Prevalence of Tuberculosis by GeneXpert Method in Karnali Academy of Health Sciences Teaching Hospital, Jumla, Nepal
Biomedical Sciences
Volume 6, Issue 3, September 2020, Pages: 56-60
Received: Jul. 27, 2020; Accepted: Aug. 8, 2020; Published: Aug. 20, 2020
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Authors
Bibek Pun Magar, Department of Clinical Biochemistry, Karnali Academy of Health Sciences, Jumla, Nepal
Niresh Thapa, Department of Emergency, Karnali Academy of Health Sciences, Jumla, Nepal
Elisha Rana, Karnali Academy of Health Sciences, Jumla, Nepal
Keshav Raj Joshi, Krown Laboratory, Kathmandu, Nepal
Narayani Maharjan, Program & Department of Clinical Laboratory Medicine, Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, China
Binita Bista, Department of Nursing, District Health Office, West Rukum, Nepal
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Abstract
Tuberculosis (TB) is a communicable disease that is a major public health problem and one of the top 10 causes of death worldwide. Globally, an estimated 10 million people fell ill with TB in 2018. The population of Nepal accounts for 0.45% of the global TB cases. GeneXpert is a molecular test method for TB which detects the presence of Mycobacterium tuberculosis, as well as tests for resistance to drug rifampicin. The study aimed to find the prevalence of TB in the rural areas of Karnali province, Jumla. This retrospective cross-sectional study was done in Karnali Academy of Health Sciences Teaching Hospital (KAHS-TH), Jumla. Required data was retrieved from the Laboratory record and medical record section. The data was collected and analyzed by SPSS version 16. Altogether 805 individuals were screened from December 2017 to May 2020. Among them, 96 (11.9%) were infected with TB in which 4 (4.16%) were rifampicin-resistant. Out of the total, 457 males screened for TB where 67 (14.66%) were positive for TB in which 2 (2.98%) were rifampicin-resistant and among 348 females screened 29 (8.33%) were positive for TB in which 2 (6.89%) were rifampicin-resistant. The highest prevalence of 20.63% was observed in the age group of 21–30 years. The study suggests TB infection is lower in Jumla as compared to the overall prevalence of Nepal and helps to identify the high-risk group of TB infection. It also implies increasing the GeneXpert test for a large population, which may help in future TB control programs in Jumla and similar geographical area.
Keywords
GeneXpert, Prevalence, Rifampicin-Resistant, Tuberculosis
To cite this article
Bibek Pun Magar, Niresh Thapa, Elisha Rana, Keshav Raj Joshi, Narayani Maharjan, Binita Bista, Prevalence of Tuberculosis by GeneXpert Method in Karnali Academy of Health Sciences Teaching Hospital, Jumla, Nepal, Biomedical Sciences. Vol. 6, No. 3, 2020, pp. 56-60. doi: 10.11648/j.bs.20200603.13
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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