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Effect of Vitamin-D Supplement in Patients Diagnosed as Chronic Rhinosinusitis with Vitamin-D Deficiency

Received: 29 October 2015    Accepted: 11 January 2016    Published: 5 July 2016
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Abstract

Introduction: Rhinosinusitis is a heterogeneous disease characterized by local inflammation of the upper airways and sinuses. The pathogenesis of chronic rhino sinusitis remains poorly defined. It was recently proposed that Vitamin D deficiency may explain some part of this pattern. The aim of study is to evaluate the effect of vitamin D supplement in patients diagnosed as chronic rhino sinusitis with vitamin D deficiency. Materials and Methods: Prospective study was performed on 57 patients diagnosed as chronic Rhinosinusitis and vitamin D deficiency. Patients received vitamin D3 tablet (1000 IU) daily for one month. Before and after drug intake all patients were asked to fill in a questionnaire in which they rated their overall symptoms. Results: (75.4%) of patients cured from smell disturbance, (22.8%) of patients cured from headache, (21.1%) cured from nasal obstruction and only 7% of patients cured from nasal discharge. (64%) of patients improve (not cured) from nasal obstruction symptoms, (63%) of patients not cure from nasal discharge. Conclusions: Vitamin D supplement shows significant improvement in symptoms of chronic Rhinosinusitis mainly smell disturbance, Vitamin D could be use as adjuvant treatment for Chronic Rhino sinusitis.

Published in International Journal of Otorhinolaryngology (Volume 2, Issue 1)
DOI 10.11648/j.ijo.20160201.11
Page(s) 1-4
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Chronic Rhino Sinusitis, Vit D, Nasal Obstruction

References
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[3] Schleimer RP, Kato A, Peters A, Conley D, Kim J, Liu MC, et al. Epithelium, inflammation, and immunity in the upper airways of humans: studies in chronic rhinosinusitis. Proc Am Thorac Soc 2009; 6: 288-94.
[4] Van Bruaene N, Derycke L, Perez-Novo CA, Gevaert P, Holtappels G, De Ruyck N, et al. TGF-beta signaling and collagen deposition in chronic rhinosinusitis. J Allergy Clin Immunol 2009; 124: 253-9.
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Cite This Article
  • APA Style

    Yosef H. Saeed Abdelkarim, Agila Al-Barasi, Essam S. Hussien. (2016). Effect of Vitamin-D Supplement in Patients Diagnosed as Chronic Rhinosinusitis with Vitamin-D Deficiency. International Journal of Otorhinolaryngology, 2(1), 1-4. https://doi.org/10.11648/j.ijo.20160201.11

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    ACS Style

    Yosef H. Saeed Abdelkarim; Agila Al-Barasi; Essam S. Hussien. Effect of Vitamin-D Supplement in Patients Diagnosed as Chronic Rhinosinusitis with Vitamin-D Deficiency. Int. J. Otorhinolaryngol. 2016, 2(1), 1-4. doi: 10.11648/j.ijo.20160201.11

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    AMA Style

    Yosef H. Saeed Abdelkarim, Agila Al-Barasi, Essam S. Hussien. Effect of Vitamin-D Supplement in Patients Diagnosed as Chronic Rhinosinusitis with Vitamin-D Deficiency. Int J Otorhinolaryngol. 2016;2(1):1-4. doi: 10.11648/j.ijo.20160201.11

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  • @article{10.11648/j.ijo.20160201.11,
      author = {Yosef H. Saeed Abdelkarim and Agila Al-Barasi and Essam S. Hussien},
      title = {Effect of Vitamin-D Supplement in Patients Diagnosed as Chronic Rhinosinusitis with Vitamin-D Deficiency},
      journal = {International Journal of Otorhinolaryngology},
      volume = {2},
      number = {1},
      pages = {1-4},
      doi = {10.11648/j.ijo.20160201.11},
      url = {https://doi.org/10.11648/j.ijo.20160201.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijo.20160201.11},
      abstract = {Introduction: Rhinosinusitis is a heterogeneous disease characterized by local inflammation of the upper airways and sinuses. The pathogenesis of chronic rhino sinusitis remains poorly defined. It was recently proposed that Vitamin D deficiency may explain some part of this pattern. The aim of study is to evaluate the effect of vitamin D supplement in patients diagnosed as chronic rhino sinusitis with vitamin D deficiency. Materials and Methods: Prospective study was performed on 57 patients diagnosed as chronic Rhinosinusitis and vitamin D deficiency. Patients received vitamin D3 tablet (1000 IU) daily for one month. Before and after drug intake all patients were asked to fill in a questionnaire in which they rated their overall symptoms. Results: (75.4%) of patients cured from smell disturbance, (22.8%) of patients cured from headache, (21.1%) cured from nasal obstruction and only 7% of patients cured from nasal discharge. (64%) of patients improve (not cured) from nasal obstruction symptoms, (63%) of patients not cure from nasal discharge. Conclusions: Vitamin D supplement shows significant improvement in symptoms of chronic Rhinosinusitis mainly smell disturbance, Vitamin D could be use as adjuvant treatment for Chronic Rhino sinusitis.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Effect of Vitamin-D Supplement in Patients Diagnosed as Chronic Rhinosinusitis with Vitamin-D Deficiency
    AU  - Yosef H. Saeed Abdelkarim
    AU  - Agila Al-Barasi
    AU  - Essam S. Hussien
    Y1  - 2016/07/05
    PY  - 2016
    N1  - https://doi.org/10.11648/j.ijo.20160201.11
    DO  - 10.11648/j.ijo.20160201.11
    T2  - International Journal of Otorhinolaryngology
    JF  - International Journal of Otorhinolaryngology
    JO  - International Journal of Otorhinolaryngology
    SP  - 1
    EP  - 4
    PB  - Science Publishing Group
    SN  - 2472-2413
    UR  - https://doi.org/10.11648/j.ijo.20160201.11
    AB  - Introduction: Rhinosinusitis is a heterogeneous disease characterized by local inflammation of the upper airways and sinuses. The pathogenesis of chronic rhino sinusitis remains poorly defined. It was recently proposed that Vitamin D deficiency may explain some part of this pattern. The aim of study is to evaluate the effect of vitamin D supplement in patients diagnosed as chronic rhino sinusitis with vitamin D deficiency. Materials and Methods: Prospective study was performed on 57 patients diagnosed as chronic Rhinosinusitis and vitamin D deficiency. Patients received vitamin D3 tablet (1000 IU) daily for one month. Before and after drug intake all patients were asked to fill in a questionnaire in which they rated their overall symptoms. Results: (75.4%) of patients cured from smell disturbance, (22.8%) of patients cured from headache, (21.1%) cured from nasal obstruction and only 7% of patients cured from nasal discharge. (64%) of patients improve (not cured) from nasal obstruction symptoms, (63%) of patients not cure from nasal discharge. Conclusions: Vitamin D supplement shows significant improvement in symptoms of chronic Rhinosinusitis mainly smell disturbance, Vitamin D could be use as adjuvant treatment for Chronic Rhino sinusitis.
    VL  - 2
    IS  - 1
    ER  - 

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Author Information
  • Otolaryngology Department, Medical College, Benghazi University, Senior Specialist in ENT Department, Benghazi Medical Center, Benghazi, Libya

  • Otolaryngology Department, Medical College, Benghazi University, Consultant in ENT Department, Benghazi Medical Center, Benghazi, libya

  • Quality Control Department, Benghazi Medical Center, Benghazi, Libya

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