chronic and crippling Central Nervous System diseases. Among the formulation strategies for enhanced nose to brain drug delivery, the use of colloidal carriers has became a revolutionary approach. The success of a therapeutic strategy by using nanocarriers depends on their ability to entrap drugs, to penetrate through anatomical barriers, to efficiently release the incorporated drugs, to show a good stability in nanometric size range and good biocompatibility. The use of vesicular systems (niosomes), in nose to brain delivery is here presented. One of the major problems associated with nasal administration is the rapid removal of drugs or drug delivery systems, from the deposition site through mucociliary clearance. This effect is responsible of reduction of contact time between drug or drug delivery systems and nasal epithelium. This problem could be solved by coating nanocarriers with a mucoadhesive agent: chitosan. In this paper the preparation and characterization of hybrid niosomes by Tween 20 and Tween 21 together with dicetyl phosphate or Span 20 and the cationic polyelectrolyte chitosan are described in order to obtain intranasal drug delivery systems. In particular through dynamic light scattering, laser Doppler electrophoresis and fluorescence measurements the aggregation behavior between vesicles and polyelectrolyte can be monitored. Overall phenomenology is well described in terms of the re-entrant condensation and charge inversion behavior, observed in different colloidal systems. The physical stability of hybrid niosomes obtained by the three different surfactants was also evaluated
Patrizia N. Hanieh,
DLS Characterization of Non-Ionic Surfactant Vesicles for Potential Nose to Brain Application, Nanoscience and Nanometrology.
Vol. 1, No. 1,
2015, pp. 8-14.
J. P. Blumling 3nd and G. A. Silva, “Targeting the brain: advances in drug delivery”, Curr. Pharm. Biotechnol., vol. 13, pp. 2417-2426, 2012.
X. Yi, D. S. Manickam, A. Brynskikh and A. V. Kabanov, “Agile delivery of protein therapeutics to CNS”, J. Controlled Release, vol. 190, pp. 637–663, 2014.
C. Marianecci, L. Di Marzio, F. Rinaldi, C. Celia, D. Paolino, F. Alhaique, S. Esposito and M. Carafa, “Niosomes from 80s to present: The state of the art”, Adv. Colloid Interface Sci., vol. 205, pp. 187–206, 2014.
M. Estanqueiro, M. H. Amaral, J. Conceição and J. M. Sousa Lobo, “Nanotechnological carriers for cancer chemotherapy: The state of the art”, Coll. Surf. B Biointerfaces, vol. 126, pp. 631-648, 2015.
K. K. Jain, “Drug Delivery to the Central Nervous System”, Berlin and Heidelberg:Springer, 2010.
S. V. Dhuria, L. R. Hanson and W. H. Frey 2nd, “Intranasal Delivery to the Central Nervous System: Mechanisms and Experimental Considerations”, J. Pharm. Sci., vol. 99, pp. 1654-1673, 2010.
F. Uchegbu and A. T. Florence, “Non-ionic surfactant vesicles (niosomes): Physical and pharmaceutical chemistry”, Adv. Colloid Interface Sci., vol. 58, pp. 1-55, 1995.
S. Sennato, F. Bordi, C. Cametti, C. Marianecci, M. Carafa and M. Cametti, “Hybrid Niosome Complexation in the Presence of Oppositely Charged Polyions”, J. Phys. Chem. B, vol. 112, pp. 3720-3727, 2008.
M. Carafa, C. Marianecci, G. Lucania, E. Marchei and E. Santucci, “New vesicular ampicillin-loaded delivery systems for topical application: characterization, in vitro permeation experiments and antimicrobial activity”, J. Controlled Release, vol. 95, pp. 67–74, 2004.
C. Marianecci, D. Paolino, C. Celia, M. Fresta, M. Carafa and F. Alhaique, “Non-ionic surfactant vesicles in pulmonary glucocorticoid delivery: characterization and interaction with human lung fibroblasts”, J. Controlled Release, vol. 147, pp. 127–135, 2010.
S. W. Provencher, “Contin: a general purpose constrained regularization program for inverting noisy linear algebraic and integral equations”, Comput. Phys. Commun., vol. 27, pp. 213-242, 1982.
C. De Vos, L. Deriemaeker and R. Finsy, “Quantitative assessment of the conditioning of the inversion of quasi-elastic and static light scattering data for particle size distributions”, Langmuir, vol. 12, pp. 2630-2636, 1996.
B. Maherani, E. Arab-Tehrany, A. Kheirolomoom, D. Geny and M. Linder, “Calcein release behavior from liposomal bilayer; influence of physicochemical/mechanical/structural properties of lipids”, Biochimie, vol. 95, pp. 2018-2033, 2013.
Y. Grosberg, T. T. Nguyen and B. I. Shklovskii, “Colloquium: The physics of charge inversion in chemical and biological systems”, Rev. Mod. Phys., vol. 74, pp. 329-345, 2002.
T. T. Nguyen and B. I. Shklovskii, “Complexation of DNA with positive spheres: Phase diagram of charge inversion and reentrant condensation”, J. Chem. Phys., vol. 115, pp. 7298-7308, 2001.
F. Bordi, C. Cametti, M. Diociaiuti and S. Sennato, “Large equilibrium clusters in low-density aqueous suspensions of polyelectrolyte-liposome complexes: A phenomenological model”, Phys. Rev. E, vol. 71, pp. 050401/1-0504014, 2005.
C. Marianecci, F. Rinaldi, M. Mastriota, S. Pieretti, E. Trapasso, D. Paolino and M. Carafa, “Anti-inflammatory activity of novel ammonium glycyrrhizinate/niosomes delivery system: human and murine models”, J. Controlled Release, vol. 164, pp. 17-25, 2012.