Head and Neck Cancers Case Control Study of HIV Positive Compared to Negative Patients in a Ugandan Population Sample

Kamulegeya Adriane; Otiti Jeff

doi:doi:10.11648/j.ijcoms.20170304.11

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Head and Neck Cancers Case Control Study of HIV Positive Compared to Negative Patients in a Ugandan Population Sample

Kamulegeya Adriane, Otiti Jeff

Published in International Journal of Clinical Oral and Maxillofacial Surgery (Volume 3, Issue 4)

Received: 23 October 2017 Accepted: 13 November 2017 Published: 21 December 2017

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Abstract

Increased availability of highly active anti-retroviral therapy (HAART) has led to a change in the spectrum of neoplastic diseases affecting people living with HIV. Some cancers such as invasive cervical carcinoma and anal cancers have not changed or instead risen while others such as Kaporsi’s sarcoma have seen a sharp decline. The aim of this study was to compare clinical findings at presentation between HIV positive and Negative patients with head and neck cancers using a retrospective case control design. The study was done at the Uganda cancer Institute by performing a manual match of records in the head and neck cancer database at a ratio of 1:2 cases: controls. The matching was done on the age group, gender and diagnosis. Clinical and demographic characteristics between HIV positive and HIV negative head and neck cancer patients were compared using chi square and a multinomial model including ECOG performance score, stage, grade and duration group was run. In the multinomial regression only duration group was significant with the HIV positive patients being more likely to present after a longer duration of the symptoms than HIV negative patients (OR=0.42 CI 0.20-0.86 p=0.02). The data does not show statistically significant difference between HIV positive and HIV negative head and neck cancer patients in terms of presentation at time of diagnosis except for duration of symptoms group. This study clearly demonstrates the need for more research on head and neck cancer in Africa in the context of HIV/AIDS, since the reasons for the high HIV prevalence among this cohort of patients hasn’t been established.

Published in	International Journal of Clinical Oral and Maxillofacial Surgery (Volume 3, Issue 4)
DOI	10.11648/j.ijcoms.20170304.11
Page(s)	20-25
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Head and Neck Cancers, HIV/AIDS, Cancer Risk Factors

References

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APA Style

Kamulegeya Adriane, Otiti Jeff. (2017). Head and Neck Cancers Case Control Study of HIV Positive Compared to Negative Patients in a Ugandan Population Sample. International Journal of Clinical Oral and Maxillofacial Surgery, 3(4), 20-25. https://doi.org/10.11648/j.ijcoms.20170304.11

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ACS Style

Kamulegeya Adriane; Otiti Jeff. Head and Neck Cancers Case Control Study of HIV Positive Compared to Negative Patients in a Ugandan Population Sample. Int. J. Clin. Oral Maxillofac. Surg. 2017, 3(4), 20-25. doi: 10.11648/j.ijcoms.20170304.11

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AMA Style

Kamulegeya Adriane, Otiti Jeff. Head and Neck Cancers Case Control Study of HIV Positive Compared to Negative Patients in a Ugandan Population Sample. Int J Clin Oral Maxillofac Surg. 2017;3(4):20-25. doi: 10.11648/j.ijcoms.20170304.11

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@article{10.11648/j.ijcoms.20170304.11,
  author = {Kamulegeya Adriane and Otiti Jeff},
  title = {Head and Neck Cancers Case Control Study of HIV Positive Compared to Negative Patients in a Ugandan Population Sample},
  journal = {International Journal of Clinical Oral and Maxillofacial Surgery},
  volume = {3},
  number = {4},
  pages = {20-25},
  doi = {10.11648/j.ijcoms.20170304.11},
  url = {https://doi.org/10.11648/j.ijcoms.20170304.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcoms.20170304.11},
  abstract = {Increased availability of highly active anti-retroviral therapy (HAART) has led to a change in the spectrum of neoplastic diseases affecting people living with HIV. Some cancers such as invasive cervical carcinoma and anal cancers have not changed or instead risen while others such as Kaporsi’s sarcoma have seen a sharp decline. The aim of this study was to compare clinical findings at presentation between HIV positive and Negative patients with head and neck cancers using a retrospective case control design. The study was done at the Uganda cancer Institute by performing a manual match of records in the head and neck cancer database at a ratio of 1:2 cases: controls. The matching was done on the age group, gender and diagnosis. Clinical and demographic characteristics between HIV positive and HIV negative head and neck cancer patients were compared using chi square and a multinomial model including ECOG performance score, stage, grade and duration group was run. In the multinomial regression only duration group was significant with the HIV positive patients being more likely to present after a longer duration of the symptoms than HIV negative patients (OR=0.42 CI 0.20-0.86 p=0.02). The data does not show statistically significant difference between HIV positive and HIV negative head and neck cancer patients in terms of presentation at time of diagnosis except for duration of symptoms group. This study clearly demonstrates the need for more research on head and neck cancer in Africa in the context of HIV/AIDS, since the reasons for the high HIV prevalence among this cohort of patients hasn’t been established.},
 year = {2017}
}

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TY  - JOUR
T1  - Head and Neck Cancers Case Control Study of HIV Positive Compared to Negative Patients in a Ugandan Population Sample
AU  - Kamulegeya Adriane
AU  - Otiti Jeff
Y1  - 2017/12/21
PY  - 2017
N1  - https://doi.org/10.11648/j.ijcoms.20170304.11
DO  - 10.11648/j.ijcoms.20170304.11
T2  - International Journal of Clinical Oral and Maxillofacial Surgery
JF  - International Journal of Clinical Oral and Maxillofacial Surgery
JO  - International Journal of Clinical Oral and Maxillofacial Surgery
SP  - 20
EP  - 25
PB  - Science Publishing Group
SN  - 2472-1344
UR  - https://doi.org/10.11648/j.ijcoms.20170304.11
AB  - Increased availability of highly active anti-retroviral therapy (HAART) has led to a change in the spectrum of neoplastic diseases affecting people living with HIV. Some cancers such as invasive cervical carcinoma and anal cancers have not changed or instead risen while others such as Kaporsi’s sarcoma have seen a sharp decline. The aim of this study was to compare clinical findings at presentation between HIV positive and Negative patients with head and neck cancers using a retrospective case control design. The study was done at the Uganda cancer Institute by performing a manual match of records in the head and neck cancer database at a ratio of 1:2 cases: controls. The matching was done on the age group, gender and diagnosis. Clinical and demographic characteristics between HIV positive and HIV negative head and neck cancer patients were compared using chi square and a multinomial model including ECOG performance score, stage, grade and duration group was run. In the multinomial regression only duration group was significant with the HIV positive patients being more likely to present after a longer duration of the symptoms than HIV negative patients (OR=0.42 CI 0.20-0.86 p=0.02). The data does not show statistically significant difference between HIV positive and HIV negative head and neck cancer patients in terms of presentation at time of diagnosis except for duration of symptoms group. This study clearly demonstrates the need for more research on head and neck cancer in Africa in the context of HIV/AIDS, since the reasons for the high HIV prevalence among this cohort of patients hasn’t been established.
VL  - 3
IS  - 4
ER  -

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Author Information

Kamulegeya Adriane

Department of Dentistry, Makerere University, Kampala, Uganda
Otiti Jeff

Department of Surgery, Uganda Cancer Institute, Kampala, Uganda

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APA Style

Kamulegeya Adriane, Otiti Jeff. (2017). Head and Neck Cancers Case Control Study of HIV Positive Compared to Negative Patients in a Ugandan Population Sample. International Journal of Clinical Oral and Maxillofacial Surgery, 3(4), 20-25. https://doi.org/10.11648/j.ijcoms.20170304.11

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ACS Style

Kamulegeya Adriane; Otiti Jeff. Head and Neck Cancers Case Control Study of HIV Positive Compared to Negative Patients in a Ugandan Population Sample. Int. J. Clin. Oral Maxillofac. Surg. 2017, 3(4), 20-25. doi: 10.11648/j.ijcoms.20170304.11

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AMA Style

Kamulegeya Adriane, Otiti Jeff. Head and Neck Cancers Case Control Study of HIV Positive Compared to Negative Patients in a Ugandan Population Sample. Int J Clin Oral Maxillofac Surg. 2017;3(4):20-25. doi: 10.11648/j.ijcoms.20170304.11

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@article{10.11648/j.ijcoms.20170304.11,
  author = {Kamulegeya Adriane and Otiti Jeff},
  title = {Head and Neck Cancers Case Control Study of HIV Positive Compared to Negative Patients in a Ugandan Population Sample},
  journal = {International Journal of Clinical Oral and Maxillofacial Surgery},
  volume = {3},
  number = {4},
  pages = {20-25},
  doi = {10.11648/j.ijcoms.20170304.11},
  url = {https://doi.org/10.11648/j.ijcoms.20170304.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcoms.20170304.11},
  abstract = {Increased availability of highly active anti-retroviral therapy (HAART) has led to a change in the spectrum of neoplastic diseases affecting people living with HIV. Some cancers such as invasive cervical carcinoma and anal cancers have not changed or instead risen while others such as Kaporsi’s sarcoma have seen a sharp decline. The aim of this study was to compare clinical findings at presentation between HIV positive and Negative patients with head and neck cancers using a retrospective case control design. The study was done at the Uganda cancer Institute by performing a manual match of records in the head and neck cancer database at a ratio of 1:2 cases: controls. The matching was done on the age group, gender and diagnosis. Clinical and demographic characteristics between HIV positive and HIV negative head and neck cancer patients were compared using chi square and a multinomial model including ECOG performance score, stage, grade and duration group was run. In the multinomial regression only duration group was significant with the HIV positive patients being more likely to present after a longer duration of the symptoms than HIV negative patients (OR=0.42 CI 0.20-0.86 p=0.02). The data does not show statistically significant difference between HIV positive and HIV negative head and neck cancer patients in terms of presentation at time of diagnosis except for duration of symptoms group. This study clearly demonstrates the need for more research on head and neck cancer in Africa in the context of HIV/AIDS, since the reasons for the high HIV prevalence among this cohort of patients hasn’t been established.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Head and Neck Cancers Case Control Study of HIV Positive Compared to Negative Patients in a Ugandan Population Sample
AU  - Kamulegeya Adriane
AU  - Otiti Jeff
Y1  - 2017/12/21
PY  - 2017
N1  - https://doi.org/10.11648/j.ijcoms.20170304.11
DO  - 10.11648/j.ijcoms.20170304.11
T2  - International Journal of Clinical Oral and Maxillofacial Surgery
JF  - International Journal of Clinical Oral and Maxillofacial Surgery
JO  - International Journal of Clinical Oral and Maxillofacial Surgery
SP  - 20
EP  - 25
PB  - Science Publishing Group
SN  - 2472-1344
UR  - https://doi.org/10.11648/j.ijcoms.20170304.11
AB  - Increased availability of highly active anti-retroviral therapy (HAART) has led to a change in the spectrum of neoplastic diseases affecting people living with HIV. Some cancers such as invasive cervical carcinoma and anal cancers have not changed or instead risen while others such as Kaporsi’s sarcoma have seen a sharp decline. The aim of this study was to compare clinical findings at presentation between HIV positive and Negative patients with head and neck cancers using a retrospective case control design. The study was done at the Uganda cancer Institute by performing a manual match of records in the head and neck cancer database at a ratio of 1:2 cases: controls. The matching was done on the age group, gender and diagnosis. Clinical and demographic characteristics between HIV positive and HIV negative head and neck cancer patients were compared using chi square and a multinomial model including ECOG performance score, stage, grade and duration group was run. In the multinomial regression only duration group was significant with the HIV positive patients being more likely to present after a longer duration of the symptoms than HIV negative patients (OR=0.42 CI 0.20-0.86 p=0.02). The data does not show statistically significant difference between HIV positive and HIV negative head and neck cancer patients in terms of presentation at time of diagnosis except for duration of symptoms group. This study clearly demonstrates the need for more research on head and neck cancer in Africa in the context of HIV/AIDS, since the reasons for the high HIV prevalence among this cohort of patients hasn’t been established.
VL  - 3
IS  - 4
ER  -

Copy | Download