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The Composite of Bone Marrow Concentrate and Nano-hydroxyapatite as an Alternative to Autologous Bone
International Journal of Clinical Oral and Maxillofacial Surgery
Volume 6, Issue 2, December 2020, Pages: 20-25
Received: Aug. 5, 2019; Accepted: Sep. 9, 2019; Published: Jun. 15, 2020
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Mahmoud Abdel Aziz El Fadly, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ain Shams University, Cairo, Egypt
Heba Abdel Wahed Selim, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ain Shams University, Cairo, Egypt
Salah Abdel Fattah Ahmed, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ain Shams University, Cairo, Egypt
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The aim of this study was to examine the evidence behind the use of the composite of bone marrow concentrate and Nano-hydroxyapatite as an alternative to autologous bone graft in the repair of bony defects. The study was conducted on 14 residual surgical non-continuity defects resulting from enucleation of benign odontogenic cysts. The defects were randomly allocated into two groups according to defect filling as follows: Group A (n=7), the defects were grafted using a composite of bone marrow concentrate (BMC) and Nano-hydroxyapatite granules; Group B (n=7), the defects were grafted using autologous bone graft. Radiographic evaluation was done using Cone beam C. T. scan, immediate, six and twelve months post-operatively to assess the volumetric changes of the grafts along the follow-up period. The results of this study revealed that there was no statistically significant difference (p>0.05) between the two groups regarding the percentage of reduction of the graft volume along the follow-up period. In the light of the radiographic results of this study it can be concluded that the use of composite of bone marrow concentrate (BMC) and Nano-hydroxyapatite granules to reconstruct surgical defects is a reliable alternative to autogenous bone graft.
Bone Marrow Concentrate, Autogenous Bone Graft, Nano-hydroxyapatite, Surgical Defects
To cite this article
Mahmoud Abdel Aziz El Fadly, Heba Abdel Wahed Selim, Salah Abdel Fattah Ahmed, The Composite of Bone Marrow Concentrate and Nano-hydroxyapatite as an Alternative to Autologous Bone, International Journal of Clinical Oral and Maxillofacial Surgery. Vol. 6, No. 2, 2020, pp. 20-25. doi: 10.11648/j.ijcoms.20200602.11
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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