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PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation

Received: 09 June 2015    Accepted: 19 June 2015    Published: 23 June 2015
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Abstract

PGC-1α was initially identified as a PPARγ-interacting protein from the brown adipose tissue and was subsequently found to associate with many nuclear receptors and transcription factors. Among many coactivators of nuclear receptors, PGC-1α is unique because of its induced expression by stimuli, such as cold stress in the brown adipose tissue, fasting in the liver, and exercise in the skeletal muscle. In this short review, we describe the molecular features and skeletal muscle metabolism function of PGC-1α.

DOI 10.11648/j.bs.20150101.12
Published in Biomedical Sciences (Volume 1, Issue 1, May 2015)
Page(s) 6-9
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Nuclear Receptor, Coactivator, Skeletal Muscle, Metabolism

References
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Author Information
  • Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan

  • Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan

  • Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan

  • Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan

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    Yasutomi Kamei, Yukino Hatazawa, Ryoji Yoshimura, Shinji Miura. (2015). PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation. Biomedical Sciences, 1(1), 6-9. https://doi.org/10.11648/j.bs.20150101.12

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    ACS Style

    Yasutomi Kamei; Yukino Hatazawa; Ryoji Yoshimura; Shinji Miura. PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation. Biomed. Sci. 2015, 1(1), 6-9. doi: 10.11648/j.bs.20150101.12

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    AMA Style

    Yasutomi Kamei, Yukino Hatazawa, Ryoji Yoshimura, Shinji Miura. PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation. Biomed Sci. 2015;1(1):6-9. doi: 10.11648/j.bs.20150101.12

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  • @article{10.11648/j.bs.20150101.12,
      author = {Yasutomi Kamei and Yukino Hatazawa and Ryoji Yoshimura and Shinji Miura},
      title = {PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation},
      journal = {Biomedical Sciences},
      volume = {1},
      number = {1},
      pages = {6-9},
      doi = {10.11648/j.bs.20150101.12},
      url = {https://doi.org/10.11648/j.bs.20150101.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.bs.20150101.12},
      abstract = {PGC-1α was initially identified as a PPARγ-interacting protein from the brown adipose tissue and was subsequently found to associate with many nuclear receptors and transcription factors. Among many coactivators of nuclear receptors, PGC-1α is unique because of its induced expression by stimuli, such as cold stress in the brown adipose tissue, fasting in the liver, and exercise in the skeletal muscle. In this short review, we describe the molecular features and skeletal muscle metabolism function of PGC-1α.},
     year = {2015}
    }
    

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    T1  - PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation
    AU  - Yasutomi Kamei
    AU  - Yukino Hatazawa
    AU  - Ryoji Yoshimura
    AU  - Shinji Miura
    Y1  - 2015/06/23
    PY  - 2015
    N1  - https://doi.org/10.11648/j.bs.20150101.12
    DO  - 10.11648/j.bs.20150101.12
    T2  - Biomedical Sciences
    JF  - Biomedical Sciences
    JO  - Biomedical Sciences
    SP  - 6
    EP  - 9
    PB  - Science Publishing Group
    SN  - 2575-3932
    UR  - https://doi.org/10.11648/j.bs.20150101.12
    AB  - PGC-1α was initially identified as a PPARγ-interacting protein from the brown adipose tissue and was subsequently found to associate with many nuclear receptors and transcription factors. Among many coactivators of nuclear receptors, PGC-1α is unique because of its induced expression by stimuli, such as cold stress in the brown adipose tissue, fasting in the liver, and exercise in the skeletal muscle. In this short review, we describe the molecular features and skeletal muscle metabolism function of PGC-1α.
    VL  - 1
    IS  - 1
    ER  - 

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