Original Research Article Novel Nano-Sized Iron Complex Application Using Folate Based Imaging Agent
American Journal of Nanosciences
Volume 3, Issue 1, March 2017, Pages: 9-18
Received: Dec. 23, 2016;
Accepted: Jan. 6, 2017;
Published: Mar. 30, 2017
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Saeed Akbarian, Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Asma Keshavarz, Pharmaceutical Branches, Islamic Azad University, Tehran, Iran
Esmaeel Mohammadi Pargoo, Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Nasser Nassiri Koopaei, Pharmaceutical Quality Assurance Research Center, Tehran University of Medical Sciences, Tehran, Iran
Hamid Moloudian, Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Mostafa Saffari, Pharmaceutical Branches, Islamic Azad University, Tehran, Iran
Hadi Hejazinia, Pharmaceutical Quality Assurance Research Center, Tehran University of Medical Sciences, Tehran, Iran
Masood Bamedi, Depertment of Periodontology and Oral and Dental Disease Research Center, Zahedan University of Medical Science, Zahedan, Iran
Mehdi Shafiee Ardestani, Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Design and evaluation of new chemically nano composites towards molecular imaging of malignant tumors is being considered as a kind of medical global research interests. In the current experiment novel nano-composite based on gadolinium ions and anionic linear globular Dendrimer G2 (as biocompatible biodegradable hybrid nanomaterial grafted to folic acid was developed and biophysically assayed. The results showed a very good Magnetic Resonance (MR) relaxivity data on T2 decreasing as well as a very good cellular uptake and tolerance. The complex was found toxic with employing apoptosis as main mechanism of action on cancerous cells respectively. Based on results it could be concluded that such nano-complex may be used as novel theranostic agent in further in vivo practices in near future.
Esmaeel Mohammadi Pargoo,
Nasser Nassiri Koopaei,
Mehdi Shafiee Ardestani,
Original Research Article Novel Nano-Sized Iron Complex Application Using Folate Based Imaging Agent, American Journal of Nanosciences.
Vol. 3, No. 1,
2017, pp. 9-18.
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