Novel BCL6 Inhibitor (FX1): Advances in Diffuse Large B-Cell Lymphomas (DLBCLs) Treatment

Md Kamrul Hasan

doi:doi:10.11648/j.bs.20170302.12

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Novel BCL6 Inhibitor (FX1): Advances in Diffuse Large B-Cell Lymphomas (DLBCLs) Treatment

Md Kamrul Hasan

Published in Biomedical Sciences (Volume 3, Issue 2)

Received: 25 November 2016 Accepted: 13 February 2017 Published: 26 April 2017

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Abstract

Diffuse large B-cell lymphomas (DLBCLs) are the most common and aggressive type of all the lymphomas. B cell lymphoma 6 (BCL6) oncogene is highly expressed in DLBCLs and one of the major reasons of treatment failure. Recent findings suggest that specific BCL6 inhibitor (FX1) disrupted formation of the BCL6 repression complex, reactivated BCL6 target genes, that in-turn suppressed growth of DLBCLs cells, primary human DLBCLs specimens, as well as induced regression of established tumors in mice derived from DLBCLs cells.

Published in	Biomedical Sciences (Volume 3, Issue 2)
DOI	10.11648/j.bs.20170302.12
Page(s)	55-57
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Diffuse Large B-Cell Lymphomas (DLBCLs), BCL6, FX1

References

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APA Style

Md Kamrul Hasan. (2017). Novel BCL6 Inhibitor (FX1): Advances in Diffuse Large B-Cell Lymphomas (DLBCLs) Treatment. Biomedical Sciences, 3(2), 55-57. https://doi.org/10.11648/j.bs.20170302.12

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ACS Style

Md Kamrul Hasan. Novel BCL6 Inhibitor (FX1): Advances in Diffuse Large B-Cell Lymphomas (DLBCLs) Treatment. Biomed. Sci. 2017, 3(2), 55-57. doi: 10.11648/j.bs.20170302.12

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AMA Style

Md Kamrul Hasan. Novel BCL6 Inhibitor (FX1): Advances in Diffuse Large B-Cell Lymphomas (DLBCLs) Treatment. Biomed Sci. 2017;3(2):55-57. doi: 10.11648/j.bs.20170302.12

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@article{10.11648/j.bs.20170302.12,
  author = {Md Kamrul Hasan},
  title = {Novel BCL6 Inhibitor (FX1): Advances in Diffuse Large B-Cell Lymphomas (DLBCLs) Treatment},
  journal = {Biomedical Sciences},
  volume = {3},
  number = {2},
  pages = {55-57},
  doi = {10.11648/j.bs.20170302.12},
  url = {https://doi.org/10.11648/j.bs.20170302.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20170302.12},
  abstract = {Diffuse large B-cell lymphomas (DLBCLs) are the most common and aggressive type of all the lymphomas. B cell lymphoma 6 (BCL6) oncogene is highly expressed in DLBCLs and one of the major reasons of treatment failure. Recent findings suggest that specific BCL6 inhibitor (FX1) disrupted formation of the BCL6 repression complex, reactivated BCL6 target genes, that in-turn suppressed growth of DLBCLs cells, primary human DLBCLs specimens, as well as induced regression of established tumors in mice derived from DLBCLs cells.},
 year = {2017}
}

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TY  - JOUR
T1  - Novel BCL6 Inhibitor (FX1): Advances in Diffuse Large B-Cell Lymphomas (DLBCLs) Treatment
AU  - Md Kamrul Hasan
Y1  - 2017/04/26
PY  - 2017
N1  - https://doi.org/10.11648/j.bs.20170302.12
DO  - 10.11648/j.bs.20170302.12
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 55
EP  - 57
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20170302.12
AB  - Diffuse large B-cell lymphomas (DLBCLs) are the most common and aggressive type of all the lymphomas. B cell lymphoma 6 (BCL6) oncogene is highly expressed in DLBCLs and one of the major reasons of treatment failure. Recent findings suggest that specific BCL6 inhibitor (FX1) disrupted formation of the BCL6 repression complex, reactivated BCL6 target genes, that in-turn suppressed growth of DLBCLs cells, primary human DLBCLs specimens, as well as induced regression of established tumors in mice derived from DLBCLs cells.
VL  - 3
IS  - 2
ER  -

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Author Information

Md Kamrul Hasan

Moores Cancer Center, University of California San Diego, La Jolla, USA

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Md Kamrul Hasan. (2017). Novel BCL6 Inhibitor (FX1): Advances in Diffuse Large B-Cell Lymphomas (DLBCLs) Treatment. Biomedical Sciences, 3(2), 55-57. https://doi.org/10.11648/j.bs.20170302.12

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ACS Style

Md Kamrul Hasan. Novel BCL6 Inhibitor (FX1): Advances in Diffuse Large B-Cell Lymphomas (DLBCLs) Treatment. Biomed. Sci. 2017, 3(2), 55-57. doi: 10.11648/j.bs.20170302.12

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AMA Style

Md Kamrul Hasan. Novel BCL6 Inhibitor (FX1): Advances in Diffuse Large B-Cell Lymphomas (DLBCLs) Treatment. Biomed Sci. 2017;3(2):55-57. doi: 10.11648/j.bs.20170302.12

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@article{10.11648/j.bs.20170302.12,
  author = {Md Kamrul Hasan},
  title = {Novel BCL6 Inhibitor (FX1): Advances in Diffuse Large B-Cell Lymphomas (DLBCLs) Treatment},
  journal = {Biomedical Sciences},
  volume = {3},
  number = {2},
  pages = {55-57},
  doi = {10.11648/j.bs.20170302.12},
  url = {https://doi.org/10.11648/j.bs.20170302.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20170302.12},
  abstract = {Diffuse large B-cell lymphomas (DLBCLs) are the most common and aggressive type of all the lymphomas. B cell lymphoma 6 (BCL6) oncogene is highly expressed in DLBCLs and one of the major reasons of treatment failure. Recent findings suggest that specific BCL6 inhibitor (FX1) disrupted formation of the BCL6 repression complex, reactivated BCL6 target genes, that in-turn suppressed growth of DLBCLs cells, primary human DLBCLs specimens, as well as induced regression of established tumors in mice derived from DLBCLs cells.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Novel BCL6 Inhibitor (FX1): Advances in Diffuse Large B-Cell Lymphomas (DLBCLs) Treatment
AU  - Md Kamrul Hasan
Y1  - 2017/04/26
PY  - 2017
N1  - https://doi.org/10.11648/j.bs.20170302.12
DO  - 10.11648/j.bs.20170302.12
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 55
EP  - 57
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20170302.12
AB  - Diffuse large B-cell lymphomas (DLBCLs) are the most common and aggressive type of all the lymphomas. B cell lymphoma 6 (BCL6) oncogene is highly expressed in DLBCLs and one of the major reasons of treatment failure. Recent findings suggest that specific BCL6 inhibitor (FX1) disrupted formation of the BCL6 repression complex, reactivated BCL6 target genes, that in-turn suppressed growth of DLBCLs cells, primary human DLBCLs specimens, as well as induced regression of established tumors in mice derived from DLBCLs cells.
VL  - 3
IS  - 2
ER  -

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