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PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation
Biomedical Sciences
Volume 1, Issue 1, May 2015, Pages: 6-9
Received: Jun. 9, 2015; Accepted: Jun. 19, 2015; Published: Jun. 23, 2015
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Authors
Yasutomi Kamei, Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan
Yukino Hatazawa, Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan
Ryoji Yoshimura, Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan
Shinji Miura, Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
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Abstract
PGC-1α was initially identified as a PPARγ-interacting protein from the brown adipose tissue and was subsequently found to associate with many nuclear receptors and transcription factors. Among many coactivators of nuclear receptors, PGC-1α is unique because of its induced expression by stimuli, such as cold stress in the brown adipose tissue, fasting in the liver, and exercise in the skeletal muscle. In this short review, we describe the molecular features and skeletal muscle metabolism function of PGC-1α.
Keywords
Nuclear Receptor, Coactivator, Skeletal Muscle, Metabolism
To cite this article
Yasutomi Kamei, Yukino Hatazawa, Ryoji Yoshimura, Shinji Miura, PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation, Biomedical Sciences. Vol. 1, No. 1, 2015, pp. 6-9. doi: 10.11648/j.bs.20150101.12
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