Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options
American Journal of Pediatrics
Volume 5, Issue 4, December 2019, Pages: 291-298
Received: Nov. 12, 2019;
Accepted: Dec. 12, 2019;
Published: Dec. 24, 2019
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Zhendong Yang, Department of Respiratory Asthma, Beijing Jingdu Children's Hospital, Beijing, China
Xuding Sun, Department of Respiratory Asthma, Beijing Jingdu Children's Hospital, Beijing, China
Jihong Wu, Department of Respiratory Asthma, Beijing Jingdu Children's Hospital, Beijing, China
Gaojun Zhou, Department of Respiratory Asthma, Beijing Jingdu Children's Hospital, Beijing, China
Yingyang Xu, Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Clinical Immunology Center, Chinese Academy of Medical Sciences, Beijing, China
Xiong Xie, Department of Pediatrics, Third Clinical Medical College of Three Gorges University (Gezhouba Central Hospital), Yichang, China
Kai Guan, Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Clinical Immunology Center, Chinese Academy of Medical Sciences, Beijing, China
Vitamin D not only promotes the health of human bones and muscles but also has an important impact on the metabolism of extraskeletal tissues. As a steroid hormone, vitamin D possesses important physiological functions, including cell differentiation and proliferation and immune regulation. Research has shown that vitamin D insufficiency (VDI) or vitamin D deficiency (VDD) can make children susceptible to asthma. Vitamin D has important immunoregulatory functions associated with preventing the occurrence of asthma or the worsening of its symptoms, improving lung function and enhancing glucocorticoid (GCS) action. An increasing number of randomized controlled intervention studies have confirmed that vitamin D affects the occurrence and development of asthmatic diseases. In recent years, accumulating laboratory and clinical research has supported the use of vitamin D as an adjuvant treatment for asthma and has achieved good clinical results. But the clinical outcome of vitamin D in the treatment of asthma is not as impressive as experimental studies. In addition to the complexity of clinical research, it may be related to clinical application methods. In order to combine theory with clinical practice, focused on exploring and selecting the most effective vitamin D adjuvant treatment of asthma, and comprehensively optimizing and applying these methods is beneficial to improve the therapeutic effect. However, there are different opinions regarding the results of the studies.
Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options, American Journal of Pediatrics.
Vol. 5, No. 4,
2019, pp. 291-298.
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