Modeling of Controlled Release of Betacarotene Microcapsules in Ethyl Acetate

Jucelio Kilinski Tavares; Antônio Augusto Ulson de Souza; José Vladimir de Oliveira; Adriano da Silva; Wagner Luiz Priamo; Selene Maria Arruda Guelli Ulson de Souza

doi:doi:10.11648/j.nsnm.20180402.11

Modeling of Controlled Release of Betacarotene Microcapsules in Ethyl Acetate

Jucelio Kilinski Tavares, Antônio Augusto Ulson de Souza, José Vladimir de Oliveira, Adriano da Silva, Wagner Luiz Priamo, Selene Maria Arruda Guelli Ulson de Souza

Published in Nanoscience and Nanometrology (Volume 4, Issue 2)

Received: 5 July 2018 Accepted: 13 September 2018 Published: 17 October 2018

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

In this work several models of mass transfer process were used for modelling and simulating active principles release of polymeric microcapsules of the matrix type. To demonstrate the performance of each model compared to the experimental data, a statistical analysis using the F test was done. The following mathematical models were used on this mass transfer problem: 2ª. Law of Fick (CDMASSA), LDF - Linear Drive Force, analytical model and others semiempiricals models. The results obtained were compared with those available in the literature. In this work the release of the active ingredient betacarotene, contained in microcapsules (PHBV) in the solvent ethyl acetate, was studied. It was observed that the model obtained from the 2ª. Law of Fick fits better on the literature data compared to the models: LDF, analytical andsemiempirical. s. The most complete model, based on the phenomenology of the problem, provide a better result, considering that it was able to represent the fundamental stages of the mass transfer process, such as the resistance to mass transfer on the microcapsule surface, werethe numerical results were very close to the experimental results.

Published in	Nanoscience and Nanometrology (Volume 4, Issue 2)
DOI	10.11648/j.nsnm.20180402.11
Page(s)	23-33
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Release, Microcapsules, Modeling, Active Principles, Simulation

References

[1]	L. Calabuig-Jiménez, E. Betoret, N. Betoret, F. Patrignani, C. Barrera, L. Seguí, R. Lanciotti, M. Dalla Rosa, High pressures homogenization (HPH) to microencapsulate L. salivarius spp. salivarius in mandarin juice. Probiotic survival and in vitro digestion, J. Food Eng. 240 (2019) 43–48. doi:10.1016/j.jfoodeng.2018.07.012.
[2]	D. França, Â. F. Medina, L. L. Messa, C. F. Souza, R. Faez, Chitosan spray-dried microcapsule and microsphere as fertilizer host for swellable − controlled release materials, Carbohydr. Polym. 196 (2018) 47–55. doi:10.1016/j.carbpol.2018.05.014.
[3]	E. Cussler, Diffusion: mass transfer in fluid systems, 3nd ed., Cambridge University Press, 2009. http://medcontent.metapress.com/index/A65RM03P4874243N.pdf (accessed October 10, 2015).
[4]	S. N. Rodrigues, I. M. Martins, I. P. Fernandes, P. B. Gomes, V. G. Mata, M. F. Barreiro, a. E. Rodrigues, Scentfashion®: Microencapsulated perfumes for textile application, Chem. Eng. J. 149 (2009) 463–472. doi:10.1016/j.cej.2009.02.021.
[5]	N. Agnihotri, R. Mishra, C. Goda, M. Arora, Microencapsulation – A Novel Approach in Drug Delivery : A Review, 2 (2012) 1–20.
[6]	M. Ahmad, P. Mudgil, A. Gani, F. Hamed, F. A. Masoodi, S. Maqsood, Nano encapsulation of catechin in starch nanoparticles: Characterization; release behavior and bioactivity retention during in-vitro digestion, Food Chem. (2018). doi:10.1016/j.foodchem.2018.07.024.
[7]	Q. Lin, R. Liang, P. A. Williams, F. Zhong, Factors affecting the bioaccessibility of β-carotene in lipid-based microcapsules: Digestive conditions, the composition, structure and physical state of microcapsules, Food Hydrocoll. 77 (2018) 187–203. doi:10.1016/j.foodhyd.2017.09.034.
[8]	W. L. Priamo, A. M. de Cezaro, S. C. Benetti, J. V. Oliveira, S. R. S. Ferreira, In vitro release profiles of β-carotene encapsulated in PHBV by means of supercritical carbon dioxide micronization technique, J. Supercrit. Fluids. 56 (2011) 137–143. doi:10.1016/j.supflu.2010.12.013.
[9]	S. V Patankar, Numerical Heat Transfer and Fluid Flow, Hemisphere Publishing Corporation, 1980. http://scholar.google.com/scholar?hl=en&btnG=Search&q=intitle:Numerical+heat+transfer+and+fluid+flow#0.
[10]	G. Frenning, A. Alderborn, Modelling of drug release from coated granular pellets, J. Control. Release. 92 (2003) 113–123.
[11]	S. Basu, D. Banerjee, R. Chowdhury, P. Bhattacharya, Controlled release of microencapsulated probiotics in food matrix, J. Food Eng. (2018). doi:S0260877418302553.
[12]	C. R. Wilke, P. Chang, Correlation of diffusion coefficients in dilute solutions, AIChE J. 1 (1955) 264–270. doi:10.1002/aic.690010222.
[13]	R. B. Bird, W. E. Stewart, E. N. Lightfoot, Transport Phenomena, John Wiley & Sons, 2007. doi:10.1051/jp4:20020462.
[14]	M. Polakovič, T. Görner, R. Gref, E. Dellacherie, Lidocaine loaded biodegradable nanospheres: II. Modelling of drug release, J. Control. Release. 60 (1999) 169–177. http://www.sciencedirect.com/science/article/pii/S0168365999000127 (accessed October 26, 2014).
[15]	N. Peppas, J. Sahlin, A simple equation for the description of solute release. III. Coupling of diffusion and relaxation, Int. J. Pharm. 57 (1989) 169–172. http://www.sciencedirect.com/science/article/pii/0378517389903062 (accessed January 16, 2015).
[16]	N. L. Vanden Braber, A. J. Paredes, Y. E. Rossi, C. Porporatto, D. A. Allemandi, C. D. Borsarelli, S. G. Correa, M. A. Montenegro, Controlled release and antioxidant activity of chitosan or its glucosamine water-soluble derivative microcapsules loaded with quercetin, Int. J. Biol. Macromol. 112 (2018) 399–404. doi:10.1016/j.ijbiomac.2018.01.085.
[17]	P. L. Ritger, N. A. Peppas, A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs, J. Control. Release. 5 (1987) 23–36.
[18]	P. L. Ritger, N. A. Peppas, A simple equation for description of solute release II. Fickian and anomalous release from swellable devices, J. Control. Release. 5 (1987) 37–42.
[19]	P. Costa, J. S. Lobo, Modeling and comparison of dissolution profiles, Eur. J. Pharm. Sci. (2001). http://www.sciencedirect.com/science/article/pii/S0928098701000951 (accessed January 19, 2015).
[20]	F. Langenbucher, Handling of computational in vitro / in vivo correlation problems by Microsoft Excel II. Distribution functions and moments, Eur. J. Pharm. Biopharm. 55 (2003) 77–84. doi:10.1016/S0.
[21]	D. Y. Arifin, L. Y. Lee, C.-H. Wang, Mathematical modeling and simulation of drug release from microspheres: Implications to drug delivery systems., Adv. Drug Deliv. Rev. 58 (2006) 1274–325. doi:10.1016/j.addr.2006.09.007.
[22]	S. Dash, P. N. Murthy, L. Nath, P. Chowdhury, Kinetic Modeling on Drug Release From Controlled Drug Delivery Systems, Acta Pol. Pharm. - Drug Res. 67 (2010) 217–223.
[23]	J. Siepmann, F. Siepmann, Mathematical modeling of drug delivery., Int. J. Pharm. 364 (2008) 328–43. doi:10.1016/j.ijpharm.2008.09.004.
[24]	J. Siepmann, F. Siepmann, Modeling of diffusion controlled drug delivery., J. Control. Release. 161 (2012) 351–62. doi:10.1016/j.jconrel.2011.10.006.
[25]	E. Nuxoll, Added release time in diffusion/dissolution coupled release., Int. J. Pharm. 494 (2015) 195–204. doi:10.1016/j.ijpharm.2015.08.017.
[26]	J. Crank, The mathematics of diffusion, 2nd ed., Oxford University Press, 1975. http://books.google.com/books?hl=en&lr=&id=eHANhZwVouYC&oi=fnd&pg=PA1&dq=The+Mathematic+of+Diffusion&ots=fy-4y-jlOW&sig=7bUh2HpsFuO4NpDhsyIGWDlulF0 (accessed October 10, 2015).
[27]	W. L. Priamo, A. M. de Cezaro, S. R. S. Ferreira, J. V. Oliveira, Precipitation and encapsulation of β-carotene in PHBV using carbon dioxide as anti-solvent, J. Supercrit. Fluids. 54 (2010) 103–109. doi:10.1016/j.supflu.2010.02.013.
[28]	A. F. M. Barton, Solubility parameters, Chem. Rev. 75 (1975) 731–753. doi:10.1021/cr60298a003.
[29]	L. Feltl, V. Pacakova, K. Stulik, K. Volka, Reliability of Carotenoid Analyses: A Review, Curr. Anal. Chem. 1 (2005) 93–102. doi:10.2174/1573411052948424.
[30]	A. Paar, Viscopedia, Viscopedia. (2015).
[31]	Royal Society of Chemistry, ChemSpider, R. Soc. Chem. (2015).
[32]	A. D. S. M. R. Pascoal, P. M. da Silva, M. N. Coelho Pinheiro, Drug dissolution profiles from polymeric matrices: Data versus numerical solution of the diffusion problem and kinetic models, Int. Commun. Heat Mass Transf. 61 (2015) 118–127. doi:10.1016/j.icheatmasstransfer.2014.12.011.
[33]	S. Sahoo, C. K. Chakraborti, P. K. Behera, Development and Evaluation of Gastroretentive Controlled Release Polymeric Suspensions Containing Ciprofloxacin and Carbopol Polymers, J. Chem. Pharm. Res. 4 (2012) 2268–2284.
[34]	F. W. Deng, J. H. Cushman, Comparison of moments for classical-, quasi-, and convolution- Fickian dispersion of a conservative tracer, Water Resour. Res. 31 (1995) 1147–1149.
[35]	P. Costa, J. M. Sousa Lobo, Evaluation of mathematical models describing drug release from estradiol transdermal systems., Drug Dev. Ind. Pharm. 29 (2003) 89–97. doi:10.1081/DDC-120016687.
[36]	J. R. Medina, D. K. Salazar, M. Hurtado, A. R. Cortés, A. M. Domínguez-Ramírez, Comparative in vitro dissolution study of carbamazepine immediate-release products using the USP paddles method and the flow-through cell system., Saudi Pharm. J. 22 (2014) 141–7. doi:10.1016/j.jsps.2013.02.001.
[37]	P. Costa, J. M. Sousa Lobo, Modeling and comparison of dissolution profiles, Eur. J. Pharm. Sci. 13 (2001) 123–133. doi:10.1016/S0928-0987(01)00095-1.
[38]	H. Umer, H. Nigam, A. M. Tamboli, M. S. M. Nainar, Microencapsulation : Process, Techniques and Applications, Int. J. Res. Pharm. Biomed. Sci. 2 (2011) 474–481.
[39]	I. a. Kouskoumvekaki, J. Abildskov, Thermodynamic Modelling as a Tool in the Design of Microsphere Controlled-Delivery Systems, Chem. Eng. Res. Des. 84 (2006) 652–663. doi:10.1205/cherd06023.
[40]	E. S. El-leithy, D. S. Shaker, M. K. Ghorab, R. S. Abdel-rashid, Optimization and characterization of diclofenac sodium microspheres prepared by a modified coacervation method, Drug Discov. Ther. 4 (2010) 208–216.
[41]	L. N. Carli, T. S. Daitx, O. Bianchi, J. S. Crespo, R. S. Mauler, Influence of the thermal degradation on the formation of the lamellar structure of PHBV evaluated by time-temperature resolved SAXS experiments, in: XIVSLAP/XII CIP, 2014: pp. 10–13.
[42]	A. Dokoumetzidis, P. Macheras, A century of dissolution research: from Noyes and Whitney to the biopharmaceutics classification system., Int. J. Pharm. 321 (2006) 1–11. doi:10.1016/j.ijpharm.2006.07.011.
[43]	P. S. C. Sacchetin, R. F. Setti, P. D. T. V. E. Rosa, Â. M. Moraes, Properties of PLA/PCL particles as vehicles for oral delivery of the androgen hormone 17α-methyltestosterone, Mater. Sci. Eng. C. 58 (2016) 870–881. doi:10.1016/j.msec.2015.09.071.

Cite This Article

Plain Text BibTeX RIS

APA Style

Jucelio Kilinski Tavares, Antônio Augusto Ulson de Souza, José Vladimir de Oliveira, Adriano da Silva, Wagner Luiz Priamo, et al. (2018). Modeling of Controlled Release of Betacarotene Microcapsules in Ethyl Acetate. Nanoscience and Nanometrology, 4(2), 23-33. https://doi.org/10.11648/j.nsnm.20180402.11

Copy | Download

ACS Style

Jucelio Kilinski Tavares; Antônio Augusto Ulson de Souza; José Vladimir de Oliveira; Adriano da Silva; Wagner Luiz Priamo, et al. Modeling of Controlled Release of Betacarotene Microcapsules in Ethyl Acetate. Nanosci. Nanometrol. 2018, 4(2), 23-33. doi: 10.11648/j.nsnm.20180402.11

Copy | Download

AMA Style

Jucelio Kilinski Tavares, Antônio Augusto Ulson de Souza, José Vladimir de Oliveira, Adriano da Silva, Wagner Luiz Priamo, et al. Modeling of Controlled Release of Betacarotene Microcapsules in Ethyl Acetate. Nanosci Nanometrol. 2018;4(2):23-33. doi: 10.11648/j.nsnm.20180402.11

Copy | Download

@article{10.11648/j.nsnm.20180402.11,
  author = {Jucelio Kilinski Tavares and Antônio Augusto Ulson de Souza and José Vladimir de Oliveira and Adriano da Silva and Wagner Luiz Priamo and Selene Maria Arruda Guelli Ulson de Souza},
  title = {Modeling of Controlled Release of Betacarotene Microcapsules in Ethyl Acetate},
  journal = {Nanoscience and Nanometrology},
  volume = {4},
  number = {2},
  pages = {23-33},
  doi = {10.11648/j.nsnm.20180402.11},
  url = {https://doi.org/10.11648/j.nsnm.20180402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.nsnm.20180402.11},
  abstract = {In this work several models of mass transfer process were used for modelling and simulating active principles release of polymeric microcapsules of the matrix type. To demonstrate the performance of each model compared to the experimental data, a statistical analysis using the F test was done. The following mathematical models were used on this mass transfer problem: 2ª. Law of Fick (CDMASSA), LDF - Linear Drive Force, analytical model and others semiempiricals models. The results obtained were compared with those available in the literature. In this work the release of the active ingredient betacarotene, contained in microcapsules (PHBV) in the solvent ethyl acetate, was studied. It was observed that the model obtained from the 2ª. Law of Fick fits better on the literature data compared to the models: LDF, analytical andsemiempirical. s. The most complete model, based on the phenomenology of the problem, provide a better result, considering that it was able to represent the fundamental stages of the mass transfer process, such as the resistance to mass transfer on the microcapsule surface, werethe numerical results were very close to the experimental results.},
 year = {2018}
}

Copy | Download

TY - JOUR
T1 - Modeling of Controlled Release of Betacarotene Microcapsules in Ethyl Acetate
AU - Jucelio Kilinski Tavares
AU - Antônio Augusto Ulson de Souza
AU - José Vladimir de Oliveira
AU - Adriano da Silva
AU - Wagner Luiz Priamo
AU - Selene Maria Arruda Guelli Ulson de Souza
Y1 - 2018/10/17
PY - 2018
N1 - https://doi.org/10.11648/j.nsnm.20180402.11
DO - 10.11648/j.nsnm.20180402.11
T2 - Nanoscience and Nanometrology
JF - Nanoscience and Nanometrology
JO - Nanoscience and Nanometrology
SP - 23
EP - 33
PB - Science Publishing Group
SN - 2472-3630
UR - https://doi.org/10.11648/j.nsnm.20180402.11
AB - In this work several models of mass transfer process were used for modelling and simulating active principles release of polymeric microcapsules of the matrix type. To demonstrate the performance of each model compared to the experimental data, a statistical analysis using the F test was done. The following mathematical models were used on this mass transfer problem: 2ª. Law of Fick (CDMASSA), LDF - Linear Drive Force, analytical model and others semiempiricals models. The results obtained were compared with those available in the literature. In this work the release of the active ingredient betacarotene, contained in microcapsules (PHBV) in the solvent ethyl acetate, was studied. It was observed that the model obtained from the 2ª. Law of Fick fits better on the literature data compared to the models: LDF, analytical andsemiempirical. s. The most complete model, based on the phenomenology of the problem, provide a better result, considering that it was able to represent the fundamental stages of the mass transfer process, such as the resistance to mass transfer on the microcapsule surface, werethe numerical results were very close to the experimental results.
VL - 4
IS - 2
ER -

Copy | Download

Author Information

Jucelio Kilinski Tavares

Chemical and Food Engineering Department, Federal University of Santa Catarina, Florianópolis, Brazil
Antônio Augusto Ulson de Souza
José Vladimir de Oliveira

Chemical and Food Engineering Department, Federal University of Santa Catarina, Florianópolis, Brazil
Adriano da Silva

Chemical and Food Engineering Department, Federal University of Santa Catarina, Florianópolis, Brazil
Wagner Luiz Priamo

Laboratory of Separation Processes, Federal Institute of Education, Science and Technology of Rio Grande do Sul State IFRS – Campus Sert?o, Sert?o, Brazil
Selene Maria Arruda Guelli Ulson de Souza

Chemical and Food Engineering Department, Federal University of Santa Catarina, Florianópolis, Brazil

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Jucelio Kilinski Tavares, Antônio Augusto Ulson de Souza, José Vladimir de Oliveira, Adriano da Silva, Wagner Luiz Priamo, et al. (2018). Modeling of Controlled Release of Betacarotene Microcapsules in Ethyl Acetate. Nanoscience and Nanometrology, 4(2), 23-33. https://doi.org/10.11648/j.nsnm.20180402.11

Copy | Download

ACS Style

Jucelio Kilinski Tavares; Antônio Augusto Ulson de Souza; José Vladimir de Oliveira; Adriano da Silva; Wagner Luiz Priamo, et al. Modeling of Controlled Release of Betacarotene Microcapsules in Ethyl Acetate. Nanosci. Nanometrol. 2018, 4(2), 23-33. doi: 10.11648/j.nsnm.20180402.11

Copy | Download

AMA Style

Jucelio Kilinski Tavares, Antônio Augusto Ulson de Souza, José Vladimir de Oliveira, Adriano da Silva, Wagner Luiz Priamo, et al. Modeling of Controlled Release of Betacarotene Microcapsules in Ethyl Acetate. Nanosci Nanometrol. 2018;4(2):23-33. doi: 10.11648/j.nsnm.20180402.11

Copy | Download

@article{10.11648/j.nsnm.20180402.11,
  author = {Jucelio Kilinski Tavares and Antônio Augusto Ulson de Souza and José Vladimir de Oliveira and Adriano da Silva and Wagner Luiz Priamo and Selene Maria Arruda Guelli Ulson de Souza},
  title = {Modeling of Controlled Release of Betacarotene Microcapsules in Ethyl Acetate},
  journal = {Nanoscience and Nanometrology},
  volume = {4},
  number = {2},
  pages = {23-33},
  doi = {10.11648/j.nsnm.20180402.11},
  url = {https://doi.org/10.11648/j.nsnm.20180402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.nsnm.20180402.11},
  abstract = {In this work several models of mass transfer process were used for modelling and simulating active principles release of polymeric microcapsules of the matrix type. To demonstrate the performance of each model compared to the experimental data, a statistical analysis using the F test was done. The following mathematical models were used on this mass transfer problem: 2ª. Law of Fick (CDMASSA), LDF - Linear Drive Force, analytical model and others semiempiricals models. The results obtained were compared with those available in the literature. In this work the release of the active ingredient betacarotene, contained in microcapsules (PHBV) in the solvent ethyl acetate, was studied. It was observed that the model obtained from the 2ª. Law of Fick fits better on the literature data compared to the models: LDF, analytical andsemiempirical. s. The most complete model, based on the phenomenology of the problem, provide a better result, considering that it was able to represent the fundamental stages of the mass transfer process, such as the resistance to mass transfer on the microcapsule surface, werethe numerical results were very close to the experimental results.},
 year = {2018}
}

Copy | Download