Volume 6, Issue 3, September 2020, Pages: 67-73
Received: Jul. 18, 2020;
Accepted: Aug. 19, 2020;
Published: Sep. 19, 2020
Views 58 Downloads 20
Elkanah Obadiah Sambo, Department of Biological Sciences, Taraba State University, Jalingo, Nigeria
Obiorah Sylvester Chibuzor, Department of Laboratory Services, Federal Medical Centre, Jalingo, Nigeria
Onyeuku Okechukwu Chinwe, Department of Laboratory Services, Taraba State Specialist Hospital, Jalingo, Nigeria
Elkanah Deborah Sambo, Department of Biological Sciences, Taraba State University, Jalingo, Nigeria
Egeonu Stephen Ugoeze, Department of Laboratory Services, Federal Medical Centre, Jalingo, Nigeria
Malaria infection is one of the most common disease of public health importance afflicting millions of people in sub-Saharan Africa. This study investigated haematological derrangement among malaria infected and non-infected patients attending some Primary Health Centres in Ardo-Kola LGA, Taraba State, Nigeria. 585 blood samples were collected and examined for Plasmodium falciparum infection. Packed Cell Volume (PCV) was done by microhaematocrit and Erythrocyte Sedimentation Rate (ESR) using Westergen methods. The overall result showed a prevalence of ESR by Westergern method. It was found that malaria with low intensity of parasitaemia infection, 217 (37.09%) was more than medium and high intensity of parasitaemia with no significant difference (χ2=9.34; P≥0.05). The mean value of haematological parameters of parasitized subjects were 0.29 for PCV and 124.3655 for platelets which were significantly lower than those of non-parasitized subjects, PCV=0.4577 and Platelets=198.7698 respectively. Erythrocyte Sedimentation Rate (ESR) was higher (33.0852) in parasitized subjects than non-parasitized (20.0504). The result of this study could be useful in identification of high-risk malaria population. This will target intervention and assessment of impact based on changes in haematological parameters associated with P. falciparum infection. Futhermore, preventive strategies like chemoprophylaxis, provision of iron supplementation and insecticide treated nets could be employed in the study area to curb the upsurge in transmission.
Elkanah Obadiah Sambo,
Obiorah Sylvester Chibuzor,
Onyeuku Okechukwu Chinwe,
Elkanah Deborah Sambo,
Egeonu Stephen Ugoeze,
Haematological Derrangement Due to P. falciparum Infection in Patients of Selected Health Centres in Ardo-Kola Local Government Area, Taraba State, Biomedical Sciences.
Vol. 6, No. 3,
2020, pp. 67-73.
WHO. World Malaria Report. Geneva, Switzerland: World Health Organization, 2017. Pp 32-42.
Smith, C., Teng, F. B. E., Chu, S., Joseph, K. S. Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy. Obstetrics & Gynecology, 2019; 134 (6): 1234-1244. doi: 10.1097/AOG.0000000000003557.
Edelu, B. O., Ndu, I. K., Igbokwe, O. O., Iloh, O. N. Severe falciparum malaria in children in Enugu, South East Nigeria. Nigerian Journal of Clinical Practice, 2018; 21: 1349-55.
Cheesbrough, M. District laboratory practice in tropical countries. New York-Cambridge Press. Part1, 2nd Edition, 2012; 249-258.
Dade, J. V. and Lewis, S. M. Practical hematology, 2001, 9th edition. London: Churchill Livingstone.
Plewes, K., Turner, G. D. H., Dondorp, A. M. Pathophysiology, clinical presentation, and treatment of coma and acute kidney injury complicating falciparum malaria, Current Opinion in Infectious Diseases, 2018; 31 (1): 69-77. doi: 10.1097/QCO.0000000000000419.
WHO. World Malaria Report, 2015. Pp 543. ISBN 978-924-156-515-8.
Henry, N. B., Sermé, S. S., Siciliano, G. et al Biology of Plasmodium falciparum gametocyte sex ratio and implications in malaria parasite transmission. Malar J 18, 70 (2019). https://doi.org/10.1186/s12936-019-2707-0
Bakhubaira, S. “Haematological parameters in severe complicated Plasmodium falciparum malaria in adult in Aden,” Turkish Journal of Haematology, 2013; 30 (40): 394-399.
Draper, S. J., Sack, B. K., King, C. R. et al. Malaria Vaccines: Recent Advances and New Horizons. Cell Host Microbe. 2018; 24 (1): 43-56. doi: 10.1016/j.chom.2018.06.008.
Francis, U., Isaac, Z., Yakubu, A., Enosakhare, A., Felix, E. Haematological Parameters of Malaria Infected Patients in the University of Calabar Teaching Hospital, Calabar, Nigeria. Journal of Hematology & Thromboembolic Diseases, 2014; 2: 171. doi: 10.4172/2329-8790.1000171.
Omarine, N. N., Nange, T. B. Assessment of Hematological Parameters in Malaria, among Adult Patients Attending the Bamenda Regional Hospital. Anemia, 2020: 3814513. doi: 10.1155/2020/3814513.
Mohamed, A. S., Bushra, S. A., Ahmed, M., Ali, A. E. Parasitaemia and Its Relation to Hematological Parameters and Liver Function among Patients Malaria in Abs, Hajjah, Northwest Yemen. Interdisciplinary Perspectives on Infectious Diseases, 2016. Article ID 5954394, 5 pages http://dx.doi.org/10.1155/2016/5954394.
Chikezie, P. C, Okpara, R. T. Haematologic and biochemical indices of Plasmodium falciparum infected inhabitants of Owerri, Imo State, Nigeria. Journal of Medical Laboratory and Diagnosis, 4 (3): 38-44. DOI: 10.5897/JMLD2013.0068.
Alves-Junior, E. R., Gomes, L. T., Dombroski, T. C., Dallabona, N., Andréia, F., Vandresen-Filho, S., Nakazato, L., Fontes, Cor J. F., Rios-Santos, F. New laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoring. Brazilian Journal of Infectious Diseases, 2020; 24 (2): 120-129. https://dx.doi.org/10.1016/j.bjid.2020.04.001.