Amelioration of Endosulfan Induced Hematological Alterations in Mice by <i>Phyllanthus emblica</i> and <i>Withania somnifera</i>

Pryuttma; Parimal K. Khan

doi:doi:10.11648/j.ajbes.20200604.11

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Amelioration of Endosulfan Induced Hematological Alterations in Mice by Phyllanthus emblica and Withania somnifera

Pryuttma, Parimal K. Khan

Published in American Journal of Biological and Environmental Statistics (Volume 6, Issue 4)

Received: 16 August 2020 Accepted: 11 September 2020 Published: 16 November 2020

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Abstract

Endosulfan is a man made insecticide which is highly controversial agrochemical due to its acute toxicity potential for bioaccumulation but still used in large scale in India even though it is being phased out globally. Endosulfan plays a great role in alteration of Hematological status of human beings. The present study was carried out to investigate the acute effects of endosulfan on Hematological parameters such as Erythrocyte count (RBC), Leucocyte count (WBC), percent Hemoglobin (Hb%), Packed cell volume (PCV%) and Mean Corpuscular Volume (MCV) on swiss albino mice. Adult male mice was segregated into four groups, each group with 6 animals. Group I, served as the control was administered with distilled water @0.1 ml/10gb.w; Group II, received endosulfan @3mg/kg b.w; Group III, concomitantly received Phyllanthus emblica; Group IV, concomitantly received Withania somnifera (Ashwagandha) 150 mg/kg b.w along with endosulfan through oral gavaging. All the treatments were continued for 3 months. The toxic effects observed upon endosulfan treatment include Erythrocyte count (RBC) gradually decreased, Leucocyte count (WBC) increased, percent Hemoglobin (Hb%) significantly decreased, Packed cell volume (PCV%) reduced significantly and Mean Corpuscular Volume (MCV) significantly increased. On contrast, treatment of extract of Phyllanthus emblica and Withania somnifera was found to alleviate the toxic consequences of endosulfan, thereby producing ameliorative effect.

Published in	American Journal of Biological and Environmental Statistics (Volume 6, Issue 4)
DOI	10.11648/j.ajbes.20200604.11
Page(s)	64-70
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Endosulfan, Phyllanthus emblica, Withania somnifera, Erythrocyte Count, Leucocyte Count, Hemoglobin, Packed Cell Volume, Mean Corpuscular Volume

References

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APA Style

Pryuttma, Parimal K. Khan. (2020). Amelioration of Endosulfan Induced Hematological Alterations in Mice by Phyllanthus emblica and Withania somnifera. American Journal of Biological and Environmental Statistics, 6(4), 64-70. https://doi.org/10.11648/j.ajbes.20200604.11

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ACS Style

Pryuttma; Parimal K. Khan. Amelioration of Endosulfan Induced Hematological Alterations in Mice by Phyllanthus emblica and Withania somnifera. Am. J. Biol. Environ. Stat. 2020, 6(4), 64-70. doi: 10.11648/j.ajbes.20200604.11

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AMA Style

Pryuttma, Parimal K. Khan. Amelioration of Endosulfan Induced Hematological Alterations in Mice by Phyllanthus emblica and Withania somnifera. Am J Biol Environ Stat. 2020;6(4):64-70. doi: 10.11648/j.ajbes.20200604.11

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@article{10.11648/j.ajbes.20200604.11,
  author = {Pryuttma and Parimal K. Khan},
  title = {Amelioration of Endosulfan Induced Hematological Alterations in Mice by Phyllanthus emblica and Withania somnifera},
  journal = {American Journal of Biological and Environmental Statistics},
  volume = {6},
  number = {4},
  pages = {64-70},
  doi = {10.11648/j.ajbes.20200604.11},
  url = {https://doi.org/10.11648/j.ajbes.20200604.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbes.20200604.11},
  abstract = {Endosulfan is a man made insecticide which is highly controversial agrochemical due to its acute toxicity potential for bioaccumulation but still used in large scale in India even though it is being phased out globally. Endosulfan plays a great role in alteration of Hematological status of human beings. The present study was carried out to investigate the acute effects of endosulfan on Hematological parameters such as Erythrocyte count (RBC), Leucocyte count (WBC), percent Hemoglobin (Hb%), Packed cell volume (PCV%) and Mean Corpuscular Volume (MCV) on swiss albino mice. Adult male mice was segregated into four groups, each group with 6 animals. Group I, served as the control was administered with distilled water @0.1 ml/10gb.w; Group II, received endosulfan @3mg/kg b.w; Group III, concomitantly received Phyllanthus emblica; Group IV, concomitantly received Withania somnifera (Ashwagandha) 150 mg/kg b.w along with endosulfan through oral gavaging. All the treatments were continued for 3 months. The toxic effects observed upon endosulfan treatment include Erythrocyte count (RBC) gradually decreased, Leucocyte count (WBC) increased, percent Hemoglobin (Hb%) significantly decreased, Packed cell volume (PCV%) reduced significantly and Mean Corpuscular Volume (MCV) significantly increased. On contrast, treatment of extract of Phyllanthus emblica and Withania somnifera was found to alleviate the toxic consequences of endosulfan, thereby producing ameliorative effect.},
 year = {2020}
}

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TY  - JOUR
T1  - Amelioration of Endosulfan Induced Hematological Alterations in Mice by Phyllanthus emblica and Withania somnifera
AU  - Pryuttma
AU  - Parimal K. Khan
Y1  - 2020/11/16
PY  - 2020
N1  - https://doi.org/10.11648/j.ajbes.20200604.11
DO  - 10.11648/j.ajbes.20200604.11
T2  - American Journal of Biological and Environmental Statistics
JF  - American Journal of Biological and Environmental Statistics
JO  - American Journal of Biological and Environmental Statistics
SP  - 64
EP  - 70
PB  - Science Publishing Group
SN  - 2471-979X
UR  - https://doi.org/10.11648/j.ajbes.20200604.11
AB  - Endosulfan is a man made insecticide which is highly controversial agrochemical due to its acute toxicity potential for bioaccumulation but still used in large scale in India even though it is being phased out globally. Endosulfan plays a great role in alteration of Hematological status of human beings. The present study was carried out to investigate the acute effects of endosulfan on Hematological parameters such as Erythrocyte count (RBC), Leucocyte count (WBC), percent Hemoglobin (Hb%), Packed cell volume (PCV%) and Mean Corpuscular Volume (MCV) on swiss albino mice. Adult male mice was segregated into four groups, each group with 6 animals. Group I, served as the control was administered with distilled water @0.1 ml/10gb.w; Group II, received endosulfan @3mg/kg b.w; Group III, concomitantly received Phyllanthus emblica; Group IV, concomitantly received Withania somnifera (Ashwagandha) 150 mg/kg b.w along with endosulfan through oral gavaging. All the treatments were continued for 3 months. The toxic effects observed upon endosulfan treatment include Erythrocyte count (RBC) gradually decreased, Leucocyte count (WBC) increased, percent Hemoglobin (Hb%) significantly decreased, Packed cell volume (PCV%) reduced significantly and Mean Corpuscular Volume (MCV) significantly increased. On contrast, treatment of extract of Phyllanthus emblica and Withania somnifera was found to alleviate the toxic consequences of endosulfan, thereby producing ameliorative effect.
VL  - 6
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ER  -

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Author Information

Pryuttma

Department of Zoology, GMRD College Mohanpur Samastipur, LNMU, Darbhanga, India
Parimal K. Khan

Department of Zoology, Patna Science College, Patna University, Patna, India

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Pryuttma, Parimal K. Khan. (2020). Amelioration of Endosulfan Induced Hematological Alterations in Mice by Phyllanthus emblica and Withania somnifera. American Journal of Biological and Environmental Statistics, 6(4), 64-70. https://doi.org/10.11648/j.ajbes.20200604.11

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ACS Style

Pryuttma; Parimal K. Khan. Amelioration of Endosulfan Induced Hematological Alterations in Mice by Phyllanthus emblica and Withania somnifera. Am. J. Biol. Environ. Stat. 2020, 6(4), 64-70. doi: 10.11648/j.ajbes.20200604.11

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AMA Style

Pryuttma, Parimal K. Khan. Amelioration of Endosulfan Induced Hematological Alterations in Mice by Phyllanthus emblica and Withania somnifera. Am J Biol Environ Stat. 2020;6(4):64-70. doi: 10.11648/j.ajbes.20200604.11

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@article{10.11648/j.ajbes.20200604.11,
  author = {Pryuttma and Parimal K. Khan},
  title = {Amelioration of Endosulfan Induced Hematological Alterations in Mice by Phyllanthus emblica and Withania somnifera},
  journal = {American Journal of Biological and Environmental Statistics},
  volume = {6},
  number = {4},
  pages = {64-70},
  doi = {10.11648/j.ajbes.20200604.11},
  url = {https://doi.org/10.11648/j.ajbes.20200604.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbes.20200604.11},
  abstract = {Endosulfan is a man made insecticide which is highly controversial agrochemical due to its acute toxicity potential for bioaccumulation but still used in large scale in India even though it is being phased out globally. Endosulfan plays a great role in alteration of Hematological status of human beings. The present study was carried out to investigate the acute effects of endosulfan on Hematological parameters such as Erythrocyte count (RBC), Leucocyte count (WBC), percent Hemoglobin (Hb%), Packed cell volume (PCV%) and Mean Corpuscular Volume (MCV) on swiss albino mice. Adult male mice was segregated into four groups, each group with 6 animals. Group I, served as the control was administered with distilled water @0.1 ml/10gb.w; Group II, received endosulfan @3mg/kg b.w; Group III, concomitantly received Phyllanthus emblica; Group IV, concomitantly received Withania somnifera (Ashwagandha) 150 mg/kg b.w along with endosulfan through oral gavaging. All the treatments were continued for 3 months. The toxic effects observed upon endosulfan treatment include Erythrocyte count (RBC) gradually decreased, Leucocyte count (WBC) increased, percent Hemoglobin (Hb%) significantly decreased, Packed cell volume (PCV%) reduced significantly and Mean Corpuscular Volume (MCV) significantly increased. On contrast, treatment of extract of Phyllanthus emblica and Withania somnifera was found to alleviate the toxic consequences of endosulfan, thereby producing ameliorative effect.},
 year = {2020}
}

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TY  - JOUR
T1  - Amelioration of Endosulfan Induced Hematological Alterations in Mice by Phyllanthus emblica and Withania somnifera
AU  - Pryuttma
AU  - Parimal K. Khan
Y1  - 2020/11/16
PY  - 2020
N1  - https://doi.org/10.11648/j.ajbes.20200604.11
DO  - 10.11648/j.ajbes.20200604.11
T2  - American Journal of Biological and Environmental Statistics
JF  - American Journal of Biological and Environmental Statistics
JO  - American Journal of Biological and Environmental Statistics
SP  - 64
EP  - 70
PB  - Science Publishing Group
SN  - 2471-979X
UR  - https://doi.org/10.11648/j.ajbes.20200604.11
AB  - Endosulfan is a man made insecticide which is highly controversial agrochemical due to its acute toxicity potential for bioaccumulation but still used in large scale in India even though it is being phased out globally. Endosulfan plays a great role in alteration of Hematological status of human beings. The present study was carried out to investigate the acute effects of endosulfan on Hematological parameters such as Erythrocyte count (RBC), Leucocyte count (WBC), percent Hemoglobin (Hb%), Packed cell volume (PCV%) and Mean Corpuscular Volume (MCV) on swiss albino mice. Adult male mice was segregated into four groups, each group with 6 animals. Group I, served as the control was administered with distilled water @0.1 ml/10gb.w; Group II, received endosulfan @3mg/kg b.w; Group III, concomitantly received Phyllanthus emblica; Group IV, concomitantly received Withania somnifera (Ashwagandha) 150 mg/kg b.w along with endosulfan through oral gavaging. All the treatments were continued for 3 months. The toxic effects observed upon endosulfan treatment include Erythrocyte count (RBC) gradually decreased, Leucocyte count (WBC) increased, percent Hemoglobin (Hb%) significantly decreased, Packed cell volume (PCV%) reduced significantly and Mean Corpuscular Volume (MCV) significantly increased. On contrast, treatment of extract of Phyllanthus emblica and Withania somnifera was found to alleviate the toxic consequences of endosulfan, thereby producing ameliorative effect.
VL  - 6
IS  - 4
ER  -

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