American Journal of Pediatrics

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Drug-Induced Liver Diseases in Children and Adolescents

Received: 09 March 2019    Accepted: 22 April 2019    Published: 20 May 2019
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Abstract

Many drugs (now it’s known more than 1200) are associated with hepatic side effects. Children (especially newborns and infants) are unique population with specific characteristics of absorption, metabolism and elimination of drugs that can predispose to hepatotoxicity. Aim of this review is to estimate risk factors of hepatotoxicity related to the patients’ peculiarities and drug itself, also to describe some mechanisms and types of drug-induced liver disease (DILD) and beside this to offer some methods of the treatment and prevention of hepatotoxicity. In children the most often mentioned drugs caused DILD are antibiotics, psychotropics and NSAIDs and the main type of DILD is acute hepatitis with mortality of 10%. To conclude it’s highly important to monitor activity of hepatic enzymes (ALT, AST, AP) during treatment by potentially hepatotoxic drugs in patients from risk groups (early age, any liver disease, diabetes mellitus, obesity, poor nutritional status) in order to timely withdraw offending drug and prescribe hepatoprotectors or even perform liver transplantation.

DOI 10.11648/j.ajp.20190502.14
Published in American Journal of Pediatrics (Volume 5, Issue 2, June 2019)
Page(s) 56-63
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Drug and Liver Disease, Risk Factors of Hepatotoxicity, Mechanisms and Types of DILD, Hepatoprotectors, Prevention of DILD

References
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Author Information
  • Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation

  • Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation

  • Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation

  • Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation

  • Chair of Clinical Pharmacology, Russian National Research Medical University Named After Pirogov, Moscow, Russian Federation

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  • APA Style

    Sergey Postnikov, Nataliya Teplova, Aleksey Ermilin, Anna Gratzhianskaya, Marya Kostyleva. (2019). Drug-Induced Liver Diseases in Children and Adolescents. American Journal of Pediatrics, 5(2), 56-63. https://doi.org/10.11648/j.ajp.20190502.14

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    ACS Style

    Sergey Postnikov; Nataliya Teplova; Aleksey Ermilin; Anna Gratzhianskaya; Marya Kostyleva. Drug-Induced Liver Diseases in Children and Adolescents. Am. J. Pediatr. 2019, 5(2), 56-63. doi: 10.11648/j.ajp.20190502.14

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    AMA Style

    Sergey Postnikov, Nataliya Teplova, Aleksey Ermilin, Anna Gratzhianskaya, Marya Kostyleva. Drug-Induced Liver Diseases in Children and Adolescents. Am J Pediatr. 2019;5(2):56-63. doi: 10.11648/j.ajp.20190502.14

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  • @article{10.11648/j.ajp.20190502.14,
      author = {Sergey Postnikov and Nataliya Teplova and Aleksey Ermilin and Anna Gratzhianskaya and Marya Kostyleva},
      title = {Drug-Induced Liver Diseases in Children and Adolescents},
      journal = {American Journal of Pediatrics},
      volume = {5},
      number = {2},
      pages = {56-63},
      doi = {10.11648/j.ajp.20190502.14},
      url = {https://doi.org/10.11648/j.ajp.20190502.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajp.20190502.14},
      abstract = {Many drugs (now it’s known more than 1200) are associated with hepatic side effects. Children (especially newborns and infants) are unique population with specific characteristics of absorption, metabolism and elimination of drugs that can predispose to hepatotoxicity. Aim of this review is to estimate risk factors of hepatotoxicity related to the patients’ peculiarities and drug itself, also to describe some mechanisms and types of drug-induced liver disease (DILD) and beside this to offer some methods of the treatment and prevention of hepatotoxicity. In children the most often mentioned drugs caused DILD are antibiotics, psychotropics and NSAIDs and the main type of DILD is acute hepatitis with mortality of 10%. To conclude it’s highly important to monitor activity of hepatic enzymes (ALT, AST, AP) during treatment by potentially hepatotoxic drugs in patients from risk groups (early age, any liver disease, diabetes mellitus, obesity, poor nutritional status) in order to timely withdraw offending drug and prescribe hepatoprotectors or even perform liver transplantation.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Drug-Induced Liver Diseases in Children and Adolescents
    AU  - Sergey Postnikov
    AU  - Nataliya Teplova
    AU  - Aleksey Ermilin
    AU  - Anna Gratzhianskaya
    AU  - Marya Kostyleva
    Y1  - 2019/05/20
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ajp.20190502.14
    DO  - 10.11648/j.ajp.20190502.14
    T2  - American Journal of Pediatrics
    JF  - American Journal of Pediatrics
    JO  - American Journal of Pediatrics
    SP  - 56
    EP  - 63
    PB  - Science Publishing Group
    SN  - 2472-0909
    UR  - https://doi.org/10.11648/j.ajp.20190502.14
    AB  - Many drugs (now it’s known more than 1200) are associated with hepatic side effects. Children (especially newborns and infants) are unique population with specific characteristics of absorption, metabolism and elimination of drugs that can predispose to hepatotoxicity. Aim of this review is to estimate risk factors of hepatotoxicity related to the patients’ peculiarities and drug itself, also to describe some mechanisms and types of drug-induced liver disease (DILD) and beside this to offer some methods of the treatment and prevention of hepatotoxicity. In children the most often mentioned drugs caused DILD are antibiotics, psychotropics and NSAIDs and the main type of DILD is acute hepatitis with mortality of 10%. To conclude it’s highly important to monitor activity of hepatic enzymes (ALT, AST, AP) during treatment by potentially hepatotoxic drugs in patients from risk groups (early age, any liver disease, diabetes mellitus, obesity, poor nutritional status) in order to timely withdraw offending drug and prescribe hepatoprotectors or even perform liver transplantation.
    VL  - 5
    IS  - 2
    ER  - 

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