PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation
Volume 1, Issue 1, May 2015, Pages: 6-9
Received: Jun. 9, 2015;
Accepted: Jun. 19, 2015;
Published: Jun. 23, 2015
Views 4591 Downloads 137
Yasutomi Kamei, Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan
Yukino Hatazawa, Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan
Ryoji Yoshimura, Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan
Shinji Miura, Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
PGC-1α was initially identified as a PPARγ-interacting protein from the brown adipose tissue and was subsequently found to associate with many nuclear receptors and transcription factors. Among many coactivators of nuclear receptors, PGC-1α is unique because of its induced expression by stimuli, such as cold stress in the brown adipose tissue, fasting in the liver, and exercise in the skeletal muscle. In this short review, we describe the molecular features and skeletal muscle metabolism function of PGC-1α.
PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation, Biomedical Sciences.
Vol. 1, No. 1,
2015, pp. 6-9.
Y, Kamei, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin SC, Heyman RA, Rose DW, Glass CK and Rosenfeld MG. "A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors." Cell. 1996, 85:403-14.
J, Torchia, Rose DW, Inostroza J, Kamei Y, Westin S, Glass CK and Rosenfeld MG. "The Transcriptional Co-Activator p/CIP Binds CBP and Mediates Nuclear-Receptor Function." Nature. 1997, 387:677-84.
P, Puigserver, Wu Z, Park CW, Graves R, Wright M and Spiegelman BM. "A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis." Cell. 1998, 92:829-39.
Z, Wu, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC and Spiegelman BM. "Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1." Cell. 1999, 98:115-24.
JJ, Lehman, Barger PM, Kovacs A, Saffitz JE, Medeiros DM and Kelly DP. "Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Promotes Cardiac Mitochondrial Biogenesis." J Clin Invest. 2000, 106:847-56.
J, Lin, Puigserver P, Donovan J, Tarr P and Spiegelman BM. "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1beta (PGC-1beta), A Novel PGC-1-Related Transcription Coactivator Associated with Host Cell Factor." J Biol Chem. 2002, 277:1645-8.
Y, Kamei, Ohizumi H, Fujitani Y, Nemoto T, Tanaka T, Takahashi N, Kawada T, Miyoshi M, Ezaki O and Kakizuka A. "PPARgamma Coactivator 1beta/ERR Ligand 1 Is an ERR Protein Ligand, Whose Expression Induces A High-Energy Expenditure And Antagonizes Obesity." Proc Natl Acad Sci U S A. 2003, 100:12378-83.
L, Twyffels, Gueydan C and Kruys V. "Shuttling Sr Proteins: More Than Splicing Factors." FEBS J. 2011, 278:3246-55.
M, Monsalve, Wu Z, Adelmant G, Puigserver P, Fan M and Spiegelman BM. "Direct Coupling of Transcription and mRNA Processing through the Thermogenic Coactivator PGC-1." Mol Cell. 2000, 6:307-16.
X, Wang, Arai S, Song X, Reichart D, Du K, Pascual G, Tempst P, Rosenfeld MG, Glass CK and Kurokawa R. "Induced ncRNAs Allosterically Modify RNA-Binding Proteins in cis to Inhibit Transcription." Nature. 2008, 454:126-30.
RB, Lanz, McKenna NJ, Onate SA, Albrecht U, Wong J, Tsai SY, Tsai MJ and O' Malley BW. "A Steroid Receptor Coactivator, SRA, Functions as an RNA and Is Present in an SRC-1 Complex." Cell. 1999, 97:17-27.
J, Lin, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R and Spiegelman BM. "Transcriptional Co-Activator PGC-1 Alpha Drives the Formation of Slow-Twitch Muscle Fibres." Nature. 2002, 418:797-801.
S, Miura, Kai Y, Ono M and Ezaki O. "Overexpression of Peroxisome Proliferator-Activated Receptor Gamma Co-activator-1alpha Down-Regulates GLUT4 mRNA in Skeletal Muscles." J Biol Chem. 2003, 278:31385-90.
M, Tadaishi, Miura S, Kai Y, Kano Y, Oishi Y and Eza-ki O. "Skeletal Muscle-Specific Expression of PGC-1alpha-B, an Exercise-Responsive Isoform, Increases Exercise Capacity and Peak Oxygen Uptake." PLoS One. 2011, 6:e28290.
Y, Hatazawa, Tadaishi M, Nagaike Y, Morita A, Ogawa Y, Ezaki O, Takai-Igarashi T, Kitaura Y, Shimomura Y, Kamei Y and Miura S. "PGC-1alpha-Mediated Branched-Chain Amino Acid Metabolism in the Skeletal Muscle." PLoS One. 2014, 9:e91006.
Y, Hatazawa, Senoo N, Tadaishi M, Ogawa Y, Ezaki O, Kamei Y, Miura S. "Metabolomic analysis of the skeletal muscle of mice overexpressing PGC-1α" PLoS One. 2015, in press.