Original Research Article Novel Nano-Sized Iron Complex Application Using Folate Based Imaging Agent
American Journal of Nanosciences
Volume 3, Issue 1, March 2017, Pages: 9-18
Received: Dec. 23, 2016;
Accepted: Jan. 6, 2017;
Published: Mar. 30, 2017
Views 1603 Downloads 102
Saeed Akbarian, Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Asma Keshavarz, Pharmaceutical Branches, Islamic Azad University, Tehran, Iran
Esmaeel Mohammadi Pargoo, Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Nasser Nassiri Koopaei, Pharmaceutical Quality Assurance Research Center, Tehran University of Medical Sciences, Tehran, Iran
Hamid Moloudian, Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Mostafa Saffari, Pharmaceutical Branches, Islamic Azad University, Tehran, Iran
Hadi Hejazinia, Pharmaceutical Quality Assurance Research Center, Tehran University of Medical Sciences, Tehran, Iran
Masood Bamedi, Depertment of Periodontology and Oral and Dental Disease Research Center, Zahedan University of Medical Science, Zahedan, Iran
Mehdi Shafiee Ardestani, Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Design and evaluation of new chemically nano composites towards molecular imaging of malignant tumors is being considered as a kind of medical global research interests. In the current experiment novel nano-composite based on gadolinium ions and anionic linear globular Dendrimer G2 (as biocompatible biodegradable hybrid nanomaterial grafted to folic acid was developed and biophysically assayed. The results showed a very good Magnetic Resonance (MR) relaxivity data on T2 decreasing as well as a very good cellular uptake and tolerance. The complex was found toxic with employing apoptosis as main mechanism of action on cancerous cells respectively. Based on results it could be concluded that such nano-complex may be used as novel theranostic agent in further in vivo practices in near future.
Esmaeel Mohammadi Pargoo,
Nasser Nassiri Koopaei,
Mehdi Shafiee Ardestani,
Original Research Article Novel Nano-Sized Iron Complex Application Using Folate Based Imaging Agent, American Journal of Nanosciences.
Vol. 3, No. 1,
2017, pp. 9-18.
Na, H. B., I. C. Song, and T. Hyeon, Inorganic nanoparticles for MRI contrast agents. Advanced Materials, 2009. 21 (21): p. 2133-2148.
Lodhia, J., et al., Development and use of iron oxide nanoparticles (Part 1): Synthesis of iron oxide nanoparticles for MRI. Biomedical imaging and intervention journal, 2010. 6 (2): p. e12.
Wang, S. H., et al., Dendrimer-Functionalized Iron Oxide Nanoparticles for Specific Targeting and Imaging of Cancer Cells. Advanced Functional Materials, 2007. 17 (16): p. 3043-3050.
Peng, X.-H., et al., Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy. International journal of nanomedicine, 2008. 3 (3): p. 311.
Choi, H., et al., Iron oxide nanoparticles as magnetic resonance contrast agent for tumor imaging via folate receptor-targeted delivery 1. Academic radiology, 2004. 11 (9): p. 996-1004.
Arsalani, N., H. Fattahi, and M. Nazarpoor, Synthesis and characterization of PVP-functionalized superparamagnetic Fe3O4 nanoparticles as an MRI contrast agent. Express Polym Lett, 2010. 4 (6): p. 329-38.
Tomalia, D., L. Reyna, and S. Svenson, Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging. Biochemical Society Transactions, 2007. 35 (1): p. 61.
Landmark, K. J., et al., Synthesis, characterization, and in vitro testing of superparamagnetic iron oxide nanoparticles targeted using folic acid-conjugated dendrimers. ACS nano, 2008. 2 (4): p. 773-783.
Rosen, J. E., et al., Iron oxide nanoparticles for targeted cancer imaging and diagnostics. Nanomedicine: Nanotechnology, Biology and Medicine, 2012. 8 (3): p. 275-290.
Swanson, S. D., et al., Targeted gadolinium-loaded dendrimer nanoparticles for tumor-specific magnetic resonance contrast enhancement. International journal of nanomedicine, 2008. 3 (2): p. 201.
Ardestani, M. S., et al., Nanosilver based anionic linear globular dendrimer with a special significant antiretroviral activity. Journal of Materials Science: Materials in Medicine, 2015. 26 (5): p. 1-8.
Karimi, N., et al., Anionic Linear Globular Dendrimer-G2-Ciprofloxacin Nano-Conjugate: Novel Agent against Wilson Disease Cell Model. Letters in Drug Design & Discovery, 2014. 11 (7): p. 908-916.